Article
Clinical Neurology
Or Koren, Ronny P. Bartsch, Zoya Katzir, Uri Rosenblum, Sharon Hassin-Baer, Rivka Inzelberg, Meir Plotnik
Summary: This study aimed to investigate the relationship between increased interhemispheric cortical synchronization and dopamine deficiency in Parkinson's disease (PD), and its correlation with motor function. The results showed that PD patients exhibit higher interhemispheric cortical synchronization during the OFF state compared to the ON state, and this increase is associated with clinical improvement. These findings may reflect neural processes related to asymmetric subcortical dopamine deficiency.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Health Care Sciences & Services
Teresa Mena-Moreno, Lucero Munguia, Rosario Granero, Ignacio Lucas, Almudena Sanchez-Gomez, Ana Camara, Yaroslau Compta, Francesc Valldeoriola, Fernando Fernandez-Aranda, Anne Sauvaget, Jose M. Menchon, Susana Jimenez-Murcia
Summary: This study presents a case of a patient with impulse control disorder (ICD) triggered by dopaminergic medication for Parkinson disease (PD). A combined intervention using cognitive behavioral therapy (CBT) and a serious game (e-Estesia) was carried out to reduce the harm of the disease. The results showed positive outcomes in terms of improved emotion regulation, reduced emotional distress, and lower levels of impulsivity.
JMIR SERIOUS GAMES
(2022)
Article
Clinical Neurology
Ana Marques, Daniel Roquet, Elie Matar, Natasha Louise Taylor, Bruno Pereira, Claire O'Callaghan, Simon J. G. Lewis
Summary: Research compared brain alterations in the reward system between idiopathic REM sleep behavior disorder (iRBD) patients, healthy controls, and PD patients, finding differences in volumetric and functional connectivity characteristics, particularly in relation to hypersexuality. The presence of impulse control disorders (ICDs) correlated with altered functional connectivity within the reward system.
JOURNAL OF NEUROLOGY
(2021)
Article
Nutrition & Dietetics
Xiong Zhang, Ke Wang, Xiao-Li Ren, Meng-Di Zhang, Kai-Nian Wu, Han Wu, Zhong-Wei Chu, Shu-Shu Liu, Xiao-Xia Jiang, Jian-Hong Zhu, Hong-Mei Wu
Summary: This study investigated the effects of zinc deficiency on behavior and dopaminergic neurons in a mouse model of Parkinson's disease. The results showed that zinc deficiency worsened movement disorders and affected the degeneration of dopaminergic neurons. These findings suggest that appropriate zinc supplementation may be beneficial for patients with Parkinson's disease.
JOURNAL OF NUTRITION
(2023)
Article
Clinical Neurology
Jared T. Hinkle, Kate Perepezko, Kelly A. Mills, Gregory M. Pontone
Summary: The study found that in Parkinson's disease patients, Punding behavior was associated with attentional dysfunction, with lower scores on the primary attention test and attention subscale being linked to Punding behaviors. Additionally, functional impairment may be a predictive factor for Punding behavior, while hobbyism behavior is not associated with it.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Neurosciences
Mennatallah Elshennawy, Omar Ouachikh, Youssef Aissouni, Shahira Youssef, Shahira S. Zaki, Franck Durif, Aziz Hafidi
Summary: This study assessed thermal nociceptive behavior in rats with 6-OHDA-induced PD, finding increased sensitivity to cold temperatures and mechanical hypersensitivity. Dopamine receptor agonist Ropinirole alleviated cold allodynia. Molecular markers of pain processes were elevated in specific brain regions in 6-OHDA-lesioned rats, indicating alterations in excitation and inhibition in the spinal dorsal horn. Overall, the study demonstrated cold thermal hypersensitivity, alongside mechanical hypersensitivity, in 6-OHDA-lesioned rats.
