Article
Parasitology
Shrouk E. Al-Sayed, Mahmoud Abdel-Latif, Heba M. Abdel-Haleem, Gamal El-Shahawy, Heba Abdel-Tawab
Summary: The study aimed to find a new therapeutic agent for murine coccidiosis from Hirudo medicinalis. Ion-exchange chromatography was performed to separate different fractions of hirudo extract antigens (HEA). The most effective fractions were identified through experimental testing and showed significant reduction in oocysts output and parasite developmental stages, along with increased goblet cell numbers and MUC2 expression. Proteomic analysis revealed the presence of Eglin C protein in the effective fractions, which showed potential as a target for therapeutic treatment or anti-inflammatory agent for coccidiosis infection.
VETERINARY PARASITOLOGY
(2023)
Article
Veterinary Sciences
Fatemah Alajmi, Tahani Al-Otaibi, Saleh Al-Quraishy, Esam M. Al-Shaebi, Nawal Al-Hoshani, Mohamed A. Dkhil, Rewaida Abdel-Gaber
Summary: Coccidiosis is a common disease among farm and domestic animals, causing significant economic loss. Resistance has been observed for all currently available drugs for controlling the disease. This study investigated the effects of Persea americana extract (PAE) as a potential alternative treatment for coccidiosis. The results showed that PAE had anti-coccidial, antioxidant, and anti-apoptotic activities during murine intestinal Eimeria papillata infection. PAE reduced fecal oocyst output and the size of parasite stages in the infected-treated group. It also counteracted the loss of antioxidant enzymes and modulated apoptotic cell expression. Additionally, PAE upregulated the mRNA expression of the goblet cell response gene MUC2. Based on these findings, PAE shows promise as a medicinal plant with multiple beneficial effects against coccidiosis.
BMC VETERINARY RESEARCH
(2023)
Article
Environmental Sciences
Mohamed A. Dkhil, Felwa A. Thagfan, Mostafa Y. Morad, Esam M. Al-Shaebi, Sherif Elshanat, Amira A. Bauomy, Murad Mubaraki, Taghreed A. Hafiz, Saleh Al-Quraishy, Rewaida Abdel-Gaber
Summary: This study investigates the action of silver nanoparticles prepared from Zingiber officinale rhizomes in the treatment of mice infected with Eimeria papillata. The results demonstrate that the nanoparticles can improve the jejunal mucosa and reduce the pathological damage associated with the infection.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
K. Rambabu, A. Thanigaivelan, G. Bharath, N. Sivarajasekar, Fawzi Banat, Pau Loke Show
Summary: The valorization of waste date palm coir into a biosorbent for hexavalent chromium ions removal was successful with high efficiency. Characterization studies and batch biosorption tests showed the promising potential of DPC for the treatment of Cr(VI) ion polluted water streams.
Article
Multidisciplinary Sciences
Naseer Ahmed, Javeria Farooq, Sultan Ayoub Meo, Farooq Pasha
Summary: This study aimed to investigate the impact of Ajwa consumption on lipid profile and HDL in the general population. The results showed that Ajwa intake had a significant effect on total cholesterol, triglycerides, LDL, and HDL, indicating its potential in improving lipid profile and raising sub-optimal HDL levels.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Biochemical Research Methods
Felwa A. Thagfan, Wafa A. Al-Megrin, Esam M. Al-Shaebi, Saleh Al-Quraishy, Mohamed A. Dkhil
Summary: The study demonstrated that Morus nigra leaf extracts have a protective effect against Eimeria papillata infection in mice, reducing oocysts in feces and alleviating histopathological injuries in the jejunum. Additionally, the extracts helped restore the levels of nitric oxide and catalase. Further research is needed to identify the active compounds in the extract and their mechanism of action.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2021)
Article
Nutrition & Dietetics
Heba Nageh Gad El-Hak, Hany Salah Mahmoud, Eman A. Ahmed, Heba M. Elnegris, Tahany Saleh Aldayel, Heba M. A. Abdelrazek, Mohamed T. A. Soliman, Menna Allah I. El-Menyawy
Summary: This study found that methanolic date flesh extract (MDFE) has the potential to alleviate cisplatin-induced hepatic injury. In a rat model, pretreatment with MDFE reduced liver damage caused by cisplatin, improved liver function, and reduced inflammation.
Article
Forestry
Mohammad Hassan Mazaherifar, Hamid Zarea Hosseinabadi, Camelia Cosereanu, Camelia Cerbu, Maria Cristina Timar, Sergiu Valeriu Georgescu
Summary: This paper presents investigations on different types of fibre-reinforced epoxy-resin hybrid composites made from date palm and Calotropis procera fibres. The mechanical performance of the resulting composites was evaluated and compared through water resistance investigation and mechanical testing. The results showed that the addition of Calotropis fibres improved the flexural strength and flexural modulus of elasticity, while five-layer composites had lower values of tensile strength, tensile modulus of elasticity, impact resistance, and higher water absorption and thickness swelling compared to the three-layer composites.
