Article
Immunology
Yanyan Liu, Yanna Liu, Qiaofang Wang, Yaodong Song, Sanyang Chen, Bo Cheng, Yan Zhang, Zongchao Cui, Zhongwei Wu, Changju Zhu
Summary: ISO-1 treatment alleviated pathological damage in pancreatic and renal tissues, reduced serum levels of serological indicators, suppressed expression of inflammatory factors, and decreased neutrophil infiltration in kidney tissue in an experimental model of SAP-associated AKI.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Environmental Sciences
Tingting Xia, Yijie Gu, Jiaqing Shen, Lu Zheng, Chunfang Xu
Summary: Research has shown that limonin has protective effects on acute pancreatitis by reducing the levels of inflammation initiators and modulating the JAK2/STAT3 signaling pathway.
ENVIRONMENTAL TOXICOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Alison Domingues, Alessandro Fantin
Summary: The vascular endothelium acts as a selective barrier to regulate macromolecule exchange, but its integrity is compromised in various pathological conditions, leading to increased vascular hyperpermeability. VEGFA is a potent permeability factor, and NRP1 may play a fundamental role in regulating VEGFA-induced responses in vascular endothelial cells.
Article
Integrative & Complementary Medicine
Jie Zhen, Wei Chen, Yang Liu, Xuefeng Zang
Summary: Baicalin exhibits therapeutic activity towards acute pancreatitis by increasing miR-15a levels and inhibiting CDC42/MAP3K1, affecting acute pancreatitis by targeting MAP2K4 and inhibiting the JNK signaling pathway.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Jing Wang, Hongwei Xu, Tianjie Chen, Changqin Xu, Xiaohua Zhang, Shule Zhao
Summary: This study found that MAGL inhibition can improve intestinal mucosal barrier injury in rats with severe acute pancreatitis (SAP) and induce differential gene expression and alternative splicing events. HNRNPDL may play an important role in improving intestinal mucosal barrier injury by affecting alternative splicing events.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Yongkang Zhang, Yingjian Jiang, Hongbo Li, Jiang Wang, Chang Li, Dianliang Zhang
Summary: Patients with severe acute pancreatitis (SAP) have compromised intestinal barrier function, and the STING signaling pathway plays an important role in intestinal inflammation. Inhibition of the STING signaling pathway can alleviate intestinal injury in SAP patients, while activation of the pathway can exacerbate the injury.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Medicine, Research & Experimental
Xue Xie, Jiulong Zhao, Wei Gao, Jie Chen, Bing Hu, Xiaojun Cai, Yuanyi Zheng
Summary: The study found that PBzyme has potential anti-oxidative and anti-inflammatory effects in the prophylactic treatment of AP, possibly involving inhibition of signaling pathways and scavenging reactive oxygen species. This provides a foundation for the clinical application of PBzyme in the preventive treatment of AP.
Article
Cell Biology
Liang Ji, Zhi-hong Wang, Yu-hua Zhang, Yi Zhou, De-sheng Tang, Chang-sheng Yan, Jia-min Ma, Kun Fang, Lei Gao, Nian-sheng Ren, Long Cheng, Xiao-yu Guo, Bei Sun, Gang Wang
Summary: In this study, the researchers investigated the role of impaired autophagy in regulating necrosis mediated by calcium/calmodulin-dependent protein kinase II (CAMKII) in acute pancreatitis (AP). They found that CAMKII was positively regulated by autophagy-related 7 (ATG7), and its incubation level correlated with AP-related necrotic injury. Additionally, they identified miR-30b-5p as an upstream regulator of CAMKII mRNA in AP and found that ATG7-enhanced impaired autophagy exacerbated AP by promoting regulated necrosis through the miR-30b-5p/CAMKII pathway.
CELL DEATH & DISEASE
(2022)
Article
Gastroenterology & Hepatology
Shang-Qing Huang, Yi Wen, Hong-Yu Sun, Jie Deng, Yao-Lei Zhang, Qi-Lin Huang, Bing Wang, Zhu-Lin Luo, Li-Jun Tang
Summary: Abdominal paracentesis drainage (APD) significantly alleviated intestinal inflammation and accompanying apoptosis induced by severe acute pancreatitis (SAP) in rats by inhibiting the HMGB1-mediated TLR4 signaling pathway, improving intestinal barrier function.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Multidisciplinary Sciences
Shujun Yang, Yaodong Song, Qiaofang Wang, Yanna Liu, Zhongwei Wu, Xiaojia Duan, Yan Zhang, Xiuqian Bi, Yuanzhang Geng, Sanyang Chen, Changju Zhu
Summary: Daphnetin pretreatment significantly alleviated SAP-induced pancreatic and lung tissue damage by inhibiting the activation of the JAK2-STAT3 signaling pathway, reducing inflammatory cytokine concentrations, decreasing cell apoptosis, and inhibiting white blood cell infiltration.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Juying Jiao, Jianjun Liu, Qi Li, Guixin Zhang, Chen Pan, Fei Luo, Qingkai Zhang, Bing Qi, Liang Zhao, Peiyuan Yin, Dong Shang
Summary: This study found that the gut microbiota-DAP-NOD1/RIP2 signaling pathway may play a critical role in the progression of acute pancreatitis and that the disease could be alleviated through intervention in the signaling pathway. These results provide potential new early warning indicators of severe acute pancreatitis and targets for intervention.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Cell Biology
Guanxiu Tang, Can Yu, Kaimin Xiang, Min Gao, Zuoliang Liu, Bingchang Yang, Mingshi Yang, Shangping Zhao
Summary: The study identified overexpression of ANXA2 in AP and its correlation to the severity of AP. Knockdown of ANXA2 alleviated inflammation and apoptosis in pancreatic acinar cells induced by cerulein and/or LPS. SRF-mediated transcriptional repression of ANXA2 protected pancreatic acinar cells against AP-like injury by repressing the NF-kappa B signaling pathway.
INFLAMMATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Chehao Lee, Guang Xin, Fan Li, Chengyu Wan, Xiuxian Yu, Lijuan Feng, Ao Wen, Yu Cao, Wen Huang
Summary: Ninjurin 1 (NINJ1) is involved in the process of plasma membrane rupture (PMR) and diffusion of inflammatory factors in severe acute pancreatitis (SAP). Knockout of NINJ1 delays PMR and alleviates SAP. Ca2+ concentration regulates NINJ1 expression in acinar cells and Ca2+ overload induces PMR through the P53/NINJ1 pathway. The study provides a potential target for SAP treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Haoyang Zhou, Dafeng Yang, Henry S. Cheng, Michael G. McCoy, Daniel Perez-Cremades, Stefan Haemmig, Danny Wong, Lei Chen, Mark W. Feinberg
Summary: The study uncovers an important role of miR-181b in regulating vascular endothelial aging through the MAP3K3-MAPK signaling pathway, revealing potential therapeutic targets for anti-aging therapy in cardiovascular disease.
Article
Pharmacology & Pharmacy
Xiaofang Yang, Huan Geng, Lijiao You, Lin Yuan, Jialei Meng, Yuhui Ma, Xuelian Gu, Ming Lei
Summary: The study investigated the protective effects of rhein against severe acute pancreatitis using in vitro and in vivo models, potentially through regulating the JAK2/STAT3 signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)