Article
Biochemistry & Molecular Biology
Keyan Wu, Guanghuai Yao, Xiaolei Shi, Huan Zhang, Qingtian Zhu, Xinnong Liu, Guotao Lu, Lianghao Hu, Weijuan Gong, Qi Yang, Yanbing Ding
Summary: The study demonstrated the protective effect of Asiaticoside (AS) on acute pancreatitis (AP) in mice through the TLR4 pathway, reducing serum amylase levels and alleviating the histopathological manifestations of pancreatic tissue. AS also showed interactions with TLR4 and protected against pancreatic acinar cells necrosis.
MOLECULAR IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Patricia G. G. Valles, Andrea Fernanda Gil Lorenzo, Rodrigo D. D. Garcia, Valeria Cacciamani, Maria Eugenia Benardon, Valeria Victoria Costantino
Summary: Acute kidney injury (AKI) is a common and devastating condition with no effective pharmacological treatment. Toll-like receptor 4 (TLR4) and its ligands play a crucial role in the pathogenesis of AKI by mediating inflammatory responses. Excessive activation of TLR4 can lead to chronic inflammation. This review discusses the role of TLR4 in ischemic/reperfusion-induced AKI and sepsis-associated AKI, as well as its potential signaling patterns in kidney injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, Research & Experimental
Ankush Kumar Jha, Shobhit Gairola, Sourav Kundu, Pakpi Doye, Abu Mohammad Syed, Chetan Ram, Upadhyayula Suryanarayana Murty, V. G. M. Naidu, Bidya Dhar Sahu
Summary: This review emphasizes the role of TLR4 signaling pathway in AKI and highlights potential compounds of natural and synthetic origin that can avert renal TLR4 signaling and offer protection against AKI in preclinical models. Targeting TLR4 and its downstream effectors could serve as an effective therapeutic intervention to prevent renal inflammation and subsequent kidney damage.
Review
Biotechnology & Applied Microbiology
Danieli F. Buccini, Beatriz C. Roriz, Julia M. Rodrigues, Octavio L. Franco
Summary: Antimicrobial peptides are important molecules in the organism's defense system. They can modulate the immune system and recognize molecules present in pathogens. Overstimulation of TLR4 can lead to uncontrolled inflammatory responses, which can be counteracted by antimicrobial peptides.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Piumi B. Wickramasinghe, Shuwen Qian, Lyndsey E. Langley, Chen Liu, Lin Jia
Summary: Accumulating evidence suggests that alcohol overconsumption is associated with insulin resistance, and this study investigated the role of hepatocyte toll-like receptor 4 (TLR4) in alcohol-induced insulin resistance. The findings indicate that hepatocyte TLR4 is both required and sufficient for the development of insulin resistance caused by alcohol overconsumption.
Review
Biochemistry & Molecular Biology
Natticha Sumneang, Pongpan Tanajak, Thura Tun Oo
Summary: Doxorubicin (Dox) is commonly used chemotherapeutic drug, but its cardiotoxicity reduces its therapeutic efficacy. Dox-induced cardiac inflammation is considered as one of the underlying mechanisms involved in Dox-induced cardiotoxicity. Understanding the role of the Toll-like receptor 4 (TLR4) signaling pathway in Dox-induced cardiac inflammation might be beneficial for developing potential therapeutic strategies.
