Article
Multidisciplinary Sciences
Andreas Horn, Martin M. Reich, Siobhan Ewert, Ningfei Li, Bassam Al-Fatly, Florian Lange, Jonas Roothans, Simon Oxenford, Isabel Horn, Steffen Paschen, Joachim Runge, Fritz Wodarg, Karsten Witt, Robert C. Nickl, Matthias Wittstock, Gerd-Helge Schneider, Philipp Mahlknecht, Werner Poewe, Wilhelm Eisner, Ann-Kristin Helmers, Cordula Matthies, Joachim K. Krauss, Gunther Deuschl, Jens Volkmann, Andrea A. Kuhn
Summary: This study retrospectively investigated the clinical results of deep brain stimulation (DBS) for cervical and generalized dystonia in 80 patients. The researchers modeled the optimal stimulation sites based on imaging and found that the optimal treatment for cervical dystonia involved modulation of the striatopallidofugal axis, while pallidothalamic bundles were responsible for optimal treatment of generalized dystonia. Additionally, the study showed a common network substrate in the form of connectivity to the cerebellum and somatomotor cortex for both types of dystonia.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Neurosciences
Chun-Hwei Tai, Sheng-Hong Tseng
Summary: Deep brain stimulation (DBS) is an effective treatment for various movement disorders, but some disorders do not respond well to current DBS therapy. Recent studies have suggested that cerebellar DBS may be beneficial for these non-responsive movement disorders. This article reviews the clinical data of cerebellar DBS, including indications, surgical targets, programming details, and outcomes, and discusses the potential mechanism of action. The study of new DBS targets in the cerebellum is important for a comprehensive treatment of movement disorders.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Clinical Neurology
Lindsay Niccolai, Stephen L. Aita, Harrison C. Walker, Victor A. Del Bene, Adam Gerstenecker, Dario Marotta, Meredith Gammon, Roy C. Martin, Olivio J. Clay, Michael Crowe, Kristen L. Triebel
Summary: This study examined the impact of pre-operative demographic, medical, and cognitive/behavioral variables on the Deep Brain Stimulation (DBS) consensus conference decisions in patients with primary dystonia. The findings showed that patients deemed ineligible for DBS surgery generally had higher cardiac risk and lower cognitive functioning.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2021)
Article
Clinical Neurology
Maximilian U. Friedrich, Hazem Eldebakey, Jonas Roothans, Philipp Capetian, Andreas Zwergal, Jens Volkmann, Martin Reich
Summary: This study investigated the combined vestibular, ocular motor and postural syndrome induced by deep brain stimulation in a patient with Parkinson's disease. The results showed that stimulation of the INC region could lead to various symptoms, including ocular tilt reaction, body lateropulsion, and torsional nystagmus. The study also found that the symptom-associated tissue activation overlapped with the dorsal ZI and the ipsilateral vestibulothalamic tract.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Xian Qiu, Tingting Peng, Zhengyu Lin, Kaiwen Zhu, Yuhan Wang, Bomin Sun, Keyoumars Ashkan, Chencheng Zhang, Dianyou Li
Summary: Most Chinese PD patients treated with DBS were satisfied with their choice of IPGs. Economic status and the remote programming function of the device were the two most critical factors influencing patients' decisions. The skill of recharging the IPG was easy to master for most patients.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Frhan Alanazi, Tameem M. Al-Ozzi, Suneil K. Kalia, Mojgan Hodaie, Andres M. Lozano, Melanie Cohn, William D. Hutchison
Summary: Parkinson's disease can be associated with cognitive impairment and dementia. Deep brain stimulation of different brain nuclei may have varying effects on cognitive decline, with the GPi being a potentially preferred target. Research on biomarkers for cognitive decline in Parkinson's disease patients may be hindered by a lack of understanding of the role of basal ganglia nuclei in cognitive processing. Neuronal activity in the GPi was found to be modulated during an auditory attention task, suggesting the involvement of GPi in non-motor cognitive tasks and potential cognitive changes post-DBS.
