Article
Cell Biology
You-Fan Peng, Hao Lin, De-Chen Liu, Xiang-Yun Zhu, Nan Huang, Ying-Xiang Wei, Ling Li
Summary: The study demonstrated that Hsp90 inhibitor 17AAG could prevent pancreatic fibrosis in caerulein-induced CP mice and inhibit the activation and extracellular matrix accumulation of PSCs in vitro. These findings suggest a potential treatment strategy for pancreatic fibrosis in CP based on Hsp90 inhibition.
CELLULAR SIGNALLING
(2021)
Review
Biochemistry & Molecular Biology
Tao Jiang, Tianshuang Xia, Fangliang Qiao, Nani Wang, Yiping Jiang, Hailiang Xin
Summary: Bones serve mechanical and defensive functions, as well as regulating calcium ions and housing bone marrow. The qualities of bones fluctuate throughout life, with functions increasing in some situations while deteriorating in others. Excessive osteoclast differentiation can lead to various bone pathologies, and the transcription factors and developmental/environmental signals play crucial roles in this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Hongkun Cai, Feng Guo, Shuang Wen, Xin Jin, Heshui Wu, Dianyun Ren
Summary: The study found that abnormal KRAS activation in pancreatic cancer led to ITGA2 overexpression, which in turn suppressed the activation of the TGF-beta pathway. Mechanistically, ITGA2 inhibited the activation of the TGF-beta pathway by transcriptionally inhibiting SMAD2 expression. Additionally, ITGA2 interacted with TFCP2, inhibiting its nuclear translocation and affecting the expression of SMAD2.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Zhuo Chen, Hanjie Yu, Xiangqin Chen, Wentian Chen, Wanghua Song, Zheng Li
Summary: TGF-beta superfamily members play important roles in various diseases, and glycosylation modification is involved in the regulation of TGF-beta signaling pathway. There is a complex mutual regulation between glycosylation and TGF-beta signaling, which affects biological processes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Cell & Tissue Engineering
Yasaman Aghazadeh, Frankie Poon, Farida Sarangi, Frances T. M. Wong, Safwat T. Khan, Xuetao Sun, Rupal Hatkar, Brian J. Cox, Sara S. Nunes, M. Cristina Nostro
Summary: This study enhanced islet transplantation by using microvessels from adipose tissue, resulting in improved cell survival and glucose response in both human islets and hESC-derived pancreatic cells, ameliorating preexisting diabetes in three mouse models of T1D.
Article
Oncology
Tiansuo Zhao, Di Xiao, Fanjie Jin, Xugang Sun, Jie Yu, Hongwei Wang, Jing Liu, Wenrun Cai, Chongbiao Huang, Xiuchao Wang, Song Gao, Zhe Liu, Shengyu Yang, Chuntao Gao, Jihui Hao
Summary: The study found that ESE3 expression was upregulated in PDAC tissues and correlated with clinical indicators. ESE3 promoted the progression of PDAC by activating PSCs. IL-1β induced ESE3 expression in PSCs and activated PSCs, thereby influencing PDAC chemoresistance and tumor growth. Inhibiting the IL-1β/ESE3 positive feedback loop may be a promising therapeutic strategy to reduce tumor fibrosis and enhance chemotherapeutic efficacy in PDAC.
BRITISH JOURNAL OF CANCER
(2022)
Article
Biochemistry & Molecular Biology
Wenxuan Jiao, Man Bai, Hanwei Yin, Jiayi Liu, Jing Sun, Xiaoxia Su, Huihui Zeng, Jinhua Wen
Summary: Butaselen inhibits liver fibrosis progression by regulating the TGF-β1/Smads pathway, inducing HSC apoptosis, and inhibiting the production of α-SMA and collagens. The study showed significant therapeutic effects against liver fibrosis through oral administration of BS.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Plant Sciences
Xiangmei Cao, Chunyan Wei, Wenyi Duan, Ying Gao, Jianfei Kuang, Mingchun Liu, Kunsong Chen, Harry Klee, Bo Zhang
Summary: Our study reveals a common regulatory mechanism in which NAC transcription factors activate the expression of alcohol acyltransferases (AATs) during fruit ripening, leading to the formation of volatile esters in multiple fruit species. The identification of key regulators such as PpNAC1 and PpAAT1 in peach, as well as their homologs in tomato and apple, sheds light on the transcriptional and epigenetic control of flavor-associated volatile synthesis pathways. Further research into these pathways could potentially lead to improved fruit flavor through targeted manipulation of these regulatory factors.