Article
Chemistry, Medicinal
Yongsheng Zhang, Xinjie Liang, Xuefei Bao, Wei Xiao, Guoliang Chen
Summary: This review discusses TLR4 inhibitors that can bind directly to TLR4 or the TLR4/MD2 complex, as well as compounds that can downregulate the expression of TLR4. The involvement of specific residues in the binding of antagonistic ligands to the TLR4/MD2 complex provides useful information for structure-based TLR4 inhibitor design.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Changliang Zhu, Hong Tao, Shikuo Rong, Lifei Xiao, Xinxiao Li, Shucai Jiang, Baorui Guo, Lei Wang, Jiangwei Ding, Caibing Gao, Haigang Chang, Tao Sun, Feng Wang
Summary: Exendin-4 was effective in inhibiting cocaine-induced CPP, facilitating the extinction of cocaine-associated reward, and attenuating reinstatement of cocaine-induced behavior. These effects may be attributed to the inhibition of TLR4, TNF-alpha, and IL-1 beta expression.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Fadwa M. AlKhulaifi, Afrah Alkhuriji, Lamjed Mansour, Abdullah Al-jurayyan, Norah M. A. Al-Mulhim, Yusra A. Tashkandy, Ghadeer S. Aldossari, Suliman Alomar
Summary: The study investigated the relationship between single nucleotide polymorphisms (SNPs), Toll-like receptor 4 (TLR4) gene expression, and the risk and prognosis of acute lymphoblastic leukemia (ALL) in the Saudi population. The results showed that specific SNPs of the TLR4 gene were associated with the risk of ALL, and the expression of TLR4 gene was significantly higher in ALL patients.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Pediatrics
Tianjing Liu, Haifeng Zong, Xiaoyu Chen, Sihang Li, Ziyun Liu, Xuewei Cui, Guoqiang Jia, Yongyan Shi
Summary: The study indicates that necroptosis is an essential pathological process of NEC, with TLR4 possibly acting as a stimulator. Inhibiting intestinal cell necroptosis may be a beneficial strategy in the treatment of NEC.
PEDIATRIC RESEARCH
(2022)
Review
Medicine, Research & Experimental
Jinrui Wei, Yan Zhang, Haopeng Li, Fuquan Wang, Shanglong Yao
Summary: This review focuses on the role and mechanism of TLR4 in various diseases, aiming to provide new research directions and therapeutic targets for clinical intervention.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Plant Sciences
Yun Ling, Lu Jin, Quanxin Ma, Yu Huang, Qinqin Yang, Minli Chen, Qiyang Shou
Summary: This study demonstrated that Salvianolic acid A (SAA) can significantly reduce the inflammatory response and injury caused by cerebral ischemia-reperfusion, possibly through the inhibition of TLR2/4 and its related signal pathway.
Article
Endocrinology & Metabolism
Hai-Yun Guan, He-Xia Xia, Xiu-Ying Chen, Lu Wang, Zhi-Jing Tang, Wei Zhang
Summary: The activation of TLR4 was found to suppress CYP19A1 expression and E2 secretion in human granulosa cells via NF-κB signaling, which has implications for follicular development and estrogen synthesis regulation.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Pharmacology & Pharmacy
Yongjian Wen, Wenhao Cai, Jingyu Yang, Xianghui Fu, Lohitha Putha, Qing Xia, John A. Windsor, Anthony R. Phillips, Joel D. A. Tyndall, Dan Du, Tingting Liu, Wei Huang
Summary: MIF is a pleiotropic cytokine implicated in inflammation and cancer, activating downstream signaling pathways through binding to CD74/CD44 and promoting immune responses, inflammation, and cancer cell proliferation and invasion. Pharmacological inhibition of MIF shows promise in treating inflammatory diseases and cancer.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Anna Piovan, Raffaella Filippini, Carla Argentini, Stefano Moro, Pietro Giusti, Morena Zusso
Summary: The blue-green alga Spirulina platensis contains phycocyanins, including C-phycocyanin (C-PC), which has hepatoprotective, nephroprotective, antioxidant, and anticancer effects. This study investigated the immunomodulatory effects of C-PC in microglia cultures and found that it upregulates the expression and release of IL-1 beta and TNF-alpha, while also promoting the nuclear translocation of the NF-kappa B transcription factor. Additionally, the study suggests that the immunoregulatory function of C-PC may involve the activation of Toll-like receptor 4 (TLR4).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Infectious Diseases
Yingying Shen, Yuzhu Li, Hangchao Li, Qi Liu, Huijie Dong, Bo Wang, Baodong Ye, Shenyun Lin, Yiping Shen, Dijiong Wu
Summary: MonoMAC syndrome is a rare disease that should be highly suspected in MDS/AML patients with recurrent mixed infections and pancytopenia, especially with monocyte absence. Genetic mutation and pathogen sequencing are important for diagnosis and treatment.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Immunology
Qi Liu, Yingying Shen, Yuzhu Li, Huijin Hu, Wenbin Liu, Yuechao Zhao, Huijie Dong, Yiping Shen, Yuhong Zhou, Baodong Ye, Dijiong Wu
Summary: The study demonstrated that ITP patients with decreased megakaryocyte responded well to eltrombopag, and abnormalities in NK cells may contribute to a poor response to eltrombopag.
