Review
Geriatrics & Gerontology
Rwei-Ling Yu, Ruey-Meei Wu
Summary: Mild cognitive impairment (MCI) is a common non-motor symptom in patients with Parkinson's disease (PD), but lacks consistent diagnostic criteria. Different types of cognitive impairments have different progression rates. This review provides an overview of the diagnostic criteria for PD-MCI and the heterogeneity of patients' cognitive function.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Chemistry, Analytical
Sara Rosenblum, Ariella Richardson, Sonya Meyer, Tal Nevo, Maayan Sinai, Sharon Hassin-Baer
Summary: Parkinson's disease is the second most common progressive neurodegenerative disorder that affects patient functioning and quality of life, with cognitive impairment having a significant impact on emotional and physical health. DailyCog is a smartphone application developed for the detection of mild cognitive impairment, utilizing a simulated environment of daily tasks and self-report questionnaires to assess cognitive levels in patients. Usability studies showed that most users were able to use the app with ease, providing valuable insights into cognitive function assessment.
Article
Neurosciences
Sara Becker, Olga Boettinger, Patricia Sulzer, Markus A. Hobert, Kathrin Brockmann, Walter Maetzler, Daniela Berg, Inga Liepelt-Scarfone
Summary: Through FAQ assessment, it was found that PD-MCI patients had more difficulties with tax records and traveling, while AD-MCI patients were more impaired in managing finances and remembering appointments. The classification accuracy of the FAQ differed between MCI related to PD and AD.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Review
Medicine, General & Internal
Ingrid Arevalo-Rodriguez, Nadja Smailagic, Marta Roque-Figuls, Agustin Ciapponi, Erick Sanchez-Perez, Antri Giannakou, Olga L. Pedraza, Xavier Bonfill Cosp, Sarah Cullum
Summary: The review included studies focusing on the conversion from MCI to all-cause dementia, Alzheimer's disease dementia, and vascular dementia. Baseline MMSE scores had a range of accuracy in predicting dementia, but alone cannot determine the direction of progression for MCI patients.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Review
Psychology, Clinical
Elizabeth R. Wallace, Suzanne C. Segerstrom, Craig G. van Horne, Frederick A. Schmitt, Lisa M. Koehl
Summary: This study conducted a meta-analysis on PD-MCI patients and found significant differences in cognitive test performance, with cognitive screeners showing the most pronounced effect. In the progression from PD-MCI to PDD, executive dysfunction exhibits a significant impact.
NEUROPSYCHOLOGY REVIEW
(2022)
Article
Geriatrics & Gerontology
Antonio Muscari, Fabio Clavarino, Vincenzo Allegri, Andrea Farolfi, Maria Macchiarulo, Lorenzo Maestri, Elisa Sessagesimi, Luca Spinardi, Maria Lia Lunardelli
Summary: This study proposed a two-step procedure to assess the risk of CAD in MCI patients, initially evaluating MMSE, MoCA, and MTA before deciding whether to perform FDG-PET. The results showed that patients with 2-3 points in the first step had a higher risk of CAD, and in the second step, FDG-PET had significant diagnostic value in identifying high-risk patients.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2021)
Article
Geriatrics & Gerontology
Ya-Wen Yu, Chun-Hsiang Tan, Hui-Chen Su, Chung-Yao Chien, Pi-Shan Sung, Tien-Yu Lin, Tsung-Lin Lee, Rwei-Ling Yu
Summary: The study aimed to simplify commonly used tools and combine cognitive and social functioning tests to detect early MCI and PDD. According to MDS diagnostic criteria, patients were grouped into PD nonMCI, PD-MCI, or PDD.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Clinical Neurology
Benjamin M. Hampstead, Anthony Y. Stringer, Alexandru D. Iordan, Robert Ploutz-Snyder, K. Sathian
Summary: Cognitive training is a potential technique for treating cognitive impairment caused by neurological injury and disease. Different training methods have different mechanisms of action and engage distinct brain regions. Mnemonic strategy training (MST) showed superior effects in the short term and increased activation and functional connectivity in multiple brain regions.
ALZHEIMERS & DEMENTIA
(2023)
Article
Biochemistry & Molecular Biology
Chieh-Hsin Lin, Hsien-Yuan Lane
Summary: This study longitudinally monitored plasma GSH levels and cognitive function in MCI patients, showing a significant decline over a 2-year period, while these levels remained relatively stable in healthy individuals. Both baseline GSH levels and changes in GSH levels were found to significantly influence cognitive decline in MCI patients, suggesting that blood GSH concentration may be a potential biomarker for monitoring cognitive changes in MCI.
