Article
Neurosciences
Shuo Xu, Wenfei Wang, Si Chen, Qianqian Wu, Chao Li, Xiangyu Ma, Teng Chen, Weiguo Li, Shujun Xu
Summary: This study evaluated the incidence and risk factors of deep brain stimulation (DBS)-associated complications in patients with advanced Parkinson's disease. The results showed that comorbid medical conditions, hypertension, early-stage operation, and unilateral electrode implantation were identified as risk factors for overall complications. As the annual number of DBS procedures increased, the incidence of complications decreased, and there was a strong correlation between surgical complications and unplanned readmission.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Neurosciences
Pietro Zeppa, Marco Fraccalvieri, Chiara Fronda, Enrico Lo Bue, Laura Rizzi, Virginia Caliendo, Michele Maria Lanotte
Summary: Skin erosion is a common complication of deep brain stimulation (DBS), which can be managed conservatively or with invasive surgical techniques. In some cases, a flap can be used to cover the implant, but removal of the implant may still be necessary, leading to worsening of symptoms. The treatment of skin erosion requires careful consideration.
Article
Clinical Neurology
Domenico Servello, Tommaso Francesco Galbiati, Guglielmo Iess, Brigida Minafra, Mauro Porta, Claudio Pacchetti
Summary: This study analyzed the complications of deep brain stimulation (DBS) procedures and found that DBS is generally a safe procedure, but further research is needed to reduce the occurrence of complications related to surgical technique and hardware design.
ACTA NEUROCHIRURGICA
(2023)
Review
Medicine, General & Internal
Marwan Hariz, Patric Blomstedtl
Summary: Parkinson's disease is a progressive neurodegenerative illness with motor and nonmotor symptoms. Deep brain stimulation is an effective symptomatic treatment that can be tailored to individual patients. DBS has significant effects on tremors, rigidity, and dyskinesias, but less responsive for axial symptoms. Specialized multidisciplinary teams are required for DBS in PD.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Clinical Neurology
Martin M. Reich, Joey Hsu, Michael Ferguson, Frederic L. W. V. J. Schaper, Juho Joutsa, Jonas Roothans, Robert C. Nickl, Anneke Frankemolle-Gilbert, Jay Alberts, Jens Volkmann, Michael D. Fox
Summary: The study demonstrates that the decline in cognitive function caused by deep brain stimulation (DBS) is related to the connectivity between the stimulation site and a specific brain network associated with memory impairment. Transforming this network into a heat map can help identify DBS patients at risk of delayed-onset side-effects and guide reprogramming efforts.
Article
Clinical Neurology
Jiping Li, Shanshan Mei, Xiaofei Jia, Yuqing Zhang
Summary: This study demonstrates that deep brain stimulation can effectively suppress levodopa-induced dyskinesia in Parkinson's disease patients without reducing levodopa dosage. The stimulation sites with good anti-dyskinesia effect are located above the subthalamic nucleus.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Abteen Mostofi, Francesca Morgante, Mark J. Edwards, Peter Brown, Erlick A. C. Pereira
Summary: Pain in Parkinson's disease is often untreated due to lack of understanding of its mechanisms. Deep brain stimulation of the subthalamic nucleus has shown potential in treating pain, but the exact type of pain it benefits and how it interferes with pain processing remain unclear.
Review
Clinical Neurology
Hengameh Zahed, Jose Rafael Pantoja Zuzuarregui, Ro'ee Gilron, Timothy Denison, Philip A. Starr, Simon Little
Summary: Sleep disturbances are common nonmotor complications of Parkinson's disease, potentially contributing to disease progression. Limited options currently exist to modulate sleep disturbances, prompting the need for further research into neurophysiological changes affecting sleep in PD.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Lais M. Oliveira, Marta Ruiz-Lopez, Alexandre Boutet, Gavin J. B. Elias, Suneil K. Kalia, Mojgan Hodaie, Andres M. Lozano, Renato P. Munhoz, Alfonso Fasano
Summary: The study found that using the advanced functions of the patient programmer delays programming optimization and is associated with a higher number of side effects. Therefore, there is a need for other faster and safer stimulation programming methods.
Article
Clinical Neurology
Michele Mainardi, Dario Ciprietti, Manuela Pilleri, Giulia Bonato, Luca Weis, Valeria Cianci, Roberta Biundo, Florinda Ferreri, Massimo Piacentino, Andrea Landi, Andrea Guerra, Angelo Antonini
Summary: This study retrospectively reviewed the clinical efficacy outcomes of 48 DBS-implanted patients and found that both STN-DBS and GPi-DBS are effective in improving motor symptoms severity and complications. However, GPi-DBS has a greater impact on motor fluctuations and motor experiences of daily living.
