Article
Gastroenterology & Hepatology
Imadh Khan, Muhammad Baig, Thrisha Bandepalle, Srinivas R. Puli
Summary: The meta-analysis suggests that cyst fluid CEA level at a cutoff of 192 ng/mL is highly specific in diagnosing mucinous cystic lesions with reasonable sensitivity.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Oncology
Szu-Yu Huang, Hung-Chun Fu, Chen-Hsuan Wu, Shao-Chi Wang, Yu-Che Ou, Ching-Chou Tsai, Ying-Yi Chen, Szu-Wei Huang, Ying-Wen Wang, Hao Lin
Summary: The aim of this study was to investigate the feasibility of using the cost-effective pretreatment tumor markers CEA and CA-125 to predict lymph node metastasis in endometrioid-type endometrial cancer (EC) and to develop a predictive model. The study found that CEA and CA-125 were independent predictors of LNM. The nomogram showed good discrimination and calibration, and the risk of LNM for markers below the cut-offs was 3.6%. This method can aid in decision-making regarding lymphadenectomy.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Surgery
Myrte Gorris, Frederike Dijk, Arantza Farina, Johannes B. Halfwerk, Gerrit K. Hooijer, Selma J. Lekkerkerker, Rogier P. Voermans, Mattheus C. Wielenga, Marc G. Besselink, Jeanin E. van Hooft
Summary: This study assessed the value of combined CEA and glucose testing in pancreatic cyst fluid, and found that this method has high specificity and sensitivity for differentiating mucinous from non-mucinous pancreatic cystic neoplasms.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Francesco Caiazza, Patricia C. Conroy, Sam L. Ivry, Tyler York, Joseph Lin, Sophia Hernandez, Thomas J. Hoffmann, Stephen S. Francis, Walter G. Park, Michele T. Yip-Schneider, C. Max Schmidt, Randall Brand, Charles S. Craik, Kimberly Kirkwood
Summary: This study compared the performance of gastricsin, glucose, and CEA as biomarkers for the classification of mucinous pancreatic cystic lesions. The results showed that gastricsin and glucose performed similarly to CEA, but required much smaller sample volumes.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Feredun Azari, Gregory T. Kennedy, Ashley Chang, Elizabeth Bernstein, Bilal Nadeem, Andre Pelegrin, Francoise Cailler, Neil T. Sullivan, John Kucharczuk, Sunil Singhal
Summary: This study suggests that CEACAM5 may serve as a potential target for targeted intraoperative molecular imaging resections in lung cancer. The study paves the way for evaluating CEACAM5 targets in future clinical trials.
ANNALS OF THORACIC SURGERY
(2023)
Article
Gastroenterology & Hepatology
Efrat Zamir, Dana Zelnik Yovel, Erez Scapa, Mati Shnell, Nir Bar, Iddo Bar Yishay, Tomer Ziv-Baran, Fadi Younis, Adam Phillips, Nir Lubezky, Oren Shibolet, Dana Ben-Ami Shor
Summary: Glucose levels in pancreatic cystic fluid are more accurate than CEA for the diagnosis of mucinous cysts. Glucometry assessment of glucose levels shows excellent correlation with laboratory measurements and may serve as a useful diagnostic test.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2022)
Article
Oncology
Ernesto Lopez, Sofia Hidalgo, Eduardo Roa, Javiera Gomez, Carlos Hermansen Truan, Evy Sanders, Cristian Carrasco, Rodrigo Pacheco, Flavio Salazar-Onfray, Manuel Varas-Godoy, Vincenzo Borgna, Alvaro Lladser
Summary: Gallbladder cancer (GBC) is often diagnosed at late stages and lacks effective treatments. This study investigates the potential of using CAR-T cells targeting CEA as a potential immunotherapy for GBC. Results show that CEA is expressed in a high percentage of GBC tumors, and CAR-T cells can recognize and kill GBC cells expressing CEA. The findings support the further development of CEA-specific CAR-T cells for GBC immunotherapy.
