Article
Biochemistry & Molecular Biology
Keyan Wu, Guanghuai Yao, Xiaolei Shi, Huan Zhang, Qingtian Zhu, Xinnong Liu, Guotao Lu, Lianghao Hu, Weijuan Gong, Qi Yang, Yanbing Ding
Summary: The study demonstrated the protective effect of Asiaticoside (AS) on acute pancreatitis (AP) in mice through the TLR4 pathway, reducing serum amylase levels and alleviating the histopathological manifestations of pancreatic tissue. AS also showed interactions with TLR4 and protected against pancreatic acinar cells necrosis.
MOLECULAR IMMUNOLOGY
(2021)
Article
Oncology
Biwei Wei, Yahui Gong, Huiying Yang, Jie Zhou, Zhou Su, Zhihai Liang
Summary: The study found that TRAF6 and caspase-1/3 signaling pathways were involved in the pathogenesis of CAE-induced AP in rats. In HPDE6C7 cells, CAE treatment and TRAF6 overexpression activated pyroptosis through the caspase-1/3 signaling pathways.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Immunology
Yifan Wang, Menglong Song, Ping Zhou, Jiandong Wang, Jun Zheng, Haidong Xu
Summary: The study demonstrated that TNFAIP3 plays a role in promoting the progression of AP by activating the RIP3/NLRP3 axis, providing a potential therapeutic target for AP treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Medicine, Research & Experimental
Ankush Kumar Jha, Shobhit Gairola, Sourav Kundu, Pakpi Doye, Abu Mohammad Syed, Chetan Ram, Upadhyayula Suryanarayana Murty, V. G. M. Naidu, Bidya Dhar Sahu
Summary: This review emphasizes the role of TLR4 signaling pathway in AKI and highlights potential compounds of natural and synthetic origin that can avert renal TLR4 signaling and offer protection against AKI in preclinical models. Targeting TLR4 and its downstream effectors could serve as an effective therapeutic intervention to prevent renal inflammation and subsequent kidney damage.
Review
Biochemistry & Molecular Biology
Patricia G. G. Valles, Andrea Fernanda Gil Lorenzo, Rodrigo D. D. Garcia, Valeria Cacciamani, Maria Eugenia Benardon, Valeria Victoria Costantino
Summary: Acute kidney injury (AKI) is a common and devastating condition with no effective pharmacological treatment. Toll-like receptor 4 (TLR4) and its ligands play a crucial role in the pathogenesis of AKI by mediating inflammatory responses. Excessive activation of TLR4 can lead to chronic inflammation. This review discusses the role of TLR4 in ischemic/reperfusion-induced AKI and sepsis-associated AKI, as well as its potential signaling patterns in kidney injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Wei Zhang, Li Xu, Xiaoyan Zhang, Jianqing Xu, Jun-O Jin
Summary: This study investigates the potential effect of FimH on macrophage polarization and activation. The results show that FimH promotes M1 macrophage activation and repolarizes M2 macrophages into the M1 phenotype via the TLR4 signaling pathway. Moreover, FimH reprograms tumor-associated macrophages in the tumor microenvironment and enhances the anti-tumor activity of immune checkpoint blockade.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Nutrition & Dietetics
Amir Hossein Faghfouri, Alireza Khabbazi, Behzad Baradaran, Yaser Khajebishak, Elham Baghbani, Saeed Noorolyai, Shima Rahmani, Seyyed Morteza Seyyed Shoura, Maedeh Alipour, Beitullah Alipour
Summary: This study found that zinc supplementation improved TLR-2 expression and nonocular IBDDAM score in BD patients. The impact on other clinical indicators and quality of life was not significant.
