Article
Oncology
Courtney M. M. Lattimore, William J. J. Kane, Shalini Subbarao, Corinne Venitti, Christopher L. L. Cramer, Lena M. M. Turkheimer, Todd W. W. Bauer, Florence E. E. Turrentine, Victor M. M. Zaydfudim
Summary: This study examined the long-term clinical outcomes of patients with branch-duct Intraductal papillary mucinous neoplasms (BD-IPMN) without high-risk stigmata (HRS) or worrisome features (WF). The results showed that 46.1% of patients experienced cyst growth and 24.3% progressed to HRS or WF. The overall 5-year survival rate was 91.5% and the 10-year survival rate was 81.5%.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Arata Sakai, Atsuhiro Masuda, Takaaki Eguchi, Takahiro Anami, Katsuhisa Nishi, Keisuke Furumatsu, Yoshihiro Okabe, Saori Kakuyama, Yu Sato, Chiharu Nishioka, Tsuyoshi Sanuki, Yosuke Yagi, Takashi Kobayashi, Hideyuki Shiomi, Yuzo Kodama
Summary: For IPMN patients exhibiting HRS who did not undergo surgery, the estimated 5-year overall survival rate was 74% and the disease-specific survival rate was 91%. The co-presence of mural nodules and main duct dilation may increase mortality risk for these patients.
JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Oncology
Domenico Tamburrino, Paolo Cortesi, Rita Facchetti, Nicolo de Pretis, Enrique Perez-Cuadrado-Robles, Laura Uribarri-Gonzalez, Zeeshan Ateeb, Giulio Belfiori, Paolo Giorgio Arcidiacono, Lorenzo Giovanni Mantovani, Marco Del Chiaro, Johanna Laukkarinen, Massimo Falconi, Stefano Crippa, Gabriele Capurso
Summary: This study evaluated the rate of correct indication for pancreatectomy in low-risk BD-IPMN patients who underwent surveillance. Only 23.8% had a high grade dysplasia, while 59.7% had a low grade dysplasia and 14.9% had invasive cancer among those who were operated. The mean surveillance cost was 194.9 euros per patient-year, with higher costs in the correct surgery group compared to the overtreatment and undertreatment groups. The rate of appropriate surgery in BD-IPMNs under surveillance is low.
Review
Oncology
Beata Jablonska, Pawel Szmigiel, Slawomir Mrowiec
Summary: Intraductal papillary mucinous neoplasms (IPMNs) are a type of pancreatic tumor, accounting for a small percentage of pancreatic neoplasms. They are categorized into different types with varying management strategies based on tumor characteristics and patient factors. There are several guidelines available for diagnosing and managing IPMNs.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2021)
Article
Oncology
Ioannis A. A. Ziogas, Salvador Rodriguez Franco, Nicholas Schmoke, Cheryl Meguid, Cassandra Murphy, Mohammed Al-Musawi, Sophoclis P. P. Alexopoulos, Richard D. D. Schulick, Marco Del Chiaro
Summary: This study compared the characteristics, management, and overall survival of pancreatic ductal adenocarcinoma (PDAC) vs. invasive intraductal papillary mucinous neoplasm (IPMN) using a US database. PDAC was more aggressive than IPMN, with fewer patients undergoing surgery but more receiving chemotherapy or radiation. The median overall survival for PDAC was 8.3 months and for IPMN it was 33.4 months. Surgery was found to improve overall survival, and efforts should focus on facilitating surgical treatment for better outcomes.
Article
Gastroenterology & Hepatology
Tsuyoshi Hamada, Hiroki Oyama, Yousuke Nakai, Shuichi Tange, Junichi Arita, Ryunosuke Hakuta, Hideaki Ijichi, Kazunaga Ishigaki, Sachiko Kanai, Yoshikuni Kawaguchi, Hirofumi Kogure, Suguru Mizuno, Kei Saito, Tomotaka Saito, Tatsuya Sato, Tatsunori Suzuki, Naminatsu Takahara, Mariko Tanaka, Keisuke Tateishi, Tetsuo Ushiku, Kiyoshi Hasegawa, Mitsuhiro Fujishiro
Summary: This study investigated the long-term effects of dilation of the main pancreatic duct (MPD) on intraductal papillary mucinous neoplasms (IPMNs) and found that MPD dilation was associated with higher incidence and prevalence of pancreatic carcinoma.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Surgery
Domenico Tamburrino, Nicolo de Pretis, Enrique Perez-Cuadrado-Robles, Laura Uribarri-Gonzalez, Zeeshan Ateeb, Giulio Belfiori, Patrick Maisonneuve, Gabriele Capurso, Giuseppe Vanella, Maria Chiara Petrone, Paolo Giorgio Arcidiacono, Yrjo Vaalavuo, Luca Frulloni, J. Enrique Dominguez-Munoz, Pierre H. Deprez, Massimo Falconi, Marco Del Chiaro, Stefano Crippa, Johanna Laukkarinen
Summary: This study describes the natural history of low-risk BD-IPMN and identifies risk factors for the development of WF/HRS and pancreatic malignancies. Conservative management of patients with low-risk BD-IPMN is safe and feasible, and a size of 15 mm at first examination seems to be associated with a low risk of progression.
