Article
Biology
Fernando Salvador, Beatriz Lobo, Lidia Goterris, Carmen Alonso-Cotoner, Javier Santos, Elena Sulleiro, Begona Bailo, David Carmena, Adrian Sanchez-Montalva, Pau Bosch-Nicolau, Juan Espinosa-Pereiro, Isabel Fuentes, Israel Molina
Summary: This study compared the detection of Blastocystis sp. in patients with irritable bowel syndrome and healthy volunteers, finding no significant differences in the occurrence of the parasite between the two groups.
Review
Medicine, General & Internal
Alireza Olyaiee, Amir Sadeghi, Abbas Yadegar, Elnaz Sadat Mirsamadi, Hamed Mirjalali
Summary: This review discusses the role of Blastocystis sp. in irritable bowel syndrome (IBS) through modulation of the gut microbiota, and comprehensively analyzes the relevant scientific findings.
FRONTIERS IN MEDICINE
(2022)
Article
Microbiology
Celine Nourrisson, Julien Scanzi, Julie Brunet, Frederic Delbac, Michel Dapoigny, Philippe Poirier
Summary: The study investigated the differences in microbiota between IBS-C patients and healthy individuals, revealing significant changes in certain microbial phyla when Blastocystis was present in IBS-C patients, notably an increase in Tenericutes phylum and Ruminococcaceae family. Colonization with Blastocystis was also associated with subtle changes in the microbial eukaryome, particularly in the Fungi taxa. The mycobiota changes varied depending on the patient group, with potentially more deleterious effects in the IBS-C group.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Migle Palivonaite, Greta Gedvilaite, Brigita Glebauskiene, Loresa Kriauciuniene, Vita Rovite, Rasa Liutkeviciene
Summary: The aim of this study was to determine the association between gene IL-10 polymorphisms and serum IL-10 levels in patients with pituitary adenoma. The results indicated that IL-10 rs1800871 and IL-10 rs1800872 may be associated with the development of inactive pituitary adenoma. However, no statistically significant association was found between IL-10 polymorphisms and invasiveness or recurrence of pituitary adenoma.
Article
Gastroenterology & Hepatology
Theodora Kalli, Tilemachos Koutouratsas, George Karamanolis, Maria Gazouli
Summary: The study found a significant association between the rs696217 genetic polymorphism and IBS susceptibility, with the GG and GT genotypes as well as the G allele being linked to IBS risk, while the T allele may have a protective effect. There was no correlation between ghrelin gene polymorphisms and different IBS subtypes.
Article
Medicine, General & Internal
Mojtaba Norouzi, Majid Pirestani, Ehsan Arefian, Abdolhossein Dalimi, Javid Sadraei, Hamed Mirjalali
Summary: This study is the first to report the release of exosome-like vesicles by the human parasite Blastocystis, demonstrating the role of this parasite, particularly ST1, in proinflammatory and anti-inflammatory cytokines and modulating the host response.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Elham Aghamohamadi, Nastaran Asri, Aylin Odak, Mohammad Rostami-Nejad, Vahid Chaleshi, Yasaman Hajinabi, Maryam Eslami, Saeed Mohammadian Haftcheshmeh, Fahimeh Sadat Gholam-Mostafaei, Hamid Asadzadeh-Aghdaei, Andrea Masotti, Mohammad Reza Zali
Summary: The expression patterns of pro-inflammatory and anti-inflammatory cytokines in intestinal biopsy specimens of patients with celiac disease and inflammatory bowel disease were similar, but the expression of anti-inflammatory cytokines was lower in celiac disease. Understanding this regulation is important for finding therapeutic protocols.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Genetics & Heredity
Kalichamy Alagarasu, Himanshu Kaushal, Pooja Shinde, Mahadeo Kakade, Urmila Chaudhary, Vikram Padbidri, Shashikala A. Sangle, Sonali Salvi, Ashish R. Bavdekar, Pradeep D'costa, Manohar Lal Choudhary
Summary: The study investigated the association of SNPs in genes coding for IL6, TNFA, IFNG, IL17A, IL10, and TGFB with disease severity in influenza A(H1N1)pdm09-affected patients. TNFA rs1800629 G/A allele frequency was significantly higher in severe cases, while IL10 rs1800896-rs1800872 G-C haplotype was significantly lower in fatal cases. IL-6 and IL-10 levels were significantly higher in fatal cases compared to survived severe cases.
Article
Health Care Sciences & Services
Tingting Zhao, Yiming Zhang, Joochul Lee, Angela R. Starkweather, Erin E. Young, Xiaomei Cong
Summary: This study found that certain genetic polymorphisms are associated with the risk and symptoms of irritable bowel syndrome, including abdominal pain, sleep disturbance, and fatigue. These findings contribute to the understanding of how genetic variations influence the development and changes of IBS symptoms over time.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Clinical Neurology
Rongmei Yang, Jinfeng Duan, Fugang Luo, Pingyu Tao, Chenling Hu
Summary: This meta-analysis suggests a potential relationship between gene polymorphisms in IL-6, IL-8, and IL-10 and predisposition to Alzheimer's disease, with specific alleles like IL-6 - 174 G/C, IL-6 - 572 G/C, and IL-10 - 1082 A/G potentially influencing AD susceptibility. The study also found significant differences in genotypic frequencies among different populations, highlighting a potential genetic component in AD predisposition.
