Article
Gastroenterology & Hepatology
Mahya Faghih, Anna E. Phillips, Louise Kuhlmann, Elham Afghani, Asbjorn M. Drewes, Dhiraj Yadav, Vikesh K. Singh, Soren S. Olesen
Summary: This study utilized pancreatic QST to differentiate patients into distinct pain phenotypes, finding that patients with widespread hyperalgesia had higher pain intensity, increased rates of constant pain, decreased quality of life and physical functioning. Psychiatric comorbidities were similar across all groups.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Ankit Maheshwari, Partha Sarathi Patra, Sukanta Ray, G. K. Dhali, Kshaunish Das
Summary: This study validated the effectiveness of COPPS in a geographically diverse patient population, demonstrating a positive correlation between COPPS severity and number of hospitalisations and days spent in hospital.
DIGESTIVE AND LIVER DISEASE
(2022)
Article
Gastroenterology & Hepatology
Florence E. M. L. de Rijk, Charlotte A. van Veldhuisen, Marinus Kempeneers, Yama A. Issa, Marja G. Boermeester, Marc C. Besselink, Johannes C. Kelder, Hjalmar van Santvoort, Pieter Jan F. C. de Jonge, Robert J. Verdonk, Marco Bruno, Dutch Pancreatitis Study Grp
Summary: This study aims to gain insight into the course and predictors of quality of life (QoL) in patients with chronic pancreatitis (CP) using prospective longitudinal data. The results showed that nutritional status, exocrine pancreatic function, employment status, and patients' coping strategy are important factors for improving QoL.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Pankaj Singh, Bidhan Chakraborty, Sujit Sarkhel, Sukanta Ray, Partha Sarathi Patra, Kshaunish Das
Summary: Patients with Idiopathic Chronic Pancreatitis (CP) experience catastrophic healthcare expenditure, malnutrition, abnormal psychological scores, and work impairment compared to healthy controls, but some of these parameters show improvement over time.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Review
Medicine, General & Internal
Santhi Swaroop Vege, Suresh T. Chari
Summary: Chronic pancreatitis is often associated with alcohol use, smoking, or genetic risk factors. Common symptoms include recurrent abdominal pain or pancreatitis, and characteristic imaging findings include pancreatic stones, dilated ducts, and atrophy. Complications include pseudocysts, biliary strictures, exocrine and endocrine pancreatic insufficiency, bone loss, and pancreatic cancer.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Daniel M. Spagnolo, Phil J. Greer, Celeste Shelton Ohlsen, Shannon Mance, Mitchell Ellison, Cameron Breze, Ben Busby, David C. Whitcomb, Mark Haupt
Summary: By analyzing a pancreatitis cohort from the UK BioBank, this study reveals a high burden of acute and chronic pancreatitis in the UK population. Gallstones and smoking are identified as key risk factors for acute and chronic pancreatitis, respectively.
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Mikael Parhiala, Anne Waage, Povilas Ignatavicus, Jakob L. Poulsen, Engjom Trond, Georg Dimcevski, Ingrid Nordaas, Amer Hadi, Evangelos Kalaitzakis, Asbjorn M. Drewes, Camilla Nojgaard, Johanna Laukkarinen
Summary: This study aimed to determine the surgical treatment strategies for chronic pancreatitis (CP) in the Scandinavian and Baltic countries. The results showed that only 7% of CP patients underwent pancreatic surgery, with 51% of them undergoing surgery for chronic pain. After surgery, 47% of the patients were pain-free and half of the patients reported no pain.
Article
Gastroenterology & Hepatology
Anne Waage, Olof Vinge-Holmquist, Knut J. Labori, Vemund Paulsen, Lars Aabakken, Harald Lenz, Henrik C. Felix Magnus, Tore Tholfsen, Truls Hauge
Summary: This study demonstrates that patients selected for surgery after evaluation by a multidisciplinary team can achieve pain relief and improved quality of life in chronic pancreatitis. The duration of preoperative pain predicts the success of treatment.