Article
Chemistry, Medicinal
Manman Ma, Xiaohua Wang, Xiaohui Liu, Yang Han, Yanhui Chu, Yanzhong Guan, Haifeng Liu
Summary: A novel tT beta RII variant, Z-tT beta RII, was designed by fusing the PDGF beta receptor-specific affibody Z(PDGF beta R) to the N-terminus of tT beta RII. Z-tT beta RII exhibited superior specific fibrotic liver-targeting potential and stronger anti-fibrotic effects in vitro and in vivo. It also showed no significant sign of potential side effects in other vital organs in liver fibrotic mice, making it a potential candidate for targeted therapy for liver fibrosis.
ARCHIVES OF PHARMACAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Xinyi Wang, Ting Liu, Yifei Huang, Yifeng Dai, Hui Lin
Summary: Fibrosis is a complex abnormal healing process that involves multiple signaling pathways, with the TGF-beta signaling pathway playing a central role. TGF-beta precisely regulates fibrogenesis by controlling gene transcription and translation, and SUMOylation has been identified as a key player in this process, providing potential therapeutic strategies for fibrosis.
Article
Biochemistry & Molecular Biology
Ching-Chung Ko, Yao-Yu Hsieh, Pei-Ming Yang
Summary: Epithelial-to-mesenchymal transition (EMT) is a biological process that promotes cancer cell dissemination and drug resistance. This study revealed that overexpression of MIR31HG in pancreatic ductal adenocarcinoma (PDAC) patients is associated with poorer disease-free survival, as well as upregulation of genes related to TGF beta signaling and EMT. In vitro experiments further demonstrated that TGF beta induces MIR31HG expression and knockdown of MIR31HG reverses TGF beta-induced EMT phenotypes and cancer cell migration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Romina J. Bevacqua, Jonathan Y. Lam, Heshan Peiris, Robert L. Whitener, Seokho Kim, Xueying Gu, Mollie S. H. Friedlander, Seung K. Kim
Summary: This study found that SIX2 and SIX3 play important roles in the functional maturation of human pancreatic beta cells, particularly in insulin secretion. SIX2 primarily regulates genes governing insulin processing and output, while SIX3 affects genes normally expressed in fetal cells and non-beta cells.
GENES & DEVELOPMENT
(2021)
Article
Biochemistry & Molecular Biology
Fuensanta Gomez-Bernal, Juan Carlos Quevedo-Abeledo, Maria Garcia-Gonzalez, Yolanda Fernandez-Cladera, Agustin F. Gonzalez-Rivero, Antonia de Vera-Gonzalez, Candelaria Martin-Gonzalez, Miguel A. Gonzalez-Gay, Ivan Ferraz-Amaro
Summary: This study aimed to investigate the relationship between serum levels of transforming growth factor beta 1 (TGF-β1) and disease characteristics, activity, damage, or severity in patients with systemic lupus erythematosus (SLE). The results showed that TGF-β1 serum levels were associated with disease severity and activity, with ocular and cardiovascular manifestations positively correlated, while gastrointestinal and musculoskeletal involvements negatively correlated with circulating TGF-β1 levels.
Review
Medicine, Research & Experimental
Savalan Babapoor-Farrokhran, Roozbeh Tarighati Rasekhi, Deanna Gill, Jafar Alzubi, Sumeet K. Mainigi
Summary: Atrial fibrillation is a common clinically significant arrhythmia with four fundamental pathophysiological mechanisms, with TGF-beta playing a key role. Studies have shown that TGF-beta 1 is involved in the development and propagation of atrial fibrillation.
Review
Biochemistry & Molecular Biology
Wilson Cheuk Wing Chan, Zhijia Tan, Michael Kai Tsun To, Danny Chan
Summary: Bone is a dynamic tissue that responds to environmental changes such as nutrition and mechanical stress. Bone homeostasis is maintained through bone remodeling in adulthood, which involves a controlled balance between bone-resorbing osteoclasts and bone-forming osteoblasts. During embryonic development, bones can form through intramembraneous or endochondral ossification.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Monique M. Williams, Angela J. Mathison, Trent Christensen, Patricia T. Greipp, Darlene L. Knutson, Eric W. Klee, Michael T. Zimmermann, Juan Iovanna, Gwen A. Lomberk, Raul A. Urrutia
Article
Biochemistry & Molecular Biology
Michael T. Zimmermann, Monique M. Williams, Eric W. Klee, Gwen A. Lomberk, Raul Urrutia
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
(2019)
Review
Multidisciplinary Sciences
Gwen Lomberk, Nelson Dusetti, Juan Iovanna, Raul Urrutia
NATURE COMMUNICATIONS
(2019)
Review
Cell Biology
Patricia Santofimia-Castano, Yi Xia, Ling Peng, Adrian Velazquez-Campoy, Olga Abian, Wenjun Lan, Gwen Lomberk, Raul Urrutia, Bruno Rizzuti, Philippe Soubeyran, Jose Luis Neira, Juan Iovanna
Article
Oncology
Guillermo Urrutia, Ann Salmonson, Jorge Toro-Zapata, Thiago M. de Assuncao, Angela Mathison, Nelson Dusetti, Juan Iovanna, Raul Urrutia, Gwen Lomberk
MOLECULAR CANCER RESEARCH
(2020)
Article
Multidisciplinary Sciences
Angela Mathison, Thiago Milech De Assuncao, Nikita R. Dsouza, Monique Williams, Michael T. Zimmermann, Raul Urrutia, Gwen Lomberk
Article
Genetics & Heredity
Reilly L. Allison, Jacob W. Adelman, Jenica Abrudan, Raul A. Urrutia, Michael T. Zimmermann, Angela J. Mathison, Allison D. Ebert
Summary: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with unclear mechanisms. A study found that glial-secreted factors may affect the expression and deposition of neurofilament proteins in motor neurons of ALS patients.
