Article
Radiology, Nuclear Medicine & Medical Imaging
Shuo Cai, Nan Lin, Yongqing Yang, Wenjing Ma, Yu Wang, Xiangtao Lin, Ximing Wang, Xinya Zhao
Summary: Contrast-enhanced portal vein imaging at the hepatobiliary phase obtained with gadobenate dimeglumine is a valuable imaging biomarker for predicting hepatic decompensation and transplant-free survival in patients with chronic liver disease (CLD).
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xavier Violas, Marlene Rasschaert, Robin Santus, Cecile Factor, Claire Corot, Sarah Catoen, Jean-Marc Idee, Philippe Robert
Summary: The aim of this set of studies was to compare gadopiclenol, a new high relaxivity Gd-based contrast agent, with gadobenate dimeglumine in terms of small brain lesion enhancement and Gd retention. The results showed that gadopiclenol provides significantly higher enhancement of brain lesions compared with gadobenate dimeglumine at the same dose, and gadopiclenol has less Gd retention after repeated injections.
INVESTIGATIVE RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Daniel Stocker, Stefanie Hectors, Octavia Bane, Naik Vietti-Violi, Daniela Said, Paul Kennedy, Jordan Cuevas, Guilherme M. Cunha, Claude B. Sirlin, Kathryn J. Fowler, Sara Lewis, Bachir Taouli
Summary: The study aimed to compare the AIF quality and perfusion parameters of HCC using gadoxetate disodium compared to Gd-BOPTA during the first 3 minutes post-contrast injection. Results showed that gadoxetate disodium provided comparable AIF quality and HCC perfusion parameters to Gd-BOPTA during dynamic phases, despite causing delayed and decreased liver enhancement.
EUROPEAN RADIOLOGY
(2021)
Article
Oncology
Sisi Zhang, Lei Huo, Juan Zhang, Yayuan Feng, Yiping Liu, Yuxian Wu, Ningyang Jia, Wanmin Liu
Summary: This study aimed to develop and validate a preoperative model based on gadobenate-enhanced MRI for predicting MVI in patients with HCC. The model showed excellent predictive performance and clinical utility in both training and test sets. The HBP imaging features of gadobenate-enhanced MRI were found to be important in predicting MVI for HCC patients. The preoperative model could help clinicians assess the risk of MVI in HCC patients and optimize treatment options.
FRONTIERS IN ONCOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Shengxiang Fu, Zhongyuan Cai, Li Liu, Xiaomin Fu, Changqiang Wu, Liang Du, Chunchao Xia, Su Lui, Qiyong Gong, Bin Song, Hua Ai
Summary: Compared to traditional branched polymers, branched polymers with Gd(III) chelates as the internal skeleton show higher kinetic stability and better relaxivity enhancement for MRI contrast agents. Different poly-DOTA branched polymers were synthesized and the Gd(III) chelates displayed excellent stability and high T1 relaxivities. In vivo studies showed that P4-Gd had the best performance in terms of MRA effect, vascular stenosis detection, and longer observation window compared to Gd-DOTA. Overall, poly-DOTA branched polymers with Gd(III) chelates are promising candidates for MRI probes with improved relaxivity enhancement.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jerome Hodel, Meike W. Vernooij, Mona K. Beyer, Mariasavina Severino, Xavier Leclerc, Alain Creange, Abir Wahab, Neesmah Badat, Sarah Toledano, Luc van den Hauwe, Ana Ramos, Antonella Castellano, Alexandre Krainik, Tarek Yousry, Alex Rovira
Summary: This study evaluated compliance with recommendations in imaging for multiple sclerosis (MS). The results showed that while MS imaging practices are relatively consistent across Europe, there is still partial adherence to recommendations.
EUROPEAN RADIOLOGY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Federica Vernuccio, Domenico Salvatore Gagliano, Roberto Cannella, Ahmed Ba-Ssalamah, An Tang, Giuseppe Brancatelli
Summary: Hepatobiliary MRI contrast agents are increasingly used for liver imaging, but most focal liver lesions do not uptake these agents. This pictorial review covers a broad spectrum of benign and malignant focal hepatic observations that may show hyperintensity on hepatobiliary phase in various clinical settings. In certain cases, such as in patients with primary or secondary vascular disorders, lesions may appear hyperintense in the hepatobiliary phase due to local hyperplastic responses to vascular alterations.