BRITISH JOURNAL OF SURGERY
(2022)
Article
Medicine, General & Internal
Tao Guo, Ya Liu, Zhu Yang, Jing Li, Kun You, Dejun Zhao, Sujuan Chen, Cong Li, Pei Yang, Hongqiang Hu, Hao Zhang
Summary: A 70-year-old man presented with acute pancreatitis and was diagnosed with IPMN originating in the accessory pancreatic duct. He underwent conservative management and DPPHR-P for treatment. Postoperative pancreatic fistula occurred but was successfully managed through endoscopic pancreatic duct stenting.
Article
Oncology
Huifeng Zhang, Yingying Cao, Shuai Ren, Kai Guo, Yaping Zhang, Tingting Lin, Yaohui Wang, Xiao Chen, Zhongqiu Wang
Summary: This study explored independent risk factors and determined the threshold value of the main pancreatic duct (MPD) diameter in identifying malignant intraductal papillary mucinous neoplasms (IPMNs). The results showed that MPD diameter and mural nodule were independent associated factors with high-risk IPMNs. A cutoff value of 0.77 cm MPD diameter may be a threshold in identifying malignant IPMNs or undergoing surgical resection.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2023)
Article
Medicine, General & Internal
Jaime de la Fuente, Arjun Chatterjee, Jacob Lui, Avinash K. Nehra, Matthew G. Bell, Ryan J. Lennon, Blake A. Kassmeyer, Rondell P. Graham, Hiroki Nagayama, Phillip J. Schulte, Karen A. Doering, Adriana M. Delgado, Santhi Swaroop Vege, Suresh T. Chari, Naoki Takahashi, Shounak Majumder
Summary: This study aimed to investigate the prevalence and associated risk of pancreatic cancer (PC) in individuals with intraductal papillary mucinous neoplasms (IPMNs). The results showed that approximately 10% of patients aged 50 years or older had IPMNs, and the PC risk in patients with IPMNs was low and not significantly different from patients without IPMNs. Moreover, approximately 10% of PC patients had IPMN-PC, and these patients had better survival compared to those with non-IPMN PC.
Article
Surgery
Naziheh Assarzadegan, Elizabeth Thompson, Kevan Salimian, Matthias M. Gaida, Lodewijk A. A. Brosens, Laura Wood, Syed Z. Ali, Ralph H. Hruban
Summary: Informed clinical decisions in the treatment of Intraductal Papillary Mucinous Neoplasms (IPMNs) are based on a deep understanding of the pathology of these lesions, with a focus on balancing the risk of over treatment with the patient's best interests.
LANGENBECKS ARCHIVES OF SURGERY
(2021)
Article
Gastroenterology & Hepatology
Hiroyuki Kato, Keisuke Tateishi, Hiroaki Fujiwara, Takuma Nakatsuka, Keisuke Yamamoto, Yotaro Kudo, Yoku Hayakawa, Hayato Nakagawa, Yasuo Tanaka, Hideaki Ijichi, Motoyuki Otsuka, Dosuke Iwadate, Hiroki Oyama, Sachiko Kanai, Kensaku Noguchi, Tatsunori Suzuki, Tatsuya Sato, Ryunosuke Hakuta, Kazunaga Ishigaki, Kei Saito, Tomotaka Saito, Naminatsu Takahara, Takahiro Kishikawa, Tsuyoshi Hamada, Ryota Takahashi, Koji Miyabayashi, Suguru Mizuno, Hirofumi Kogure, Yousuke Nakai, Yoshihiro Hirata, Atsushi Toyoda, Kazuki Ichikawa, Wei Qu, Shinichi Morishita, Junichi Arita, Mariko Tanaka, Tetsuo Ushiku, Kiyoshi Hasegawa, Mitsuhiro Fujishiro, Kazuhiko Koike
Summary: Our study identified the MNX1-HNF1B axis to be biologically significant in IPMN lineages, and this axis is crucial for the regulation of genes such as MYC, SOX9, and OLFM4.