Editorial Material
Cell Biology
Natalia Jimenez-Moreno, Jon D. Lane
Summary: Parkinson's disease is caused by the loss of dopaminergic neurons in the substantia nigra pars compacta. In our recent study, we found that the transcription factors LMX1A and LMX1B play crucial roles in autophagy gene expression for stress protection in the developed brain. We propose a novel role for ATG8 proteins as transcriptional co-factors for autophagy genes in protecting dopaminergic neurons in Parkinson's disease.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ji Hwan Kim, Jonghu Jeon, Young Lee, Seung Min Kim, Miju Cheon, Jun Yup Kim
Summary: This study aimed to understand the development of dysphagia in patients with Parkinson's disease (PD) and identify potential target regions for neuromodulation by analyzing the distribution of dopamine transporter availability in the striatum. The results showed that decreased dopamine transporter availability in specific subregions of the striatum may explain the dysphagia in PD, particularly in the pharyngeal phase.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Neurosciences
Liting Hang, Ziyin Wang, Aaron S. C. Foo, Geraldine W. Y. Goh, Huey Ching Choong, John Thundyil, Shengli Xu, Kong-Peng Lam, Kah-Leong Lim
Summary: Emerging studies suggest that energy dysregulation is a key factor in Parkinson's disease, and AMP kinase (AMPK) plays a crucial role in maintaining neuronal energy homeostasis. Loss of AMPK function can promote dopaminergic neurodegeneration and increase susceptibility to toxin-induced damage, making the AMPK pathway a promising therapeutic target for PD.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Multidisciplinary Sciences
Zahra Nodehi, Hajar Mehdizadeh, Akram Azad, Maryam Mehdizadeh, Elham Reyhanian, Zakieh Sadat Saberi, Mahsa Meimandi, Akbar Soltanzadeh, Mahtab Roohi-Azizi, Behnoosh Vasaghi-Gharamaleki, Mohamad Parnianpour, Kinda Khalaf, Ghorban Taghizadeh
Summary: This study found that Parkinson's disease patients with high levels of anxiety exhibit greater motor control deficits in dual-task conditions, with dopaminergic medication having no effect on grasp kinematics. The results suggest that high levels of anxiety may worsen upper limb motor control inefficiency in PD patients, especially in high demanding cognitive conditions.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Article
Neurosciences
Xiaoyi Xu, Xin He, Zeyan Zhang, Yanyi Chen, Junyu Li, Shanshan Ma, Qiaoying Huang, Mingtao Li
Summary: This study identified that the inactivation of CREB and decreased expression of NURR1 are associated with nigral dopaminergic neurodegeneration in Parkinson's disease (PD). The mechanism underlying CREB inactivation involves the interaction between HDAC1/PP1y complex and CREB, and disrupting this interaction can restore CREB activity and protect dopaminergic neurons.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Cynthia Kwan, Stephen G. Nuara, Jim C. Gourdon, Philippe Huot
Summary: Parkinson's disease psychosis is a complex condition affecting over half of patients and is influenced by multiple factors including dopamine replacement therapy and disease state. Studying novel stereotypical behaviors in MPTP-lesioned marmosets may provide valuable insights for interventions targeting PD psychosis symptoms.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Cell Biology
Petros Stathakos, Natalia Jimenez-Moreno, Lucy A. Crompton, Paul A. Nistor, Jennifer L. Badger, Peter A. Barbuti, Talitha L. Kerrigan, Andrew D. Randall, Maeve A. Caldwell, Jon D. Lane
Summary: Macroautophagy/autophagy cytoplasmic quality control pathways are crucial for neural development and maintaining functional neuronal populations in the adult brain. Declining neuronal autophagy pathways contribute to neurodegenerative diseases, including Parkinson's disease, highlighting the need for reliable human neuronal model systems for research and therapeutic interventions. HiPSC neural model systems show promise in meeting this demand but may face limitations in generating ventral midbrain dopaminergic neurons efficiently for functional and imaging-based in vitro assays.
Article
Clinical Neurology
Bonnie M. Scott, Robert S. Eisinger, Amtul-noor Rana, Jared F. Benge, Robin C. Hilsabeck, Michael S. Okun, Aysegul Gunduz, Dawn Bowers
Summary: Patients with both apathy and ICD exhibit significantly greater symptoms of positive and negative urgency, consummatory anhedonia, lack of premeditation and perseverance. Patients with apathy only showed significantly greater anticipatory anhedonia than those with ICD only or neither.
