期刊
PARASITOLOGY INTERNATIONAL
卷 58, 期 4, 页码 475-477出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.parint.2009.07.002
关键词
Leishmania donovani; Autophagy; Bone marrow macrophages; LC3B
类别
Autophagy is a homeostatic process promoting cell survival in periods of stress. The induction of the autophagic machinery has also been implicated in both innate and adaptive immunity. Leishmania donovani, which is the causative pathogen of visceral leishmaniasis, is an intracellular parasite that invades and multiplies in bone marrow macrophages. We describe the induction of host cell autophagic machinery during acute natural bone marrow infection by L. donovani complex, detected by LC3B immunoblot. The successful treatment with liposomal amphotericin B resulted in the resolution of this phenomenon. Even though the role of autophagy in parasite biology has been previously studied, our findings show for the first time the in vivo host cell LC3B conversion as a marker of the induction of the autophagic machinery during infection with Leishmania parasite in real time conditions. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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