Article
Ophthalmology
Michela Cennamo, Francesco Dragotto, Eleonora Favuzza, Alberto Morelli, Rita Mencucci
Summary: This case report describes a patient with bilateral corneal opacities and edema after long-term treatment with amantadine for Parkinson's Disease. Clinical remission was achieved after discontinuation of amantadine, but complete resolution of the corneal edema was not observed at the ultrastructural level. Persistent endothelial degradation was noted on in vivo confocal microscopy.
Article
Biochemistry & Molecular Biology
Seongjun So, Yoonkyung Park, Soon Suk Kang, Jongsuk Han, Jeong Hye Sunwoo, Whanseo Lee, Jin Kim, Eun Ah Ye, Jae Yong Kim, Hungwon Tchah, Eunju Kang, Hun Lee
Summary: Corneal endothelial cells (CECs) cannot proliferate or recover, causing decreased cell density and loss of pump/barrier function. The study investigated the efficacy and safety of transplanting induced pluripotent stem cell (iPSC)-derived CECs into a corneal endothelial dysfunction (CED) rabbit model. Results showed successful differentiation of iPSCs into CECs and improved corneal transparency after transplantation. iPSC-derived CECs may be a promising cellular resource for treating CED.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Juan Yu, Nianye Yu, Yao Tian, Yifan Fang, Bin An, Guihai Feng, Jun Wu, Liu Wang, Jie Hao, Liqiang Wang, Qi Zhou, Wei Li, Yukai Wang, Baoyang Hu
Summary: Our study presents an improved protocol for differentiating clinical-grade hESCs into iCECs using xeno-free medium and cryopreservation. The generated iCECs express typical CECs markers and exhibit transendothelial potential properties. After rigorous quality control, the cells meeting release criteria were available for in vivo studies. Grafts of iCECs did not show overgrowth or tumorigenicity in immunodeficient mice and successfully ameliorated edema and corneal opacity in rabbit models.
CELL AND BIOSCIENCE
(2023)
Article
Clinical Neurology
Chi-Chuan Wang, Tsai-Ling Wu, Fang-Ju Lin, Chun-Hwei Tai, Chin-Hsien Lin, Ruey-Meei Wu
Summary: The study found that early treatment with amantadine may delay the onset of levodopa-induced dyskinesia in patients with Parkinson's disease more effectively than treatment with other symptomatic agents. Further research is needed to validate this finding and explore the mechanism by which amantadine delays LID onset.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Qian-Ya Fan, Xiao-Dong Zhang, Ze-Di Hu, Shi-Shi Huang, Shi-Guo Zhu, Cai-Ping Chen, Xiong Zhang, Jian-Yong Wang
Summary: This case report presents a patient with Parkinson's disease who developed blepharospasm during the peak-dose dyskinesia period. The symptom was improved by taking amantadine. This expands the understanding of peak-dose dyskinesia in Parkinson's disease to include dystonic blepharospasm, which may respond to amantadine despite the dystonic appearance of movements.
FRONTIERS IN NEUROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Michael Poledniczek, Christoph Neumayer, Christoph W. Kopp, Oliver Schlager, Thomas Gremmel, Alicja Jozkowicz, Michael E. Gschwandtner, Renate Koppensteiner, Patricia P. Wadowski
Summary: Inflammation plays a crucial role in the development and progression of atherosclerosis. It negatively affects endothelial barrier properties, glycocalyx, and extracellular matrix composition, leading to vascular remodeling, aneurysm formation, and reduced tissue perfusion. This review discusses the molecular and clinical effects of inflammatory processes on micro- and macrovasculature, with a focus on peripheral artery disease.
Review
Biochemistry & Molecular Biology
Firoz Anwar, Salma Naqvi, Fahad A. Al-Abbasi, Nauroz Neelofar, Vikas Kumar, Ankit Sahoo, Mohammad Amjad Kamal
Summary: The global impact of the SARS-CoV-2 outbreak has put elderly Parkinson's disease (PD) patients at risk, highlighting the need for timely adjustment of treatment plans. Approved drugs for PD have established mechanisms of action, but further research is required to assess their efficacy in treating COVID-19.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Cell & Tissue Engineering
Peng Sun, Lin Shen, Yuan-Bin Li, Li-Qun Du, Xin-Yi Wu
Summary: In this study, human corneal endothelial cells (HCECs) were cultivated using a conditioned medium from orbital adipose-derived stem cells (OASC-CM) and then transplanted into animal models with corneal endothelial dysfunction. Long-term observation revealed successful outcomes, with transparent corneas and maintained cell morphology. This research demonstrates a promising prospect for cell-based therapy for corneal endothelial diseases.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Clinical Neurology
Shyamal H. Mehta, Rajesh Pahwa, Caroline M. Tanner, Robert A. Hauser, Reed Johnson
Summary: This analysis suggests potential benefits of Gocovri treatment for daytime sleepiness and depression symptoms in dyskinetic PD patients. Overall, improvement in non-motor symptom scores correlated with improvement in dyskinesia.