Article
Oncology
Nicolas A. Fraunhoffer, Analia Meilerman Abuelafia, Martin Bigonnet, Odile Gayet, Julie Roques, Remy Nicolle, Gwen Lomberk, Raul Urrutia, Nelson Dusetti, Juan Iovanna
Summary: This study developed a Master Regulators (MR)-Gradient model based on transcriptomic profiles derived from both PDAC epithelial and microenvironment cells to reveal the transcriptional networks, epigenomic states, and metabolic pathways underlying PDAC heterogeneity. Integration of methylome and metabolome datasets, along with experimental measurements, showed a close association between PDAC prognosis, tumor epithelial cell phenotype, and immunological component. Metabolic analysis indicated a positive correlation between favorable PDAC phenotype and enzymes involved in complex lipid biosynthesis, while an unfavorable phenotype exhibited an OXPHOS independent metabolism centered on the Warburg effect and glutaminolysis. The study also identified key deregulated pathways in PDAC related to epigenetics.
NPJ PRECISION ONCOLOGY
(2022)
Article
Biology
Patricia Santofimia-Castano, Can Huang, Xi Liu, Yi Xia, Stephane Audebert, Luc Camoin, Ling Peng, Gwen Lomberk, Raul Urrutia, Philippe Soubeyran, Jose Luis Neira, Juan Iovanna
Summary: Mutations or treatment with the NUPR1 inhibitor ZZW-115 can inhibit the activity of PARP1 and induce cell death. Treatment with ZZW-115 or genetic inactivation of NUPR1 leads to mitochondrial catastrophe, which can be partially rescued by olaparib and NAD(+) precursor nicotinamide mononucleotide.
COMMUNICATIONS BIOLOGY
(2022)
Article
Cell Biology
Yizeng Yang, Dharmendra Bhargava, Xiao Chen, Taicheng Zhou, Gizem Dursuk, Wenpeng Jiang, Jinshen Wang, Zhen Zong, Sharyn I. Katz, Gwen A. Lomberk, Raul A. Urrutia, Jonathan P. Katz
Summary: In non-transformed human squamous epithelial cells, the decision of whether to arrest or undergo apoptosis in response to stress is mediated by the interaction between p53 and the zinc-finger transcription factor KLF5. The levels of cellular stress determine the specific outcome, with moderate stress leading to cell survival and severe stress resulting in apoptosis.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Young-In Chi, Davin R. Jensen, Brian C. Smith, Brian F. Volkman, Angela J. Mathison, Gwen Lomberk, Michael T. Zimmermann, Raul Urrutia
Summary: This study investigates the functional significance of various variants of uncertain significance in the EHMT1 protein. By combining traditional tools with computational methods, the researchers were able to classify the variants into different categories based on their structural and dynamic properties. The damaging variants were found to be located near important functional sites. This study improves upon conventional tools for variant interpretation and provides a molecular mechanism for variant dysfunction.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Guilherme Piovezani Ramos, Mary R. Sagstetter, Manuel Bonfim Braga Neto, Joseph M. Gaballa, Olga F. Sarmento, Michelle Gonzalez, Adebowale O. Bamidele, Raul Urrutia, Gwen Lomberk, William Faubion
Article
Gastroenterology & Hepatology
Rosa Martin-Mateos, Thiago M. De Assuncao, Juan Pablo Arab, Nidhi Jalan-Sakrikar, Usman Yagoob, Thomas Greuter, Vikas K. Verma, Angela J. Mathison, Sheng Cao, Gwen Lomberk, Philippe Mathurin, Raul Urrutia, Robert C. Huebert, Vijay H. Shah
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2019)