Article
Clinical Neurology
Keke Liang, Xiaohuan Li, Jianjun Ma, Hongqi Yang, Xiaoxue Shi, Yongyan Fan, Dawei Yang, Dashuai Guo, Chuanze Liu, Linrui Dong, Qingqing Chang, Qi Gu, Siyuan Chen, Dongsheng Li
Summary: In this study, the incidence of and risk factors for dopamine dysregulation syndrome (DDS) in patients with early Parkinson's disease (PD) were explored. It was found that early PD patients with hypersexuality, compulsive eating, compulsive shopping, anxiety, and lower Hoehn-Yahr stage were at increased risk for DDS. Early identification of risk factors for DDS is crucial for improving the quality of life of PD patients.
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Jorryt G. Tichelaar, Ceyda Sayali, Rick C. Helmich, Roshan Cools
Summary: Tichelaar et al. investigated the impact of dopaminergic medication on reward learning in Parkinson's disease, specifically focusing on patients with impulse control disorders. They found that these patients were more sensitive to rewards when taking medication, and this sensitivity was associated with increased value signalling in the medial prefrontal cortex. The study also revealed individual differences in medication effects, suggesting that dopamine's effects on reinforcement learning vary depending on comorbid impulse control disorder and that they reflect deficits in value computation in the medial frontal cortex rather than in reward prediction error signalling in the striatum.
Article
Clinical Neurology
Sara C. Staubo, Ole Martin Fuskevag, Mathias Toft, Ingeborg H. Lie, Kirsti M. J. Alvik, Pal Jostad, Stein H. Tingvoll, Hallvard Lilleng, Kristina Rosqvist, Elisabet Storset, Per Odin, Espen Dietrichs, Erik Sveberg Dietrichs
Summary: The study suggests that the occurrence of impulse control disorders (ICDs) among patients using ropinirole is dependent on serum concentration and drug exposure, while the use of pramipexole may inherently increase ICD risk.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Aysegul Gunduz, Talha Ciftci, Ahmet Can Erbil, Gizem Senoglu, Merve Hazal Ser, Huelya Apaydin
Summary: This retrospective analysis examined impulse control disorders (ICDs) in the treatment of Parkinson's disease. Among the Parkinson's disease patients, 7% had ICDs, including compulsive shopping, compulsive eating, and pathological gambling. The study also found that ICDs can occur at relatively lower doses of dopamine agonists. It is suggested that personal traits associated with dopamine agonists and potential electrophysiological or genetic markers should be further investigated in the treatment of these patients.
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Alexander K. Song, Kaitlyn R. Hay, Paula Trujillo, Megan Aumann, Adam J. Stark, Yan Yan, Hakmook Kang, Manus J. Donahue, David H. Zald, Daniel O. Claassen
Summary: This study demonstrates that reward-based behaviors in Parkinson's disease are regulated by ventral striatal dopamine release, and suggests that loss of inhibitory feedback from midbrain autoreceptors may underlie the manifestation of impulsive-compulsive behaviors.
Article
Clinical Neurology
Xiaobo Zhu, Jing Gan, Na Wu, Ying Wan, Lu Song, Zhenguo Liu, Yu Zhang
Summary: This study explored the predictors of impulse control behaviors (ICBs) in Parkinson's disease (PD) and the biological correlates of ICBs. Over a period of 5 years, the prevalence of ICBs increased in PD while it decreased in healthy controls. The presence of ICBs in PD was associated with depression, anxiety, autonomic dysfunction, and excessive daytime sleepiness, but not with cognitive dysfunction or motor severity. Treatment with dopamine agonists and certain baseline characteristics were identified as predictors for the development of ICBs in early PD.
FRONTIERS IN NEUROLOGY
(2023)
Review
Neurosciences
Andrea Augustine, Catharine A. Winstanley, Vaishnav Krishnan
Summary: Parkinson's disease patients are not only affected by motor impairments, but also at risk for impulse control disorders. There is currently a lack of consensus on the best approach to addressing these symptoms.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Endocrinology & Metabolism
Serdar Sahin, Tugce Sudutan, Yasin Kavla, Emre Durcan, Yeliz Yagiz Ozogul, Burc Cagri Poyraz, Muge Sayitoglu, Hande Mefkure Ozkaya, Pinar Kadioglu
Summary: This study aims to investigate the genetic component of dopamine agonist-induced impulse control disorder (ICD) in patients with prolactinoma. By evaluating polymorphisms of dopamine receptors and other genes, it is found that there is a significant increase in genetic diversity associated with DA-induced ICD in patients receiving dopamine agonist treatment for prolactinoma.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Neurosciences
Yufei Liu, Long Niu, Xinyao Liu, Cheng Cheng, Weidong Le
Summary: Parkinson's disease (PD) is the second most common neurodegenerative disease, characterized by both motor and non-motor symptoms, with circadian rhythm dysregulation emerging as a key feature that may play a pivotal role in the pathogenesis of PD. Recent research progress has focused on understanding altered circadian rhythm in PD, from clinical manifestations to underlying causes of circadian disorders in PD.
