Article
Health Care Sciences & Services
Sotirios Polychronis, Grigorios Nasios, Efthimios Dardiotis, Lambros Messinis, Gennaro Pagano
Summary: The exact pathophysiological mechanism of drooling in Parkinson's disease (PD) is not fully understood, but it is associated with various clinical features and neuroimaging findings.
Review
Clinical Neurology
David Nascimento, Jaqueline Carmona, Tiago Mestre, Joaquim J. Ferreira, Isabel Guimaraes
Summary: This study evaluated six drooling rating scales, finding heterogeneous characteristics and incomplete reliability analysis. Among them, only the ROMP-saliva scale was classified as recommended for people with Parkinson's disease due to its substantial evidence of clinimetric properties adequacy.
PARKINSONISM & RELATED DISORDERS
(2021)
Review
Clinical Neurology
David Nascimento
Summary: Drooling in Parkinson's disease is a complex issue that involves multiple clinical features and is not caused by a single factor. Some factors contribute to the onset of drooling while others are associated with it.
NEUROLOGICAL SCIENCES
(2021)
Article
Environmental Sciences
Gladis Yohana Arboleda-Montealegre, Roberto Cano-de-la-Cuerda, Cesar Fernandez-de-las-Penas, Carlos Sanchez-Camarero, Ricardo Ortega-Santiago
Summary: Drooling in Parkinson's disease patients is associated with swallowing difficulties but not with health-related quality of life. Age, gender, disease duration, and the H & Y stage seem to be similar between PD patients with and without drooling.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Otorhinolaryngology
Natalia Silva Cavalcanti, Leo Sekine, Denise Manica, Mauricio Farenzena, Catia de Souza Saleh Neto, Paulo Jose Cauduro Marostica, Claudia Schweiger
Summary: The drooling impact scale has been translated to Brazilian Portuguese and validated in this study. Results showed adequate internal validity of the scale in Brazilian Portuguese, enabling physicians and caregivers to better manage patients with drooling problems.
BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY
(2022)
Review
Clinical Neurology
Wei Lin Toh, Caitlin Yolland, Caroline Gurvich, James Barnes, Susan L. Rossell
Summary: This study conducted a systematic review on non-visual hallucinations in Parkinson's disease, exploring their prevalence, phenomenology, and clinical-cognitive correlates. The findings revealed that non-visual hallucinations are prevalent in Parkinson's disease and have clinical significance, highlighting the need for further research and clinical attention.
JOURNAL OF NEUROLOGY
(2023)
Review
Pediatrics
E. Sforza, R. Onesimo, C. Leoni, V Giorgio, F. Proli, F. Notaro, E. M. Kuczynska, A. Cerchiari, A. Selicorni, D. Rigante, G. Zampino
Summary: This review aimed to identify and analyze different measurement tools for sialorrhea in children. Several outcome measures were found, including the 5-min Drooling Quotient for frequency assessment, the Drooling Impact Scale for evaluating treatment effects, and the modified drooling questionnaire for measuring severity and social acceptability of sialorrhea. These tests showed adequate measurement properties and further research is needed to confirm their reliability, validity, and responsiveness.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Neurosciences
Ting Huang, Li-Li Tang, Jin-Ying Zhao, Songan Shang, Yu-Chen Chen, You-Yong Tian, Ying-Dong Zhang
Summary: This study aimed to investigate the causal interaction between significant sensorimotor network (SMN) regions and other brain regions in Parkinson's disease patients with drooling. The results showed abnormal effective connectivity (EC) in the right caudate nucleus (CAU.R) and right postcentral gyrus in droolers, which was positively correlated with clinical characteristics. ROC curve analysis indicated the significance of these abnormal ECs in diagnosing drooling in PD.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Clinical Neurology
Diego Santos-Garcia, Teresa de Deus Fonticoba, Carlos Cores Bartolome, Maria J. Feal Painceiras, Maria Cristina Iniguez-Alvarado, Silvia Jesus, Maria Teresa Buongiorno, Lluis Planellas, Marina Cosgaya, Juan Garcia Caldentey, Nuria Caballol, Ines Legarda, Jorge Hernandez Vara, Iria Cabo, Lydia Lopez Manzanares, Isabel Gonzalez Aramburu, Maria A. Avila Rivera, Victor Gomez Mayordomo, Victor Nogueira, Victor Puente, Julio Dotor Garcia-Soto, Carmen Borrue, Berta Solano Vila, Maria Alvarez Sauco, Lydia Vela, Sonia Escalante, Esther Cubo, Francisco Carrillo Padilla, Juan C. Martinez Castrillo, Pilar Sanchez Alonso, Maria G. Alonso Losada, Nuria Lopez Ariztegui, Itziar Gaston, Jaime Kulisevsky, Marta Blazquez Estrada, Manuel Seijo, Javier Ruiz Martinez, Caridad Valero, Monica Kurtis, Oriol de Fabregues, Jessica Gonzalez Ardura, Ruben Alonso Redondo, Carlos Ordas, Luis M. L. Lopez Diaz, Darrian McAfee, Pablo Martinez-Martin, Pablo Mir
Summary: This study aimed to examine the prevalence of drooling in Parkinson's disease (PD) patients and compare it with a control group. The results showed that drooling was frequent in PD patients, even at the early stages of the disease, and it was associated with greater motor severity and nonmotor symptom burden.