Article
Biochemistry & Molecular Biology
Saqib Bilal, Taimoor Khan, Sajjad Asaf, Nasir Ali Khan, Syed Saad Jan, Muhammad Imran, Ahmed Al-Rawahi, Abdul Latif Khan, In-Jung Lee, Ahmed Al-Harrasi
Summary: Climate changes abruptly affect plant physiology and productivity. This study investigated the effects of low-temperature stress on date palm growth and physiological indicators with the application of silicon (Si). The application of Si improved plant morphology, biomass, photosynthetic pigments, and water content, while reducing oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Yousef A. Al-Dashti, Roberta R. Holt, Carl L. Keen, Robert M. Hackman
Summary: Research on cardioprotective foods like dates is essential for addressing global public health needs. While animal studies show promising results, more human research is needed to fully understand the potential benefits of date fruit on vascular health. Conducting thorough clinical trials and assessing functional markers of vascular disease will provide valuable information for human health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Analytical
Rabbia Zahid, Syeda Nayab Batool Rizvi, Zahid Qureshi, Muhammad Imran Din
Summary: In this study, gold nanoparticles biogenically synthesized from Date palm seeds were found to have significant anti-diabetic properties, leading to a significant decrease in blood glucose levels and recovery of organ tissue damage caused by Alloxan.
VIBRATIONAL SPECTROSCOPY
(2022)
Article
Nutrition & Dietetics
Hesham S. Ghazzawy, Mostafa M. Gouda, Nabil S. Awad, Nadi Awad Al-Harbi, Mesfer M. Alqahtani, Maha M. Abdel-Salam, Mohamed A. Abdein, Sanad M. Al-Sobeai, Asmaa A. Hamad, Hassan M. Alsberi, Gamal A. Gabr, Dalia M. Hikal
Summary: The different parts of the Khalas palm cultivar (KPC) exhibit significant antiproliferative activity against prostate and pancreatic cancer cells. The leaves extract of KPC showed the highest activity, while the seeds extract induced apoptosis in the cells.
FRONTIERS IN NUTRITION
(2022)
Article
Plant Sciences
Maria F. Torres, Yasmin A. Mohamoud, Shameem Younuskunju, Karsten Suhre, Joel A. Malek
Summary: This study delves into the understanding of sex control in the Phoenix genus, identifying three conserved male genes and confirming an XY sex chromosome system. By investigating male-specific sequences in the date palm Y chromosome, it was found that these sequences have likely spread in defined events, appearing as blocks of varying density.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Microbiology
Mohd Adnan, Arif Jamal Siddiqui, Syed Amir Ashraf, Fevzi Bardakci, Mousa Alreshidi, Riadh Badraoui, Emira Noumi, Bektas Tepe, Manojkumar Sachidanandan, Mitesh Patel
Summary: This study explores the anti-fungal potential of phytochemicals from Ajwa dates using network pharmacology, molecular docking, and dynamics simulations, revealing the molecular mechanisms underlying their activity and providing a rational basis for developing new therapeutic strategies against candidiasis in humans.
Review
Food Science & Technology
Zeshan Ali, Jianke Li, Yuhuan Zhang, Naureen Naeem, Shoaib Younas, Farah Javeed
Summary: Date palm, with its fruit and vinegar, is a traditional medicinal plant that shows potential in treating various diseases and possesses beneficial properties such as hepatoprotective, antihyperlipidemic, and antioxidant activities.
FOOD REVIEWS INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Abdulsalam Alkhudhayri, Ahmed E. Abdel Moneim, Sara Rizk, Amira A. Bauomy, Mohamed A. Dkhil
Summary: Echinops spinosus is a medicinal plant with various pharmacological effects, including antioxidant, anti-inflammatory, and antibacterial properties. This study found that E. spinosus extract has neuroprotective and anticonvulsant characteristics, reducing seizure duration and preventing cell death. It also showed potential as a natural anticonvulsant.