ACTA NEUROLOGICA BELGICA
(2021)
Article
Neurosciences
Ugne Masilionyte, Greta Gedvilaite, Kriste Kaikaryte, Alvita Vilkeviciute, Loresa Kriauciuniene, Brigita Glebauskiene, Renata Balnyte, Rasa Liutkeviciene
Summary: This study investigated the association between IL-10 gene polymorphisms and serum levels with multiple sclerosis (MS). The results showed that IL-10 SNPs and serum levels were not associated with MS development. However, individuals carrying rare IL-10 haplotypes were associated with increased odds of MS.
Review
Immunology
Xian-Ling Cao, Xuan-You Zhou, Nai-Xin Xu, Song-Chang Chen, Chen-Ming Xu
Summary: This study conducted a systematic review and meta-analysis to investigate the relationship between IL-4 and IL-10 gene polymorphisms and preterm birth (PTB). The findings suggest that the over-dominant gene model AA + GG vs. AG of IL-10-1082A/G (rs1800896) polymorphism may be associated with genetic susceptibility to PTB and may have a protective function against PTB risk. However, no clear association was found between IL-4-590C/T (rs2243250), IL-10-592A/C (rs1800872), and IL-10-819T/C (rs1800871) polymorphisms and PTB. Further research is needed to confirm these findings due to the limitations of the included studies and the risk of publication bias.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Virology
Dayvson Mauricio da Silva, Juliana Prado Goncales, Jose Valter Joaquim Silva Junior, Thaisa Regina Rocha Lopes, Luan Araujo Bezerra, Virginia Maria Barros de Lorena, Maria Rosangela Cunha Duarte Coelho
Summary: In HIV/HHV-8 coinfection, levels of cytokines IL-4, IL-6, and IL-10 are higher in patients compared to those infected with only HIV, potentially indicating the development of HHV-8-related diseases. On the other hand, levels of IL-2, TNF-alpha, and IFN-gamma show no significant difference between the two groups.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Gastroenterology & Hepatology
Maeva Meynier, Elodie Baudu, Nathalie Rolhion, Manon Defaye, Marjolene Straube, Valentine Daugey, Morgane Modoux, Ivan Wawrzyniak, Frederic Delbac, Romain Villeger, Mathieu Meleine, Esther Borras Nogues, Catherine Godfraind, Nicolas Barnich, Denis Ardid, Philippe Poirier, Harry Sokol, Jean-Marc Chatel, Philippe Langella, Valerie Livrelli, Mathilde Bonnet, Frederic Antonio Carvalho
Summary: This study explores the relationship between brain/gut/microbiota axis and Irritable Bowel Syndrome (IBS), focusing on tryptophan metabolism and microbiota-induced AhR expression. The results show that IL-22 cytokine can alleviate post-infectious IBS symptoms such as colonic hypersensitivity, cognitive impairments, and anxiety-like behaviors, by acting on intestinal mucosa integrity. Therapeutic strategies targeting this pathway could potentially be developed for the treatment of IBS patients suffering from chronic abdominal pain and associated well-being disorders.
Article
Multidisciplinary Sciences
Renata Rocha da Silva, Fernanda de Santana Fontes Vasconcelos, Debora dos Santos Tavares, Priscila Lima dos Santos
Summary: This study conducted a systematic review and meta-analysis to investigate the association between IL-10 single nucleotide polymorphisms (SNPs) and the progression of leishmaniasis. The results showed that IL-10 SNPs were not significantly associated with leishmaniasis progression and were not considered a risk factor.
