Review
Food Science & Technology
Kaiyuan Huang, Hesham R. El-Seedi, Baojun Xu
Summary: This study comprehensively summarizes the chemical composition of Agaricus blazei Murrill (AbM) and thoroughly characterizes its health promotion effects such as antitumor and antidiabetic impacts. AbM is composed of abundant bioactive substances including polysaccharides, lipids, proteins, and vitamins. Research has shown that AbM polysaccharides have immunoregulation, anti-inflammatory, hepato-protective, and antitumor functions. Furthermore, AbM extracts are believed to have potential in treating diabetes and bacterial infections, as well as exhibiting anticarcinogenic and antimutagenic functions. However, some of the mechanisms behind these health promotion effects remain unclear, and there is a need for further clinical trials.
CURRENT RESEARCH IN FOOD SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Yanping Zhao, Nana Tian, Hongjun Wang, Hong Yan
Summary: Sulfated modifications of Agaricus blazei Murill (AbM) polysaccharides have shown strong anti-HIV properties, making them promising candidates for biomedical applications in HIV/AIDS treatment.
CHEMISTRY & BIODIVERSITY
(2021)
Article
Biochemistry & Molecular Biology
Matheus Morais Saraiva, Matheus da Silva Campelo, Joao Francisco Camara Neto, Maria Leonia da Costa Gonzaga, Maria do Socorro Rocha Bastos, Sandra de Aguiar Soares, Nagila Maria Pontes Silva Ricardo, Gilberto Santos Cerqueira, Renata Ferreira de Carvalho Leita, Maria Elenir Nobre Pinho Ribeiro
Summary: This study investigated the potential of polysaccharides from Agaricus blazei Murill mushroom (PAbs) as wound dressings. The results showed that PAbs had no significant impact on the viability of human neutrophils in a concentration range of 1-100 μg mL-1. Moreover, PAbs improved the mechanical properties, thickness, and water vapor permeation of the films, and promoted wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Matheus da Silva Campelo, Cecilia Brilhante Araga, Izabell Maria Martins Teixeira, Erlania Alves de Siqueira, Carlos Jose Alves da Silva-Filho, Nagila Maria Pontes Silva Ricardo, Sandra de Aguiar Soares, Cristiani Lopes Capistrano Goncalves de Oliveira, Celli Rodrigues Muniz, Francisco Geraldo Barbosa, Jair Mafezoli, Tiago Lima Sampaio, Maria Elenir Nobre Pinho Ribeiro
Summary: Pentacyclic triterpene-loaded emulsions were stabilized using polysaccharides from Agaricus blazei Murill mushroom (PAb). Compatibility tests showed no physicochemical incompatibilities between the drug and excipient. The addition of PAb at 0.75% resulted in stable emulsions with small droplet size, moderate polydispersity, and high zeta-potential. Encapsulation of the drug in PAb-stabilized emulsions improved its cytocompatibility against PC12 and murine astrocyte cells, reducing cytotoxicity and maintaining mitochondrial function.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Food Science & Technology
Wenshuai Wang, Min Liu, Mengyu Zhang, Wenxue Sun, Jianjun Zhang, Le Jia
Summary: The study evaluated the protective effects of Agaricus blazei Murill polysaccharides (ABMP) on liver and lung in MODS mice induced by zymosan. Results showed that ABMP improved the survival rate, alleviated abnormal physiological behavior, and reduced tissue oxidative stress in MODS mice. Additionally, ABMP inhibited the activation of NF-kappa B signaling pathway and decreased the expressions of inflammatory cytokines.