Article
Gastroenterology & Hepatology
Rajiv M. Mehta, Stephen J. Pandol, Prachi R. Joshi
Summary: Chronic pancreatitis is a complex disease with gene-gene or gene-environment interactions, where the idiopathic form has shown an increasing incidence and changing phenotypes. While the beneficial effects of antioxidant therapy for CP remain unclear, research is ongoing to identify drugs that can improve symptoms and alter the natural history of the disease.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Chemistry, Medicinal
Reyhaneh Gudarzi, Fatemeh Shabani, Sakineh Mohammad-Alizadeh-Charandabi, Elham Naghshineh, Elnaz Shaseb, Mojgan Mirghafourvand
Summary: This study aimed to determine the effect of curcumin on painful symptoms and quality of life in women with endometriosis. The results showed that curcumin did not have a significant impact on pain symptoms or quality of life. Future clinical trials are needed to further investigate the role of curcumin in endometriosis.
PHYTOTHERAPY RESEARCH
(2023)
Article
Medicine, General & Internal
Ji-Yao Guo, Jia-Hui Zhu, Jun Pan, Yuan-Chen Wang, Yang-Yang Qian, Liang-Hao Hu, Chao-Hui He, Wen-Bin Zou
Summary: This study aimed to evaluate the safety and success rate of therapeutic ERCP in geriatric patients with chronic pancreatitis (CP). The results showed that therapeutic ERCP is safe and feasible in elderly patients with CP, but geriatric patients have a higher risk of moderate to severe complications compared to younger patients.
Article
Psychiatry
Wen Lin Teh, Jianlin Liu, Pratika Satghare, Ellaisha Samari, Yee Ming Mok, Mythily Subramaniam
Summary: This study examined the mediating role of pain interference in the relationship between depressive symptoms and HRQOL, finding that pain interference fully mediated the relationship between depressive symptoms and physical HRQOL. At high pain levels, depressive symptoms may interfere with physical quality of life through pain interference.
Article
Medicine, General & Internal
Justyna Mazurek, Blazej Cieslik, Patryk Szary, Sebastian Rutkowski, Jan Szczegielniak, Joanna Szczepanska-Gieracha, Robert Gajda
Summary: The study found that headache is a common symptom during COVID-19, with females being more likely to experience it. Headache is associated with depression, anxiety, and perceived stress level, which may affect the quality of life during the post-COVID-19 rehabilitation phase.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Mostafa M. Khodeir, Hassan A. Shabana, Zafar Rasheed, Abdullah S. Alkhamiss, Mohamed Khodeir, Mohammad S. Alkhowailed, Sami Alharbi, Mansour Alsoghair, Suliman A. Alsagaby, Waleed Al Abdulmonem
Summary: Long-term symptoms after recovery from COVID-19 are common, including general fatigue, weakness, neurological symptoms like mood changes and insomnia, and sensory symptoms like loss of taste and smell. Further studies are needed to fully understand the recovery process from COVID-19.
Article
Medicine, General & Internal
Mikael Parhiala, Juhani Sand, Johanna Laukkarinen
Summary: Surgical interventions for chronic pancreatitis are rare in Finland, with most patients undergoing endoscopic procedures prior to surgery. Patients who returned questionnaires reported reduced pain and good quality of life during the 14-year follow-up period.
WORLD JOURNAL OF CLINICAL CASES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Emily Steinkohl, Soren Schou Olesen, Tine Maria Hansen, Asbjorn Mohr Drewes, Jens Brondum Frokjaer
Summary: This study investigated the correlation between magnetic resonance elastography (MRE)-derived stiffness and T1 relaxation times with gland volume and pancreatic functions in patients with chronic pancreatitis (CP). The results showed a positive correlation between MRE-derived stiffness and T1 relaxation times, but no correlation was found between MRE-derived stiffness and gland volume. T1 relaxation time was correlated with gland volume in CP patients but not in the healthy controls. The study suggests that MRE-derived stiffness and T1 relaxation times may be useful for the non-invasive and early identification of CP.