Article
Gastroenterology & Hepatology
Long Zou, Shengwei Mo, Congwei Jia, Junyi Pang, Xiaoyan Chang, Jie Chen
Summary: The tumoral microbiome of IPMN is distinct from IPMN-IC, with specific microbial enrichments. Bifidobacterium pseudolongum is associated with better overall survival in IPMN-IC patients, while the presence of Staphylococcus aureus is linked to poor prognosis. These findings highlight the potential impact of tumoral microbiome on the progression and outcomes of IPMN.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Medicine, General & Internal
Hidekazu Tanaka, Kosuke Minaga, Yasuo Otsuka, Yasuhiro Masuta, Ken Kamata, Kentaro Yamao, Mamoru Takenaka, Tomoko Hyodo, Masatomo Kimura, Tomohiro Watanabe, Masatoshi Kudo
Summary: In this case report, a rare pancreatic neuroendocrine carcinoma (PanNEC) mimicking intraductal papillary mucinous carcinoma is described. The patient was diagnosed through imaging and biopsy, but due to the rapid progression of the disease, the patient died. These findings suggest that POPS-guided biopsy could be a useful diagnostic modality.
FRONTIERS IN MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Devarshi R. Ardeshna, Shiva Rangwani, Troy Cao, Timothy M. Pawlik, Peter P. Stanich, Somashekar G. Krishna
Summary: Hereditary pancreatic cancer accounts for about 10% of pancreatic cancer diagnoses. Early detection of pre-cancerous pancreatic cysts, such as intraductal papillary mucinous cystic neoplasms (IPMNs), has become an important focus to reduce pancreatic cancer incidence and mortality. This review explores the prevalence of IPMNs in patients with hereditary pancreatic cancer and their relatives, and discusses the need for surveillance changes in high-risk individuals.
Article
Gastroenterology & Hepatology
Katsuyoshi Ando, Mikihiro Fujiya, Yoshiki Nomura, Yuhei Inaba, Yuya Sugiyama, Yu Kobayashi, Takuya Iwama, Masami Ijiri, Keitaro Takahashi, Nobuhiro Ueno, Shin Kashima, Kentaro Moriichi, Hiroki Tanabe, Yusuke Mizukami, Kazumi Akasaka, Satoshi Fujii, Satoshi Yamada, Hiroshi Nakase, Toshikatsu Okumura
Article
Gastroenterology & Hepatology
Yuko Omori, Yusuke Ono, Mishie Tanino, Hidenori Karasaki, Hiroshi Yamaguchi, Toru Furukawa, Katsuro Enomoto, Jun Ueda, Atsuko Sumi, Jin Katayama, Miho Muraki, Kenzui Taniue, Kuniyuki Takahashi, Yoshiyasu Ambo, Toshiya Shinohara, Hiroshi Nishihara, Junpei Sasajima, Hiroyuki Maguchi, Yusuke Mizukami, Toshikatsu Okumura, Shinya Tanaka
Article
Gastroenterology & Hepatology
Keitaro Takahashi, Mikihiro Fujiya, Nobuhiro Ueno, Takeshi Saito, Yuya Sugiyama, Yuki Murakami, Takuya Iwama, Takahiro Sasaki, Masami ijiri, Kazuyuki Tanaka, Aki Sakatani, Katsuyoshi Ando, Yoshiki Nomura, Shin Kashima, Mitsuru Goto, Kentaro Moriichi, Toshikatsu Okumura
Article
Pathology
Kazumasa Nagai, Yusuke Mizukami, Yuko Omori, Toshifumi Kin, Kei Yane, Kuniyuki Takahashi, Yusuke Ono, Ayumu Sugitani, Hidenori Karasaki, Toshiya Shinohara, Toru Furukawa, Tsuyoshi Hayashi, Toshikatsu Okumura, Hiroyuki Maguchi, Akio Katanuma
Article
Oncology
Yasutaka Aoki, Masamichi Mizuma, Tatsuo Hata, Takeshi Aoki, Yuko Omori, Yusuke Ono, Yusuke Mizukami, Michiaki Unno, Toru Furukawa