Article
Plant Sciences
Joao Francisco Camara Neto, Matheus da Silva Campelo, Gilberto Santos Cerqueira, Joao Antonio Leal de Miranda, Jhonyson Arruda Carvalho Guedes, Raimundo Rafael de Almeida, Sandra de Aguiar Soares, Nilce Viana Gramosa, Guilherme Juliao Zocolo, Icaro Gusmao Pinto Vieira, Nagila Maria Pontes Silva Ricardo, Maria Elenir Nobre Pinho Ribeiro
Summary: This study aimed to characterize the chemical profile of Agaricus blazei Murill extract and evaluate its gastroprotective effect. The results showed that the extract had antioxidant activity and could protect the gastric mucosa.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Food Science & Technology
Hatem Salama Ali, Ahmed Noah Badr, Tawfiq Alsulami, Mohamed Gamal Shehata, Mohamed Mahmoud Youssef
Summary: This study aimed to improve the quality and safety of tahini products by combating microbial hazards and mycotoxins. The results showed that fortifying tahini with Agaricus blazei can increase protein, fiber, and bioactive content, as well as exhibit antimicrobial and antioxidant properties. The fortified samples also demonstrated better emulsion and oxidative stability. Moreover, the fortification process effectively eliminated bacteria and degraded mycotoxins during storage.
Article
Chemistry, Physical
Thiago Magalhaes Farias Menezes, Matheus da Silva Campelo, Ana Beatriz Nogueira Lima, Joao Francisco Camara Neto, Matheus Morais Saraiva, Joao Antonio Costa de Sousa, Maria Leonia da Costa Gonzaga, Luzia Kalyne Almeida Moreira Leal, Maria Elenir Nobre Pinho Ribeiro, Nagila Maria Pontes Silva Ricardo, Sandra de Aguiar Soares
Summary: This study evaluated the effects of polysaccharides from Lentinus edodes Berk and Agaricus blazei Murill mushrooms on the gelation process of the Pluronic (R) F127 copolymer. The results showed that these polysaccharides have good rheological properties and potential for pharmaceutical formulation development.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Entomology
Uros Glavinic, Jevrosima Stevanovic, Marko Ristanic, Milan Rajkovic, Dajana Davitkov, Nada Lakic, Zoran Stanimirovic
Summary: Nosemosis is a disease in bees that severely affects their vitality, reproduction, and productivity. Treatment traditionally involves the use of the antibiotic fumagillin, but recent issues with its production and registration have led to a search for alternative non-antibiotic treatments. Scientists globally are seeking medication or supplements to control Nosema, with a focus on natural extracts such as from the Agaricus blazei mushroom.
Review
Biochemistry & Molecular Biology
Matheus da Silva Campelo, Joao Francisco Camara Neto, Ana Beatriz Nogueira Lima, Francisco Cirineu das Chagas Neto, Maria Leonia da Costa Gonzaga, Sandra de Aguiar Soares, Luzia Kalyne Almeida Moreira Leal, Maria Elenir Nobre Pinho Ribeiro, Nagila Maria Pontes Silva Ricardo
Summary: ABM, a species native to Brazil, has potential pharmaceutical value with its polysaccharides, which may be used in prevention or treatment of inflammatory diseases such as cancer, diabetes, and atherosclerosis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Junhong Wang, Jing Wu, Ryuhei Ogura, Hajime Kobori, Jae-Hoon Choi, Hirofumi Hirai, Yuichi Takikawa, Hirokazu Kawagishi
Summary: This study isolated five compounds, including a new compound, from the mycelia of the mushroom Agaricus blazei. Compound 2 was isolated for the first time from nature. The structures of these compounds were determined using spectroscopic data interpretation. In bioassays, all the compounds showed inhibition effects on the growth of Clavibacter michiganensis, while compounds 3 and 4 also exhibited weak inhibitory activity against Burkholderia glumae.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2022)
Article
Engineering, Biomedical
Matheus da Silva Campelo, Lucas Barroso Mota, Joao Francisco Camara Neto, Maria Lucianny Lima Barbosa, Maria Leonia da Costa Gonzaga, Luzia Kalyne Almeida Moreira Leal, Maria do Socorro Rocha Bastos, Sandra de Aguiar Soares, Nagila Maria Pontes Silva Ricardo, Gilberto Santos Cerqueira, Maria Elenir Nobre Pinho Ribeiro
Summary: This study aimed to develop and evaluate the wound healing activity of films based on sodium alginate, polyvinyl alcohol, and Agaricus blazei extract. The films showed promising water vapor barrier properties and enhanced antioxidant and tissue repairing capabilities for wound healing.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2023)
Article
Multidisciplinary Sciences
Boushra Hola, Ramzi Murshed, Mouwafak Jbour
Summary: This research studied the chemical composition, phenolic compounds, and antioxidant activity of six edible Syrian wild mushroom strains. The wild strains showed good chemical composition and some had nutritional value and distinctive biological properties.
