期刊
PARASITOLOGY RESEARCH
卷 107, 期 4, 页码 847-853出版社
SPRINGER
DOI: 10.1007/s00436-010-1938-3
关键词
-
类别
资金
- National Health and Medical Research Council of Australia
- Australian Centre for International and Tropical Health
- National Institutes of Health, U.S.A [AI75527]
This study investigates the susceptibility of a clinically metronidazole (Mz)-resistant isolate of Trichomonas vaginalis to alternative anti-trichomonal compounds. The microaerobic minimal inhibitory concentration (MIC) of the 5-nitroimidazole (NI) drug, Mz, against a typical Mz-susceptible isolate of T. vaginalis is around 3.2 A mu M Mz while the clinically, highly Mz-resistant isolate has an MIC of 50-100 A mu M. This isolate was cross-resistant to other members of the 5-NI family of compounds including tinidazole and other experimental compounds and maintained resistance under anaerobic conditions. In addition, this isolate was cross-resistant to the 5-nitrothiazole compound nitazoxanide and the 5-nitrofuran derivative, furazolidone. Adenosine analogues toyocamycin and 2-fluoro-2'-deoxyadenosine with no nitro group were also less effective against the clinically Mz-resistant isolate than a Mz-susceptible one. Three other isolates which were determined to be Mz-resistant soon after isolation lost resistance in the long term. One other isolate has maintained some level of permanent Mz resistance (MIC of 25 A mu M). A multi-drug resistance mechanism may be involved in these clinically Mz-resistant isolates.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据