Editorial Material
Cell Biology
Zhuang-Yao D. Wei, Ashok K. Shetty
Summary: This article discusses a recent study that suggests using a miRNA triad, consisting of miR-181a-5p, miR-146a-5p, and miR-148a-3p, for diagnosing ACI, MCI, and AD. The study explores the impact of elevated levels of this miRNA triad on neural plasticity and cognitive function in the brain and the potential of inhibiting it to improve cognitive function in MCI and AD.
Review
Biochemistry & Molecular Biology
Kyoungjoo Cho
Summary: Cognitive impairment is a serious condition associated with aging and disruption of inflammation and innate immunity. Recent studies have shown that the innate immune system is prevalent in patients with Alzheimer's disease, and peripheral neutrophil markers can predict a decline in cognitive function in patients with mild cognitive impairment. Furthermore, altered levels of pro-inflammatory interleukins have been reported in patients with mild cognitive impairment, potentially playing a role in the progression from early cognitive impairment to dementia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Health Care Sciences & Services
Carolina Lopez, Miren Altuna
Summary: Population aging increases the risk of neurodegenerative diseases and cognitive impairment. Early diagnosis and social awareness have led to an increase in the number of diagnosed individuals, but also pose new challenges. Understanding the psychosocial impact of diagnosis and developing strategies to address them are crucial.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Clinical Neurology
Michela Garon, Luca Weis, Eleonora Fiorenzato, Francesca Pistonesi, Annachiara Cagnin, Alessandra Bertoldo, Mariagiulia Anglani, Diego Cecchin, Angelo Antonini, Roberta Biundo
Summary: This study investigated the impact of beta-amyloid (Aβ) on the clinical and cognitive manifestations as well as regional brain volumes in Parkinson's disease with mild cognitive impairment (PD-MCI). The results showed that the presence of Aβ worsened executive functions in PD-MCI patients, but did not affect motor and global cognitive abilities. Aβ deposition was found in specific brain regions, and higher amyloid load correlated with worse executive performances. However, Aβ may not be the main cause of cognitive deterioration in PD-MCI.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Teresa de Deus Fonticoba, Carlos Cores Bartolome, Maria J. Feal Painceiras, Iago Garcia Diaz, Maria Cristina iniguez Alvarado, Jose Manuel Paz, Silvia Jesus, Marina Cosgaya, Juan Garcia Caldentey, Nuria Caballol, Ines Legarda, Jorge Hernandez Vara, Iria Cabo, Lydia Lopez Manzanares, Isabel Gonzalez Aramburu, Maria A. avila Rivera, Victor Gomez Mayordomo, Victor Nogueira, Julio Dotor Garcia-Soto, Carmen Borrue, Berta Solano Vila, Maria alvarez Sauco, Lydia Vela, Sonia Escalante, Esther Cubo, Zebenzui Mendoza, Juan C. Martinez Castrillo, Pilar Sanchez Alonso, Maria G. Alonso Losada, Nuria Lopez Ariztegui, Itziar Gaston, Jaime Kulisevsky, Manuel Seijo, Caridad Valero, Ruben Alonso Redondo, Maria Teresa Buongiorno, Carlos Ordas, Manuel Menendez-Gonzalez, Darrian McAfee, Pablo Martinez-Martin, Pablo Mir, A. D. Adarmes, A. D. Adarmes, M. Almeria, M. G. Alonso Losada, A. Alonso Canovas, F. Alonso Frech, R. Alonso Redondo, I. alvarez, M. alvarez Sauco, A. Aneiros Diaz, S. Arnaiz, S. Arribas, A. Ascunce Vidondo, M. Aguilar, M. A. avila, N. Nernardo Lambrich, H. Bejr-Kasem, M. Blazquez Estrada, M. Boti, C. Borrue, M. T. Buongiorno, C. Cabello Gonzalez, I. Cabo Lopez, N. Caballol, A. Camara Lorenzo, H. Canfield Medina, E. Carabajal Pendon, F. Carrillo, F. J. Carrillo Padilla, E. Casas, M. J. Catalan, P. Clavero, A. Cortina Fernandez, M. Cosgaya, A. Cots Foraster, A. Crespo Cuevas, E. Cubo, T. de Deus Fonticoba, O. de Fabregues-Boixar, M. Diez-Fairen, J. Dotor Garcia-Soto, E. Erro, S. Escalante, EEstelrich Peyret, N. Fernandez Guillan, P. Gamez, M. Gallego, J. Garcia Caldentey, C. Garcia Campos, C. Garcia Diez, J. M. Garcia Moreno, I. Gaston, M. P. Gomez Garre, V. Gomez Mayordomo, J. Gonzalez Aloy, I. Gonzalez-Aramburu, J. Gonzalez Ardura, B. Gonzalez Garcia, M. J. Gonzalez Palmas, G. R. Gonzalez Toledo, A. Golpe Diaz, M. Grau Sola, G. Guardia, J. Hernandez