Article
Neurosciences
Ruchi Singh, Nirendra K. Rai, Sunil Chouhan, Abhijit Pakhare
Summary: This study translated and validated the Parkinson's disease sleep scale-2 (PDSS-2) in Hindi for its use among Hindi-speaking Indian patients. The results showed that the Hindi version of PDSS-2 (H-PDSS-2) had similar psychometric attributes as the original PDSS-2, suggesting its usefulness in assessing sleep problems among Indian Parkinson's disease patients.
Article
Chemistry, Analytical
Yi-Feng Ko, Pei-Hsin Kuo, Ching-Fu Wang, Yu-Jen Chen, Pei-Chi Chuang, Shih-Zhang Li, Bo-Wei Chen, Fu-Chi Yang, Yu-Chun Lo, Yi Yang, Shuan-Chu Vina Ro, Fu-Shan Jaw, Sheng-Huang Lin, You-Yin Chen
Summary: This study utilizes a smartwatch-based sensor as a convenient tool to detect Rapid Eye Movement (REM) sleep behavior disorder (RBD) in Parkinson's disease (PD) patients. The sensor is able to record comprehensive sleep physiological data, providing ubiquity, long-term monitoring, and wearable convenience. A machine learning-based three-stage sleep staging method is implemented using accelerometer and heart-rate data for sleep/awake detection, sleep-stage detection, and REM-stage detection. The results show significant differences in abnormal REM and deep sleep stage between control and PD groups. The sensor is effective in investigating sleep stage in PD patients and determining the effect of clonazepam on reducing abnormal REM.
Review
Biology
Sumire Matsumoto, Tomomi Tsunematsu
Summary: Protein misfolding and aggregation are associated with various neurodegenerative diseases like AD and PD. Sleep impairments in these diseases can serve as both accompanying symptoms and potential biomarkers for early diagnosis. The relationship between sleep disturbances and neurodegenerative diseases is a topic of interest for future research and potential treatment strategies.
Article
Clinical Neurology
Cecile Di Folco, Raphael Couronne, Isabelle Arnulf, Graziella Mangone, Smaranda Leu-Semenescu, Pauline Dodet, Marie Vidailhet, Jean-Christophe Corvol, Stephane Lehericy, Stanley Durrleman
Summary: This study proposes a disease course map for Parkinson's disease (PD) and investigates the progression profiles of patients with or without rapid eye movement sleep behavioral disorders (RBD). The findings reveal distinct patterns of progression between PD patients with and without RBD, emphasizing the importance of understanding heterogeneity in PD progression for precision medicine.
MOVEMENT DISORDERS
(2023)
Review
Medicine, Research & Experimental
Stefania Diaconu, Oana Falup-Pecurariu, Diana Tint, Cristian Falup-Pecurariu
Summary: Rapid eye movement (REM) sleep behavior disorder (RBD) is a sleep disorder characterized by abnormal movements during REM state, which can be idiopathic or secondary. RBD is associated with Parkinson's disease and may precede the specific motor symptoms of PD by several years. In addition to video polysomnography, clinical scales and questionnaires can also be used for screening RBD in clinical practice. Management options include ensuring patient safety and pharmacological treatment with medications such as clonazepam, melatonin, or certain antiparkinsonian drugs.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Clinical Neurology
Fucheng Qiu, Ping Gu, Wencong Liu, Dong Li
Summary: This study revealed that lower levels of total cholesterol, triglyceride, and uric acid were associated with Parkinson's disease occurrence, while higher levels of homocysteine, sleep quality index, and sleep-related issues were seen in the late-stage group of PD patients.
NEUROLOGICAL SCIENCES
(2022)
Article
Neurosciences
Eun Jin Yoon, Oury Monchi
Summary: The study found that probable RBD in PD patients is associated with changes in neural structures leading to decreased cognitive performance, and linked with volume decrease in the left caudate nucleus, pallidum, and amygdala.
NPJ PARKINSONS DISEASE
(2021)
Article
Clinical Neurology
Milan Nigam, Ines Ayadi, Camille Noiray, Ana Catarina Branquino-Bras, Erika Herraez Sanchez, Smaranda Leu-Semenescu, Marie Vidailhet, Pauline Dodet, Isabelle Arnulf
Summary: The study found that taste impairment is present in isolated REM sleep behavior disorder and comparable to participants with PD, independent of olfactory dysfunction and other factors like age, disease duration, cognition, or autonomic function.
