Article
Biochemistry & Molecular Biology
Daria Di Molfetta, Stefania Cannone, Maria Raffaella Greco, Rosa Caroppo, Francesca Piccapane, Tiago Miguel Amaral Carvalho, Concetta Altamura, Ilaria Saltarella, Diana Tavares Valente, Jean Francois Desaphy, Stephan J. J. Reshkin, Rosa Angela Cardone
Summary: Intracellular pH (pHi) regulation is crucial for the exocrine pancreas, and dysregulation of ion transporters, including bicarbonate transporters and NHE1, is observed in PDAC. The progression of PDAC is facilitated by the acidosis in Collagen-I rich ECM. Our study on organotypic cultures of normal human pancreatic cells (HPDE), parenchymal cancer cells (CPCs), and cancer stem cells (CSCs) reveals that the ECM composition and pHe fluctuations contribute to pHi dysregulation and the presence of NaHCO3 gradients similar to that in tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Monika Kapszewicz, Ewa Malecka-Wojciesko
Summary: The poor prognosis of PDAC is attributed to a lack of effective treatment and late diagnosis, while early detection could significantly decrease mortality. Ideal biomarkers for PDAC should be cost-effective, detectable in easily accessible biological material, and present in sufficient concentration in the earliest possible phase of the disease.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Yangyang Guo, Zhixuan Wu, Kenan Cen, Yongheng Bai, Ying Dai, Yifeng Mai, Kai Hong, Liangchen Qu
Summary: Consensus clustering and LASSO regression analysis were used to identify the prognostic impact of ubiquitination-related genes (URGs) in PDAC patients. A URGs signature consisting of three genes was developed, and it was highly correlated with patients' prognoses. By combining the URGs signature with clinicopathological characteristics, a predictive nomogram was established. The URGs signature outperformed individual predictors, and also showed differences in immune microenvironment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Ailin Wei, Huiling Zhao, Xue Cong, Linyao Wang, Yiyang Chen, Juxiang Gou, Ziyi Hu, Xiuying Hu, Yali Tian, Ka Li, Yufeng Deng, Haojiang Zuo, Mei Rosemary Fu
Summary: This study investigated the association between oral mycobiota and pancreatic ductal adenocarcinoma (PDAC). The findings suggest that PDAC patients have increased fungal abundance and decreased fungal diversity compared to healthy controls. Certain fungal species, such as Aspergillus and Cladosporium, showed high classification powers in distinguishing PDAC patients from healthy controls. The findings highlight the potential of using oral mycobiota as a biomarker for early detection and prevention of PDAC.
Article
Multidisciplinary Sciences
Abigail C. Buenafe, Craig Dorrell, Ashok P. Reddy, John Klimek, Daniel L. Marks
Summary: Extracellular vesicles (EVs) derived from pancreatic ductal adenocarcinoma (PDAC) and healthy organoids exhibit distinct protein profiles related to vesicular transport, tumorigenesis, and cellular homeostasis, respectively. Tumor-promoting candidates LAMA5, SDCBP, and TENA were found to be consistently upregulated in PDAC EVs, highlighting their potential as biomarkers for monitoring disease progression. Disease-associated changes in EV protein profiles provide insights into alterations in cellular programming with disease progression.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Julie Lecuelle, Anne Aarnink, Zoe Tharin, Caroline Truntzer, Francois Ghiringhelli
Summary: This study demonstrates that exome sequencing can be used to predict survival in patients with advanced pancreatic ductal adenocarcinoma undergoing FOLFIRINOX treatment, with genomic features playing a crucial role in prognosis prediction for these patients.
Review
Oncology
Ryan McGowan, Aine Sally, Anthony McCabe, Brian Michael Moran, Karen Finn
Summary: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and deadly cancer often diagnosed at a late stage due to nonspecific symptoms and a lack of reliable biomarkers. This review highlights the potential use of circulating nucleic acid-based biomarkers for early detection and monitoring of PDAC. However, the lack of prognostic biomarkers remains a challenge for assessing treatment efficacy.