APPLIED NEUROPSYCHOLOGY-ADULT
(2022)
Article
Clinical Neurology
Weidong Cai, Christina B. Young, Rui Yuan, Byeongwook Lee, Sephira Ryman, Jeehyun Kim, Laurice Yang, Victor W. Henderson, Kathleen L. Poston, Vinod Menon
Summary: Dopaminergic medication can normalize aberrant causal signalling in working memory circuits in patients with Parkinson's disease, and such signalling is predictive of cognitive response to medication. The findings reveal the neurobiological mechanisms by which dopaminergic medication improves cognitive control.
Letter
Clinical Neurology
Jae Young Joo, Jihoon G. Yoon, Seoungbok Lee, Jangsup Moon, Han-Joon Kim
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Hee Jin Chang, Han-Joon Kim, Kyung Ah Woo, Jung Hwan Shin, Ki-Young Jung
Summary: This study evaluated the effect of CPAP on the quality of life in patients with MSA and their caregivers. The results showed that CPAP treatment had a beneficial effect on sleep complaints and QoL of the patients and improved caregivers' QoL.
SLEEP AND BREATHING
(2023)
Editorial Material
Clinical Neurology
Kyung Ah Woo, Han-Joon Kim, Beomseok Jeon
JOURNAL OF MOVEMENT DISORDERS
(2023)
Letter
Clinical Neurology
Hyoshin Son, Jihoon G. Yoon, Man Jin Kim, Jangsup Moon, Han-Joon Kim
JOURNAL OF MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Hee Jin Chang, Cheol-Min Shin, Jin Whan Cho, Seong-Beom Koh, YoungSoon Yang, Hee Tae Kim, Jong-Min Kim, Jee-Young Lee
Summary: This study aimed to investigate the sex differences in gastrointestinal dysfunctions among patients with Parkinson's disease (PD). The findings showed that female patients experience worse gastrointestinal symptoms than males, with specific symptoms such as inability to finish a regular meal and nausea being significantly worse in females.
NEUROLOGICAL SCIENCES
(2023)
Letter
Clinical Neurology
Jae Young Joo, Hee Jin Chang, Kyung Ah Woo, Han Sang Lee, Han-Joon Kim
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Neurosciences
Jung Hwan Shin, Heejung Kim, Yu Kyeong Kim, Eun Jin Yoon, Hyunwoo Nam, Beomseok Jeon, Jee-Young Lee
Summary: This study investigated the longitudinal evolution of cortical thickness signature in individuals with isolated rapid-eye-movement sleep behavior disorder (iRBD) and its predictive value in determining the conversion to dementia. The results showed that the cortical thickness signature can effectively predict the conversion to dementia-first phenotype and differentiate between dementia-first and parkinsonism-first conversions.
TRANSLATIONAL NEURODEGENERATION
(2023)
Letter
Clinical Neurology
Chaewon Shin, Seong-Ik Kim, Sung-Hye Park, Jung Hwan Shin, Chan Young Lee, Han-Joon Kim, Hyuk-Joon Lee, Seong-Ho Kong, Yun-Suhk Suh, Han-Kwang Yang, Beomseok Jeon
JOURNAL OF MOVEMENT DISORDERS
(2023)
Letter
Clinical Neurology
Sangmin Park, Jung Hwan Shin, Seung Ho Jeon, Chan Young Lee, Han-Joon Kim, Beomseok Jeon
JOURNAL OF MOVEMENT DISORDERS
(2023)
Review
Clinical Neurology
Priya Jagota, Shen-Yang Lim, Pramod Kumar Pal, Jee-Young Lee, Prashanth Lingappa Kukkle, Shinsuke Fujioka, Huifang Shang, Onanong Phokaewvarangkul, Roongroj Bhidayasiri, Norlinah Mohamed Ibrahim, Yoshikazu Ugawa, Zakiyah Aldaajani, Beomseok Jeon, Cid Diesta, Cholpon Shambetova, Chin-Hsien Lin
Summary: The increasing availability of molecular genetic testing has changed the landscape of both genetic research and clinical practice. These advancements lead to the awareness that some genetic movement disorders may cluster in certain ethnic populations and genetic pleiotropy may result in unique clinical presentations in specific ethnic groups. Recognition of a particular clinical phenotype, combined with information about the ethnic origin of patients could lead to early and correct diagnosis and assist the development of future personalized medicine for patients with these disorders.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Kyung Ah Woo, Joo Hong Joun, Eun Jin Yoon, Chan Young Lee, Beomseok Jeon, Yu Kyeong Kim, Jee-Young Lee