SCIENTIFIC REPORTS
(2023)
Article
Infectious Diseases
Fernanda Silva Almeida, Vitor Partite Moreira, Edson dos Santos Silva, Leonardo Lima Cardoso, Pedro Henrique de Sousa Palmeira, Luiz Henrique Agra Cavalcante-Silva, Demetrius A. M. de Araujo, Ian P. G. do Amaral, Eduardo Rene Perez Gonzalez, Tatjana S. L. Keesen
Summary: Leishmaniasis is a neglected tropical infectious disease, particularly visceral leishmaniasis, which is of great concern to global health. Guanidine-bearing compounds showed antimicrobial activity against Leishmania infantum and caused significant apoptosis in amastigotes. Further research is needed to fully understand their mechanism of action and potential as anti-leishmanial molecules.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Bruna Taciane da Silva Bortoleti, Mariana Barbosa Detoni, Manoela Daiele Goncalves, Fernanda Tomiotto-Pellissier, Taylon Felipe Silva, Virginia Marcia Concato, Ana Carolina Jacob Rodrigues, Amanda Cristina Carloto, Ricardo Luis Nascimento de Matos, Victor Fattori, Nilton Syogo Arakawa, Waldiceu Ap. Verri Jr, Idessania Nazareth Costa, Ivete Conchon-Costa, Milena Menegazzo Miranda-Sapla, Pryscilla Fanini Wowk, Wander Rogerio Pavanelli
Summary: This study investigates the mechanism of SOL treatment in L. amazonensis-infected mice. The results show that SOL treatment does not induce toxicity and can reduce lesion size and parasite load, promote antioxidant and oxidative balance, and enhance anti-inflammatory responses, leading to accelerated wound healing and tissue repair.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Immunology
Marco Antonio Cabrera Gonzalez, Ana Alice Maia Goncalves, Jennifer Ottino, Jaqueline Costa Leite, Lucilene Aparecida Resende, Otoni Alves Melo-Junior, Patricia Silveira, Mariana Santos Cardoso, Ricardo Toshio Fujiwara, Lilian Lacerda Bueno, Renato Lima Santos, Tatiane Furtado de Carvalho, Giani Martins Garcia, Paulo Ricardo de Oliveira Paes, Alexsandro Sobreira Galdino, Miguel Angel Chavez-Fumagalli, Marilia Martins Melo, Denise Silveira-Lemos, Olindo Assis Martins-Filho, Walderez Ornelas Dutra, Vanessa Carla Furtado Mosqueira, Rodolfo Cordeiro Giunchetti
Summary: Visceral leishmaniasis (VL) is a fatal disease caused by Leishmania infantum, and dogs are the main reservoirs. A vaccine against canine visceral leishmaniasis (CVL) is important in controlling human and CVL infections by reducing L. infantum infection. This study evaluated the potential of two polymeric nanoformulations loaded with Leishmania amazonensis antigens as a VL vaccine using golden hamsters as a model. The results showed that the vaccines had no adverse reactions and significantly reduced the parasitic load in the liver and spleen. These vaccines may be promising candidates for a VL vaccine.
Review
Microbiology
Reysla Maria da Silveira Mariano, Ana Alice Maia Goncalves, Diana Souza de Oliveira, Helen Silva Ribeiro, Diogo Fonseca Soares Pereira, Ingrid Soares Santos, Daniel Ferreira Lair, Augusto Ventura da Silva, Alexsandro Sobreira Galdino, Miguel Angel Chavez-Fumagalli, Denise da Silveira-Lemos, Walderez Ornelas Dutra, Rodolfo Cordeiro Giunchetti
Summary: Malaria is a parasitic infection that poses a significant public health concern with high mortality rates worldwide. Strategies to control vectors have proven ineffective, and the development of a preventive vaccine is necessary due to parasite resistance to antimalarial drugs. This review discusses novel strategies for malaria vaccine design, focusing on the target stages within the parasite's life cycle.