Article
Chemistry, Analytical
Ruina Wang, Yun Huang, Yuwu Chi
Summary: An ECL immunosensor for the detection of carcinoembryonic antigen (CEA) was constructed using oxidized multi-walled carbon nanotube/nano-gold (AuNP-ox-MWCNT) composites with strong electrochemiluminescence (ECL) activity. The immunosensor showed a wide linear response range and a low detection limit, and was simple to fabricate and label-free.
Article
Chemistry, Multidisciplinary
Priyanka Singh, Pranav K. Katkar, Umakant M. Patil, Raghvendra A. Bohara
Summary: This study successfully developed an immunosensor for detecting carcinoembryonic antigen by coating silver nanoparticles with silica, improving sensitivity and stability of the reaction with a detection limit of 0.01 ng/mL.
Article
Endocrinology & Metabolism
Xi-Yu Liu, Chai Jin, Yan Zhou
Summary: This study found a high prevalence of abnormal CEA in diabetic inpatients, especially those with poor glycemic control. Blood glucose levels, age, and body mass index were correlated with CEA levels. These findings are important for understanding the CEA levels in diabetic patients and their relationship with glycemic control.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)
Review
Gastroenterology & Hepatology
Thomas R. McCarty, Swathi Paleti, Tarun Rustagi
Summary: The molecular analysis of KRAS and GNAS mutations in EUS-acquired pancreatic cyst fluid shows high sensitivity and specificity, significantly improving diagnostic accuracy for IPMNs and MCLs compared to using CEA alone.
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Chemistry, Analytical
Mengya Cao, Lijun Zhang, Haoran Tang, Xia Qiu, Yongxin Li
Summary: Solid-state nanopores provide a nanoconfined space for single-molecule sensing strategy. In this study, an aptamer-functionalized nanopore was used as a sensing platform for the kinetic analysis of carcinoembryonic antigen (CEA). The results showed that this platform could be used for protein sensing and immunoassays.
ANALYTICAL CHEMISTRY
(2022)
Review
Oncology
Huiping Wang, Weibiao Jin, Chuanqi Wan, Chen Zhu
Summary: The combined use of serum tumor markers CEA, CA19-9, and CA72-4 has higher sensitivity and specificity in the diagnosis of gastric cancer.
TRANSLATIONAL CANCER RESEARCH
(2022)
Article
Medical Laboratory Technology
Rangrang Zhang, Weidong Jin, Minglei Han, Yonglan Hou
Summary: Atrial fibrillation (AF) is a common clinical arrhythmia associated with increased risk of death, stroke, and peripheral vascular embolism. Catheter ablation (CA) is an effective treatment, but a high recurrence rate remains a challenge. Identifying biomarkers for prediction of AF recurrence after CA is important for personalized treatment. Carbohydrate antigen 125 (CA-125) has been widely studied and may serve as a useful marker for AF.
CLINICA CHIMICA ACTA
(2023)
Article
Environmental Sciences
Yi-Jen Fang, Lukas Jyuhn-Hsiarn Lee, Kuei-Hau Luo, Po-Sheng Fang, Chen-Cheng Yang, Hung-Yi Chuang
Summary: The study found a significant relationship between short-term exposure to air pollutants ozone and carbon monoxide and serum CEA concentration, although the mechanism is still unclear. Moreover, further evaluation is needed regarding the long-term exposure to air pollution and changes in CEA concentration.