Summary: This study investigated the relationship between monoaminergic degeneration and ocular motor abnormalities in newly diagnosed Parkinson's disease (PD) patients. The results showed that saccadic accuracy was related to motor severity, while latency was related to cognitive function. Degeneration in the anterior and posterior putamen was associated with reduced saccadic accuracy, while degeneration in the dorsal raphe was associated with decreased smooth pursuit gain.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Hee Jin Chang, Jiae Kim, Jae Young Joo, Han-Joon Kim
Summary: This study aimed to evaluate the feasibility and efficacy of online video-call speech therapy for patients with Parkinson's disease. By comparing two groups of patients who received online speech therapy and in-person therapy, it was found that online video-call therapy was as effective as traditional therapy in improving speech difficulties and was feasible.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Chan Young Lee, Hyesook Kim, Han-Joon Kim, Jung Hwan Shin, Hee Jin Chang, Kyung Ah Woo, Ki-Young Jung, Oran Kwon, Beomseok Jeon
Summary: The study found no significant association between diet quality and the probability of developing Parkinson's disease and its risk or prodromal markers in patients with isolated rapid eye movement (REM) sleep behavior disorder (iRBD). However, in patients under the age of 70, legume consumption was negatively correlated with the probability of developing Parkinson's disease, and patients with fewer prodromal markers had significantly higher legume consumption.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Kyung Ah Woo, Heejung Kim, Eun Jin Yoon, Jung Hwan Shin, Hyunwoo Nam, Beomseok Jeon, Yu Kyeong Kim, Jee-Young Lee
Summary: This study investigated the structural and functional connectivity changes in brain olfactory-related structures in isolated REM sleep behavior disorder (iRBD) and their correlations with clinical symptoms, longitudinal evolution, and predictive values for phenoconversion to Lewy body disease. The findings suggest that progressive atrophy of central olfactory structures may indicate the progression of Lewy body disease in iRBD patients.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Letter
Clinical Neurology
Hee Jin Chang, Kyung Ah Woo, Han-Joon Kim, Beomseok Jeon
JOURNAL OF CLINICAL NEUROLOGY
(2023)
Article
Clinical Neurology
Jun-Pyo Hong, Hanim Kwon, Euyhyun Park, Sun-Uk Lee, Chan-Nyoung Lee, Byung-Jo Kim, Ji-Soo Kim, Kun-Woo Park
Summary: In patients with mild-to-moderate PD, vestibular function assessed by video head-impulse tests appears relatively preserved and has minimal impact on the risk of falls. Risk of postural instability is associated with the severity of clinical symptoms in PD.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yaqin Xiang, XiuRong Huang, Qian Xu, Zhenhua Liu, Yase Chen, Qiying Sun, Junling Wang, Hong Jiang, Lu Shen, Xinxiang Yan, Beisha Tang, Jifeng Guo
Summary: Using the novel data-driven method DEBM, this study determined the sequence of several common biomarker changes in Parkinson's disease (PD). The left putamen was found to be the earliest biomarker to become abnormal, followed by the right putamen, CSF alpha-synuclein, right caudate, left caudate, and serum NfL. The estimated disease stages showed significant differences between PD and healthy controls, and achieved a high accuracy for distinguishing PD from HC.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yan Li, David J. McLernon, Carl E. Counsell, Angus D. Macleod
Summary: This study aimed to investigate the incidence and risk factors for institutionalisation in Parkinson's disease (PD) and atypical parkinsonism (AP). The study found that institutionalisation was more frequent in AP compared to PD and controls. Age, poorer cognition, and more-severe parkinsonian impairment were independent predictors of institutionalisation.
PARKINSONISM & RELATED DISORDERS
(2024)