NEUROBIOLOGY OF DISEASE
(2021)
Review
Clinical Neurology
Mitch R. Paro, Michal Dyrda, Srinath Ramanan, Grant Wadman, Stacey -Ann Burke, Isabella Cipollone, Cory Bosworth, Sarah Zurek, Patrick B. Senatus
Summary: This systematic review summarizes the case studies of deep brain stimulation (DBS) for poststroke movement disorders. The results suggest that DBS may be an effective and safe option for improving function in patients with movement disorders after a stroke, even years after the initial event.
JOURNAL OF NEUROSURGERY
(2023)
Article
Clinical Neurology
Aaron Loh, David Gwun, Clement T. Chow, Alexandre Boutet, Jordy Tasserie, Jurgen Germann, Brendan Santyr, Gavin Elias, Kazuaki Yamamoto, Can Sarica, Artur Vetkas, Ajmal Zemmar, Radhika Madhavan, Alfonso Fasano, Andres M. Lozano
Summary: This article provides a comprehensive overview of studies that have used fMRI during active DBS to investigate its effects on various disorders. It discusses the stimulated brain regions, experimental designs, and insights gained from stimulation-induced fMRI responses.
Article
Clinical Neurology
Laura A. Gilbert, Darcy L. Fehlings, Paul Gross, Michael C. Kruer, Wendy Kwan, Jonathan W. Mink, Michele Shusterman, Bhooma R. Aravamuthan
Summary: Dystonia in cerebral palsy is a common and debilitating condition that has received little research attention. A community-driven research agenda was developed using input from the cerebral palsy community, researchers, and clinicians. The top-prioritized research themes included developing new treatments, assessing various management approaches, improving diagnosis and severity assessments, and increasing family awareness.
Article
Clinical Neurology
Matteo Guidetti, Sara Marceglia, Aaron Loh, Irene E. Harmsen, Sara Meoni, Guglielmo Foffani, Andres M. Lozano, Elena Moro, Jens Volkmann, Alberto Priori
Summary: Adaptive deep brain stimulation (aDBS) shows promise in treating movement disorders, but its application in cognitive and psychiatric disorders remains challenging.
Article
Clinical Neurology
Hicham El Otmani, Bouchra El Moutawakil, Mohamed Daghi, Omar Fadili, Ilham Slassi, Abdessamad El Azhari, Fatiha Essodegui, Lahoucine Barrou, Mohammed Abdoh Rafai, Abdelhakim Lakhdar
Summary: This study reports the experience of Ibn Rochd University Hospital in Morocco in treating dystonia using deep brain stimulation (DBS). The results show that DBS treatment can effectively improve symptoms in patients, but there may be some complications related to the surgery.
PEDIATRIC NEUROLOGY
(2023)
Article
Neurosciences
Zixiao Yin, Yin Jiang, Timon Merk, Wolf-Julian Neumann, Ruoyu Ma, Qi An, Yutong Bai, Baotian Zhao, Yichen Xu, Houyou Fan, Quan Zhang, Guofan Qin, Ning Zhang, Jun Ma, Hua Zhang, Huanguang Liu, Lin Shi, Anchao Yang, Fangang Meng, Guanyu Zhu, Jianguo Zhang
Summary: This study found that the oscillatory pattern of the pallidum in multiple movement disorders changes during sleep, and these changes can be used to differentiate sleep stages. Machine learning approaches can classify sleep stages in patients with different diseases based on the pallidal oscillatory features. These findings have broad translational prospects for the development of adaptive deep brain stimulation systems targeting sleep problems.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Biotechnology & Applied Microbiology
Ro'ee Gilron, Simon Little, Randy Perrone, Robert Wilt, Coralie de Hemptinne, Maria S. Yaroshinsky, Caroline A. Racine, Sarah S. Wang, Jill L. Ostrem, Paul S. Larson, Doris D. Wang, Nick B. Galifianakis, Ian O. Bledsoe, Marta San Luciano, Heather E. Dawes, Gregory A. Worrell, Vaclav Kremen, David A. Borton, Timothy Denison, Philip A. Starr
Summary: The use of an implantable two-way neural interface enables wireless neural monitoring and stimulation for up to 15 months following implantation. This technological approach may have wide applicability to brain disorders treatable by invasive neuromodulation.