Article
Pathology
Tomoaki Naka, Taiki Hashimoto, Hourin Cho, Noriko Tanabe, Teruhiko Yoshida, Yasushi Yatabe, Takaki Yoshikawa, Seiichiro Abe, Shigeki Sekine
Summary: Gastric foveolar-type adenoma (FA) is a rare benign neoplasm that can either occur sporadically or in patients with familial adenomatous polyposis (FAP). This study aimed to investigate the molecular features of FA and the relationship between sporadic and syndromic lesions. The results showed that sporadic FA includes at least two morphologically and genetically distinct subtypes: flat and raspberry-like FA. Additionally, it was found that flat FA represents a sporadic counterpart of FAP-associated FA.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2023)
Article
Oncology
Masaya Yotsukura, Yuji Muraoka, Yukihiro Yoshida, Kazuo Nakagawa, Kouya Shiraishi, Takashi Kohno, Yasushi Yatabe, Shun-ichi Watanabe
Summary: This study found that the prognosis and survival of lung cancer patients after 5 years of surgery were associated with age rather than stage classification. It suggests that the long-term follow-up strategy does not need to be modified based on stage classification, and screening for secondary primary lung cancer should be considered.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Go Ikeda, Susumu Hijioka, Yoshikuni Nagashio, Yuta Maruki, Akihiro Ohba, Yuya Hisada, Motohiro Yoshinari, Shota Harai, Hidetoshi Kitamura, Takehiko Koga, Yumi Murashima, Kosuke Maehara, Mao Okada, Daiki Yamashige, Kohei Okamoto, Hidenobu Hara, Yuya Hagiwara, Daiki Agarie, Tetsuro Takasaki, Kotaro Takeshita, Yuki Kawasaki, Shunsuke Kondo, Chigusa Morizane, Hideki Ueno, Nobuyoshi Hiraoka, Yasushi Yatabe, Yutaka Saito, Katsuhiko Iwakiri, Takuji Okusaka
Summary: This study investigated the suitability of endoscopic ultrasound-guided tissue acquisition (EUS-TA) for comprehensive genomic profiling (CGP) and found that the use of a 19G fine-needle biopsy (FNB) significantly increased the suitability for CGP analysis. The success rate of actual CGP analysis was 100% for patients who underwent the procedure.
DIGESTIVE ENDOSCOPY
(2023)
Article
Cardiac & Cardiovascular Systems
Takaki Akamine, Masaya Yotsukura, Yukihiro Yoshida, Kazuo Nakagawa, Yasushi Yatabe, Shun-ichi Watanabe
Summary: In this study, we found that segmentectomy is a feasible procedure with comparable safety outcomes and better surgical margins and cancer control than wedge resection, particularly for clinical stage IA2 NSCLC. Segmentectomy significantly improved the recurrence-free survival compared with wedge resection, especially for patients with clinical stage IA. Subgroup analysis also demonstrated that segmentectomy had better recurrence-free survival in clinical stage IA2 and pure-solid tumors compared to wedge resection.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Medicine, General & Internal
Kotaro Takeshita, Susumu Hijioka, Yoshikuni Nagashio, Yuta Maruki, Yuki Kawasaki, Kosuke Maehara, Yumi Murashima, Mao Okada, Go Ikeda, Natsumi Yamada, Tetsuro Takasaki, Daiki Agarie, Hidenobu Hara, Yuya Hagiwara, Kohei Okamoto, Daiki Yamashige, Akihiro Ohba, Shunsuke Kondo, Chigusa Morizane, Hideki Ueno, Yutaka Saito, Yuichiro Ohe, Takuji Okusaka
Summary: The diagnostic ability of performing endoscopic ultrasound-guided tissue acquisition (EUS-TA) using a 19G needle has been retrospectively reviewed. The 19G TopGain needle showed favorable sensitivity, specificity, and accuracy for confirmed diagnosis. However, the use of 19G fine-needle biopsy (FNB) needles may increase adverse events. EUS-TA with a 19G FNB needle is mainly indicated in lesions where comprehensive genomic profiling may be necessary or the diagnosis could not be determined via EUS-TA using the 22G needle.