Article
Gastroenterology & Hepatology
Moeen Ud-Din, Bassam Karout, Wiktoria M. Torbe, Johan Lunding, Anne-Marie Wegeberg, Asbjorn M. Drewes, Christina Brock, Per M. Hellstrom
Summary: The study aims to develop a clinical decision-support tool to differentiate the underlying disease in gastrointestinal symptoms of diabetes patients. By collecting basic characteristics and patient reported outcomes, using statistical analysis and machine learning techniques, and searching for biomarkers for autonomic neuropathy, the study hopes to provide better healthcare for diabetes patients.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Reem A. Alharbi, Hossam Elfeki, Katrine J. Emmertsen, Alexander R. Mortensen, Asbjorn M. Drewes, Peter Christensen, Soren Laurberg, Therese Juul
Summary: The chronic pain score (CP score) has been translated and validated in a cohort of colon cancer patients. The score demonstrated good convergent and discriminative validity, and was able to differentiate between different genders and age groups. It also showed the ability to identify patients with a major impact on quality of life.
COLORECTAL DISEASE
(2023)
Article
Medicine, Research & Experimental
Mathias E. Cook, Cecilie S. Knoph, Camilla A. Fjelsted, Jens B. Frokjaer, Anders E. Bilgrau, Srdan Novovic, Maiken Thyregod Jorgensen, Michael B. Mortensen, Liv B. J. Nielsen, Amer Hadi, Mark Berner-Hansen, Wiktor Rutkowski, Miroslav Vujasinovic, Matthias Lohr, Asbjorn M. Drewes, Soren S. Olesen
Summary: This study aims to investigate whether naldemedine can alter the natural course of pancreatitis in patients with recurrent acute pancreatitis and improve patient outcomes.
Article
Endocrinology & Metabolism
Suganthiya S. Croosu, Mimoza Gjela, Johan Roikjer, Tine M. Hansen, Carsten D. Morch, Jens B. Frokjaer, Niels Ejskjaer
Summary: Previous studies suggest that cognitive impairment is more prevalent in individuals with painful and painless diabetic peripheral neuropathy (DPN). This study investigated cognitive function in adults with type 1 diabetes mellitus (T1DM) and the association to painful/painless DPN and clinical parameters. The results showed that T1DM participants had lower cognitive scores and longer reaction times compared to healthy controls, and memory scores were lower in those with painless DPN.
ENDOCRINOLOGY DIABETES & METABOLISM
(2023)
Article
Clinical Neurology
Johan Roikjer, Suganthiya Santhiapillai Croosu, Mette Krabsmark Borbjerg, Tine Maria Hansen, Jens Brondum Frokjaer, Lars Arendt-Nielsen, Niels Ejskjaer, Carsten Dahl Morch
Summary: This study aimed to evaluate the diagnostic performance of histamine-induced flare response and optimize the time required for assessment. The results showed that flare area size had better diagnostic performance than mean flare intensity and could distinguish people with and without diabetic peripheral neuropathy after 4 minutes. Flare area size achieved a diagnostic performance comparable to a full examination after 6-7 minutes.
Article
Gastroenterology & Hepatology
Morten Hasselstrom Jensen, Simon Lebech Cichosz, Ole Hejlesen, Stine Dam Henriksen, Asbjorn Mohr Drewes, Soren Schou Olesen
Summary: This nationwide population-based retrospective cohort study examined the 3-year cumulative incidence of pancreatic ductal adenocarcinoma (PDAC) in people 50 years and older with new onset diabetes (NOD). The study found that the risk of PDAC among this population was approximately 0.6%. People with pancreatic cancer-related diabetes (PCRD) had distinct demographic and clinical profiles compared to those with type 2 diabetes (T2D), including different trajectories of plasma HbA1c and triglyceride levels.
