期刊
PARASITES & VECTORS
卷 4, 期 -, 页码 -出版社
BIOMED CENTRAL LTD
DOI: 10.1186/1756-3305-4-186
关键词
Toll Like Receptors; Helminth; Inflammatory Bowel Disease
资金
- National S & T Major Program [2008ZX10004-11]
- MOST [2010CB530000, 2011AA10A200]
- National Natural Science Foundation of China [NSFC: 30825033, 31030064, 30972177, 81070311, 31072124]
- Jilin University [20101058]
Helminth infection may modulate the expression of Toll like receptors (TLR) in dendritic cells (DCs) and modify the responsiveness of DCs to TLR ligands. This may regulate aberrant intestinal inflammation in humans with helminthes and may thus help alleviate inflammation associated with human inflammatory bowel disease (IBD). Epidemiological and experimental data provide further evidence that reducing helminth infections increases the incidence rate of such autoimmune diseases. Fine control of inflammation in the TLR pathway is highly desirable for effective host defense. Thus, the use of antagonists of TLR-signaling and agonists of their negative regulators from helminths or helminth products should be considered for the treatment of IBD.
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