INSIGHTS INTO IMAGING
(2021)
Article
Oncology
Wanmin Liu, Kairong Song, Wei Zheng, Lei Huo, Sisi Zhang, Xiaowen Xu, Peijun Wang, Ningyang Jia
Summary: The purpose of this study was to establish a model for predicting early recurrence of hepatocellular carcinoma (HCC) after anatomical hepatectomy based on the hepatobiliary phase imaging characteristics of gadobenate-enhanced MRI. The study found that preoperative HBP imaging features significantly improved the model performance, and the HBP-pre model was selected as the optimal model.
FRONTIERS IN ONCOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Anna Koudrina, Erin M. McConnell, Joseph A. Zurakowski, Greg O. Cron, Suzan Chen, Eve C. Tsai, Maria C. DeRosa
Summary: The study successfully prepared a fibrin-targeting MRI contrast agent, Gd(III)-NOTA-FA, which can specifically accumulate at the location of blood clots, enhancing contrast capabilities.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Claudia Green, Gregor Jost, Thomas Frenzel, Janina Boyken, Carsten Schwenke, Hubertus Pietsch
Summary: The study aimed to investigate the possible influence of age-related changes in the brain on relaxometric and relaxation time-weighted MRI parameters in the deep cerebellar nuclei and the globus pallidus. The results showed that with increasing age, there was a shortening of T1 and T2 relaxation times in the globus pallidus and an increase in T2-weighted signal intensity ratio in the deep cerebellar nuclei/pons and a decrease in the globus pallidus/piriform cortex ratio. These age-related changes may potentially bias the assessment of gadolinium presence in the brain using MRI.
INVESTIGATIVE RADIOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Mike Jeon, Mackenzie Halbert, Zachary R. Stephen, Miqin Zhang
Summary: Gadolinium-based chelates are commonly used contrast agents for MRI, but their toxicity and potential retention in patients' bodies have raised safety concerns. Iron oxide nanoparticles have emerged as a promising alternative due to their non-toxic and biodegradable nature, but their development as T-1 contrast agents is complex and challenging. Progress is being made in exploring IONPs as safe and improved alternatives, but there are still many hurdles to overcome before they can be used clinically.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Gaoji Wang, Goran Angelovski
Summary: A novel Gd3+ chelate has been developed that can selectively recognize Zn2+ and exhibit a significant increase in longitudinal relaxivity, representing a new momentum in developing suitable contrast agents for functional molecular imaging studies of Zn2+.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mark C. DeLano, Maria Vittoria Spampinato, Eric Y. Chang, Richard G. Barr, Richard J. Lichtenstein, Cesare Colosimo, Josef Vymazal, Zhibo Wen, Doris D. M. Lin, Miles A. Kirchin, Gianpaolo Pirovano
Summary: The study compared the effects of using 0.05 mmol/kg and 0.1 mmol/kg gadobenate in patients undergoing enhanced MRI, showing that 0.05 mmol/kg gadobenate was noninferior to 0.1 mmol/kg gadobenate in terms of lesion visualization and imaging performance.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Chemistry, Multidisciplinary
Zhongtao Li, Jing Guo, Mengmeng Zhang, Guohua Li, Liguo Hao
Summary: Magnetic resonance molecular imaging can provide anatomical, functional, and molecular information. This study presents a novel T-1 contrast agent, Gd2O3@MSN, which utilizes gadolinium-doped mesoporous silica nanoparticles for magnetic imaging. The results show that Gd2O3@MSN has a higher T-1 relaxivity, making it a potential candidate for in-vivo MRI contrast agents.
FRONTIERS IN CHEMISTRY
(2022)
Article
Oncology
Yueming Li, Jianwei Chen, Shuping Weng, Chuan Yan, Rongping Ye, Yuemin Zhu, Liting Wen, Dairong Cao, Jinsheng Hong
Summary: The study demonstrated that hepatobiliary phase (HBP) hypointensity acquired from Gd-BOPTA-MRI can significantly improve the diagnostic performance for hepatocellular carcinoma (HCC), especially for small HCCs. Including HBP hypointensity in imaging criteria can enhance sensitivity and specificity in the diagnosis of HCC.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