MOVEMENT DISORDERS
(2021)
Article
Neurosciences
Yinyin Jiang, Jun Zhu, Yang Zhao, Dongfeng Li, Yaning Chen, Yaxi Wang, Xu Jiang, Bo Shen, Yang Pan, Jun Yan, Feng Han, Li Zhang
Summary: This study aimed to explore the association of minor hallucinations (MHs) in Parkinson's disease (PD) patients with probable rapid eye movement sleep behavior disorder (pRBD). Results showed that among the 291 PD patients, 69 (23.7%) had pRBD, and 35 (50.7%) of them had MHs, which was significantly higher compared to patients without RBD. The main type of MHs in pRBD was presence hallucinations with variable content. Older age, longer disease duration, and use of levodopa or dopamine-receptor agonists were observed in the pRBD with MHs group.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Clinical Neurology
Michela Figorilli, Mario Meloni, Giuseppe Lanza, Elisa Casaglia, Rosamaria Lecca, Francesca Lea Saibene, Patrizia Congiu, Monica Puligheddu
Summary: Rapid eye movement (REM) sleep behavior disorder (RBD) is characterized by dream-enacting behavior due to the loss of muscle tone inhibition during REM sleep and is considered a precursor to neurodegenerative diseases. Patients with isolated RBD (iRBD) have a high risk of developing a neurodegenerative disease. RBD occurring in the context of Parkinson's disease (PDRBD) identifies a more severe phenotype with increased cognitive decline and treatment options remain limited.
NATURE AND SCIENCE OF SLEEP
(2023)
Review
Neurosciences
Jeremy Hunt, Elizabeth J. Coulson, Rajendram Rajnarayanan, Henrik Oster, Aleksandar Videnovic, Oliver Rawashdeh
Summary: The use of animal models is crucial for understanding the mechanisms of Parkinson's disease. This review examines the extent to which different mouse models accurately reflect the sleep and circadian abnormalities observed in Parkinson's disease.
MOLECULAR NEURODEGENERATION
(2022)
Article
Clinical Neurology
Femke Dijkstra, Nathan Reyn, Barbara de Bruyn, Karlien van den Bossche, Ilse de Volder, Marc Willemen, Mineke Viaene, Jo Leenders, Patrick Cras, David Crosiers
Summary: The study found that in the prodromal stages of Parkinson's disease (PD), patients showed higher RSWA variables and a higher percentage of nocturnal supine body position, regardless of RBD status. These results suggest that these PSG abnormalities may serve as prodromal biomarkers for PD.
Article
Clinical Neurology
Mahsa Dolatshahi, Amir Ashraf-Ganjouei, I-Wei Wu, Yu Zhang, Mohammad Hadi Aarabi, Duygu Tosun
Summary: This study aimed to investigate white-matter integrity differences in PD patients with and without comorbid pRBD and ICDs. Results showed that PD patients with only ICDs had higher white-matter integrity, while those with only pRBD showed lower white-matter integrity in specific brain regions.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Paulo Bugalho, Filipa Ladeira, Raquel Barbosa, Joao Pedro Marto, Claudia Borbinha, Laurete da Conceicao, Manuel Salavisa, Marlene Saraiva, Bruna Meira, Marco Fernandes
Summary: This study suggests that PSG data could be valuable for predicting the progression of cognitive and sleep dysfunction in PD patients. Lower N3 percentage at baseline was associated with cognitive decline, while baseline PLMS index and presence of RBD were linked to worsening daytime sleep dysfunction. Severity of RBD was a predictor for nighttime sleep symptom progression.
