Article
Multidisciplinary Sciences
Workagegnehu Hailu, Rezika Mohamed, Helina Fikre, Saba Atnafu, Azeb Tadesse, Ermias Diro, Johan van Grienvsen
Summary: This study in Ethiopia found that acute kidney injury (AKI) had a prevalence of 17.4% among visceral leishmaniasis patients, with HIV co-infection and other concomitant infections significantly associated with AKI. Further research is needed to evaluate the impact of AKI on treatment course, morbidity, and mortality in VL patients.
Article
Public, Environmental & Occupational Health
Ushnish Guha, Moytrey Chatterjee, Ashif Ali Sardar, Kingsuk Jana, Pabitra Saha, Ardhendu Kumar Maji, Subhasish Kamal Guha
Summary: Despite the long-term endemicity of the disease, the knowledge level about kala-azar was found to be poor in the community, attributed to low education level and socioeconomic status. However, the attitude and practices towards the disease were good, indicating room for improvement in knowledge through proper health education.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Multidisciplinary Sciences
Habtu Debash, Habtye Bisetegn, Marye Nigatie, Getu Abeje, Daniel Getacher Feleke
Summary: A retrospective study conducted in a hospital in Northeast Ethiopia found that 23.4% of the medical records analyzed were confirmed cases of visceral leishmaniasis, a life-threatening parasitic disease. The disease was most prevalent among males, individuals aged 15-29, and urban residents. Common clinical symptoms included fever, splenomegaly, and general weakness. Hematological findings showed a high prevalence of anemia, thrombocytopenia, leucopenia, neutropenia, and pancytopenia.
SCIENTIFIC REPORTS
(2023)
Article
Infectious Diseases
Om Prakash Singh, Puja Tiwary, Anurag Kumar Kushwaha, Shakti Kumar Singh, Dhiraj Kumar Singh, Phillip Lawyer, Edgar Rowton, Rahul Chaubey, Abhishek Kumar Singh, Tulika Kumari Rai, Michael P. Fay, Jaya Chakravarty, David Sacks, Shyam Sundar
Summary: This study evaluated the infectiousness of patients with active visceral leishmaniasis, post-kala-azar dermal leishmaniasis, and asymptomatic infection to the sandfly vector. The findings suggest that early diagnosis and treatment of active cases could effectively reduce transmission, and asymptomatic individuals do not play a significant role in maintaining the transmission cycle.
Article
Multidisciplinary Sciences
Tiget Ayelgn Mengstie, Hiwot Tezera Endale, Tadele Mulaw, Aman Mossa Abdella, Rezika Mohammed, Tabarak Malik, Gashaw Dessie
Summary: This study found that VL patients treated with sodium stibogluconate and paromomycin combined drugs had elevated serum amylase and lipase levels during treatment, with significant associations between age and serum amylase and lipase.
Article
Infectious Diseases
Aschalew Tamiru, Rezika Mohammed, Saba Atnafu, Girmay Medhin, Asrat Hailu
Summary: The study evaluated the efficacy and safety of a combined regimen of SSG/PM in treating HIV-negative visceral leishmaniasis patients. The results demonstrated good initial cure rates with this regimen, and a high final cure rate after 6 months of follow-up.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Dawit Gebreegzabher Hagos, Yazezew Kebede Kiros, Mahmud Abdulkader, Zekarias Gessessew Arefaine, Etsay Nigus, Henk H. D. F. Schallig, Dawit Wolday
Summary: The LAMP assay showed high sensitivity and specificity in diagnosing visceral leishmaniasis from blood samples, even in patients coinfected with HIV.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Multidisciplinary Sciences
Dawit Gebreegzabher Hagos, Yazezew Kebede, Mahmud Abdulkader, Etsay Nigus, Zekarias Gessesse Arefaine, Gebreab Nega, Henk D. F. Schallig, Dawit Wolday
Summary: The study found that a significant proportion of patients with a positive rK39 result were undertreated, and the lack of microscopy was associated with poor clinical outcomes. There is an urgent need to include an additional simple point-of-care assay in the diagnostic work-up to accurately identify VL cases and prevent morbidity and mortality associated with the disease.