Article
Neurosciences
Karla Lucia F. Alvarez, Jorge Alberto Aguilar-Pineda, Michelle M. Ortiz-Manrique, Marluve F. Paredes-Calderon, Bryan C. Cardenas-Quispe, Karin Jannet Vera-Lopez, Luis D. Goyzueta-Mamani, Miguel Angel Chavez-Fumagalli, Gonzalo Davila-Del-Carpio, Antero Peralta-Mestas, Patricia L. Musolino, Christian Lacks Lino Cardenas
Summary: Evidence suggests that there may be racial differences in risk factors associated with the development of Alzheimer's disease and related dementia (ADRD). Whole-genome sequencing analysis revealed a novel combination of three pathogenic variants in a Peruvian family with a strong clinical history of ADRD. In silico and in vitro studies indicated that these variants may affect the neurovascular unit and key molecular pathways associated with dementia spectrum disorders.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Microbiology
Daniel Silva Dias, Juliana Martins Machado, Patricia Aparecida Fernandes Ribeiro, Amanda Sanchez Machado, Fernanda Fonseca Ramos, Lais Moreira Nogueira, Ana Alice Maia Goncalves, Luana de Sousa Ramos, Isadora Braga Gandra, Flaviane Silva Coutinho, Michelli dos Santos, Jonatas Oliveira da Silva, Miguel Angel Chavez-Fumagalli, Rafael Goncalves Teixeira-Neto, Ana Thereza Chaves, Mariana Campos-da-Paz, Amanda A. Souza, Rodolfo Cordeiro Giunchetti, Sonia Maria Freitas, Sandra Lyon, Danielle Ferreira de Magalhaes-Soares, Julia Angelica Goncalves Silveira, Eduardo Sergio Silva, Eduardo Antonio Ferraz Coelho, Alexsandro Sobreira Galdino
Summary: Background: Visceral leishmaniasis (VL) is a critical public health problem in over ninety countries, and control measures in Brazil have been insufficient. A chimeric protein called rMELEISH was developed for the accurate diagnosis of VL in dogs and humans. In trials, rMELEISH showed 100% sensitivity and specificity in distinguishing VL cases from other diseases and healthy samples. These preliminary results suggest that rMELEISH has potential for future diagnostic studies in the field.
Article
Microbiology
Juliana Martins Machado, Isabela Amorim Goncalves Pereira, Ana Clara Gontijo Maia, Mariana Ferraz Chaves Francisco, Lais Moreira Nogueira, Isadora Braga Gandra, Anna Julia Ribeiro, Kamila Alves Silva, Carlos Ananias Aparecido Resende, Jonatas Oliveira da Silva, Michelli dos Santos, Ana Alice Maia Goncalves, Grasiele de Sousa Vieira Tavares, Miguel Angel Chavez-Fumagalli, Mariana Campos-da-Paz, Rodolfo Cordeiro Giunchetti, Manoel Otavio da Costa Rocha, Ana Thereza Chaves, Eduardo Antonio Ferraz Coelho, Alexsandro Sobreira Galdino
Summary: This study aimed to develop a new recombinant multiepitope protein, rTC, for the diagnosis of Chagas disease. The results showed that rTC could differentiate between indeterminate and cardiac cases, as well as cross-reactive diseases and healthy samples, with 98.28% sensitivity and 96.67% specificity, respectively. These findings suggest the potential of rTC to be tested in future studies against a larger serological panel for Chagas disease diagnosis.