Article
Clinical Neurology
Yi-Qun Yan, Jia-Li Pu, Ran Zheng, Yi Fang, Lu-Yan Gu, Tao Guo, Xiao-Li Si, Cheng Zhou, Ying Chen, Yi Liu, Xiao-Jun Guan, Xiao-Jun Xu, Ya-Ping Yan, Xin-Zhen Yin, Min-Ming Zhang, Zhi-Hua Tao, Bao-Rong Zhang
Summary: The study suggests that both plasma total exosomal alpha-Syn and neural-derived exosomal alpha-Syn were elevated in Parkinson's disease (PD) patients, while only neural-derived exosomal alpha-Syn was elevated in probable idiopathic rapid eye movement sleep behavior disorder (pRBD) patients. Additionally, the adaptor protein of inflammasome ASC is correlated with alpha-Syn and may play a role in synucleinopathy.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Rehabilitation
Ana Carolina Leonardi Dutra, Nayron Medeiros Soares, Nathalie Ribeiro Artigas, Gabriela Magalhaes Pereira, Julia Schneider Krimberg, Angelica Cristiane Ovando, Artur Francisco Schumacher Schuh, Carlos Roberto de Mello Rieder
Summary: Life-space mobility (LSM) is an important measure to assess the physical and social environments in which individuals with Parkinson's disease move during their daily lives. This study found that age, disease severity, cognition, motor subtype, balance self-efficacy, and balance performance are all associated with LSM. Improving balance and self-efficacy in people with Parkinson's disease could have positive effects on their community mobility and overall health.
Article
Clinical Neurology
Karen Jansen, Mateus Grellert, Adile Nexha, Jean Pierre Oses, Ricardo Azevedo da Silva, Luciano Dias de Mattos Souza, Flavio Kapczinski, Benicio N. Frey, Taiane de Azevedo Cardoso
Summary: This study examines whether the link between mothers diagnosed with bipolar disorder and emotional and behavioral problems in their offspring is mediated by disruptions in the offspring's biological rhythms. The findings show that offspring of mothers with bipolar disorder have more difficulty in maintaining biological rhythms and a higher prevalence of emotional and behavioral problems compared to offspring of mothers without bipolar disorder. Therefore, disruptions in the biological rhythms of the offspring fully mediate the impact of the mother's bipolar disorder on their emotional and behavioral problems.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Leonardo Carvalho Oliveira, Natalia Wirowski, Pedro Borges de Souza, Andressa Schneider Lobato, Karen Jansen, Taiane de Azevedo Cardoso, Thaise Campos Mondin, Jean Pierre Oses, Flavio Kapczinski, Luciano Dias de Mattos Souza, Ricardo Azevedo da Silva, Fernanda Pedrotti Moreira
Summary: This study aims to compare the serum cytokine levels between controls, individuals with a current depressive episode (CDE) with childhood trauma and individuals with CDE without childhood trauma. The study found that individuals with CDE had elevated levels of certain cytokines compared to the control group, while other cytokines showed decreased levels. However, there was no significant difference in cytokine levels between individuals with CDE, with and without trauma. The findings suggest that monitoring cytokine levels may be beneficial in preventing the development of a CDE.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Psychiatry
Coral Rakovski, Pedro L. Ballester, Bruno Braga Montezano, Luciano Dias de Mattos Souza, Karen Jansen, Ricardo Azevedo da Silva, Thaise Campos Mondin, Fernanda Pedrotti Moreira, Raquel Brandini De Boni, Benicio N. Frey, Flavio Kapczinski, Taiane de Azevedo Cardoso
Summary: This study employed machine learning techniques to identify predictors of illicit substance abuse/dependence among a large community sample of young adults in Brazil. The strongest predictors included alcohol abuse/dependence, tobacco abuse/dependence, current major depressive episode, history of a lifetime manic episode, current suicide risk, and male sex. The findings indicate that machine learning techniques can accurately predict illicit substance abuse/dependence among young adults using sociodemographic/clinical characteristics.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Medicine, General & Internal
Cesar Eduardo Fernandes, Jose Eduardo Lutaif Dolci, Leonardo Sobral Navarro, Marcelo Allevato, Clovis Francisco Constantino, Rodrigo Pastor Alves Pereira, Carlos Roberto de Mello Rieder, Flavia Torino, Wanderley Marques Bernardo
Summary: The Guidelines Project, launched by the Brazilian Medical Association, aims to standardize doctors' conduct and assist in their decision-making by combining information from the medical field. Physicians need to critically evaluate the information provided by this project and apply it according to the individual conditions and clinical state of each patient. The deadline for the guideline conclusion is January 5, 2023, with submission due on January 6, 2023.