NEUROCHEMICAL RESEARCH
(2023)
Article
Environmental Sciences
Mona A. Ibrahim, Sherif R. Mohamed, Mohamed A. Dkhil, Felwa A. Thagfan, Rewaida Abdel-Gaber, Doaa Soliman
Summary: The aim of this study was to evaluate the therapeutic anticancer role of Moringa oleifera leaf extracts (MLE) in urethane-induced lung cancer in male albino rats. Results showed that MLE treatment reduced lung index, improved oxidative stress markers, and increased EGFR-mRNA expression. Furthermore, MLE decreased collagen fiber distribution and tumor mass, leading to restoration of normal lung histology. These findings suggest that MLE may serve as an alternative treatment for lung cancer.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Marwa M. Esawy, Amir Abd-elhameed, Ahmed F. Gomaa, Shereen A. Baioumy, Moataz A. ElKot, Mohammed A. Hegab, Ahmed S. Alazzouni, Felwa A. Thagfan, Rewaida Abdel-Gaber, Mohamed A. Dkhil, Marwa A. Shabana
Summary: This study investigated the roles of LncRNA-GAS5 and S-catenin in predicting asymptomatic organ damage (AOD) in hypertensive nondiabetic patients. It found that decreased LncRNA-GAS5 expression and elevated S-catenin levels were associated with AOD in hypertensive patients. LncRNA-GAS5 expression was a better diagnostic predictor of AOD than S-catenin.
Article
Veterinary Sciences
Mona Saleh, Abdel-Azeem S. Abdel-Baki, Mohamed A. Dkhil, Mansour El-Matbouli, Saleh Al-Quraishy
Summary: The study demonstrates the crucial role of heat shock protein 90 (HSP90) in the growth and development of Ichthyophthirius multifiliis, suggesting it as a potential therapeutic target. By using antisense oligonucleotides to knock down the HSP90 gene, it was shown that the growth and development of the parasite were significantly limited, and the infectivity of treated parasites was reduced in fish.
BMC VETERINARY RESEARCH
(2023)
Article
Anatomy & Morphology
Rewaida Abdel-Gaber, Maysar Abu Hawsah, Esam M. Al-Shaebi, Tahani Al-Otaibi, Felwa A. Thagfan, Saleh Al-Quraishy, Mohamed A. Dkhil
Summary: The biosynthesized nano-selenium from Azadirachta indica leaf extracts (BNS) showed promising therapeutic effects against Eimeria papillata-induced infection in mice. It not only suppressed the oocyst output by 97.21% but also improved feed intake and exhibited antioxidant activity. BNS could be a potential treatment for coccidiosis.
MICROSCOPY RESEARCH AND TECHNIQUE
(2023)
Article
Immunology
Rewaida Abdel-Gaber, Maysar Abu Hawsah, Tahani Al-Otaibi, Ghada Alojayri, Esam M. Al-Shaebi, Osama B. Mohammed, Manal F. Elkhadragy, Saleh Al-Quraishy, Mohamed A. Dkhil
Summary: The study aimed to determine whether biosynthesized selenium nanoparticles (Bio-SeNPs) using Azadirachta indica leaves extract could treat mice with Eimeria papillata infection in the jejunal tissue. The results showed that Bio-SeNPs significantly reduced the oocyst output in mice feces and the number of developmental parasitic stages in the jejunal tissues. Additionally, Bio-SeNPs lowered oxidative stress and inflammatory indicators, protecting the mice against jejunal damage caused by infection.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Rewaida Abdel-Gaber, Masheil Alghamdi, Saleh Al Quraishy, Esam M. Al-Shaebi, Manal F. Elkhadragy, Saeed El-Ashram, Mohamed A. Dkhil
Summary: Fish products are a significant source of animal protein but can also contain various parasites, including monogeneans. This study focused on the monogenean parasites infecting the soldier bream Argyrops filamentosus from the Red Sea coast of Jeddah, Saudi Arabia. One species, Haliotrema susanae, was found to infect 50% of the investigated fish species. This study provides the first report of Haliotrema species as ectoparasites of sparid fish and adds a new genetic sequence for this parasite species.
Article
Multidisciplinary Sciences
Hanadi B. Baghdadi, Rewaida Abdel-Gaber, Saleh Al Quraishy, Marwa M. Abou Hadied, Tahani Al-Otaibi, Manal F. Elkhadragy, Esam M. Al-Shaebi, Mohamed Dkhil
Summary: The focus of this study was to examine the potential parasites' ability to serve as bio-indicators of pollution in marine ecosystems. Forty samples of the king soldier bream were collected from the Red Sea for this purpose. Only 25 fish samples were found to be infected with a nematode parasite, Hysterothylacium reliquens, and the levels of certain metals were detected in both the parasite stages and the fish host tissues. The study revealed that fish nematodes could be helpful bioindicators for assessing heavy metal contamination in aquatic ecosystems.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Felwa A. Thagfan, Mohamed A. Dkhil, Esam M. Al-Shaebi, Rewaida Abdel-Gaber, Saleh Al-Quraishy, Sherif Elshanat
Summary: This study compared the response of the liver to induced coccidiosis on treatment with nanosilver synthesized from Zingiber officinale (NS) and the reference anticoccidial drug amprolium in Eimeriapapillate-infected mice. The results showed that NS was able to inhibit the sporulation of E. papillate by approximately 73% and improve the liver function in mice. Treatment with NS also improved the parasite-induced liver histological injury and increased the levels of glutathione and glutathione peroxidase. Overall, NS outperformed amprolium in E. papillata-induced mice.