PARKINSONS DISEASE
(2023)
Article
Medicine, General & Internal
Saskia E. Kok, Joris Lemson, Frank J. A. van den Hoogen
Summary: The aim of this study was to evaluate the airway management and complications after submandibular duct relocation (SMDR). A historic cohort of 96 patients who underwent SMDR for excessive drooling were analysed. Postoperative swelling of the floor of the mouth or tongue was reported in 31 patients (32.3%). The airway was compromised in 4.2% of the patients. Overall, SMDR is a well-tolerated procedure, but careful monitoring of postoperative swelling is necessary.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Angeliki Zarkali, Peter McColgan, Louise Ann Leyland, Andrew John Lees, Rimona Sharon Weil
Summary: Patients with Parkinson's disease hallucinations show significant white matter changes, particularly in posterior connections and thalamic nuclei. Cortical thickness changes are less extensive. Thalamic nucleus of the right medial mediodorsal showed both connectivity and volume loss in PD hallucinations.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Pediatrics
Davide Zanon, Cristina Tumminelli, Anna Maria Chiara Galimberti, Lucio Torelli, Alessandra Maestro, Egidio Barbi, Natalia Maximova
Summary: The study showed that a compounded glycopyrrolate syrup effectively improved sialorrhea and Quality of Life (QoL) in patients, while also reducing treatment costs.
ITALIAN JOURNAL OF PEDIATRICS
(2021)
Article
Neurosciences
Paolo Solla, Carla Masala, Ilenia Pinna, Tommaso Ercoli, Francesco Loy, Gianni Orofino, Laura Fadda, Giovanni Defazio
Summary: This study found that olfactory hallucinations occur frequently in Parkinson's disease patients, especially in women, and often coexist with visual and auditory hallucinations. Visual and auditory hallucinations, along with gender, were identified as the main predictors of olfactory hallucinations in PD patients.
Article
Nutrition & Dietetics
Raissa Dias Fernandez, Graziela Maria Benevenuto Bezerra, Lane Viana Krejcova, Daniela Lopes Gomes
Summary: This study evaluated the correlation between anthropometric variables and the quality of life in individuals with Parkinson's disease. The results showed that quality of life was worse in terms of body discomfort, social support, and mobility, and it deteriorated with advanced age. There were also correlations between the worst scores in quality of life dimensions and nutritional status.
Review
Clinical Neurology
Siobhan Reilly, Simran Dhaliwal, Usman Arshad, Antonella Macerollo, Nusrat Husain, Antonio Da Costa
Summary: There is evidence that rivastigmine is beneficial for rapid eye movement sleep behavior disorder (RBD) and apathy in Parkinson's disease patients without dementia. There is also high level evidence that rivastigmine reduces the risk of falls.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Editorial Material
Clinical Neurology
Adam Margolius, Hubert H. Fernandez
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Multidisciplinary Sciences
Anna Kamieniarz, Justyna Michalska, Wojciech Marszalek, Magdalena Stania, Kajetan J. Slomka, Agnieszka Gorzkowska, Grzegorz Juras, Michael S. Okun, Evangelos A. Christou
Summary: Balance changes in early and moderate stage PD were quantified and compared to healthy controls using clinical assessments and posturography. Power spectral density of the center of pressure differentiated PD stages, indicating early balance deficits. Larger sample sizes are needed to confirm these findings.