NATURE BIOTECHNOLOGY
(2021)
Article
Neurosciences
Jana Peeters, Tine Van Bogaert, Alexandra Boogers, Till Anselm Dembek, Robin Gransier, Jan Wouters, Wim Vandenberghe, Philippe De Vloo, Bart Nuttin, Myles Mc Laughlin
Summary: This study aims to investigate whether combining DBS-evoked potentials (EPs) with imaging can predict the optimal contact configuration for deep brain stimulation (DBS) in patients with Parkinson's disease (PD). The results showed that EPs can accurately predict the best contact configuration, outperforming random contact selection. These prediction tools could potentially simplify the programming of DBS for PD patients.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Xian Qiu, Yuhan Wang, Zhengyu Lin, Yunhao Wu, Wenying Xu, Yiwen Wu, Bomin Sun, Keyoumars Ashkan, Chencheng Zhang, Dianyou Li
Summary: The study evaluated patient preferences and satisfaction with rechargeable and non-rechargeable batteries for IPGs after DBS treatment. Most patients were satisfied with the treatment and implanted device, with economic factors influencing their choice of battery. Confidence in recharging the battery was high among patients with r-IPGs, but more training sessions may be needed to improve understanding of the process.
FRONTIERS IN NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Anna Kamieniarz, Justyna Michalska, Wojciech Marszalek, Magdalena Stania, Kajetan J. Slomka, Agnieszka Gorzkowska, Grzegorz Juras, Michael S. Okun, Evangelos A. Christou
Summary: Balance changes in early and moderate stage PD were quantified and compared to healthy controls using clinical assessments and posturography. Power spectral density of the center of pressure differentiated PD stages, indicating early balance deficits. Larger sample sizes are needed to confirm these findings.
Letter
Gastroenterology & Hepatology
Bhavana Patel, Joseph Legacy, Michael S. Okun, Karen Wheeler-Hegland, Nicole E. Herndon
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Psychology, Clinical
Adrianna M. Ratajska, Francesca Lopez, Lauren Kenney, Charles Jacobson, Kelly D. Foote, Michael S. Okun, Dawn Bowers
Summary: The study identified three cognitive subtypes of ET patients undergoing DBS, with 27.4% meeting criteria for MCI. The majority of MCI cases were in the Low Executive or Low Memory Multi-Domain groups, with the latter having a higher percentage of members classified as MCI. Future work should focus on examining these subgroups for progression to dementia.
CLINICAL NEUROPSYCHOLOGIST
(2022)
Article
Psychology, Multidisciplinary
Adrianna M. Ratajska, Anne N. Nisenzon, Francesca Lopez, Alexandra L. Clark, Didem Gokcay, Michael S. Okun, Dawn Bowers
Summary: The study found that patients with left-sided symptom onset in Parkinson's disease were slower to initiate anger and happiness facial expressions compared to patients with right-sided symptom onset and healthy controls.