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
(2023)
Review
Health Care Sciences & Services
Vinod Metta, Guy Chung-Faye, Hani T. S. Benamer, Rukmini Mrudula, Vinay Goyal, Cristian Falup-Pecurariu, Neha Muralidharan, Desh Deepak, Mohammed Abdulraheem, Rupam Borgohain, Kallol Ray Chaudhuri
Summary: Parkinson's disease is a chronic and progressive neurological disorder, ranking as the second most common neurodegenerative condition. This study highlights the prevalence, pathophysiology, and evidence-based treatment strategies for three commonly overlooked symptoms in Parkinson's disease: hiccups, hypersalivation, and hallucinations. Early recognition and treatment are crucial for improving the quality of life for patients.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Neurosciences
Vanise Grassi, Mauro Eduardo Jurno, Alan Christmann Froehlich, Carlos Roberto de Mello Rieder, Elder Machado Sarmento, Julia Kassia Pereira, Leonardo Lima Silva, Liselotte Menke Barea, Luiz Ernesto Besen Poli, Luiz Paulo Queiroz, Marcelo Cedrinho Ciciarelli, Mario Fernando Prieto Peres, Pedro Augusto Sampaio Rocha Filho, Rebeca Veras de Andrade Vieira, Renata Gomes Londero, Fernando Kowacs
Summary: The Brazilian Headache Society proposed the Brazilian Headache Registry and conducted a pilot study in three specialist centers for headache care in southern and southeastern Brazil. The study found that primary headaches accounted for 85.3% of the diagnoses, with medication overuse headache being the most frequent type among secondary headaches.
ARQUIVOS DE NEURO-PSIQUIATRIA
(2023)
Review
Clinical Neurology
Paula Saffie Awad, Daniel Teixeira-dos-Santos, Bruno Lopes Santos-Lobato, Sarah Camargos, Mario Cornejo-Olivas, Carlos Roberto de Mello Rieder, Ignacio F. Mata, Pedro Chana-Cuevas, Christine Klein, Artur F. Schumacher Schuh
Summary: This study conducted a systematic review and meta-analysis on genetic parkinsonism in Latin America, finding pathogenic variants in 19 different genes among Latin American patients. The frequency of pathogenic variants in LRRK2, PRKN, and GBA1 genes were 1.38%, 1.16%, and 4.17% respectively. Further research is needed in the region for better understanding and personalized therapies.
MOVEMENT DISORDERS
(2023)
Letter
Clinical Neurology
Dafne Dalledone Moura, Vanderci Borges, Henrique Ballalai Ferraz, Artur F. S. Schuh, Carlos Roberto de Mello Rieder, Ignacio F. Mata, Manuelina Mariana Capellari Macruz Brito, Vitor Tumas, Bruno Lopes Santos-Lobato
Summary: The prevalence of Parkinson's disease (PD) is increasing worldwide, and there may be a connection between household pesticide exposure and this trend. Our study revealed that individuals with high exposure to household pesticides have twice the risk of developing PD. Exposure to household pesticides does not affect the age at which PD symptoms appear.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Ali Shojaie, Ahmad Al Khleifat, Sarah Opie-Martin, Payam Sarraf, Ammar Al-Chalabi
Summary: This study aimed to examine the nature and extent of non-motor symptoms in ALS. Through an online questionnaire and sharing on social media platforms, a total of 1018 responses were received, including 506 people with ALS and 421 unaffected individuals. The study found that people with ALS were more likely to report autonomic symptoms, pain, and psychiatric symptoms, which significantly impacted their quality of life. Therefore, the identification and management of non-motor symptoms are crucial in the clinical care of ALS patients.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
(2023)
Review
Clinical Neurology
Kausar Raheel, Gemma Deegan, Irene Di Giulio, Diana Cash, Katarina Ilic, Valentina Gnoni, K. Ray Chaudhuri, Panagis Drakatos, Rosalyn Moran, Ivana Rosenzweig
Summary: Past research suggests that there are more cases and severe clinical manifestations of alpha-synucleinopathies in men, indicating potential neuroprotective properties of female sex hormones, especially estrogen. However, the underlying mechanisms of this effect are not well understood. This study aimed to systematically review and critically assess the current evidence on sex and gender differences in alpha-synucleinopathies.