Article
Gastroenterology & Hepatology
Serena Nauser, Emily Steinkohl, Soren Schou Olesen, Asbjorn Mohr Drewes, Jens Brondum Frokjaer
Summary: Magnetic resonance elastography (MRE) was used to investigate the co-existence of hepatic and pancreatic fibrosis in chronic pancreatitis (CP), as well as the association between hepatic and pancreatic stiffness. Results showed that 15% of CP patients had abnormal liver stiffness and 5.6% had F1 fibrosis. There was a positive association between hepatic and pancreatic stiffness, and alcoholic etiology of CP was associated with increased hepatic stiffness.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Davide Bertoli, Esben B. Mark, Donghua Liao, Christina Brock, Birgitte Brock, Filip K. Knop, Klaus Krogh, Jens B. Frokjaer, Asbjorn M. Drewes
Summary: In this study, a pan-alimentary framework for the evaluation of gastrointestinal motility and different static endpoints based on MRI was developed and tested. The results showed an increase in stomach and small bowel volume after meal intake, while there was no change in colonic fecal water content. This framework can help unravel complex gastrointestinal symptoms.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Multidisciplinary Sciences
Thomas Arendt Nielsen, Soren Lundbye-Christensen, Yoanna Krasimirova Dimitrova, Sam Riahi, Birgitte Brock, Asbjorn Mohr Drewes, Christina Brock
Summary: Heart rate variability during tonic cold pain can potentially reveal cardiac autonomic neuropathy in individuals with type 1 diabetes mellitus. Compared to healthy controls, patients with type 1 diabetes mellitus have lower heart rate variability, which is further diminished during exposure to cold pain.
SCIENTIFIC REPORTS
(2023)
Article
Endocrinology & Metabolism
Johan Roikjer, Suganthiya Santhiapillai Croosu, Tine Maria Hansen, Jens Brondum Frokjaer, Christina Brock, Carsten Dahl Morch, Niels Ejskjaer
Summary: This study aims to investigate the co-existence of diabetic peripheral neuropathy (DPN), painful diabetic peripheral neuropathy (PDPN), and cardiac autonomic neuropathy (CAN), and establish a model to predict CAN based on peripheral measurements. The results showed that CAN predominantly co-exists with DPN and the prediction model based on logistic regression has a certain accuracy.
ACTA DIABETOLOGICA
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Soren Schou Olesen, Emily Steinkohl, Tine Maria Hansen, Asbjorn Mohr Drewes, Jens Brondum Frokjaer
Summary: The study aimed to evaluate the performance of advanced magnetic resonance imaging (MRI) techniques for diagnosing and grading the severity of chronic pancreatitis (CP), with a focus on detecting CP with preserved pancreatic function. The results showed that quantitative assessments of T1 relaxation time and MRE-derived stiffness hold promise in diagnosing CP at different functional stages, and when combined with a multiparametric MRI-index, can be used for early identification, staging, and monitoring of CP.
ABDOMINAL RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jens Borgbjerg, Emily Steinkohl, Soren S. Olesen, Fatih Akisik, Anne Bethke, Edita Bieliuniene, Heidi S. Christensen, Trond Engjom, Ingfrid S. Haldorsen, Nikolaos Kartalis, Maria Lisitskaya, Gintare Naujokaite, Srdan Novovic, Imanta Ozola-Zalite, Anna E. Phillips, Jordan K. Swensson, Asbjorn M. Drewes, Jens B. Frokjaer
Summary: This study aimed to evaluate inter- and intraobserver variability in CT measurements of ductal and gland diameters in chronic pancreatitis (CP) patients. The results showed substantial variability in pancreatic two-point measurements, especially in the parenchymal and ductal diameters of the pancreatic head. These findings challenge the implementation of two-point measurements as the foundation for quantitative imaging scoring systems in CP.
ABDOMINAL RADIOLOGY
(2023)
