Article
Multidisciplinary Sciences
Eric Chevrier, Elena Moro, Pierre Pelissier, Anna Castrioto, Paul Krack, Valerie Fraix, Bettina Debu
Summary: Balance disorders are common in Parkinson's disease (PD), and one-leg stance performance can predict fall risk. This study investigated one-leg stance strategies in PD patients and found that they tend to choose and perform better on the leg with less impairment. However, the most stable leg is not always chosen, and the side of the chosen leg may switch after seven years of disease duration. It is important to identify PD patients who choose the least stable leg as they may be at a higher risk of falls and may benefit from specific rehabilitation strategies.
Review
Geriatrics & Gerontology
Marcos Paulo Braz de Oliveira, Daniel Ferreira Moreira Lobato, Suhaila Mahmoud Smaili, Cristiano Carvalho, Juliana Bassalobre Carvalho Borges
Summary: Aerobic exercise can promote improvements in gait, mobility, and lower limb muscle strength in individuals with Parkinson's disease in mild to moderate stages, but does not significantly improve quality of life.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2021)
Review
Neurosciences
Taylor Landry, Hu Huang
Summary: Recent evidence suggests a strong association between metabolism and adult hippocampal neurogenesis, crucial for cognitive function. Interventions promoting energy balance have shown promising potential in enhancing hippocampal neurogenesis and cognitive function.
NEUROSCIENCE LETTERS
(2021)
Review
Biochemistry & Molecular Biology
Berenice A. Gutierrez, Agenor Limon
Summary: Neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, result from the dysfunction and death of neurons. The presence of small soluble oligomers, such as amyloid beta and Tau oligomers in Alzheimer's, and alpha-synuclein oligomers in Parkinson's, is toxic and relevant to the development of these diseases. These oligomers increase during the early stages of pathology, leading to disruption of synaptic plasticity, synapse loss, inflammation, imbalance between excitatory and inhibitory transmission, and cognitive impairment. The absence of Tau oligomers at synapses in individuals with advanced Alzheimer's pathology but preserved cognition suggests that resilience mechanisms may depend on the interactions between soluble oligomers and their synaptic targets.
Review
Rehabilitation
Alessandro Picelli, Marianna Capecci, Mirko Filippetti, Valentina Varalta, Cristina Fonte, Rita Di Censo, Alessandro Zadra, Irene Chignola, Stefano Scarpa, Angelo P. Amico, Roberto Antenucci, Alessio Baricich, Paolo Benanti, Luciano Bissolotti, Paolo Boldrini, Donatella Bonaiuti, Enrico Castelli, Loredana Cavalli, Giuseppina Di Stefano, Francesco Draicchio, Vincenzo Falabella, Silvia Galeri, Francesca Gimigliano, Mauro Grigioni, Johanna Jonsdodttir, Carmelo Lentino, Perla Massai, Stefano Mazzoleni, Stefano Mazzon, Franco Molteni, Sandra Morelli, Giovanni Morone, Daniele Panzeri, Maurizio Petrarca, Federico Posteraro, Michele Senatore, Elisa Taglione, Giuseppe Turchetti, Thomas Bowman, Antonio Nardone
Summary: Robot-assisted gait training shows therapeutic effects on postural instability in patients with Parkinson's disease, especially in terms of balance and freezing of gait. The research results indicate a high level of evidence that robot-assisted gait training can improve patients' quality of life.
EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE
(2021)
Article
Behavioral Sciences
Beatriz Regina Legutke, Lilian Teresa Bucken Gobbi, Diego Orcioli-Silva, Paulo Cezar Rocha dos Santos, Gabriel Antonio Gazziero Moraca, Rodrigo Vitorio, Victor Spiandor Beretta
Summary: Balance impairments in people with Parkinson's disease may be attributed to deficits in brain structures involved in postural control. This study analyzed the effects of transcranial direct current stimulation (tDCS) on the center of pressure (CoP) parameters during an adapted tandem position in people with PD. The results showed that a single session of 2 mA tDCS did not improve the postural control in people with PD.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Clinical Neurology
Francesco Ferraro, Dario Calafiore, Claudio Curci, Francesco Fortunato, Irene Carantini, Filippo Genovese, Giuseppe Lucchini, Andrea Merlo, Antonio Ammendolia, Alessandro de Sire
Summary: This real-practice retrospective study aimed to assess the effectiveness of an intensive neurorehabilitation protocol on muscle strength and functioning in CMT patients. The study found that after intensive rehabilitation treatment, all outcomes significantly improved, but this improvement was lost at the 1-year mark.
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Franco Franchignoni, Marco Godi, Stefano Corna, Andrea Giordano
Summary: This study examined the psychometric properties of the Mini-BESTest in individuals with Parkinson disease and found that it has good reliability and validity in measuring balance. The study also created two forms of the test that can help interpret results and calculate more precise change scores.