JOURNAL OF PATHOLOGY
(2020)
Article
Oncology
Shin Kashima, Hiroki Tanabe, Mishie Tanino, Yu Kobayashi, Yuki Murakami, Takuya Iwama, Takahiro Sasaki, Takehito Kunogi, Keitaro Takahashi, Katsuyoshi Ando, Nobuhiro Ueno, Kentaro Moriichi, Masahide Fukudo, Yoshikazu Tasaki, Masao Hosokawa, Yusuke Mizukami, Mikihiro Fujiya, Toshikatsu Okumura
FRONTIERS IN ONCOLOGY
(2019)
Article
Cell Biology
Shuxi Qiao, Siang-Boon Koh, Varunika Vivekanandan, Devika Salunke, Krushna Chandra Patra, Elma Zaganjor, Kenneth Ross, Yusuke Mizukami, Sarah Jeanfavre, Athena Chen, Mari Mino-Kenudson, Sridhar Ramaswamy, Clary Clish, Marcia Haigis, Nabeel Bardeesy, Leif W. Ellisen
GENES & DEVELOPMENT
(2020)
Article
Pathology
Yuko Omori, Yusuke Ono, Toshikazu Kobayashi, Fuyuhiko Motoi, Hidenori Karasaki, Yusuke Mizukami, Naohiko Makino, Yoshiyuki Ueno, Michiaki Unno, Toru Furukawa
Article
Oncology
Shion Tachibana, Yusuke Mizukami, Yusuke Ono, Yuya Sugiyama, Tetsuhiro Okada, Arisa Kitazaki, Junpei Sasajima, Motoya Tominaga, Jun Sakamoto, Keisuke Kimura, Yuko Omori, Toru Furukawa, Taichi Kimura, Shinya Tanaka, Kazuo Nagashima, Hidenori Karasaki, Tomoyuki Ohta, Toshikatsu Okumura
FRONTIERS IN ONCOLOGY
(2020)
Article
Gastroenterology & Hepatology
Kentaro Moriichi, Hiroki Tanabe, Yusuke Ono, Yu Kobayashi, Yuki Murakami, Takuya Iwama, Takehito Kunogi, Takahiro Sasaki, Keitaro Takahashi, Katsuyoshi Ando, Nobuhiro Ueno, Shin Kashima, Hidehiro Takei, Yusuke Mizukami, Mikihiro Fujiya, Toshikatsu Okumura
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2020)
Article
Medicine, General & Internal
Hiroki Sato, Junpei Sasajima, Tetsuhiro Okada, Akihiro Hayashi, Hidemasa Kawabata, Takuma Goto, Kazuya Koizumi, Nobue Tamamura, Hiroki Tanabe, Mikihiro Fujiya, Shin-ichi Chiba, Mishie Tanino, Yusuke Ono, Yusuke Mizukami, Toshikatsu Okumura
Article
Genetics & Heredity
Hiroki Tanabe, Kentaro Moriichi, Keitaro Takahashi, Yusuke Ono, Yu Kobayashi, Yuki Murakami, Takuya Iwama, Takehito Kunogi, Takahiro Sasaki, Katsuyoshi Ando, Nobuhiro Ueno, Shin Kashima, Hidehiro Takei, Yusuke Mizukami, Mikihiro Fujiya, Toshikatsu Okumura
MOLECULAR GENETICS & GENOMIC MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Kenzui Taniue, Tanzina Tanu, Yuki Shimoura, Shuhei Mitsutomi, Han Han, Rika Kakisaka, Yusuke Ono, Nobue Tamamura, Kenji Takahashi, Youichiro Wada, Yusuke Mizukami, Nobuyoshi Akimitsu
Summary: This study provides evidence for the amplification of the EXOSC4 gene in multiple cancer types and its association with poor prognosis in pancreatic cancer patients. The study also demonstrates the essential role of EXOSC4 in the survival of pancreatic cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Meeting Abstract
Medicine, Research & Experimental
Yuko Omori, Yusuke Ono, Mishie Tanino, Hidenori Karasaki, Hiroshi Yamaguchi, Yusuke Mizukami, Hiroyuki Maguchi, Toru Furukawa, Shinya Tanaka
LABORATORY INVESTIGATION
(2019)
Meeting Abstract
Pathology
Yuko Omori, Yusuke Ono, Mishie Tanino, Hidenori Karasaki, Hiroshi Yamaguchi, Yusuke Mizukami, Hiroyuki Maguchi, Toru Furukawa, Shinya Tanaka