Vara, A. Horta-Barba, DIdoate Calderon, J. Infante, S. Jesus, J. Kulisevsky, M. Kurtis, C. Labandeira, M. A. Labrador, F. Lacruz, M. Lage Castro, S. Lastres Gomez, I. Legarda, NLopez Ariztegui, L. M. Lopez Diaz, D. Lopez Dominguez, L. Lopez Manzanares, B. Lopez Seoane, S. Lucas del Pozo, Y. Macias, M. Mata, G. Marti Andres, M. J. Marti, J. C. Martinez Castrillo, P. Martinez-Martin, D. McAfee, M. T. Meitin, Z. Mendoza Plasencia, M. Menendez Gonzalez, C. Mendez del Barrio, P. Mir, J. Miranda Santiago, M. I. Morales Casado, A. Moreno Dieguez, I. Muro Garcia, V. Nogueira, A. Novo Amado, S. Novo Ponte, C. Ordas, J. Pagonabarraga, I. Parees, B. Pascual-Sedano, P. Pastor, A. Perez Fuertes, R. Perez Noguera, A. Planas-Ballve, L. Planellas, M. A. Prats, C. Prieto Jurczynska, V. Puente, M. Pueyo Morlans, A. Puig Davi, N. Redondo Rafales, L. Rodriguez Mendez, ABRodriguez Perez, F. Roldan, M. Ruiz De Arcos, J. Ruiz Martinez, P. Sanchez Alonso, M. Sanchez-Carpintero, G. Sanchez Diez, A. Sanchez Rodriguez, P. Santacruz, D. Santos Garcia, J. C. Segundo Rodriguez, M. Seijo, M. Sierra Pena, B. Solano Vila, E. Suarez Castro, J. P. Tartari, C. Valero, L. Vargas, L. Vela, C. Villanueva
Summary: This study aimed to analyze the change in cognitive function in patients with young-onset Parkinson's disease (YOPD) compared to those with a later onset and controls. The results showed that YOPD patients had better cognitive function compared to non-YOPD patients and controls, while non-YOPD patients experienced a significant decline in cognitive function during the study. At the end of the study, the incidence of dementia and mild cognitive impairment was significantly higher in non-YOPD patients than in YOPD patients.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Deepika Dinesh, Qing Shao, Madhuri Palnati, Sarah McDannold, Quanwu Zhang, Amir Abbas Tahami Monfared, Guneet K. Jasuja, Heather Davila, Weiming Xia, Lauren R. Moo, Donald R. Miller, Natalia Palacios
Summary: Based on electronic health records data, a study found that US veterans have a unique dementia risk profile that may be changing over time. From 2000 to 2019, the incidence and prevalence of Alzheimer's disease (AD) and related dementias (ADRD) decreased, while ADRD prevalence increased primarily due to an increase in dementia not otherwise specified. The prevalence and incidence of mild cognitive impairment (MCI) sharply increased, especially after 2010. The highest prevalence and incidence of AD, ADRD, and MCI were observed in the oldest veterans, female veterans, and African American and Hispanic veterans.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Jun-Pyo Hong, Hanim Kwon, Euyhyun Park, Sun-Uk Lee, Chan-Nyoung Lee, Byung-Jo Kim, Ji-Soo Kim, Kun-Woo Park
Summary: In patients with mild-to-moderate PD, vestibular function assessed by video head-impulse tests appears relatively preserved and has minimal impact on the risk of falls. Risk of postural instability is associated with the severity of clinical symptoms in PD.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yaqin Xiang, XiuRong Huang, Qian Xu, Zhenhua Liu, Yase Chen, Qiying Sun, Junling Wang, Hong Jiang, Lu Shen, Xinxiang Yan, Beisha Tang, Jifeng Guo
Summary: Using the novel data-driven method DEBM, this study determined the sequence of several common biomarker changes in Parkinson's disease (PD). The left putamen was found to be the earliest biomarker to become abnormal, followed by the right putamen, CSF alpha-synuclein, right caudate, left caudate, and serum NfL. The estimated disease stages showed significant differences between PD and healthy controls, and achieved a high accuracy for distinguishing PD from HC.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yan Li, David J. McLernon, Carl E. Counsell, Angus D. Macleod
Summary: This study aimed to investigate the incidence and risk factors for institutionalisation in Parkinson's disease (PD) and atypical parkinsonism (AP). The study found that institutionalisation was more frequent in AP compared to PD and controls. Age, poorer cognition, and more-severe parkinsonian impairment were independent predictors of institutionalisation.
PARKINSONISM & RELATED DISORDERS
(2024)