Review
Oncology
Bi-Xia Liu, Chao-Tao Tang, Xi-Jian Dai, Ling Zeng, Fei Cheng, Youxiang Chen, Chunyan Zeng
Summary: S100P overexpression is associated with poor overall survival in patients with digestive system cancers, particularly as a prognostic indicator in non-gastrointestinal tract cancers.
FRONTIERS IN ONCOLOGY
(2021)
Review
Clinical Neurology
Jimin He, Yao Jiang, Liang Liu, Zhihua Zuo, Chun Zeng
Summary: A meta-analysis was conducted on 24 studies involving a total of 2,170 glioma patients and 1,456 healthy participants, which revealed the potential of circulating miRNAs as diagnostic biomarkers for gliomas, pending validation through large prospective studies.
FRONTIERS IN NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Rosanna Villani, Francesca Di Cosimo, Moris Sangineto, Antonino Davide Romano, Gaetano Serviddio
Summary: Pseudocirrhosis mimics liver cirrhosis in patients without chronic liver disease. This systematic review and meta-analysis evaluated the literature on pseudocirrhosis, investigating its epidemiology and clinical features. The study found that breast cancer was the most common associated condition, with most patients presenting clinical signs of portal hypertension and ascites. The median time from pseudocirrhosis diagnosis to death was a few months, and the use of anticancer drugs was associated with pseudocirrhosis development.
SCIENTIFIC REPORTS
(2022)
Review
Immunology
Sicong Li, Lanxing Li, Tianyan Pan, Xiaoqun Li, Yujia Tong, Yongdong Jin
Summary: High expression of TIGIT is associated with poorer prognosis in East Asian patients with solid cancers. TIGIT is coexpressed with genes encoding immunostimulators, immunoinhibitors, chemokines, chemokine receptors, and major histocompatibility complex (MHC), especially in gastroesophageal cancer. TMB and MSI are also associated with TIGIT upregulation in diverse kinds of cancers.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Qiang Zhou, Zhihua Jiao, Yuxi Liu, Peter N. Devreotes, Zhenyu Zhang
Summary: Statin therapy is associated with significant benefits in overall survival and cancer-specific survival for advanced-stage cancer patients, regardless of study design, study regions, cancer types, or other medical care.
FRONTIERS IN ONCOLOGY
(2023)
Review
Immunology
Jiawei Xu, Yongfeng Wu, Yuedan Xu, Yuan Qiu, Xiaobo Li, Yumeng Song, Ling Zhang
Summary: This study evaluated the safety of neoadjuvant immunotherapy. The results showed that neoadjuvant ICIs plus chemotherapy had a higher incidence of all-grade and high-grade adverse events compared to neoadjuvant ICIs alone. However, neoadjuvant immunotherapy had a low rate of progressive diseases, surgical delays, and deaths.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Quan Wu, Fagen Ye
Summary: Through a meta-analysis, it was found that patients with lower Geriatric Nutritional Risk Index (GNRI) had a higher risk of worse overall survival, recurrence-free survival/progression-free survival, and cancer-specific survival in urological cancer patients. GNRI has significant predictive value in assessing the prognosis of UCs patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Yonghua Guo, Meng Gao, Ye Yao, Jinghua Li, Xi Chen, Xingxing Wang, Zhang Chen, Yufeng Yuan, Weijie Ma
Summary: This study evaluated the impact of CSN5 levels on the survival and clinicopathological parameters of digestive system neoplasm patients. The results showed that high expression of CSN5 was associated with poorer overall survival and worse clinicopathological features in digestive system tumors. However, there was no correlation between CSN5 expression and age, gender, tumor stage, tumor size, or vascular invasion.
Article
Oncology
Christos Fountzilas, Alex Adjei, Mateusz Opyrchal, Rachel Evans, Mohammad Ghasemi, Kristopher Attwood, Adrienne Groman, Wiam Bshara, Andrew Goey, John Wilton, Wen Wee Ma, Renuka Iyer
Summary: Ceritinib in combination with gemcitabine and gemcitabine/cisplatin has manageable toxicity profile, showing potential efficacy in tumors with ALK or ROS1 fusions.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Review
Immunology
Arduino A. A. Mangoni, Angelo Zinellu
Summary: This systematic review and meta-analysis study demonstrates that the systemic inflammation index (SII) on admission is significantly associated with disease severity and mortality in Covid-19 patients. Therefore, this inflammatory biomarker derived from routine hematological parameters can be helpful for early risk stratification in this group.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Yingji Fang, Tingting Zheng, Chengling Zhang
Summary: A high CRP/Alb ratio in patients with gynecological cancers is associated with poor overall survival and progression-/disease-free survival. Additionally, it predicts the risk of stages III-IV disease.
FRONTIERS IN ONCOLOGY
(2021)
Review
Pediatrics
Yuga Komaki, Fukiko Komaki, Akihiro Yamada, Dejan Micic, Akio Ido, Atsushi Sakuraba
Summary: Patients with pediatric-onset IBD have a higher risk of developing cancer compared to the general population, though the incidence appears to be decreasing in recent years.
JOURNAL OF PEDIATRICS
(2021)
Review
Nutrition & Dietetics
B. S. Te Fang, Yang Gong, Yue Wang
Summary: Gastric cancer is a common and deadly cancer worldwide. Recent studies have shown inconsistent conclusions about the predictive power of myosteatosis for overall survival in patients with gastric cancer. This meta-analysis aims to systematically quantify the predictive power of myosteatosis for overall survival in the gastric cancer setting.
Review
Medicine, General & Internal
Pasquale Ambrosino, Antimo Papa, Agostino Buonauro, Marco Mosella, Ilenia Calcaterra, Giorgio Alfredo Spedicato, Mauro Maniscalco, Matteo Nicola Dario Di Minno
Summary: Endothelial dysfunction is documented in patients with HFpEF, with a direct association between the severity of diastolic dysfunction and endothelial dysfunction. Strategies targeting endothelial dysfunction may provide a promising therapeutic option.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Immunology
Liqiu Kou, Qinglian Wen, Xiaolu Xie, Xiu Chen, Jun Li, Yaling Li
Summary: This study aims to investigate the incidence and distribution of adverse events in immune checkpoint inhibitors (ICI) for digestive system cancers and provide a reference for their safe, rational, and effective use. The results showed that the incidence, characteristics, and distribution of adverse events vary depending on the cancer type, treatment modality, and agent type.
FRONTIERS IN IMMUNOLOGY
(2022)