Review
Oncology
Yu Wu, Qi Zhou, Fangyue Guo, Mingming Chen, Xufeng Tao, Deshi Dong
Summary: Pancreatic cancer is a highly malignant tumor in the digestive system with limited specific interventions available. The S100 protein family, expressed only in vertebrates, has potential as a biomarker for cancer progression and prognosis. Understanding the functions of S100 proteins could lead to new therapeutic targets for preventing or treating pancreatic cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Neel I. Nissen, Astrid Z. Johansen, Inna Chen, Julia S. Johansen, Rasmus S. Pedersen, Carsten P. Hansen, Morten A. Karsdal, Nicholas Willumsen
Summary: This study established an in vitro fibroblast model related to pancreatic ductal adenocarcinoma (PDAC) and used collagen biomarkers as a screening tool for anti-fibrotic drugs. The findings suggest that collagen biomarkers can quantify fibroblast activity in vitro and predict the survival rate in PDAC patients.
Review
Oncology
Kylie E. Shockley, Briana To, Wei Chen, Gerard Lozanski, Zobeida Cruz-Monserrate, Somashekar G. Krishna
Summary: Intraductal papillary mucinous neoplasms (IPMNs) are benign pancreatic cysts with the potential to become pancreatic cancer. Identifying high-risk IPMNs and potential biomarkers can help prevent unnecessary surgery. This review summarizes the changes within IPMNs that promote their progression to pancreatic adenocarcinoma and highlights potential biomarkers for identifying high-risk IPMNs.
Article
Gastroenterology & Hepatology
Leiling Pan, Medhanie A. Mulaw, Johann Gout, Min Guo, Hina Zarrin, Peggy Schwarz, Bernd Baumann, Thomas Seufferlein, Martin Wagner, Franz Oswald
Summary: This study found that downregulation of RBPJ in PDAC patients promotes KRAS-mediated transformation of pancreatic acinar cells and development of fibrosis. This finding provides important clues for the development mechanism of PDAC and offers a theoretical basis for finding new treatment strategies.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Pharmacology & Pharmacy
Paolo Zuccolini, Paola Gavazzo, Michael Pusch
Summary: BK is a potassium channel with allosteric regulation by Ca2+ binding and voltage. It plays various physiological roles in different tissues, including regulation of pancreatic juice composition. Studies suggest a potential pharmacological role of BK in PDAC, but caution is needed due to potential misleading effects on cancer cells.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Andrea Resovi, Perla Persichitti, Laura Brunelli, Lucia Minoli, Patrizia Borsotti, Giulia Garattini, Matteo Tironi, Erica Dugnani, Miriam Redegalli, Giulia De Simone, Roberta Pastorelli, Maria Rosa Bani, Lorenzo Piemonti, Deane F. Mosher, Raffaella Giavazzi, Giulia Taraboletti, Dorina Belotti
Summary: The pancreatic microenvironment can have a tumor-suppressive role, but can also promote cancer development. This study demonstrates that fibronectin fragments generated by pancreatic spheroids inhibit tumor growth in pancreatic ductal adenocarcinoma (PDAC) through the inhibition of integrin α5β1, FAK, and FGFR1 signaling pathways.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yan Deng, Yong Li, Jia-Long Wu, Ting Zhou, Meng-Yue Tang, Yong Chen, Hou-Dong Zuo, Wei Tang, Tian-Wu Chen, Xiao-Ming Zhang
Summary: This study demonstrates that radiomics models based on multi-sequence MRI have the potential to predict MUC4 expression levels in PDAC, which may aid in the diagnosis and treatment of PDAC.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yan Deng, Yong Li, Jia-Long Wu, Ting Zhou, Meng-Yue Tang, Yong Chen, Hou -Dong Zuo, Wei Tang, Tian -Wu Chen, Xiao-Ming Zhang
Summary: Radiomics models based on multi-sequence MRI have the potential to predict MUC4 expression levels in PDAC.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)