IMMUNOLOGIC RESEARCH
(2022)
Article
Cell Biology
Yanting Gao, Qi Liu, Yingying Shen, Yuzhu Li, Keding Shao, Baodong Ye, Yiping Shen, Yuhong Zhou, Dijiong Wu
Summary: This study reported a single-center study of avatrombopag, a novel drug for the treatment of severe and refractory chemotherapy-induced thrombocytopenia (CIT). The results demonstrated that avatrombopag was effective in 8 out of 13 patients (61.5%), with most patients no longer requiring platelet transfusion at the end of the study. Hemoglobin level and platelet count could serve as predictors of treatment response. This study provides a new and effective treatment option for CIT.
Article
Integrative & Complementary Medicine
Hangchao Li, Lina Ji, Yingying Shen, Danqing Fu, Dijiong Wu, Baodong Ye
Summary: This study demonstrated the therapeutic effects of BSJPQYF in aplastic anemia, which could alleviate myelosuppression through inhibiting the expression of the PI3K/AKT/NF-kappa B signaling pathway.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Integrative & Complementary Medicine
Nanxi Dong, Xujie Zhang, Dijiong Wu, Zhiping Hu, Wenbin Liu, Shu Deng, Baodong Ye
Summary: This study explores the medication rules for aplastic anemia (AA) in traditional Chinese medicine (TCM) using data mining methods. The results reveal commonly used herbs, their properties, and the clustering of medications. Association rule analysis identifies the relationships between high-frequency herbs.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Qi Liu, Huijie Dong, Yuzhu Li, Yingying Shen, Yilei Hong, Ying Chen, Shan Liu, Xiaolian Wu, Wenbin Liu, Huijin Hu, Yuechao Zhao, Shenyun Lin, Yiping Shen, Yuhong Zhou, Baodong Ye, Dijiong Wu
Summary: This study aimed to explore the relationship between serum lipid changes and responses to ATG-based IST treatment for newly diagnosed SAA/VSAA patients. The results demonstrated that lower levels of Apo-A were associated with better event-free survival.
LIPIDS IN HEALTH AND DISEASE
(2022)
Article
Hematology
Yingying Shen, Qi Liu, Hangchao Li, Wenbin Liu, Huijin Hu, Yuechao Zhao, Yuzhu Li, Ying Chen, Shan Liu, Qinghong Yu, Haifeng Zhuang, Liqiang Wu, Zhiping Hu, Zhiyin Zheng, Jianping Shen, Shenyun Lin, Yiping Shen, Yuhong Zhou, Baodong Ye, Dijiong Wu
Summary: Acquired aplastic anemia (AA) is a bone marrow failure disorder characterized by low blood cell count, and immunosuppressive therapy (IST) is a common treatment option. This study found a high prevalence of FANC heterozygous germline mutations in AA patients, which were associated with poor response to IST.
