期刊
PARKINSONISM & RELATED DISORDERS
卷 15, 期 5, 页码 383-389出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.parkreldis.2008.10.001
关键词
Parkinson's disease progression; Cerebrospinal fluid; Dopamine turnover; Dyskinesia
资金
- Ministero Salute
- Italian Space Agency
- Alzheimers Research UK [ART-PPG2005A-2] Funding Source: researchfish
To assess possible differences in dopamine metabolism that could parallel disease progression in Parkinson's disease (PD), we measured dopamine (DA) and its metabolites in the cerebrospinal fluid (CSF) in PD patients at different stages of disease: de novo (DEN), advanced not showing dyskinesias (ADV), and advanced with dyskinesias (DYS). DA, homovanillic acid (HVA) and dihydroxyphenylacetic acid (DOPAC) were significantly higher in DEN patients compared with other groups. A negative exponential correlation related DA level and disease duration. The HVA/DA ratio was significantly higher in the ADV and DYS group than that found in DEN group. Our data show that disease Progression produces an early large decay of DA levels, followed by a stabilization, On the contrary, a late change in DA turnover (increased HVA/DA ratio) is documented in patients with longer disease duration. Our results Suggest that the appearance of dyskinesia may not be related to a further loss of DA terminals but to a different, abnormal, DA turnover. (C) 2008 Elsevier Ltd. All rights reserved.
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