Letter
Gastroenterology & Hepatology
Bhavana Patel, Joseph Legacy, Michael S. Okun, Karen Wheeler-Hegland, Nicole E. Herndon
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Neurosciences
Anson B. Rosenfeldt, Mandy Miller Koop, Hubert H. Fernandez, Jay L. Alberts
Summary: This study aimed to investigate the effects of high-intensity exercise on information processing and movement execution in individuals with Parkinson's disease. The results showed that aerobic exercise improved movement execution and information processing, with improvements persisting even after the exercise intervention ceased. Antiparkinsonian medication improved motor execution, but not information processing. The findings suggest that high-intensity exercise may enhance neural processing and non-motor pathways, providing a potential candidate for disease modification.
EXPERIMENTAL BRAIN RESEARCH
(2021)
Article
Psychology, Clinical
Adrianna M. Ratajska, Francesca Lopez, Lauren Kenney, Charles Jacobson, Kelly D. Foote, Michael S. Okun, Dawn Bowers
Summary: The study identified three cognitive subtypes of ET patients undergoing DBS, with 27.4% meeting criteria for MCI. The majority of MCI cases were in the Low Executive or Low Memory Multi-Domain groups, with the latter having a higher percentage of members classified as MCI. Future work should focus on examining these subgroups for progression to dementia.
CLINICAL NEUROPSYCHOLOGIST
(2022)
Article
Clinical Neurology
Melissa J. Armstrong, Kathryn Moore, Charles E. Jacobson, Noheli Bedenfield, Bhavana Patel, Jennifer L. Sullivan
Summary: Suicidal ideation was reported in 18.9% of individuals with Lewy body dementia, with associations to depression, anxiety, and emotional well-being. Routine screening for psychiatric symptoms in this population is emphasized for timely intervention. Further research is needed to assess suicide risks and potential contributors in larger and more diverse LBD populations.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Psychology, Multidisciplinary
Adrianna M. Ratajska, Anne N. Nisenzon, Francesca Lopez, Alexandra L. Clark, Didem Gokcay, Michael S. Okun, Dawn Bowers
Summary: The study found that patients with left-sided symptom onset in Parkinson's disease were slower to initiate anger and happiness facial expressions compared to patients with right-sided symptom onset and healthy controls.
Article
Neurosciences
Takashi Tsuboi, Yuki Satake, Keita Hiraga, Katsunori Yokoi, Makoto Hattori, Masashi Suzuki, Kazuhiro Hara, Adolfo Ramirez-Zamora, Michael S. Okun, Masahisa Katsuno
Summary: Selegiline, rasagiline, and safinamide, three MAO-BIs drugs, have different effects on the quality of life and non-motor symptoms of patients with Parkinson's disease. However, the understanding of these effects is still unclear and further high-quality studies are needed to verify them.
NPJ PARKINSONS DISEASE
(2022)
Article
Psychology, Clinical
Adrianna M. Ratajska, Bonnie M. Scott, Francesca V. Lopez, Lauren E. Kenney, Kelly D. Foote, Michael S. Okun, Catherine Price, Dawn Bowers
Summary: This study compared the severity of mood symptoms in PD, ET, and HC groups and examined the relationship between mood and cognition. The results showed that both PD and ET groups reported more mood symptoms and lower cognitive scores compared to the HC group. The relationship between mood and cognition differed between PD and ET groups.
JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY
(2022)
Article
Clinical Neurology
Bonnie M. Scott, Robert S. Eisinger, Amtul-noor Rana, Jared F. Benge, Robin C. Hilsabeck, Michael S. Okun, Aysegul Gunduz, Dawn Bowers
Summary: Patients with both apathy and ICD exhibit significantly greater symptoms of positive and negative urgency, consummatory anhedonia, lack of premeditation and perseverance. Patients with apathy only showed significantly greater anticipatory anhedonia than those with ICD only or neither.