Editorial Material
Biochemistry & Molecular Biology
Veerle Visser-Vandewalle, Pablo Andrade, Philip E. Mosley, Benjamin D. Greenberg, Rick Schuurman, Nicole C. McLaughlin, Valerie Voon, Paul Krack, Kelly D. Foote, Helen S. Mayberg, Martijn Figee, Brian H. Kopell, Mircea Polosan, Eileen M. Joyce, Stephan Chabardes, Keith Matthews, Juan C. Baldermann, Himanshu Tyagi, Paul E. Holtzheimer, Chris Bervoets, Clement Hamani, Carine Karachi, Damiaan Denys, Ludvic Zrinzo, Patric Blomstedt, Matilda Naesstrom, Aviva Abosch, Steven Rasmussen, Volker A. Coenen, Thomas E. Schlaepfer, Darin D. Dougherty, Philippe Domenech, Peter Silburn, James Giordano, Andres M. Lozano, Sameer A. Sheth, Terry Coyne, Jens Kuhn, Luc Mallet, Bart Nuttin, Marwan Hariz, Michael S. Okun
Summary: Deep brain stimulation is an effective but underutilized treatment for obsessive-compulsive disorder. Psychologists, psychiatrists, and insurers should take action to make this therapy accessible to patients with otherwise intractable cases, in order to improve their mental health.
Article
Neurosciences
Takashi Tsuboi, Yuki Satake, Keita Hiraga, Katsunori Yokoi, Makoto Hattori, Masashi Suzuki, Kazuhiro Hara, Adolfo Ramirez-Zamora, Michael S. Okun, Masahisa Katsuno
Summary: Selegiline, rasagiline, and safinamide, three MAO-BIs drugs, have different effects on the quality of life and non-motor symptoms of patients with Parkinson's disease. However, the understanding of these effects is still unclear and further high-quality studies are needed to verify them.
NPJ PARKINSONS DISEASE
(2022)
Article
Psychology, Clinical
Adrianna M. Ratajska, Bonnie M. Scott, Francesca V. Lopez, Lauren E. Kenney, Kelly D. Foote, Michael S. Okun, Catherine Price, Dawn Bowers
Summary: This study compared the severity of mood symptoms in PD, ET, and HC groups and examined the relationship between mood and cognition. The results showed that both PD and ET groups reported more mood symptoms and lower cognitive scores compared to the HC group. The relationship between mood and cognition differed between PD and ET groups.
JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY
(2022)
Article
Clinical Neurology
Bonnie M. Scott, Robert S. Eisinger, Amtul-noor Rana, Jared F. Benge, Robin C. Hilsabeck, Michael S. Okun, Aysegul Gunduz, Dawn Bowers
Summary: Patients with both apathy and ICD exhibit significantly greater symptoms of positive and negative urgency, consummatory anhedonia, lack of premeditation and perseverance. Patients with apathy only showed significantly greater anticipatory anhedonia than those with ICD only or neither.
APPLIED NEUROPSYCHOLOGY-ADULT
(2022)
Article
Clinical Neurology
Frederick L. Hitti, Alik S. Widge, Patricio Riva-Posse, Donald A. Malone Jr, Michael S. Okun, Maryam M. Shanechi, Kelly D. Foote, Sarah H. Lisanby, Elizabeth Ankudowich, Srinivas Chivukula, Edward F. Chang, Aysegul Gunduz, Clement Hamani, Ashley Feinsinger, Cynthia S. Kubu, Winston Chiong, Jennifer A. Chandler, Rafael Carbunaru, Binith Cheeran, Robert S. Raike, Rachel A. Davis, Casey H. Halpern, Nora Vanegas-Arroyave, Dejan Markovic, Sarah K. Bick, Cameron C. McIntyre, R. Mark Richardson, Darin D. Dougherty, Brian H. Kopell, Jennifer A. Sweet, Wayne K. Goodman, Sameer A. Sheth, Nader Pouratian
Summary: Despite advances in treatment, neuromodulation, such as deep brain stimulation, has not gained widespread adoption as a potential therapy for psychiatric diseases. In 2016, the American Society for Stereotactic and Functional Neurosurgery organized a meeting to discuss the future path forward. A follow-up meeting in 2022 aimed to review the current state of the field and identify barriers and milestones for progress.