Review
Medicine, General & Internal
Juan Jeferson Vilca-Alosilla, Mayron Antonio Candia-Puma, Katiusca Coronel-Monje, Luis Daniel Goyzueta-Mamani, Alexsandro Sobreira Galdino, Ricardo Andrez Machado-de-Avila, Rodolfo Cordeiro Giunchetti, Eduardo Antonio Ferraz Coelho, Miguel Angel Chavez-Fumagalli
Summary: This paper presents a systematic review and meta-analysis evaluating the reliability of COVID-19 diagnostic tests. Ninety-nine scientific articles were analyzed to assess the specificity and sensitivity of these tests. Molecular tests, such as RT-PCR and CRISPR, performed better in terms of accuracy compared to serological tests. The study highlights the need to improve the performance of these diagnostic tests to effectively control COVID-19 outbreaks.
Article
Biology
Danniele L. Vale, Camila S. Freitas, Vivian T. Martins, Gabriel J. L. Moreira, Amanda S. Machado, Fernanda F. Ramos, Isabela A. G. Pereira, Raquel S. Bandeira, Marcelo M. de Jesus, Grasiele S. V. Tavares, Fernanda Ludolf, Miguel A. Chavez-Fumagalli, Alexsandro S. Galdino, Ricardo T. Fujiwara, Lilian L. Bueno, Bruno M. Roatt, Myron Christodoulides, Eduardo A. F. Coelho, Daniela P. Lage
Summary: Our study used an immunotherapeutic approach combining a vaccine and drug to successfully treat mice infected with Leishmania parasites. This approach significantly reduced the parasite load in the animals' internal organs and increased the production of protective antibodies. The inclusion of the vaccine and adjuvant also reduced the toxicity of the drug.
Article
Parasitology
Daniela P. Lage, Vivian T. Martins, Danniele L. Vale, Camila S. Freitas, Breno L. Pimenta, Gabriel J. L. Moreira, Fernanda F. Ramos, Isabela A. G. Pereira, Raquel S. Bandeira, Marcelo M. de Jesus, Fernanda Ludolf, Grasiele S. V. Tavares, Miguel A. Chavez-Fumagalli, Bruno M. Roatt, Myron Christodoulides, Eduardo A. F. Coelho
Summary: The treatment of visceral leishmaniasis (VL) is limited by issues such as drug toxicity, high cost, and resistant strains. This study evaluated an immunotherapy protocol using a combination of recombinant LiHyp1, monophosphoryl-lipid A (MPLA), and amphotericin B (AmpB) in a murine model. Results showed that this combination led to the lowest parasite burden, higher levels of protective immune response, and minimal organ damage. These findings suggest that the rLiHyp1/MPLA/AmpB combination could be a potential immunotherapy protocol for VL treatment.
Article
Virology
Fernanda F. Ramos, Isabela A. G. Pereira, Mariana M. Cardoso, Raquel S. Bandeira, Daniela P. Lage, Rahisa Scussel, Rafaela S. Anastacio, Victor G. Freire, Marina F. N. Melo, Joao A. Oliveira-da-Silva, Vivian T. Martins, Grasiele S. V. Tavares, Danniele L. Vale, Camila S. Freitas, Ana Thereza Chaves, Julia F. M. Caporali, Paula F. Vassallo, Cecilia G. Ravetti, Vandack Nobre, Flavio G. Fonseca, Myron Christodoulides, Ricardo A. Machado-de-avila, Eduardo A. F. Coelho, Fernanda Ludolf
Summary: The impact of the COVID-19 pandemic has emphasized the importance of laboratory tests in controlling the disease. In this study, a novel recombinant chimeric antigen (N4S11-SC2) was developed using specific B-cell epitopes from the SARS-CoV-2 virus. The N4S11-SC2 antigen showed high sensitivity and specificity in detecting specific antibodies in serum and urine samples, making it a potential alternative marker for diagnosing SARS-CoV-2 infection.