NEUROLOGICAL SCIENCES
(2023)
Review
Psychology, Multidisciplinary
Joshua A. Wilt, Amanda R. Merner, Jaclyn Zeigler, Michelle Montpetite, Cynthia S. Kubu
Summary: Deep Brain Stimulation (DBS) is a safe and effective treatment for Parkinson's Disease (PD) in improving motor symptoms, but concerns about its effects on patients' personality remain. Research shows that while there is little evidence of changes in dispositional traits following DBS, there is some positive progress in characteristic adaptations. Further research is needed in exploring the impact on narrative identity after DBS treatment for PD.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Clinical Neurology
Gian D. Pal, Daniel M. Corcos, Leo Verhagen Metman, Zvi Israel, Hagai Bergman, David Arkadir
Summary: Genetic subtyping of patients with Parkinson's disease may help predict the cognitive and motor outcomes of subthalamic deep brain stimulation. However, there are still controversies and gaps in understanding the effects of STN-DBS on PD patients with pathogenic variants in the GBA1 gene. Further research is needed to determine the clinical significance, risk-to-benefit ratio, and strategies to minimize the negative effects of STN-DBS. Genetic testing for GBA1 may be considered in PD patients considering DBS to properly assess the potential risks and benefits.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Khaled Moussawi, Min Jae Kim, Sydney Baybayan, Myles Wood, Kelly A. Mills
Summary: The study investigated the behavioral responses of Parkinson's disease patients under globus pallidus internus DBS settings, revealing a negative correlation between the volume of tissue activation connected to the right prefrontal cortex and impulsivity, while greater overlap with the non-prefrontally-connected globus pallidus internus was associated with increased impulsivity.
Article
Medicine, General & Internal
Tianqi Hu, Hutao Xie, Yu Diao, Houyou Fan, Delong Wu, Yifei Gan, Fangang Meng, Yutong Bai, Jianguo Zhang
Summary: This study aimed to investigate the effects of STN-DBS on PD patients with different levels of depression and identify predictors of these effects. The results showed that patients with moderate depression had better improvement, and gender (female) and preoperative HAMA scores were predictors of the effects of STN-DBS on PD depression.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Neurosciences
Faisal Alosaimi, Jackson Tyler Boonstra, Sonny Tan, Yasin Temel, Ali Jahanshahi
Summary: DBS is a successful paradigm for treating movement disorders, but its specific mechanisms and effects on neurotransmitter dynamics are still not fully understood. This review discusses the role of neurotransmitter dynamics in mediating DBS effects in Parkinson's disease.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Computer Science, Interdisciplinary Applications
Rick van Veen, Vita Gurvits, Rosalie Kogan, Sanne K. Meles, Gert-Jan de Vries, Remco J. Renken, Maria C. Rodriguez-Oroz, Rafael Rodriguez-Rojas, Dario Arnaldi, Stefano Raffa, Bauke M. de Jong, Klaus L. Leenders, Michael Biehl
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2020)
Editorial Material
Clinical Neurology
Oihana Errea, Maria Cruz Rodriguez-Oroz
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Shenghong He, Fahd Baig, Abteen Mostofi, Alek Pogosyan, Jean Debarros, Alexander L. Green, Tipu Z. Aziz, Erlick Pereira, Peter Brown, Huiling Tan
Summary: The study proposed an innovative approach for essential tremor treatment by detecting tremor-provoking movements and delivering stimulation in real-time, achieving effective therapeutic outcomes. Results showed a high percentage of stimulation time when tremors were triggered, with tremor suppression achieved while conserving energy.
MOVEMENT DISORDERS
(2021)
Editorial Material
Clinical Neurology
Wolf-Julian Neumann, Maria C. Rodriguez-Oroz
MOVEMENT DISORDERS
(2021)
Article
Cell Biology
Karol M. Cordoba, Irantzu Serrano-Mendioroz, Daniel Jerico, Maria Merino, Lei Jiang, Ana Sampedro, Manuel Alegre, Fernando Corrales, Maria J. Garrido, Paolo G. Martini, Jose Luis Lanciego, Jesus Prieto, Pedro Berraondo, Antonio Fontanellas
Summary: The administration of a recombinant protein, rhApoAI-PBGD, is shown to enhance hepatic enzymatic activity and protect against acute attacks of AIP.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Review
Clinical Neurology
Antonio Martin-Bastida, Manuel Delgado-Alvarado, Irene Navalpotro-Gomez, Maria Cruz Rodriguez-Oroz
Summary: Dementia, mild cognitive impairment, and neuropsychiatric symptoms are common non-motor symptoms of Parkinson's disease. Neuroimaging studies play a critical role in early diagnosis, monitoring, and understanding the pathophysiology of cognitive and neuropsychiatric symptoms associated with PD. This literature review provides an update on the latest neuroimaging findings for assessing cognitive dysfunction and impulse control disorders in PD.