Article
Neurosciences
Bradley J. Wilkes, Emily R. Tobin, David J. Arpin, Wei-en Wang, Michael S. Okun, Michael S. Jaffee, Nikolaus R. McFarland, Daniel M. Corcos, David E. Vaillancourt
Summary: Objective measures of disease progression using the Purdue Pegboard Test (PPT) were conducted in patients with Parkinson's disease (PD), atypical Parkinsonism, and healthy controls. The decline in PPT performance in PD patients correlated with motor symptom progression, while no such decline was seen in controls. Neuroimaging measures from the basal ganglia were significant predictors of PPT performance in PD, and cortical, basal ganglia, and cerebellar regions were predictors for atypical Parkinsonism. Accelerometry in PD patients showed diminished acceleration range and irregular patterns, which correlated with PPT scores.
NPJ PARKINSONS DISEASE
(2023)
Article
Clinical Neurology
Robert S. Eisinger, Michael S. Okun, Stephanie Cernera, Jackson Cagle, Matthew Beke, Adolfo Ramirez-Zamora, B. Hope Kim, Daniel A. N. Barbosa, Liming Qiu, Pavan Vaswani, Whitley W. Aamodt, Casey H. Halpern, Kelly D. Foote, Aysegul Gunduz, Leonardo Almeida
Summary: Weight loss in Parkinson's disease patients accelerates before death. Patients who underwent deep brain stimulation surgery gained weight, and higher post-operative weight correlates with longer survival.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Yoon Jin Choi, Basma Yacoubi, Agostina Casamento-Moran, Stefan Delmas, Bradley J. Wilkes, Christopher W. Hess, Aparna Wagle Shukla, Kelly D. Foote, David E. Vaillancourt, Michael S. Okun, Evangelos A. Christou
Summary: The study found that VIM DBS was effective in improving gait and balance in ET DBS patients. The improvements in gait and postural balance were associated with a reduction in axial tremor during the tasks.
TREMOR AND OTHER HYPERKINETIC MOVEMENTS
(2022)
Article
Clinical Neurology
Alaina Giacobbe, Ka Loong Kelvin Au, Oliver T. Nguyen, Kathryn Moore, Emily Dinh, Adolfo Ramirez-Zamora, Michael S. Okun, Leonardo Almeida
Summary: The study found that movement disorders patients from underserved areas traveled further for specialized care compared to closer centers. Reasons for underutilization of closer care could include research opportunities, availability of specific treatments or procedures, insurance restrictions, and limited specialist availability. Despite this, underserved patients were underrepresented at the institution, highlighting the need for increased awareness of care options for this population.
TREMOR AND OTHER HYPERKINETIC MOVEMENTS
(2021)
Article
Clinical Neurology
Jun-Pyo Hong, Hanim Kwon, Euyhyun Park, Sun-Uk Lee, Chan-Nyoung Lee, Byung-Jo Kim, Ji-Soo Kim, Kun-Woo Park
Summary: In patients with mild-to-moderate PD, vestibular function assessed by video head-impulse tests appears relatively preserved and has minimal impact on the risk of falls. Risk of postural instability is associated with the severity of clinical symptoms in PD.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yaqin Xiang, XiuRong Huang, Qian Xu, Zhenhua Liu, Yase Chen, Qiying Sun, Junling Wang, Hong Jiang, Lu Shen, Xinxiang Yan, Beisha Tang, Jifeng Guo
Summary: Using the novel data-driven method DEBM, this study determined the sequence of several common biomarker changes in Parkinson's disease (PD). The left putamen was found to be the earliest biomarker to become abnormal, followed by the right putamen, CSF alpha-synuclein, right caudate, left caudate, and serum NfL. The estimated disease stages showed significant differences between PD and healthy controls, and achieved a high accuracy for distinguishing PD from HC.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yan Li, David J. McLernon, Carl E. Counsell, Angus D. Macleod
Summary: This study aimed to investigate the incidence and risk factors for institutionalisation in Parkinson's disease (PD) and atypical parkinsonism (AP). The study found that institutionalisation was more frequent in AP compared to PD and controls. Age, poorer cognition, and more-severe parkinsonian impairment were independent predictors of institutionalisation.
PARKINSONISM & RELATED DISORDERS
(2024)