Article
Gastroenterology & Hepatology
Kotaro Takeshita, Susumu Hijioka, Yoshikuni Nagashio, Yuta Maruki, Akihiro Ohba, Yuki Kawasaki, Yuya Hisada, Motohiro Yoshinari, Shota Harai, Hidetoshi Kitamura, Takehiko Koga, Kosuke Maehara, Yumi Murashima, Natsumi Yamada, Mao Okada, Tetsuro Takasaki, Daiki Agarie, Hidenobu Hara, Yuya Hagiwara, Kohei Okamoto, Daiki Yamashige, Shunsuke Kondo, Chigusa Morizane, Hideki Ueno, Yutaka Saito, Takuji Okusaka
Summary: This study evaluated the clinical efficacy of using a novel self-expandable metallic stent (SEMS) for endoscopic ultrasound-guided intervention without fistula dilation (EUS-IV WoD). The results showed a technical success rate of 100% and a clinical success rate of 72.8% for EUS-IV WoD. Early adverse events, including mild abdominal pain and moderate bleeding, were observed in 27.3% of the patients. The novel stent may be useful for EUS-IV WoD, especially in EUS-biliary drainage.
ENDOSCOPY INTERNATIONAL OPEN
(2023)
Article
Medicine, General & Internal
Hidenori Suzuki, Gaku Takano, Satoshi Tsukushi, Masashi Ando, Yasushi Yatabe, Takeshi Kodaira, Daisuke Nishikawa, Shintaro Beppu, Yasuhisa Hasegawa, Nobuhiro Hanai
Summary: The present study aimed to investigate the relationship between age at surgery and survival outcomes in patients with sarcoma in the head and neck. A total of 26 patients who underwent surgery for head and neck sarcoma from 2003 to 2017 were included. Patients who did not receive chemotherapy were significantly older at the time of surgery. Receiver operating curve analysis determined 55 years as the cutoff age for predicting death. Older age was associated with shorter overall, disease-specific, local recurrence-free, and disease-free survival rates. Multivariate analysis using Cox's proportional hazards model adjusted for chemotherapy (absence/presence) showed that age (>= 55 years/<55 years) was correlated with shorter overall survival. In conclusion, older age predicts worse overall survival in patients with head and neck sarcoma.
Article
Pathology
Hirotake Fujii, Yosuke Yamada, Kentaro Yamamura, Yoshihiro Ishida, Marina Tsujimura, Kazuhisa Matsumoto, Satona Tanaka, Hiroshi Date, Tadaaki Nishikawa, Yukihiro Yoshida, Jumpei Kashima, Yasushi Yatabe, Seishi Ogawa, Alexander Marx, Thomas M. Ulbright, Hironori Haga
Summary: VMT is a new type of tumor that occurs in mediastinal germ cell tumors after chemotherapy, characterized by abnormal vessels. Patients with VMT in residual tumors have an increased risk of developing sarcomas or hematopoietic malignancies.
Article
Multidisciplinary Sciences
Jianxin Shi, Kouya Shiraishi, Jiyeon Choi, Keitaro Matsuo, Tzu-Yu Chen, Juncheng Dai, Rayjean J. Hung, Kexin Chen, Xiao-Ou Shu, Young Tae Kim, Maria Teresa Landi, Dongxin Lin, Wei Zheng, Zhihua Yin, Baosen Zhou, Bao Song, Jiucun Wang, Wei Jie Seow, Lei Song, I-Shou Chang, Wei Hu, Li-Hsin Chien, Qiuyin Cai, Yun-Chul Hong, Hee Nam Kim, Yi-Long Wu, Maria Pik Wong, Brian Douglas Richardson, Karen M. Funderburk, Shilan Li, Tongwu Zhang, Charles Breeze, Zhaoming Wang, Batel Blechter, Bryan A. Bassig, Jin Hee Kim, Demetrius Albanes, Jason Y. Y. Wong, Min-Ho Shin, Lap Ping Chung, Yang Yang, She-Juan An, Hong Zheng, Yasushi Yatabe, Xu-Chao Zhang, Young-Chul Kim, Neil E. Caporaso, Jiang Chang, James Chung Man Ho, Michiaki Kubo, Yataro Daigo, Minsun Song, Yukihide Momozawa, Yoichiro Kamatani, Masashi Kobayashi, Kenichi Okubo, Takayuki Honda, Dean H. Hosgood, Hideo Kunitoh, Harsh Patel, Shun-ichi Watanabe, Yohei