FRONTIERS IN NEUROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Iro Boura, Mubasher A. Qamar, Francesco Daddoveri, Valentina Leta, Karolina Poplawska-Domaszewicz, Cristian Falup-Pecurariu, K. Ray Chaudhuri
Summary: This article reviews the research on the relationship between COVID-19 and PD over the past three years, finding that COVID-19 may worsen PD symptoms and increase mortality in PD patients. Additionally, new-onset parkinsonism or PD following COVID-19 infection has been reported, although this link remains hypothetical.
Article
Clinical Neurology
Jason Aldred, Eric Freire-Alvarez, Alexander V. Amelin, Angelo Antonini, Bruno Bergmans, Filip Bergquist, Manon Bouchard, Kumar Budur, Camille Carroll, K. Ray Chaudhuri, Susan R. Criswell, Erik H. Danielsen, Florin Gandor, Jia Jia, Thomas E. Kimber, Hideki Mochizuki, Weining Z. Robieson, Amy M. Spiegel, David G. Standaert, Saritha Talapala, Maurizio F. Facheris, Victor S. C. Fung
Summary: This article reports the results of a 52-week open-label registrational trial that evaluated the safety, tolerability, and efficacy of 24-hour foslevodopa/foscarbidopa continuous subcutaneous infusion in patients with advanced Parkinson's disease. The findings suggest that this treatment has the potential to improve motor control, sleep quality, and quality of life in patients with Parkinson's disease.
NEUROLOGY AND THERAPY
(2023)
Editorial Material
Clinical Neurology
K. Ray Chaudhuri, Lucia Batzu
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Neurosciences
Nayron Medeiros Soares, Gabriela Magalhaes Pereira, Ana Carolina Leonardi Dutra, Nathalie Ribeiro Artigas, Julia Schneider Krimberg, Bruno Elkfury Monticelli, Artur Francisco Schumacher-Schuh, Rosa Maria Martins de Almeida, Carlos Roberto de Mello Rieder
Summary: This study investigated the relationship between serum uric acid (UA) levels and levodopa-induced dyskinesia (LID) in Parkinson's disease (PD) patients, as well as the associations between UA levels and clinical features of PD. The results showed that the dyskinesia group had lower serum UA levels compared to the no dyskinesia group, which was also observed in both men and women. Multivariate analysis demonstrated that lower UA levels were significantly associated with the presence of dyskinesia. Additional analysis revealed that serum UA levels were inversely correlated with depressive symptoms, disease duration, MDS-UPDRS IV, and time spent with dyskinesia, while positively correlated with age at onset of PD symptoms.
ARQUIVOS DE NEURO-PSIQUIATRIA
(2023)
Article
Clinical Neurology
Jun-Pyo Hong, Hanim Kwon, Euyhyun Park, Sun-Uk Lee, Chan-Nyoung Lee, Byung-Jo Kim, Ji-Soo Kim, Kun-Woo Park
Summary: In patients with mild-to-moderate PD, vestibular function assessed by video head-impulse tests appears relatively preserved and has minimal impact on the risk of falls. Risk of postural instability is associated with the severity of clinical symptoms in PD.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yaqin Xiang, XiuRong Huang, Qian Xu, Zhenhua Liu, Yase Chen, Qiying Sun, Junling Wang, Hong Jiang, Lu Shen, Xinxiang Yan, Beisha Tang, Jifeng Guo
Summary: Using the novel data-driven method DEBM, this study determined the sequence of several common biomarker changes in Parkinson's disease (PD). The left putamen was found to be the earliest biomarker to become abnormal, followed by the right putamen, CSF alpha-synuclein, right caudate, left caudate, and serum NfL. The estimated disease stages showed significant differences between PD and healthy controls, and achieved a high accuracy for distinguishing PD from HC.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yan Li, David J. McLernon, Carl E. Counsell, Angus D. Macleod
Summary: This study aimed to investigate the incidence and risk factors for institutionalisation in Parkinson's disease (PD) and atypical parkinsonism (AP). The study found that institutionalisation was more frequent in AP compared to PD and controls. Age, poorer cognition, and more-severe parkinsonian impairment were independent predictors of institutionalisation.
PARKINSONISM & RELATED DISORDERS
(2024)