Article
Multidisciplinary Sciences
Doaa Soliman, Mona A. Ibrahim, Sherif R. Mohamed, Felwa A. Thagfan, Manal F. El-khadragy, Wafa A. Al-Megrin, Murad A. Mubaraki, Mohamed A. Dkhil
Summary: The study aims to evaluate the antitumor effect of propolis extract (PE) against urethane-induced lung cancer compared to Cisplatin (CIS) in rats. Various tests and analyses were conducted, which indicated that PE can improve oxidative stress, gene expression, and histopathology caused by urethane, and increase the expression of EGFR-mRNA. Furthermore, PE can reduce abnormal collagen fiber distribution, papillary adenocarcinoma growth, bronchial wall thickening, inflammation, and alveolar collapse. Therefore, PE can be considered as an excellent source of natural chemicals that fight lung cancer.
JOURNAL OF TAIBAH UNIVERSITY FOR SCIENCE
(2023)
Article
Health Care Sciences & Services
Marwa M. Esawy, Amany M. Ebaid, Amir Abd-elhameed, Felwa A. Thagfan, Murad A. Mubaraki, Ahmed S. Alazzouni, Mohamed A. Dkhil, Marwa A. Shabana
Summary: Ankylosing spondylitis (AS) is a chronic inflammatory disease that causes severe pain and stiffness in the joints. The role of lncRNA H19 in AS was investigated and it was found to play a key role in the pathogenesis of the disease. The expression of lncRNA H19 was significantly upregulated in AS patients compared to healthy controls and was positively correlated with disease activity and inflammatory markers.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Veterinary Sciences
A. S. Fathalla, M. A. Ibrahim, S. R. Mohamed, M. A. Dkhil, F. A. Thagfan, R. Abdel-Gaber, D. Soliman
Summary: This study evaluated the anticancer performance of Cassia alata methanolic leaf extracts (CMLE) in ethyl carbamate-stimulated lung adenocarcinoma (LAD) and compared it with the function of Cisplatin (CIPL). The results showed that CMLE treatment had a good anticancer effect with less toxicity compared to Cisplatin.
ARQUIVO BRASILEIRO DE MEDICINA VETERINARIA E ZOOTECNIA
(2023)
Article
Parasitology
Tahani Al-Otaibi, Maysar Abu Hawsah, Ghada Alojayri, Mohammed M. Mares, Hossam M. A. Aljawdah, Saleh N. Maodaa, Esam M. Al-Shaebi, Mohamed A. Dkhil, Felwa A. Thagfan, Saleh Al-Quraishy, Rewaida Abdel-Gaber
Summary: This study evaluated the anticoccidial activity of Persea americana fruit extract (PAFE) in mice and found that the 500 mg/kg dose was the most effective in reducing oocyst output and parasite stages, while increasing goblet cell count. PAFE also showed antioxidant and anti-inflammatory activities, making it a promising treatment for coccidiosis.
PARASITOLOGY INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Murad A. Mubaraki, Ayman Faqihi, Fatmah Alqhtani, Taghreed A. Hafiz, Ahmed Alalhareth, Felwa A. Thagfan, Sherif Elshanat, Rewaida A. Abdel-Gaber, Mohamed A. Dkhil
Summary: This study aimed to evaluate the utility of peripheral blood parameters as neonatal sepsis biomarkers and the diagnostic performance of the monocyte distribution width (MDW) in sepsis in a neonatal intensive care unit. The results showed a significant correlation between haematological parameters and neonatal sepsis, with MDW being the most significant parameter. The MDW demonstrated high diagnostic ability in predicting neonatal sepsis.
MEDICINA-LITHUANIA
(2023)
Article
Environmental Sciences
Mohamed A. Dkhil, Felwa A. Thagfan, Mostafa Y. Morad, Esam M. Al-Shaebi, Sherif Elshanat, Amira A. Bauomy, Murad Mubaraki, Taghreed A. Hafiz, Saleh Al-Quraishy, Rewaida Abdel-Gaber
Summary: This study investigates the action of silver nanoparticles prepared from Zingiber officinale rhizomes in the treatment of mice infected with Eimeria papillata. The results demonstrate that the nanoparticles can improve the jejunal mucosa and reduce the pathological damage associated with the infection.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)