期刊
PARASITOLOGY RESEARCH
卷 105, 期 1, 页码 275-279出版社
SPRINGER
DOI: 10.1007/s00436-009-1394-0
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类别
资金
- Ethics Committee on the Use of Laboratorial Animals [004/2002]
- FIOCRUZ
- RENORBIO
- CNPq
- FINEP
- MCT
- INSEAR
Malaria is one of the most important tropical diseases and mainly affects populations living in developing countries. Reduced sensitivity of Plasmodium sp. to formerly recommended antimalarial drugs places an increasing burden on malaria control programs as well as on national health systems in endemic countries. The present study aims to evaluate the antimalarial activity of betulinic acid and its derivative compounds, betulonic acid, betulinic acid acetate, betulinic acid methyl ester, and betulinic acid methyl ester acetate. These substances showed antiplasmodial activity against chloroquine-resistant Plasmodium falciparum parasites in vitro, with IC50 values of 9.89, 10.01, 5.99, 51.58, and 45.79 mu M, respectively. Mice infected with Plasmodium berghei and treated with betulinic acid acetate had a dose-dependent reduction of parasitemia. Our results indicate that betulinic acid and its derivative compounds are candidates for the development of new antimalarial drugs.
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