Article
Gastroenterology & Hepatology
Bomi Lee, Elaina K. Jones, Murli Manohar, Liang Li, Dhiraj Yadav, Darwin L. Conwell, Phil A. Hart, Santhi Swaroop Vege, Evan L. Fogel, Jose Serrano, Dana Andersen, Melena D. Bellin, Mark D. Topazian, Stephen K. Van Den Eeden, Stephen J. Pandol, Chris E. Forsmark, William E. Fisher, Walter G. Park, Sohail Z. Husain, Aida Habtezion
Summary: This study examined the potential use of serum immune profiling as biomarkers for pancreatitis. The analysis of 92 immune markers identified 33 markers that could differentiate pancreatitis patients from healthy individuals. IL17 signaling was found to play a crucial role in chronic pancreatitis, and was associated with smoking, alcohol, and diabetes status.
Article
Gastroenterology & Hepatology
Gavin E. Arteel, Ajay Singhvi, Robert Feldman, Andrew D. Althouse, Ramon Bataller, Melissa Saul, Dhiraj Yadav
Summary: The study investigated the prevalence and coexistence of ALD and ALP in patients with an alcohol use disorder, highlighting a higher risk for ALP in the presence of ALD among blacks. Further research is needed to define the clinical impact of coexistent disease on presentation and outcomes.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Review
Medicine, General & Internal
Santhi Swaroop Vege, Suresh T. Chari
Summary: Chronic pancreatitis is often associated with alcohol use, smoking, or genetic risk factors. Common symptoms include recurrent abdominal pain or pancreatitis, and characteristic imaging findings include pancreatic stones, dilated ducts, and atrophy. Complications include pseudocysts, biliary strictures, exocrine and endocrine pancreatic insufficiency, bone loss, and pancreatic cancer.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Nutrition & Dietetics
David Nutt, Alexandra Hayes, Leon Fonville, Rayyan Zafar, Emily O. C. Palmer, Louise Paterson, Anne Lingford-Hughes
Summary: Alcohol affects the brain in various harmful ways, including damage during intoxication, withdrawal effects, and peripheral factors like poor diet and vitamin deficiencies. Prenatal alcohol exposure can also have lasting impacts on brain development.
Article
Neurosciences
M. Adrienne McGinn, Brendan J. Tunstall, Joel E. Schlosburg, Adriana Gregory-Flores, Olivier George, Giordano de Guglielmo, Barbara J. Mason, Hazel J. Hunt, George F. Koob, Leandro F. Vendruscolo
Summary: The study demonstrated the potential of GR modulators in reducing alcohol consumption, with different effects observed in different circumstances. These findings provide insights for the development of treatments for AUD.
Article
Gastroenterology & Hepatology
Nan Ru, Jia-Hui Zhu, Liang-Hao Hu, Sheng-Yong Wu, Jun Pan, Xiao-Nan Xu, Lei Wang, Fei-Fei Yu, Zi-Jun Yan, Ji-Yao Guo, Zhao-Shen Li, Wen-Bin Zou, Zhuan Liao
Summary: Before the diagnosis of CP, 72.1% of patients had a history of AP. Smoking and heavy alcohol consumption were risk factors for AP, while age at CP onset, harboring the SPINK1 mutation, diabetes, and steatorrhea were protective factors. Alcoholic CP was the only independent risk factor for recurrent AP attacks.
DIGESTIVE AND LIVER DISEASE
(2021)
Review
Oncology
Guillaume Le Cosquer, Charlotte Maulat, Barbara Bournet, Pierre Cordelier, Etienne Buscail, Louis Buscail
Summary: Chronic alcoholic pancreatitis is a major risk factor for pancreatic cancer. The risk is higher for hereditary pancreatitis, with PRSS1 and SPINK1 mutations having a risk of 19% and 12% respectively. The diagnosis is difficult due to the similarity in clinical and radiological features of chronic pancreatitis and pancreatic cancer. Endoscopic ultrasound-guided fine-needle biopsy with molecular biology can assist in diagnosis. Short-term follow-up is necessary for chronic pancreatitis patients with clinical and radiological suspicion of cancer, and pancreatic surgery may be required if doubt persists.