JOURNAL OF NEUROLOGIC PHYSICAL THERAPY
(2022)
Review
Neurosciences
Sara De Angelis, Alessandro Antonio Princi, Fulvio Dal Farra, Giovanni Morone, Carlo Caltagirone, Marco Tramontano
Summary: Postural instability and fear of falling are two major factors affecting mobility and quality of life in patients with cerebrovascular and neurological diseases. Rehabilitation strategies incorporating sensorimotor intervention and active patient involvement have been developed, with vibrotactile feedback (VF) emerging as a potential therapeutic approach for balance and gait rehabilitation in these patients. Despite the lack of high-quality studies, VF-based interventions appear to be safe and effective, but further research is needed to verify their efficacy.
Review
Rehabilitation
Marcos Paulo Braz de Oliveira, Luciana Maria dos Reis, Natalia Duarte Pereira
Summary: The study indicates that resistance exercise can improve body structure and function in individuals with Parkinson's Disease, particularly in upper limb muscle strength, cardiovascular function, and postural balance. However, it may not significantly improve participation (quality of life) for these individuals.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Article
Neurosciences
Anna Brachman, Wojciech Marszalek, Anna Kamieniarz, Justyna Michalska, Michal Pawlowski, Grzegorz Juras
Summary: This study found that balance-based exercise training had positive effects on both static and dynamic balance in patients with PD, with exergaming training showing more significant improvements in dynamic balance measures. Posturography was effective in revealing the differential effects of the training interventions for both groups. These findings highlight the potential benefits of incorporating exergaming training into exercise programs for individuals with PD.
Article
Rehabilitation
Busaba Chuatrakoon, Sureeporn Uthaikhup, Shirley P. Ngai, Chalerm Liwsrisakun, Chaicharn Pothirat, Somporn Sungkarat
Summary: An eight-week home-based balance training combined with pulmonary rehabilitation program can effectively improve balance, dyspnea, and well-being in individuals with COPD.
EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE
(2022)
Review
Rehabilitation
Francesco Lena, Nicola Modugno, Giulio Greco, Monica Torre, Simone Cesarano, Marco Santilli, Auwal Abdullahi, Giuseppe Giovannico, Mohammad Etoom
Summary: Postural instability is a clinical manifestation of Parkinson disease and rehabilitation interventions have shown promising effects in improving balance. This study aimed to review literature evidence and summarize the effects of rehabilitation interventions on balance-related outcomes in Parkinson disease.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2023)
Article
Medicine, General & Internal
Loredana Raciti, Loris Pignolo, Valentina Perini, Massimo Pullia, Bruno Porcari, Desiree Latella, Marco Isgro, Antonino Naro, Rocco Salvatore Calabro
Summary: This study aimed to evaluate the improvement of hand function in patients with Parkinson's Disease (PD) using an upper extremity exoskeleton for semi-autonomous exercises. The results showed that the experimental group, trained with Armeo (R) Spring, had greater improvement in the nine-hole peg test, upper limb mobility, and disease burden compared to the control group.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Luciano Furlanetti, Asfand Baig Mirza, Ahmed Raslan, Maria Alexandra Velicu, Charlotte Burford, Melika Akhbari, Elaine German, Romi Saha, Michael Samuel, Keyoumars Ashkan
Summary: Parkinson's disease is a complex neurodegenerative disorder that impairs various neurological faculties. Deep Brain Stimulation (DBS) combined with optimized clinical treatment has been shown to improve quality of life, motor, and non-motor symptoms. However, there are no specific guidelines regarding driving restrictions following DBS, highlighting the need for standardized evaluations.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Jun-Pyo Hong, Hanim Kwon, Euyhyun Park, Sun-Uk Lee, Chan-Nyoung Lee, Byung-Jo Kim, Ji-Soo Kim, Kun-Woo Park
Summary: In patients with mild-to-moderate PD, vestibular function assessed by video head-impulse tests appears relatively preserved and has minimal impact on the risk of falls. Risk of postural instability is associated with the severity of clinical symptoms in PD.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yaqin Xiang, XiuRong Huang, Qian Xu, Zhenhua Liu, Yase Chen, Qiying Sun, Junling Wang, Hong Jiang, Lu Shen, Xinxiang Yan, Beisha Tang, Jifeng Guo
Summary: Using the novel data-driven method DEBM, this study determined the sequence of several common biomarker changes in Parkinson's disease (PD). The left putamen was found to be the earliest biomarker to become abnormal, followed by the right putamen, CSF alpha-synuclein, right caudate, left caudate, and serum NfL. The estimated disease stages showed significant differences between PD and healthy controls, and achieved a high accuracy for distinguishing PD from HC.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yan Li, David J. McLernon, Carl E. Counsell, Angus D. Macleod
Summary: This study aimed to investigate the incidence and risk factors for institutionalisation in Parkinson's disease (PD) and atypical parkinsonism (AP). The study found that institutionalisation was more frequent in AP compared to PD and controls. Age, poorer cognition, and more-severe parkinsonian impairment were independent predictors of institutionalisation.
PARKINSONISM & RELATED DISORDERS
(2024)