CLINICAL NUTRITION
(2022)
Review
Pharmacology & Pharmacy
Yongjian Wen, Wenhao Cai, Jingyu Yang, Xianghui Fu, Lohitha Putha, Qing Xia, John A. Windsor, Anthony R. Phillips, Joel D. A. Tyndall, Dan Du, Tingting Liu, Wei Huang
Summary: MIF is a pleiotropic cytokine implicated in inflammation and cancer, activating downstream signaling pathways through binding to CD74/CD44 and promoting immune responses, inflammation, and cancer cell proliferation and invasion. Pharmacological inhibition of MIF shows promise in treating inflammatory diseases and cancer.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Ejas Palathingal Bava, John George, Mohammad Tarique, Srikanth Iyer, Preeti Sahay, Beatriz Gomez Aguilar, Dujon B. Edwards, Bhuwan Giri, Vrishketan Sethi, Tejeshwar Jain, Prateek Sharma, Utpreksha Vaish, Harrys K. C. Jacob, Anthony Ferrantella, Craig L. Maynard, Ashok K. Saluja, Rajinder K. Dawra, Vikas Dudeja
Summary: This study evaluated the efficacy of pirfenidone in treating acute pancreatitis. The results showed that pirfenidone can reduce local and systemic injury and inflammation caused by pancreatitis, suggesting its potential therapeutic effects. Pirfenidone acts by decreasing cytokine release and disrupting cellular interactions.
Article
Biology
Biwei Wei, Zhou Su, Huiying Yang, Yong Feng, Chunmei Meng, Zhihai Liang
Summary: The study aimed to investigate the role of TRAF6 in pyroptosis during HTG-AP. The results showed that inhibition of TRAF6 alleviated inflammation and pyroptosis in HTG-AP, suggesting its potential as a therapeutic target for HTG-AP.
Article
Environmental Sciences
Wisurumuni Arachchilage Hasitha Maduranga Karunarathne, Ilandarage Menu Neelaka Molagoda, Yung Hyun Choi, Sang Rul Park, Seungheon Lee, Gi-Young Kim
Summary: Low concentrations of BPA induce inflammation by activating the NF-kappa B signaling pathway and increasing the release of proinflammatory mediators. Molecular modeling suggests that BPA binds to the TLR4/MD2 complex to initiate downstream molecules and elicit an immune response.
ENVIRONMENTAL POLLUTION
(2021)
Article
Anatomy & Morphology
Biwei Wei, Qing Wu, Xuexia Yang, Chen Lai, Zhou Su, Zhihai Liang
Summary: This study demonstrates that TRAF6 inhibitor can alleviate intestinal injury induced by acute pancreatitis, possibly through inhibition of the TLR4/NF-kappa B signaling pathway to regulate the inflammatory response and intestinal barrier injury.
Article
Physiology
Seigo Ito, Hiroyuki Nakashima, Takuya Ishikiriyama, Masahiro Nakashima, Akira Yamagata, Toshihiko Imakiire, Manabu Kinoshita, Shuhji Seki, Hiroo Kumagai, Naoki Oshima
Summary: The study indicates that TLR9 plays a significant role in the pathogenesis of diabetic nephropathy, with potential therapeutic implications through its inhibition. Activation of TLR9 enhanced TNF-alpha production in BM-Mφs and ROS production in Res-Mφs in diabetic nephropathy model mice. INCB3344 reduced DN pathology by suppressing TLR9 expression and ROS production, suggesting a new therapeutic strategy.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Danieli F. Buccini, Beatriz C. Roriz, Julia M. Rodrigues, Octavio L. Franco
Summary: Antimicrobial peptides are important molecules in the organism's defense system. They can modulate the immune system and recognize molecules present in pathogens. Overstimulation of TLR4 can lead to uncontrolled inflammatory responses, which can be counteracted by antimicrobial peptides.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Piumi B. Wickramasinghe, Shuwen Qian, Lyndsey E. Langley, Chen Liu, Lin Jia
Summary: Accumulating evidence suggests that alcohol overconsumption is associated with insulin resistance, and this study investigated the role of hepatocyte toll-like receptor 4 (TLR4) in alcohol-induced insulin resistance. The findings indicate that hepatocyte TLR4 is both required and sufficient for the development of insulin resistance caused by alcohol overconsumption.