Article
Pharmacology & Pharmacy
Paulo Fernando Santos Mendes, Daiane Claydes Baia-da-Silva, Wallacy Watson Pereira Melo, Leonardo Oliveira Bittencourt, Renata Duarte Souza-Rodrigues, Luanna Melo Pereira Fernandes, Cristiane do Socorro Ferraz Maia, Rafael Rodrigues Lima
Summary: Alcohol consumption is a common issue that leads to socioeconomic and public health problems. This study aimed to analyze and map the knowledge in the field of alcohol neurotoxicology based on the 100 most cited articles. The results showed a high prevalence of studies on fetal alcohol syndrome and the effects of ethanol on neurodevelopment, with the majority of research being from the United States.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Gastroenterology & Hepatology
Nan Ru, Xiao-Nan Xu, Yu Cao, Jia-Hui Zhu, Liang-Hao Hu, Sheng-Yong Wu, Yang-Yang Qian, Jun Pan, Wen-Bin Zou, Zhao-Shen Li, Zhuan Liao
Summary: This study conducted a research on a large cohort of chronic pancreatitis patients and found that alcohol consumption and smoking are closely related to the development of pancreatic insufficiency. However, rare pathogenic gene mutations did not show significant correlation with pancreatic insufficiency.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Vikesh K. Singh, David C. Whitcomb, Peter A. Banks, Samer AlKaade, Michelle A. Anderson, Stephen T. Amann, Randall E. Brand, Darwin L. Conwell, Gregory A. Cote, Timothy B. Gardner, Andres Gelrud, Nalini Guda, Christopher E. Forsmark, Michele Lewis, Stuart Sherman, Thiruvengadam Muniraj, Joseph Romagnuolo, Xiaoqing Tan, Gong Tang, Bimaljit S. Sandhu, Adam Slivka, C. Mel Wilcox, Dhiraj Yadav
Summary: In a well-defined North American cohort, it was found that approximately 70.7% of patients with chronic pancreatitis had a history of acute pancreatitis, with the majority occurring more than 5 years prior to the diagnosis of chronic pancreatitis. Patients with multiple episodes of acute pancreatitis were diagnosed with chronic pancreatitis an average of 5 years earlier compared to those with only one episode.
Article
Biochemistry & Molecular Biology
Tanya Scerbina, Robert Gerlai
Summary: This study investigates the effects of acute alcohol administration in zebrafish, suggesting that alcohol may influence behavior through dopaminergic mechanisms. Significant interactions and main effects of alcohol and D1-R antagonist are found on behavioral phenotypes and neurochemical levels, hinting at potential strain differences in identifying molecular mechanisms underlying acute alcohol effects.
Article
Neurosciences
Andreas-Christian Hade, Mari-Anne Philips, Ene Reimann, Toomas Jagomae, Kattri-Liis Eskla, Tanel Traks, Ele Prans, Sulev Koks, Eero Vasar, Marika Vali
Summary: In this study, significant molecular changes were found in the mediodorsal thalamus of subjects with alcohol use disorder (AUD), including upregulation of genes related to glutamatergic and GABAergic neurotransmission, cellular metabolism, and neurodevelopment. Additionally, 42 differentially expressed genes were identified to have strong associations with AUD and/or alcohol use phenotypes.
Article
Medicine, General & Internal
Akira Yamamiya, Keiichi Tominaga, Koki Hoshi, Kazunori Nagashima, Takahito Minaguchi, Yasuo Haruyama, Atsushi Irisawa
Summary: This study aimed to investigate risk factors for the progression from AP to CP in patients with past-history of AP. The results showed that alcohol-related AP and post-AP AUDIT-C score of >=6 points (male) and 4 points (female) were significant risk factors for CP progression.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Ishani Shah, Rachel Bocchino, Awais Ahmed, Steven D. Freedman, Darshan J. Kothari, Sunil G. Sheth
Summary: This study aimed to identify the risk factors, clinical presentation, and outcomes in patients with recurrent acute pancreatitis (RAP) who develop chronic pancreatitis (CP). The results showed that younger age, smoking, and alcohol use were associated with a higher risk of progression from RAP to CP. These patients had more severe symptoms and utilized more healthcare resources, suggesting a poorer prognosis. Early identification and counseling may help slow down disease progression.
Article
Pharmacology & Pharmacy
Francisca Villavicencio-Tejo, Osvaldo Flores-Bastias, Lucas Marambio-Ruiz, Diliana Perez-Reytor, Eduardo Karahanian
Summary: High ethanol intake induces neuroinflammation and decreases GLT-1 expression, leading to long-term drinking behavior. Fibrates can inhibit neuroinflammation, reduce ethanol consumption, and normalize glutamatergic tone by reverting astrogliosis and NF-kappa B activation.
FRONTIERS IN PHARMACOLOGY
(2021)