SCIENTIFIC REPORTS
(2022)
Article
Hematology
Mercedes Piedad de Leon Bautista, Mirza Romero-Valdovinos, Beatriz Zavaleta-Villa, Arony Martinez-Flores, Angelica Olivo-Diaz
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
(2018)
Article
Parasitology
Patricia Alarcon-Valdes, Guiehdani Villalobos, Williams Arony Martinez-Flores, Eduardo Lopez-Escamilla, Nelly Raquel Gonzalez-Arenas, Mirza Romero-Valdovinos, Fernando Martinez-Hernandez, Jonnathan Guadalupe Santillan-Benitez, Pablo Maravilla
PARASITES & VECTORS
(2018)
Article
Surgery
Josue Emiliano Lopez-Martinez, Adolfo Chavez-Negrete, Arturo Abraham Rodriguez-Gonzalez, Mario Antonio Molina-Ayala, Silvia Villanueva-Recillas, Pablo Maravilla, Aida Monserrat Resendiz-Barragan, Enrique Renteria-Palomo, Martin Edgardo Rojano-Rodriguez
Article
Infectious Diseases
Teivi Laurimae, Liina Kinkar, Thomas Romig, Gerald Umhang, Adriano Casulli, Rihab A. Omer, Mitra Sharbatkhori, Hossein Mirhendi, Francisco Ponce-Gordo, Lorena E. Lazzarini, Silvia Soriano, Antonio Varcasia, Mohammad Rostami-Nejad, Vanesa Andresiuk, Pablo Maravilla, Luis Miguel Gonzalez, Monika Dybicz, Jakub Gawor, Mindaugas Sarkunas, Viliam Snabel, Tetiana Kuzmina, Eshrat Beigom Kia, Urmas Saarma
INFECTION GENETICS AND EVOLUTION
(2019)
Article
Parasitology
Fernando Martinez-Hernandez, Jose Alejandro Martinez-Ibarra, Eduardo Lopez-Escamilla, Claudia Villanueva-Garcia, Claudia Irais Munoz-Garcia, Emilio Rendon-Franco, Pablo Maravilla, Guiehdani Villalobos
PARASITOLOGY RESEARCH
(2020)
Article
Parasitology
Yolanda Escutia-Guzman, Williams Arony Martinez-Flores, Joel Martinez-Ocana, Ramon Martinez-Pimentel, Marisol Benitez-Ramirez, Fernando Martinez-Hernandez, Sara Arroyo-Escalante, Mirza Romero-Valdovinos, Guadalupe Erendira Orozco-Mosqueda, Pablo Maravilla
KOREAN JOURNAL OF PARASITOLOGY
(2020)
Article
Parasitology
Guiehdani Villalobos, Fabiola Sanchez-Aguillon, Marcia Veronica Carmona-Maldonado, Nelly Raquel Gonzalez-Arenas, Eduardo Lopez-Escamilla, Rigoberto Hernandez-Castro, Mirza Romero-Valdovinos, Williams Arony Martinez-Flores, Juan Pablo Ramirez-Hinojosa, Pablo Maravilla, Fernando Martinez-Hernandez
Summary: This study reported the first identification of different subtypes of Blastocystis in samples from patients infected with Trichomonas vaginalis, suggesting potential contamination through incorrect cleaning of the genital area or other pathways.
KOREAN JOURNAL OF PARASITOLOGY
(2022)
Article
Virology
Fabiola Sanchez-Aguillon, Patricia Alarcon-Valdes, Martin Rojano-Rodriguez, Aurora Ibarra-Arce, Angelica Olivo-Diaz, Jonnathan Guadalupe Santillan-Benitez, Fernando Martinez-Hernandez, Pablo Maravilla, Mirza Romero-Valdovinos
Summary: This study reported the presence of adenovirus 36 (Ad36) and its viral load in fat tissue of obese and normal-weight individuals. Phylogenetic analysis revealed low genetic variability and high gene flow of the Ad36 E1a gene. The results suggest that Ad36 may not be a low-risk factor for obesity.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Microbiology
Fernando Martinez-Hernandez, Fabiola Sanchez-Aguillon, Joel Martinez-Ocana, Nelly Raquel Gonzalez-Arenas, Mirza Romero-Valdovinos, Eduardo Lopez-Escamilla, Pablo Maravilla, Guiehdani Villalobos
Summary: This study evaluated the genetic variability of the ITS region and pfor A gene of Trichomonas vaginalis from female patients and explored its implications in the host-parasite relationship. Results showed two main clusters in the ITS haplotypes and suggested that pfor A could be used as a marker for confirming trichomonads genus and species.
Article
Infectious Diseases
Patricia Alarcon-Valdes, Fabiola Sanchez-Aguillon, Fernando Martinez-Hernandez, Angelica Olivo-Diaz, Pablo Maravilla, Jonnathan Guadalupe Santillan-Benitez, Mirza Romero-Valdovinos
Summary: Human Adenovirus 36 (HAdV-36) can infect renal epithelial monkey cells and long-term infection in Vero cell culture may serve as a promising model for studying fundamental aspects of HAdV-36 biology.
REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO
(2022)
Article
Infectious Diseases
Joel Martinez-Ocana, Williams Arony Martinez-Flores, Angelica Olivo-Diaz, Mirza Romero-Valdovinos, Fernando Martinez-Hernandez, Guillermo Aguilar-Osorio, Ana Flisser, Pablo Maravilla
Summary: This study identified ALFuc as a secretion product of Blastocystis sp. for the first time through experimental data, suggesting its potential important role during intestinal colonization. The alfuc gene is also considered a promising candidate for a phylogenetic marker, showing a conserved classification similar to the SSU-rDNA gene.
REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO
(2022)
Article
Infectious Diseases
Fernando Martinez-Hernandez, Maria Elisa Vega-Memije, Guiehdani Villalobos, Diego Perez-Rojas, Daniel Asz-Sigall, Nancy Rivas, Ricardo Alejandre, Pablo Maravilla, Mirza Romero Valdovinos
REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO
(2019)