期刊
PARKINSONISM & RELATED DISORDERS
卷 16, 期 4, 页码 294-297出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.parkreldis.2009.11.009
关键词
GIGYF2; Parkinson's disease; Chinese population
资金
- National Program of Basic Research of China [2006cb500706, 2010CB945200]
- National Natural Science Fund [30872729, 30971031, 30700888]
- Shanghai Key Discipline Program [S30202]
- Program for Outstanding Medical Academic Leader of Shanghai [LJ 06003]
In order to determine the prevalence of GIGYF2 (Grb10-Interacting GYF Protein 2) variants in the Chinese population and to better understand the association between GIGYF2 and Parkinson's disease (PD), we conducted the genetic screening of GIGYF2 in the Chinese population. Twelve exonic variants were identified in 52 familial PD probands and 56 healthy controls. Non-synonymous point variants (Thr25Ala, Asn457Th and Pro460Th) were analyzed in 510 PD patients and 481 healthy controls of Chinese Han ethnicity. The insertion and deletion variants in Exon 25 (Ins Q 1212, Ins QQ 1217, Del Q 1210, Del Q 1216 and Del PPQ1217_1219) are not related to the onset of familial PD. Our data indicate the GIGYF2 variants are not associated with PD in the mainland Chinese Population. (C) 2009 Elsevier Ltd. All rights reserved.
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