NEUROSCIENCE BULLETIN
(2021)
Review
Clinical Neurology
Johann Faouzi, Jean-Christophe Corvol, Louise-Laure Mariani
Summary: Recent studies have found that prevalence of impulse control disorders and related behaviors increases during Parkinson's disease progression, with around 10% annual incidence in patients receiving dopaminergic therapy. Management is focused on reducing dopamine agonist use, while cognitive behavioral therapy and deep brain stimulation have also shown improvement. Research into individual prediction models and the use of machine learning in precision medicine is ongoing.
CURRENT OPINION IN NEUROLOGY
(2021)
Article
Clinical Neurology
Mahsa Dolatshahi, Amir Ashraf-Ganjouei, I-Wei Wu, Yu Zhang, Mohammad Hadi Aarabi, Duygu Tosun
Summary: This study aimed to investigate white-matter integrity differences in PD patients with and without comorbid pRBD and ICDs. Results showed that PD patients with only ICDs had higher white-matter integrity, while those with only pRBD showed lower white-matter integrity in specific brain regions.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Review
Geriatrics & Gerontology
Lihua Gu, Hao Shu, Yanjuan Wang, Hui Xu
Summary: The present study analyzed neuroimaging studies to compare Parkinson's disease (PD) patients with and without impulse control disorder (PD-ICD). The results showed significant differences in brain structure and function between PD-ICD patients and PD-no ICD patients, particularly in the frontal, temporal, and basal ganglia regions.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Clinical Neurology
Chloe Laurencin, Noemie Timestit, Ana Marques, Domitille Dilly Duchez, Caroline Giordana, Sara Meoni, Marine Huddlestone, Teodor Danaila, Mathieu Anheim, Helene Klinger, Tiphaine Vidal, Marion Fatisson, Catherine Caire, Mikail Nourredine, Philippe Boulinguez, Carole Dhelens, Benedicte Ballanger, Stephane Prange, Sylvie Bin, Stephane Thobois
Summary: This study aimed to evaluate the efficacy of clonidine, an Alpha 2-adrenergic receptor agonist, in reducing impulse control disorders (ICDs) in patients with Parkinson's disease (PD). The results of an 8-week, randomized, double-blind, placebo-controlled trial showed that clonidine had a modest effect in reducing ICD symptoms and was well tolerated. However, larger-scale studies are needed to confirm its effectiveness due to the small sample size.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Marie des Neiges Santin, Paul Voulleminot, Agathe Vrillon, Elodie Hainque, Matthieu Bereau, Ouhaid Lagha-Boukbiza, Thomas Wirth, Solveig Montaut, Eric Bardinet, Maeva Kyheng, Anne-Sophie Rolland, Jimmy Voirin, Sophie Drapier, Franck Durif, Alexandre Eusebio, Caroline Giordana, Nicolas Auzou, Jean-Luc Houeto, Cecile Hubsch, Bechir Jarraya, Chloe Laurencin, David Maltete, Mylene Meyer, Olivier Rascol, Tiphaine Rouaud, Melissa Tir, Caroline Moreau, Jean-Christophe Corvol, Francois Proust, David Grabli, David Devos, Christine Tranchant, Mathieu Anheim
Summary: The impact of subthalamic deep brain stimulation on impulse control disorders in patients with Parkinson's disease remains controversial. This study showed that subthalamic DBS can lead to improvement in impulse control disorders, with dopamine agonist dose reduction being the main driver. Patients with preoperative impulse control disorders were prone to postoperative apathy, while preoperative apathy increased the risk of developing postoperative de novo impulse control disorders.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Manuela Contin, Giovanna Lopane, Luca Marini, Susan Mohamed, Luisa Sambati, Patrizia De Massis, Maria Guarino, Simonetta Sermi, Chiara Persichella, Pietro Cortelli, Giovanna Calandra-Buonaura
Summary: This study investigated the relationship between dopamine agonist (DA) plasma concentrations and impulse control disorders (ICDs) in Parkinson's disease (PD) patients. The results showed that there were no significant differences in DA plasma levels between PD patients with positive and negative screening for ICDs. However, patients with positive screening showed higher levels of motor impulsiveness. The Barratt Impulsiveness Scale (BIS-11) may be a useful tool for screening PD patients eligible for DA therapy.