Article
Chemistry, Medicinal
Alejandro Gomez-Garcia, Daniel A. Acuna Jimenez, William J. Zamora, Haruna L. Barazorda-Ccahuana, Miguel A. Chavez-Fumagalli, Marilia Valli, Adriano D. Andricopulo, Vanderlan da S. Bolzani, Dionisio A. Olmedo, Pablo N. Solis, Marvin J. Nunez, Johny R. Rodriguez Perez, Hoover A. Valencia Sanchez, Hector F. Cortes Hernandez, Jose L. Medina-Franco
Summary: The Latin American Natural Products Database (LANaPDB) is a public compound collection that gathers chemical information of natural products from various databases in Latin America. The current version includes chemical structures from six countries, with terpenoids, phenylpropanoids, and alkaloids being the most abundant compounds. LANaPDB covers a wide chemical space and many compounds exhibit drug-like properties.
Review
Veterinary Sciences
Geralda Gabriele da Silva, Maykelin Fuentes Zaldivar, Lucilene Aparecida Resende Oliveira, Reysla Maria da Silveira Mariano, Daniel Ferreira Lair, Renata Antunes de Souza, Alexsandro Sobreira Galdino, Miguel Angel Chavez-Fumagalli, Denise da Silveira-Lemos, Walderez Ornelas Dutra, Ricardo Nascimento Araujo, Lorena Lopes Ferreira, Rodolfo Cordeiro Giunchetti
Summary: The infestation of blood-sucking mites in poultry farming has caused significant damage to the industry. This article analyzes the impact of these mites on poultry health, discusses chemical and non-chemical control methods, and explores the development of vaccines as a new approach to pest control.
VETERINARY SCIENCES
(2023)
Article
Parasitology
Kiswendsida Thierry Guiguemde, Patindoilba Marcel Sawadogo, Adama Zida, Apollinaire Kima, Roland Windtare Bougma, Mamadou Serme, Ibrahim Sangare, Clarisse Bougouma, Sanata Bamba
Summary: This study assessed the transmission of onchocerciasis in the Cascades region of Burkina Faso and found that the resumption of ivermectin treatment has significantly reduced the prevalence of the disease since 2011.
PARASITOLOGY INTERNATIONAL
(2024)
Article
Parasitology
K. D. Steffen, M. L. Gos, J. M. Unzaga, M. C. Venturini, R. O. Ariasc, G. More
Summary: The dynamics of anti-T. gondii antibodies and seroconversion in naturally infected goats from the last third of pregnancy to 100 days of lactation were evaluated, and their relationship with hematological and dehydration parameters was examined. The results showed that seroconversion occurred in goats of different physiological states and ages, and it was not related to hydration status.
PARASITOLOGY INTERNATIONAL
(2024)
Article
Parasitology
Maho Kotake, Yuho Watanabe, Naoki Itoh, Tomoyoshi Yoshinaga
Summary: This study examined the effects of light exposure on the theront excystment circadian rhythm in Cryptocaryon irritans. The results showed that light reception is essential for circadian rhythm entrainment and both light duration and temperature have an impact on the entrainment of circadian rhythm.
PARASITOLOGY INTERNATIONAL
(2024)
Review
Parasitology
Olivier Ndogo Eteme, Ernestine Nkwengoua Zondegoumba, Yasmin Saegusa Tadayozzi, Jessica Aparecida Serafim, Wendell Queiroz Leite, Mariane de Freitas Genari Severino, Eduardo Festozo Vicente
Summary: The high mortality rate caused by parasitic worms on their hosts is a major concern. Current drugs on the market are often toxic with numerous side effects, necessitating the search for new, more potent molecules. Medicinal plants have been found to contain a wide range of novel molecules that can effectively combat different types of helminths. This review provides an overview of the methods, activities, and mechanisms of action of cyclic peptides, specifically cyclotides, for treating helminthic infections.
PARASITOLOGY INTERNATIONAL
(2024)
Article
Parasitology
Lucas de Assis Silva Andrade, Carlos Nei Ortuzar-Ferreira, Mariana de Souza Oliveira, Sergian Vianna Cardozo, Viviane Moreira de Lima, Bruno Pereira Berto
Summary: A new species of Isospora Schneider, 1881 has been identified from V. chivi in Southeastern Brazil. Morphological and molecular analyses confirmed the identity of this new species.
PARASITOLOGY INTERNATIONAL
(2024)