FRONTIERS IN NEUROLOGY
(2021)
Article
Environmental Sciences
William D. Moscoso-Barrera, Elena Urrestarazu, Manuel Alegre, Alejandro Horrillo-Maysonnial, Luis Fernando Urrea, Luis Mauricio Agudelo-Otalora, Luis F. Giraldo-Cadavid, Secundino Fernandez, Javier Burguete
Summary: This study focuses on the development of a simple and autonomous processing system for detecting obstructive sleep apnea. The system analyzes polysomnography signals and shows good estimation of awake/sleep states and apneas/hypopneas, making it suitable for possible OSA treatments.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Neuroimaging
Teresa Esteban-Penalba, Pedro M. Paz-Alonso, Irene Navalpotro-Gomez, Maria C. Rodriguez-Oroz
Summary: Our findings indicate that PD patients with ICD completed the inhibition task correctly, showing altered engagement of inhibitory and attentional areas. During proactive inhibition they showed bilateral hyperactivation of two inhibitory regions, while during restrained inhibition they showed additional involvement of attentional areas responsible for alerting and orienting.
NEUROIMAGE-CLINICAL
(2021)
Meeting Abstract
Clinical Neurology
J. Carte-Garcia, A. Gorospe, I. Aviles, A. Martin-Bastida, O. Parras, A. Arcadi, M. Fernandez, L. Gonzalez, J. Guridi, M. C. Rodriguez-Oroz
MOVEMENT DISORDERS
(2021)
Meeting Abstract
Clinical Neurology
T. Esteban-Penalba, P. Paz-Alonso, I. Navalpotro-Gomez, M. Rodriguez-Oroz
MOVEMENT DISORDERS
(2021)
Meeting Abstract
Clinical Neurology
I. Aviles-Olmos, A. Martin-Bastida, A. Gorospe-Osinalde, J. Carte-Garcia, P. Manrique, A. Arcadi, O. Parras, M. Fernandez-Martinez, L. Armengou-Garcia, L. Gonzalez-Quarante, J. Guridi, M. C. Rodriguez-Oroz
MOVEMENT DISORDERS
(2021)
Meeting Abstract
Clinical Neurology
S. Basaia, F. Agosta, I. Diez Palacio, E. Bueicheku, F. d'Oleire Uquillas, M. Delgado-Alvarado, C. Caballero-Gaudes, M. Rodriguez-Oroz, T. Stojkovic, V. Kostic, M. Filippi, J. Sepulcre
MOVEMENT DISORDERS
(2021)
Review
Psychology, Multidisciplinary
Angela Milan-Tomas, Marta Fernandez-Matarrubia, Maria Cruz Rodriguez-Oroz
Summary: Lewy body dementias (LBDs) comprise dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD), sharing neuropathological features. Updated diagnostic criteria now include biomarker information, with the major clinical distinction being the time interval of dementia onset relative to parkinsonism.
BEHAVIORAL SCIENCES
(2021)
Article
Clinical Neurology
Elena Cacho-Asenjo, Cristina Honorato-Cia, Jorge M. Nunez-Cordoba, Miguel Fernandez-Martinez, Lain H. Gonzalez-Quarante, Iciar Aviles-Olmos, Maria Aranzazu Gorospe, Alfredo Panadero, Maria Cruz Rodriguez-Oroz, Jorge Guridi, Antonio Martinez-Simon
Summary: Headache was associated with skull density ratio and thickness, while nausea was related to sex. Women had higher odds of experiencing nausea compared to men. Dexmedetomidine did not reduce headache or nausea, but increased the number and duration of sonications.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2021)
Meeting Abstract
Clinical Neurology
P. Manrique-de-Lara, J. A. Martin, I. Aviles, A. Gorospe, J. Guridi, L. Gonzalez, M. Alegre, G. Besne, M. C. Rodriguez-Oroz
MOVEMENT DISORDERS
(2020)
Article
Clinical Neurology
Jun-Pyo Hong, Hanim Kwon, Euyhyun Park, Sun-Uk Lee, Chan-Nyoung Lee, Byung-Jo Kim, Ji-Soo Kim, Kun-Woo Park
Summary: In patients with mild-to-moderate PD, vestibular function assessed by video head-impulse tests appears relatively preserved and has minimal impact on the risk of falls. Risk of postural instability is associated with the severity of clinical symptoms in PD.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yaqin Xiang, XiuRong Huang, Qian Xu, Zhenhua Liu, Yase Chen, Qiying Sun, Junling Wang, Hong Jiang, Lu Shen, Xinxiang Yan, Beisha Tang, Jifeng Guo
Summary: Using the novel data-driven method DEBM, this study determined the sequence of several common biomarker changes in Parkinson's disease (PD). The left putamen was found to be the earliest biomarker to become abnormal, followed by the right putamen, CSF alpha-synuclein, right caudate, left caudate, and serum NfL. The estimated disease stages showed significant differences between PD and healthy controls, and achieved a high accuracy for distinguishing PD from HC.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yan Li, David J. McLernon, Carl E. Counsell, Angus D. Macleod
Summary: This study aimed to investigate the incidence and risk factors for institutionalisation in Parkinson's disease (PD) and atypical parkinsonism (AP). The study found that institutionalisation was more frequent in AP compared to PD and controls. Age, poorer cognition, and more-severe parkinsonian impairment were independent predictors of institutionalisation.
PARKINSONISM & RELATED DISORDERS
(2024)