期刊
PARASITOLOGY
卷 138, 期 11, 页码 1341-1353出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0031182011001296
关键词
actin; ookinetes; midgut invasion
类别
资金
- CONACYT [g-37186M, CB200801107006]
The description of Plasmodium ookinete surface proteins and their participation in the complex process of mosquito midgut invasion is still incomplete. In this study, using phage display, a consensus peptide sequence (PWWP) was identified in phages that bound to the Plasmodium berghei ookinete surface and, in selected phages, bound to actin and enolase in overlay assays with ookinete protein extracts. Actin was localized on the surface of fresh live ookinetes by immunofluorescence and electron microscopy using specific antibodies. The overall results indicated that enolase and actin can be located on the surface of ookinetes, and suggest that they could participate in Plasmodium invasion of the mosquito midgut.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据