Article
Infectious Diseases
Astrid Cruaud, Veronique Lehrter, Guenaelle Genson, Jean-Yves Rasplus, Jerome Depaquit
Summary: This study explored the phylogeny and biogeographical history of the subgenus Paraphlebotomus, a group of sand flies transmitting Leishmania parasites, using next-generation sequencing techniques. The subgenus was found not to be monophyletic, leading to a revision in taxonomy and the creation of a new subgenus. The study suggested that Paraphlebotomus originated around 10 million years ago and its historical biogeography can be summarized into three phases.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Infectious Diseases
Jon Badiola, Leopoldo Munoz-Medina, Jose Luis Callejas, Alicia Delgado-Garcia, Manuel Jurado, Jose Hernandez-Quero
Summary: This study found that Leishmania is the predominant trigger of adult HLH in our region, and RT-PCR is the best tool to identify Leishmania.
ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
(2021)
Article
Public, Environmental & Occupational Health
Acacio W. F. Andrade, Carlos D. F. Souza, Rodrigo F. Carmo
Summary: This study analyzed the spatiotemporal dynamics of human visceral leishmaniasis in Bahia and found a significant correlation between the disease and social vulnerability. The findings provide valuable information for action planning and organizing healthcare services.
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE
(2022)
Article
Infectious Diseases
Vijay Kumar, Niyamat A. Siddiqui, Timothy M. Pollington, Rakesh Mandal, Sushmita Das, Shreekant Kesari, Vidyanand R. Das, Krishna Pandey, T. Deirdre Hollingsworth, Lloyd A. C. Chapman, Pradeep Das
Summary: Visceral leishmaniasis (VL) is declining in India, and the goal of eliminating it as a public health problem by 2020, set by the World Health Organization (WHO), is nearing achievement. Intensified combined interventions may help reach this goal, although their impact has not been assessed. A pilot study in the highly-endemic Vaishali district, which implemented intensified interventions, showed a substantial decrease in VL cases. This approach should be considered in other highly-endemic districts.
Review
Agriculture, Multidisciplinary
Isabelli Sayuri Kono, Amanda Bertao-Santos, Douglas Aparecido Silva, Roberta Lemos Freire, Italmar Teodorico Navarro, Pablo Menegon Castilho, Eloiza Teles Caldart
Summary: This systematic review collected information on the spatial distribution of the sandfly Migonemyia migonei in southern Brazil, which is a possible vector of visceral leishmaniasis. A total of 36 articles were included in the review, covering municipalities in Parana, Santa Catarina, and Rio Grande do Sul. The wide distribution of Mg. migonei in Parana highlights the need for increased monitoring and control efforts in this region, while further studies on visceral leishmaniasis are required in Santa Catarina and Rio Grande do Sul.
SEMINA-CIENCIAS AGRARIAS
(2023)
Article
Infectious Diseases
Anurag Kumar Kushwaha, Ashish Shukla, Breanna M. Scorza, Tulika Kumari Rai, Rahul Chaubey, Dharmendra Kumar Maurya, Shweta Srivastva, Shreya Upadhyay, Abhishek Kumar Singh, Paritosh Malviya, Om Prakash Singh, Vivek Kumar Scholar, Puja Tiwary, Shakti Kumar Singh, Phillip Lawyer, Edgar Rowton, Scott A. Bernhardt, Christine A. Petersen, Shyam Sundar
Summary: This study provides clinical evidence that domestic animals, other than humans, do not play a significant role in transmitting Leishmania donovani to sand flies on the Indian subcontinent. Monitoring the absence of transmission in the post-elimination phase is crucial to prevent the establishment of a non-human reservoir.
PLOS NEGLECTED TROPICAL DISEASES
(2022)