Article
Surgery
Kai Liu, Xin-Zu Chen, Yu-Chen Zhang, Wei-Han Zhang, Xiao-Long Chen, Li-Fei Sun, Kun Yang, Bo Zhang, Zong-Guang Zhou, Jian-Kun Hu
Summary: The study suggests that spleen-preserving splenic hilar lymph node dissection should be considered as an essential procedure in patients undergoing total gastrectomy for gastric cancer to improve survival outcomes.
Article
Surgery
Hua Yang, Wei-Han Zhang, Kai Liu, Yu-Qing Dan, Xin-Zu Chen, Kun Yang, Zhi-Xin Chen, Jia-Ping Chen, Zong-Guang Zhou, Jian-Kun Hu
Summary: This study aimed to compare the effectiveness of clockwise modularized laparoscopic lymphadenectomy with traditional open surgery in gastric cancer patients. The results showed that the CML group had more examined lymph nodes, less intraoperative blood loss, and a longer surgical duration compared to the OG group, but similar rates of postoperative complications and postoperative hospital stay.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Review
Oncology
Kun Yang, Zhi-Yun Zang, Kai-Fan Niu, Li-Fei Sun, Wei-Han Zhang, Yue-Xin Zhang, Xiao-Long Chen, Zong-Guang Zhou, Jian-Kun Hu
Summary: This meta-analysis found that splenectomy does not increase overall survival rate or postoperative mortality for gastric cancer patients, but it significantly raises the incidence of postoperative complications.
FRONTIERS IN ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Hai-Ning Chen, Yang Shu, Fei Liao, Xue Liao, Hongying Zhang, Yun Qin, Zhu Wang, Maochao Luo, Qiuluo Liu, Zhinan Xue, Minyuan Cao, Shouyue Zhang, Wei-Han Zhang, Qianqian Hou, Xuyang Xia, Han Luo, Yan Zhang, Lie Yang, Jian-Kun Hu, Xianghui Fu, Bo Liu, Hongbo Hu, Canhua Huang, Yong Peng, Wei Cheng, Lunzhi Dai, Li Yang, Wei Zhang, Biao Dong, Yuan Li, Yuquan Wei, Heng Xu, Zong-Guang Zhou
Summary: The study provides insights into the genomic evolution and metastatic patterns of colorectal cancer, suggesting that biopsy/sequencing of metastases should be considered for patients with multiorgan or late postoperative metastasis.
Article
Gastroenterology & Hepatology
Xuyang Yang, Chaoyang Gu, Tao Hu, Mingtian Wei, Wenjian Meng, Ziqiang Wang, Xiangbing Deng, Zongguang Zhou
Summary: Selective lateral lymph node dissection (sLLND) is important for rectal cancer patients, with the pretreatment maximum short-axis diameter of lateral lymph node (>= 8 mm) being a crucial indication for the procedure. Patients with lateral lymph node metastasis (LLNM) have worse prognosis compared to those without LLNM.
TECHNIQUES IN COLOPROCTOLOGY
(2021)
Article
Medicine, General & Internal
Wenhan Wu, Zongguang Zhou
Summary: This study developed and validated prediction models for predicting hospital death in patients with AMI using traditional statistics and machine learning. The machine learning model showed better clinical utility and accuracy compared to the traditional statistics prediction model, suggesting that a combined nomogram-machine learning predictive model may improve care for AMI patients.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Kun Yang, Yu-Qing Dan, Yoon Young Choi, Zong-Guang Zhou, Woo Jin Hyung, Jian-Kun Hu, Sung Hoon Noh
Summary: This study aimed to determine the prognostic significance of perineural invasion in gastric cancer patients. The results showed that PNI frequently occurs in these patients, but it is not an independent prognostic factor except for those in stage III, providing predictive value for their survival outcomes.