NEUROLOGY AND THERAPY
(2021)
Article
Ophthalmology
Lauren J. Jeang, Curtis E. Margo, Edgar M. Espana
Summary: The corneal endothelial monolayer and Descemet's membrane complex are crucial for corneal function, with various diseases potentially affecting these structures and causing impaired vision.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Neurosciences
Ning-Ning Che, Shuai Chen, Qiu-Huan Jiang, Si-Yuan Chen, Zhen-Xiang Zhao, Xue Li, Rayaz A. Malik, Jian-Jun Ma, Hong-Qi Yang
Summary: This study investigated the use of corneal confocal microscopy (CCM) to assess autonomic symptoms in Parkinson's disease (PD). The results showed that PD patients with autonomic symptoms had lower corneal nerve fiber density compared to those without autonomic symptoms. CCM could serve as an objective ophthalmic imaging technique to identify patients with PD and autonomic symptoms.
NPJ PARKINSONS DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Eun Ah Ye, Ho Seok Chung, Yoonkyung Park, Jeong Hye Sunwoo, Whanseo Lee, Jin Kim, Hungwon Tchah, Hun Lee, Jae Yong Kim
Summary: This study demonstrated the differentiation of human umbilical cord-derived mesenchymal stem cells (UC-MSCs) into corneal endothelial cells (CECs). The efficacy of MSC-induced CEC injection was investigated in a rabbit model of corneal endothelial dysfunction (CED). The results showed that MSC-induced CEC injection improved corneal opacity and neovascularization in the rabbit model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Yanru Duan, Shihan Zhang, Yuanyuan Xing, Ye Wu, Wen Zhao, Pinxue Xie, Huina Zhang, Xinxiao Gao, Yanwen Qin, Yajing Wang, Xinliang Ma, Yunhui Du, Huirong Liu
Summary: This study revealed that adiponectin inhibits diabetic endothelial inflammatory response by activating the Wnt/beta-catenin signaling pathway and promoting the expression of CD44 through APPL1. These findings provide a new avenue for the inhibition of diabetic endothelial inflammation.
Article
Physiology
Alexander Kogel, Sven Fikenzer, Luisa Uhlmann, Lena Opitz, Jasmin M. Kneuer, Karl Georg Haeusler, Matthias Endres, Juergen Kratzsch, Viktoria Schwarz, Christian Werner, Hermann Kalwa, Susanne Gaul, Ulrich Laufs
Summary: The study investigates the effects of acute extensive exercise on the levels of extracellular ASC specks and their impact on endothelial cells. It is found that there is a transient increase in circulating ASC specks immediately after marathon running, followed by a decrease during the post-run recovery period. Endothelial cells are capable of internalizing extracellular NLRP3 inflammasome particles and this internalization leads to an inflammatory response characterized by increased expression of the cell adhesion molecule ICAM1 and enhanced monocyte adhesion.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Clinical Neurology
Sze Hway Lim, Maryam Ferdousi, Alise Kalteniece, Ziyad R. Mahfoud, Ioannis N. Petropoulos, Rayaz A. Malik, Christopher Kobylecki, Monty Silverdale
Summary: Corneal confocal microscopy (CCM) is a useful tool to identify neurodegeneration in patients with Parkinson's disease (PD). This study found that corneal nerve fiber density was significantly lower in PD participants compared to healthy controls, and those with lower CNFD at baseline showed greater worsening in Movement Disorder Society Unified Parkinson's Disease Rating Scale over 12 months.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Jun-Pyo Hong, Hanim Kwon, Euyhyun Park, Sun-Uk Lee, Chan-Nyoung Lee, Byung-Jo Kim, Ji-Soo Kim, Kun-Woo Park
Summary: In patients with mild-to-moderate PD, vestibular function assessed by video head-impulse tests appears relatively preserved and has minimal impact on the risk of falls. Risk of postural instability is associated with the severity of clinical symptoms in PD.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yaqin Xiang, XiuRong Huang, Qian Xu, Zhenhua Liu, Yase Chen, Qiying Sun, Junling Wang, Hong Jiang, Lu Shen, Xinxiang Yan, Beisha Tang, Jifeng Guo
Summary: Using the novel data-driven method DEBM, this study determined the sequence of several common biomarker changes in Parkinson's disease (PD). The left putamen was found to be the earliest biomarker to become abnormal, followed by the right putamen, CSF alpha-synuclein, right caudate, left caudate, and serum NfL. The estimated disease stages showed significant differences between PD and healthy controls, and achieved a high accuracy for distinguishing PD from HC.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yan Li, David J. McLernon, Carl E. Counsell, Angus D. Macleod
Summary: This study aimed to investigate the incidence and risk factors for institutionalisation in Parkinson's disease (PD) and atypical parkinsonism (AP). The study found that institutionalisation was more frequent in AP compared to PD and controls. Age, poorer cognition, and more-severe parkinsonian impairment were independent predictors of institutionalisation.
PARKINSONISM & RELATED DISORDERS
(2024)