Miyagi, Haruhiko Nakayama, Shingo Matsumoto, Hidehito Horinouchi, Masahiro Tsuboi, Ryuji Hamamoto, Koichi Goto, Yuichiro Ohe, Atsushi Takahashi, Akiteru Goto, Yoshihiro Minamiya, Megumi Hara, Yuichiro Nishida, Kenji Takeuchi, Kenji Wakai, Koichi Matsuda, Yoshinori Murakami, Kimihiro Shimizu, Hiroyuki Suzuki, Motonobu Saito, Yoichi Ohtaki, Kazumi Tanaka, Tangchun Wu, Fusheng Wei, Hongji Dai, Mitchell J. Machiela, Jian Su, Yeul Hong Kim, In-Jae Oh, Victor Ho Fun Lee, Gee-Chen Chang, Ying-Huang Tsai, Kuan-Yu Chen, Ming-Shyan Huang, Wu-Chou Su, Yuh-Min Chen, Adeline Seow, Jae Yong Park, Sun-Seog Kweon, Kun-Chieh Chen, Yu-Tang Gao, Biyun Qian, Chen Wu, Daru Lu, Jianjun Liu, Ann G. Schwartz, Richard Houlston, Margaret R. Spitz, Ivan P. Gorlov, Xifeng Wu, Ping Yang, Stephen Lam, Adonina Tardon, Chu Chen, Stig E. Bojesen, Mattias Johansson, Angela Risch, Heike Bickeboeller, Bu-Tian Ji, H-Erich Wichmann, David C. Christiani, Gadi Rennert, Susanne Arnold, Paul Brennan, James McKay, John K. Field, Sanjay S. Shete, Loic Le Marchand, Geoffrey Liu, Angeline Andrew, Lambertus A. Kiemeney, Shan Zienolddiny-Narui, Kjell Grankvist, Mikael Johansson, Angela Cox, Fiona Taylor, Jian-Min Yuan, Philip Lazarus, Matthew B. Schabath, Melinda C. Aldrich, Hyo-Sung Jeon, Shih Sheng Jiang, Jae Sook Sung, Chung-Hsing Chen, Chin-Fu Hsiao, Yoo Jin Jung, Huan Guo, Zhibin Hu, Laurie Burdett, Meredith Yeager, Amy Hutchinson, Belynda Hicks, Jia Liu, Bin Zhu, Sonja I. Berndt, Wei Wu, Junwen Wang, Yuqing Li, Jin Eun Choi, Kyong Hwa Park, Sook Whan Sung, Li Liu, Chang Hyun Kang, Wen-Chang Wang, Jun Xu, Peng Guan, Wen Tan, Chong-Jen Yu, Gong Yang, Alan Dart Loon Sihoe, Ying Chen, Yi Young Choi, Jun Suk Kim, Ho-Il Yoon, In Kyu Park, Ping Xu, Qincheng He, Chih-Liang Wang, Hsiao-Han Hung, Roel C. H. Vermeulen, Iona Cheng, Junjie Wu, Wei-Yen Lim, Fang-Yu Tsai, John K. C. Chan, Jihua Li, Hongyan Chen, Hsien-Chih Lin, Li Jin, Jie Liu, Norie Sawada, Taiki Yamaji, Kathleen Wyatt, Shengchao A. Li, Hongxia Ma, Meng Zhu, Zhehai Wang, Sensen Cheng, Xuelian Li, Yangwu Ren, Ann Chao, Motoki Iwasaki, Junjie Zhu, Gening Jiang, Ke Fei, Guoping Wu, Chih-Yi Chen, Chien-Jen Chen, Pan-Chyr Yang, Jinming Yu, Victoria L. Stevens, Joseph F. Fraumeni, Nilanjan Chatterjee, Olga Y. Gorlova, Chao Agnes Hsiung, Christopher I. Amos, Hongbing Shen, Stephen J. Chanock, Nathaniel Rothman, Takashi Kohno, Qing Lan
Summary: This study identified 12 novel susceptibility variants for lung adenocarcinoma and a total of 28 loci associated with the disease in East Asian populations. Additionally, new candidate genes were discovered, contributing to the understanding of the disease etiology. These findings have important implications for the research and translational applications of lung adenocarcinoma in individuals from East Asian populations.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Taiki Hashimoto, Daisuke Takayanagi, Junpei Yonemaru, Tomoaki Naka, Kengo Nagashima, Erika Machida, Takashi Kohno, Yasushi Yatabe, Yukihide Kanemitsu, Ryuji Hamamoto, Atsuo Takashima, Kouya Shiraishi, Shigeki Sekine
Summary: This study aimed to clarify the clinicopathological and molecular features of HER2-amplified and HER2-low colorectal cancers (CRCs). The results showed that HER2-amplified and HER2-low CRCs have different clinicopathological and molecular features, and HER2 expression can be assessed through biopsy. Therefore, this study is of great significance for the identification of CRC patients eligible for systemic HER2-targeted therapy.