APPLIED NEUROPSYCHOLOGY-ADULT
(2022)
Article
Neurosciences
Bradley J. Wilkes, Emily R. Tobin, David J. Arpin, Wei-en Wang, Michael S. Okun, Michael S. Jaffee, Nikolaus R. McFarland, Daniel M. Corcos, David E. Vaillancourt
Summary: Objective measures of disease progression using the Purdue Pegboard Test (PPT) were conducted in patients with Parkinson's disease (PD), atypical Parkinsonism, and healthy controls. The decline in PPT performance in PD patients correlated with motor symptom progression, while no such decline was seen in controls. Neuroimaging measures from the basal ganglia were significant predictors of PPT performance in PD, and cortical, basal ganglia, and cerebellar regions were predictors for atypical Parkinsonism. Accelerometry in PD patients showed diminished acceleration range and irregular patterns, which correlated with PPT scores.
NPJ PARKINSONS DISEASE
(2023)
Article
Clinical Neurology
Robert S. Eisinger, Michael S. Okun, Stephanie Cernera, Jackson Cagle, Matthew Beke, Adolfo Ramirez-Zamora, B. Hope Kim, Daniel A. N. Barbosa, Liming Qiu, Pavan Vaswani, Whitley W. Aamodt, Casey H. Halpern, Kelly D. Foote, Aysegul Gunduz, Leonardo Almeida
Summary: Weight loss in Parkinson's disease patients accelerates before death. Patients who underwent deep brain stimulation surgery gained weight, and higher post-operative weight correlates with longer survival.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Yoon Jin Choi, Basma Yacoubi, Agostina Casamento-Moran, Stefan Delmas, Bradley J. Wilkes, Christopher W. Hess, Aparna Wagle Shukla, Kelly D. Foote, David E. Vaillancourt, Michael S. Okun, Evangelos A. Christou
Summary: The study found that VIM DBS was effective in improving gait and balance in ET DBS patients. The improvements in gait and postural balance were associated with a reduction in axial tremor during the tasks.
TREMOR AND OTHER HYPERKINETIC MOVEMENTS
(2022)
Article
Clinical Neurology
Alaina Giacobbe, Ka Loong Kelvin Au, Oliver T. Nguyen, Kathryn Moore, Emily Dinh, Adolfo Ramirez-Zamora, Michael S. Okun, Leonardo Almeida
Summary: The study found that movement disorders patients from underserved areas traveled further for specialized care compared to closer centers. Reasons for underutilization of closer care could include research opportunities, availability of specific treatments or procedures, insurance restrictions, and limited specialist availability. Despite this, underserved patients were underrepresented at the institution, highlighting the need for increased awareness of care options for this population.
TREMOR AND OTHER HYPERKINETIC MOVEMENTS
(2021)
Article
Clinical Neurology
Jun-Pyo Hong, Hanim Kwon, Euyhyun Park, Sun-Uk Lee, Chan-Nyoung Lee, Byung-Jo Kim, Ji-Soo Kim, Kun-Woo Park
Summary: In patients with mild-to-moderate PD, vestibular function assessed by video head-impulse tests appears relatively preserved and has minimal impact on the risk of falls. Risk of postural instability is associated with the severity of clinical symptoms in PD.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yaqin Xiang, XiuRong Huang, Qian Xu, Zhenhua Liu, Yase Chen, Qiying Sun, Junling Wang, Hong Jiang, Lu Shen, Xinxiang Yan, Beisha Tang, Jifeng Guo
Summary: Using the novel data-driven method DEBM, this study determined the sequence of several common biomarker changes in Parkinson's disease (PD). The left putamen was found to be the earliest biomarker to become abnormal, followed by the right putamen, CSF alpha-synuclein, right caudate, left caudate, and serum NfL. The estimated disease stages showed significant differences between PD and healthy controls, and achieved a high accuracy for distinguishing PD from HC.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yan Li, David J. McLernon, Carl E. Counsell, Angus D. Macleod
Summary: This study aimed to investigate the incidence and risk factors for institutionalisation in Parkinson's disease (PD) and atypical parkinsonism (AP). The study found that institutionalisation was more frequent in AP compared to PD and controls. Age, poorer cognition, and more-severe parkinsonian impairment were independent predictors of institutionalisation.
PARKINSONISM & RELATED DISORDERS
(2024)