ANNALS OF HEMATOLOGY
(2023)
Meeting Abstract
Hematology
Qi Liu, Huijie Dong, Yingying Shen, Yuzhu Li, Yilei Hong, Ying Chen, Shan Liu, Wenbin Liu, Huijin Hu, Yuechao Zhao, Shengyun Lin, Yiping Shen, Yuhong Zhou, Baodong Ye, Dijiong Wu
Meeting Abstract
Hematology
Yilei Hong, Yingying Shen, Qi Liu, Jingjie Dong, Jingjing Xiang, Wenbin Liu, Yiping Shen, Liqiang Wu, Yuhong Zhou, Baodong Ye, Dijiong Wu
Meeting Abstract
Hematology
Yuzhu Li, Yingying Shen, Wenbin Liu, Qi Liu, Ying Chen, Shan Liu, Yun Zhang, Shu Deng, Haifeng Zhuang, Zhiping Hu, Qinghong Yu, Shengyun Lin, Yuhong Zhou, Jianping Shen, Baodong Ye, Dijiong Wu
Review
Hematology
Hangchao Li, Chenjie Zhou, Yingying Shen, Min Xu, Dijiong Wu, Baodong Ye
Summary: In recent years, the research on the hematopoietic microenvironment of AA has made some progress, providing new ideas for the clinical treatment of AA. Although the focus has been on immune abnormalities, there has been less research on the hematopoietic microenvironment of AA.
EUROPEAN JOURNAL OF HAEMATOLOGY
(2023)
Article
Hematology
Yilei Hong, Yingying Shen, Qi Liu, Jingjie Dong, Jingjing Xiang, Yiping Shen, Liqiang Wu, Yuhong Zhou, Baodong Ye, Dijiong Wu
Summary: The study aimed to investigate the efficacy and safety of combining low-dose cyclosporine with eltrombopag in the management of patients with refractory ITP. The results showed that 76.2% of the patients responded to the combination therapy, with no significant drug-related adverse events.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Medicine, General & Internal
Yingying Shen, Yuzhu Li, Qi Liu, Wenbin Liu, Qinghong Yu, Huijin Hu, Shan Liu, Jingjie Dong, Min Xu, Yaonan Hong, Ying Chen, Shu Deng, Haifeng Zhuang, Zhiping Hu, Shenyun Lin, Yiping Shen, Jianping Shen, Yuhong Zhou, Baodong Ye, Dijiong Wu
Summary: This study compares the efficacy and long-term outcomes of anti-thymocyte globulin (ATG)-based immunosuppressive therapy (IST) and allogeneic hematopoietic stem cell transplantation (allo-HSCT) in patients with transfusion-dependent non-severe aplastic anemia (TD-NSAA). The results show that frontline IST has a higher overall response rate and event-free survival compared to non-frontline treatment, particularly in patients with a shorter disease duration. However, for patients with a longer disease duration, allo-HSCT offers better treatment outcomes than IST.
ANNALS OF MEDICINE
(2023)
Review
Cell Biology
Qi Liu, Tonglin Hu, Hangchao Li, Yingying Shen, Dijiong Wu, Baodong Ye
Summary: Chimeric antigen receptor-T-cell (CAR-T-cell) therapy is a promising immunotherapy for relapsed/refractory haematologic malignancies, but prolonged haematologic toxicity (PHT) is a common yet underestimated side effect. The incidence, risk factors, and management of PHT vary across studies due to heterogeneity in populations, CAR-T cells used, diseases treated, and definitions of PHT. This review aims to provide narrative and evidence-based insights into PHT following CAR-T-cell therapy to enhance systematic understanding and treatment strategies.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Medicine, Research & Experimental
Yuzhu Li, Yilei Hong, Yingying Shen, Qi Liu, Ying Chen, Keding Shao, Yiping Shen, Baodong Ye, Dijiong Wu
Summary: This article presents a case of acute rhabdomyolysis developing during HLA-haploidentical HSCT in a patient with hepatitis-associated aplastic anemia. Despite timely diagnosis and treatment, the patient ultimately died of multi-organ failure. Whole-exome sequencing revealed a genetic mutation. The authors suggest genetic analysis should be performed during HSCT to better understand the pathological changes of this complication.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)