NEUROLOGICAL SCIENCES
(2023)
Article
Medicine, General & Internal
Caitlin W. Hicks, Dan Wang, B. Gwen Windham, Elizabeth Selvin
Summary: The study found a significant association between peripheral neuropathy and erectile dysfunction, especially in adult men without diabetes.
AMERICAN JOURNAL OF MEDICINE
(2021)
Article
Surgery
Benjamin F. Bigelow, Nicholas Siegel, Gregory R. Toci, Jeffrey A. Elsner, Caitlin W. Hicks, Christopher J. Abularrage
Summary: The study found that vascular surgery residents who matched into top 10 RO-IVSR programs typically had higher research productivity, with having 2 or more publications significantly increasing the likelihood of attending a top 10 program. Top programs are likely to consider an applicants' research productivity as an important qualification category and predictor of future success.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Surgery
Sarah E. Deery, Earl Goldsborough, Chen Dun, Christopher J. Abularrage, James H. Black, Martin A. Makary, Caitlin W. Hicks
Summary: This study aimed to identify factors associated with the use of intravascular ultrasound (IVUS) during first-time femoropopliteal peripheral vascular interventions (PVI). The results showed significant associations between IVUS utilization and claudication, stenting, and atherectomy. Higher-volume providers and those with high rates of service provided in an office-based laboratory were more likely to use IVUS. Radiologists and cardiologists used IVUS more frequently than vascular surgeons.
ANNALS OF VASCULAR SURGERY
(2022)
Article
Surgery
Caitlin W. Hicks, Ashley K. Vavra, Earl Goldsborough, Michelle Rebuffatti, Jose Almeida, Yazan M. Duwayri, Mounir Haurani, Charles B. Ross, Samir K. Shah, Paula K. Shireman, Christopher J. Smolock, Jeniann Yi, Karen Woo
Summary: This study aimed to summarize and evaluate patient-reported outcome measures (PROMs) relevant to diseases treated by vascular surgeons, as well as to assess perceptions, barriers, and concerns regarding the implementation of PROMs. The survey results showed a lack of awareness among vascular surgeons regarding existing PROMs, as well as confusion about the development and validation process of PROMs and how they should be used in clinical practice.
JOURNAL OF VASCULAR SURGERY
(2021)
Article
Surgery
Ekaterina Fedorova, George Q. Zhang, Paula K. Shireman, Karen Woo, Caitlin W. Hicks
Summary: Preoperative vein mapping is associated with favorable configurations and outcomes of hemodialysis access. Patients who underwent preoperative vein mapping were more likely to receive AVF creation and choose forearm location compared to those who did not. Preoperative vein mapping also reduces the incidence of secondary access occlusion.
JOURNAL OF VASCULAR SURGERY
(2022)
Review
Cardiac & Cardiovascular Systems
Rebecca Sorber, Caitlin W. Hicks
Summary: This review summarizes the current management strategies for acute aortic syndromes, emphasizing the importance of early identification and appropriate algorithm. Recent trials suggest the increasing usefulness of TEVAR in stabilizing pathology, while considering the potential complications.
CURRENT CARDIOLOGY REPORTS
(2022)
Editorial Material
Surgery
George Q. Zhang, Caitlin W. Hicks
AMERICAN JOURNAL OF SURGERY
(2022)
Article
Surgery
Caitlin W. Hicks, David P. Stonko, Sarah E. Deery, Yasaman Kavousi, James H. Black, Ying Wei Lum, Bruce A. Perler, Christopher J. Abularrage
Summary: This study compared mid-term outcomes of different treatment methods for failing infrainguinal bypasses. The results showed that everolimus drug-eluting stents (eDES) had superior primary patency rates compared to plain balloon angioplasty (PTA), percutaneous cutting balloon (PCB), and drug-coated balloon (DCB), and it exhibited good patency within 24 months.