Article
Oncology
Xiang Gao, Xi Zhong, Hai-Ning Chen, Dujanand Singh, Lie Yang, Li-Bin Huang, Cun Wang, Zong-Guang Zhou
Summary: This study developed nomograms for predicting cancer-specific survival and overall survival in patients with invasive extramammary Paget's disease (iEMPD) using retrospective data of 1955 patients. The nomograms showed good calibration, discrimination, and clinical utility, providing a reliable tool for treatment design and prognostic evaluation of iEMPD.
Article
Biochemistry & Molecular Biology
Jiayang Liu, Zhao Huang, Hai-Ning Chen, Siyuan Qin, Yan Chen, Jingwen Jiang, Zhe Zhang, Maochao Luo, Qin Ye, Na Xie, Zong-Guang Zhou, Yuquan Wei, Ke Xie, Canhua Huang
Summary: ZNF37A plays a critical role in promoting metastasis in poorly differentiated colorectal cancer by enhancing TGF-beta signaling and activating cancer-associated fibroblasts through transcriptional repression of THSD4. This suggests ZNF37A as a potential biomarker for CRC progression and differentiation.
Article
Surgery
Kun Yang, Wei-Han Zhang, Kai Liu, Xin-Zu Chen, Xiao-Long Chen, Zong-Guang Zhou, Jian-Kun Hu
Summary: Laparoscopic dissection of infrapyloric lymph nodes through the right bursa omentalis approach is both feasible and safe for achieving a more complete No.6 lymphadenectomy in gastric cancer surgery. Postoperative complications, if they occur, can be effectively treated with conservative therapy.
Review
Biochemistry & Molecular Biology
Qiu-Luo Liu, Zhe Zhang, Xiawei Wei, Zong-Guang Zhou
Summary: Non-coding RNAs play a crucial role in cancer metastasis and their dysregulation may offer novel insights for diagnosis and treatment strategies.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Oncology
Haoyan Wu, Chuanwen Fan, Chao Fang, Libin Huang, Yuan Li, Zongguang Zhou
Summary: The addition of consolidation chemotherapy to preoperative short-course radiotherapy can enhance pathologic response in locally advanced rectal cancer, without increasing toxicity. Short-course radiotherapy followed by consolidation chemotherapy is recommended as a neoadjuvant treatment option for locally advanced rectal cancer.
RADIATION ONCOLOGY
(2022)
Article
Oncology
Rui Ge, Kai Liu, Weihan Zhang, Kun Yang, Xiaolong Chen, Linyong Zhao, Zongguang Zhou, Jiankun Hu
Summary: This study evaluated the safety and feasibility of laparoscopic gastrectomy for locally advanced gastric cancer after neoadjuvant chemotherapy. The results showed that laparoscopic assisted gastrectomy resulted in less intraoperative blood loss and shorter postoperative hospital stays compared to traditional open gastrectomy. There were no significant differences in operative duration, number of harvested lymph nodes, and postoperative complication rates between the two groups.
JOURNAL OF ONCOLOGY
(2022)
Article
Medicine, General & Internal
Kun Yang, Mo-Xi Chen, Yoon Young Choi, Zong-Guang Zhou, Woo Jin Hyung, Sung Hoon Noh, Jian-Kun Hu
Summary: This study found that age is an independent prognostic factor in pT1bN0 and pT2N0 gastric cancer patients. Postoperative chemotherapy may offer survival benefits to pT2N0 patients with more than two risk factors.
YONSEI MEDICAL JOURNAL
(2021)
Article
Medicine, Research & Experimental
Chunqi Liu, Liang Wang, Xiaocong Liu, Yuping Tan, Lei Tao, Yuzhou Xiao, Pengchi Deng, Huijuan Wang, Qianyi Deng, Yiyun Lin, Hui Jie, Huaqin Zhang, Jing Zhang, Yong Peng, Hu Zhang, Zongguang Zhou, Qingxiang Sun, Xiaobo Cen, Yinglan Zhao
Summary: The study revealed a novel nonmetabolic function of SHMT2 in stabilizing beta-catenin to prevent its ubiquitylation-mediated degradation, providing a potential therapeutic strategy for colorectal cancer therapy.