BRITISH JOURNAL OF CANCER
(2023)
Article
Multidisciplinary Sciences
Kohtaro Eguchi, Kenya Kobayashi, Yoshitaka Honma, Eijitsu Ryo, Airi Sakyo, Kazuki Yokoyama, Takane Watanabe, Yusuke Aihara, Azusa Sakai, Yoshifumi Matsumoto, Toshihiko Sakai, Go Omura, Yasushi Yatabe, Seiichi Yoshimoto, Taisuke Mori
Summary: The incidence of second primary neoplasms arising in the skin reconstructive flap (SNAF) is increasing. The prognosis, optimal treatment, and clinicopathological-genetic features of SNAFs are difficult to determine. This study retrospectively reviewed SNAFs over a 20-year period and found that they are slow-growing tumors with good prognoses, characterized by altered p53 and TP53 rates and high p16 positivity.
SCIENTIFIC REPORTS
(2023)
Article
Gastroenterology & Hepatology
Rintaro Nagayama, Toshiharu Ueki, Yasuhiro Shimizu, Susumu Hijioka, Masafumi Nakamura, Masayuki Kitano, Kazuo Hara, Atsushi Masamune, Toshifumi Kin, Keiji Hanada, Shinsuke Koshita, Reiko Yamada, Mamoru Takenaka, Takao Itoi, Akio Yanagisawa, Takao Otuka, Seiko Hirono, Atsushi Kanno, Noboru Ideno, Takamichi Kuwahara, Akinori Shimizu, Ken Kamata, Yasuji Asai, Yoshifumi Takeyama
Summary: This study found that preoperative pancreatic juice cytology (PJC) has low accuracy in differentiating malignant and non-malignant lesions in intraductal papillary mucinous neoplasm (IPMN) of the pancreas and is not recommended as a routine examination. Although the sensitivity is low, the positive predictive value is high, suggesting that PJC should only be performed when the patient is uncertain about surgery.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Review
Oncology
Shinkichi Takamori, Yasushi Yatabe, Atsushi Osoegawa, Keiju Aokage, Hiroshige Yoshioka, Tomohiro Miyoshi, Takahiro Mimae, Makoto Endo, Aritoshi Hattori, Masaya Yotsukura, Tetsuya Isaka, Mitsuhiro Isaka, Tomohiro Maniwa, Ryu Nakajima, Shun-ichi Watanabe, Lung Canc Surgical Study Grp LCSSG, Japan Clinical Oncology Grp JCOG
Summary: Salivary gland-type lung tumors (SGT), primarily mucoepidermoid carcinoma and adenoid cystic carcinoma, are rare and present with symptoms of bronchial obstruction. Surgical resection with lymphadenectomy is recommended, and radiation therapy varies by subtype. The diagnosis and treatment of SGT remain challenging.
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Cell Biology
Yasushi Yatabe
Summary: Currently, lung cancer treatment involves multiple therapeutic options, including molecular-targeted therapy and immune check-point inhibitors. The efficacy of these treatments varies based on the molecular pathogenesis of lung cancer and the characteristics of different subtypes.