ANNALS OF VASCULAR SURGERY
(2022)
Article
Public, Environmental & Occupational Health
Caitlin W. Hicks, Dan Wang, Frank R. Lin, Nicholas Reed, B. Gwen Windham, Elizabeth Selvin
Summary: The study found that there is an association between peripheral neuropathy and vision and hearing impairment, independent of diabetes.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2023)
Review
Endocrinology & Metabolism
Katherine McDermott, Michael Fang, Andrew J. M. Boulton, Elizabeth Selvin, Caitlin W. Hicks
Summary: Diabetic foot ulcers are a preventable cause of morbidity in adults with diabetes, leading to functional decline, infection, hospitalization, amputation, and death. The lifetime risk of foot ulcer is increasing and recurrent ulcers are common. Amputation and mortality rates are high and linked to poor diabetes management. Prevention and early detection through multidisciplinary care are crucial to reduce morbidity and disparities associated with diabetic foot ulcers.
Article
Surgery
Helen Xun, David P. Stonko, Earl Goldsborough, Alana Keegan, Tara Srinivas, Sanuja Bose, Katherine M. Mcdermott, M. Libby Weaver, Caitlin W. Hicks
Summary: Gender disparities exist in vascular surgery innovation, with underrepresentation of women. While there have been improvements in the representation of women in surgical research, there is still room for improvement in funding parity and innovation representation.
ANNALS OF VASCULAR SURGERY
(2023)
Article
Hematology
Caitlin W. Hicks, Dan Wang, Katherine McDermott, Kunihiro Matsushita, Olive Tang, Justin B. Echouffo-Tcheugui, John W. McEvoy, Robert H. Christenson, Elizabeth Selvin
Summary: This study aimed to explore the associations of NT-proBNP, hs-troponin T, and hs-troponin I with lower extremity disease in adults without known cardiovascular disease. The results showed that elevated cardiac biomarkers were significantly associated with cardiovascular and all-cause mortality in adults with PAD or PN.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Geriatrics & Gerontology
Caitlin W. Hicks, Dan Wang, Natalie Daya, Stephen P. Juraschek, Kunihiro Matsushita, B. Gwen Windham, Elizabeth Selvin
Summary: This study found that peripheral neuropathy (PN) detected by monofilament testing is common in older adults, even in the absence of diabetes. These individuals have an increased risk of falls and fractures. Therefore, screening with monofilament testing may help identify older adults at high risk for falls.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Surgery
Sanuja Bose, Katie M. Mcdermott, Alana Keegan, James H. Black III, Laura M. Drudi, Ying-Wei Lum, Devin S. Zarkowsky, Caitlin W. Hicks
Summary: Non-Hispanic Black race is associated with worse in-hospital and long-term outcomes following carotid revascularization, even after accounting for neighborhood socioeconomic deprivation.
JOURNAL OF VASCULAR SURGERY
(2023)
Article
Geriatrics & Gerontology
Caitlin W. Hicks, Dan Wang, Andrea L. C. Schneider, Michelle C. Johansen, Rebecca F. Gottesman, Kunihiro Matsushita, Josef Coresh, B. Gwen Windham, Elizabeth Selvin
Summary: This study found an association between peripheral neuropathy and mild cognitive impairment and dementia in older adults. The association remained regardless of diabetes status, suggesting a connection between peripheral neuropathy and cognitive impairment.
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
(2022)
Article
Clinical Neurology
Jun-Pyo Hong, Hanim Kwon, Euyhyun Park, Sun-Uk Lee, Chan-Nyoung Lee, Byung-Jo Kim, Ji-Soo Kim, Kun-Woo Park
Summary: In patients with mild-to-moderate PD, vestibular function assessed by video head-impulse tests appears relatively preserved and has minimal impact on the risk of falls. Risk of postural instability is associated with the severity of clinical symptoms in PD.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yaqin Xiang, XiuRong Huang, Qian Xu, Zhenhua Liu, Yase Chen, Qiying Sun, Junling Wang, Hong Jiang, Lu Shen, Xinxiang Yan, Beisha Tang, Jifeng Guo
Summary: Using the novel data-driven method DEBM, this study determined the sequence of several common biomarker changes in Parkinson's disease (PD). The left putamen was found to be the earliest biomarker to become abnormal, followed by the right putamen, CSF alpha-synuclein, right caudate, left caudate, and serum NfL. The estimated disease stages showed significant differences between PD and healthy controls, and achieved a high accuracy for distinguishing PD from HC.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yan Li, David J. McLernon, Carl E. Counsell, Angus D. Macleod
Summary: This study aimed to investigate the incidence and risk factors for institutionalisation in Parkinson's disease (PD) and atypical parkinsonism (AP). The study found that institutionalisation was more frequent in AP compared to PD and controls. Age, poorer cognition, and more-severe parkinsonian impairment were independent predictors of institutionalisation.
PARKINSONISM & RELATED DISORDERS
(2024)
