Review
Nutrition & Dietetics
Sandhya Sahye-Pudaruth, David W. L. Ma
Summary: There has been increased interest in the health benefits of n-3 polyunsaturated fatty acids (PUFA) in reducing chronic diseases. However, inconsistent findings in the literature call for a review of the evidence from randomized controlled trials (RCTs) in n-3 PUFA research. Factors such as varying doses and sources of n-3 PUFA, trial duration, and population characteristics may contribute to the inconsistency in the literature.
Article
Health Care Sciences & Services
Lesley Dunleavy, Nancy Preston, Catherine Walshe
Summary: This study explores how clinicians recruit participants for palliative care trials and the reasons behind their recruitment strategies. The results indicate that the recruitment process is influenced not only by the social marketing mix framework, but also by wider contextual issues such as emotional labor, power relationships, and hierarchies. Therefore, trial planners need to ensure that recruiters receive training and support to address the emotional labor involved in the recruitment process.
PALLIATIVE MEDICINE
(2023)
Review
Health Care Sciences & Services
India Rogers-Shepp, Souradeep Bhattacharya, Haran A. Mennillo, Ritika Kumar, Ben Hsieh, Gowri Anandarajah
Summary: This study conducted a systematic review and descriptive evidence synthesis of eight randomized controlled trials to assess the palliative effects of lifestyle exercise interventions on advanced cancer patients. The results showed some improvements but no generalizable conclusions can be made. Further research is needed.
PALLIATIVE MEDICINE
(2023)
Article
Biology
Nora Hutchinson, Hannah Moyer, Deborah A. Zarin, Jonathan Kimmelman
Summary: This article describes the importance of informativeness in guiding clinical, policy, or research decisions. The study found that the majority of randomized interventional trials designed to guide clinical practice possess features that may compromise their ability to do so.
Article
Obstetrics & Gynecology
Wentao Li, Esmee M. Bordewijk, Ben W. Mol
Summary: Randomized controlled trials are crucial in evidence-based medicine, but compromised data integrity and research misconduct pose risks to patients and undermine the authority of this scientific tool. There is a need for better methods to detect and prevent research misconduct, as well as improved mechanisms for investigating data manipulation and prioritizing patient and reader interests over trial authors and institutions.
OBSTETRICS AND GYNECOLOGY
(2021)
Article
Multidisciplinary Sciences
Ulrich Trautwein, Jessika Golle, Ann-Kathrin Jaggy, Marcus Hasselhorn, Benjamin Nagengast
Summary: This article describes how the Hector Children's Academy Talent Development Program utilizes randomized controlled trials (RCTs) to test the effectiveness of their core courses, generating mutual benefits for research and practice. The program provides STEMM courses for talented primary school students and employs RCTs to evaluate the efficacy of their courses.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Review
Clinical Neurology
Carina Winkler S. orensen, Charlotte Sonne, Maria Sacha, Maria Kristiansen, Sigrid Zeuthen Hannemose, Dan J. Stein, Jessica Carlsson
Summary: Most randomized controlled trials of mood and anxiety disorders rely on quantitative methods alone. However, supplementing quantitative data with qualitative methods can offer additional insights. This systematic review examined RCTs that used mixed-method approaches to explore participants' perspectives, identifying the number of such studies, describing their characteristics, and highlighting the potential advantages of this approach.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Primary Health Care
Christian Ruchon, Roland Grad, Mark H. Ebell, David C. Slawson, Pierre Pluye, Kristian B. Filion, Mathieu Rousseau, Emelie Braschi, Soumya Sridhar, Anupriya Grover-Wenk, Jennifer Ren-Si Cheung, Allen F. Shaughnessy
Summary: The study found that about 9% of randomized controlled trials (RCTs) relevant to primary care are reversed over a period of 12-17 years, indicating a high level of stability in the evidence. Information alerting services that apply strict criteria for relevance and validity of clinical information are likely to identify RCTs whose findings remain stable over time.
Review
Health Care Sciences & Services
Thomas Y. T. Lam, Max F. K. Cheung, Yasmin L. Munro, Kong Meng Lim, Dennis Shung, Joseph J. Y. Sung
Summary: The number of AI studies in medicine is rapidly increasing, but there is a lack of clear quantification of the clinical benefits. This systematic review of RCTs found that AI-assisted tools showed improved performance in clinical practice, but the available RCTs are limited and heterogeneous. More RCTs integrating AI-assisted tools into clinical practice are needed to advance the role of AI in medicine.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Oncology
Lisa Linge-Dahl, Rainer Kreuz, Mieke Stoffelen, Sonja Heintz, Willibald Ruch, Eckart von Hirschhausen, Lukas Radbruch
Summary: This study evaluated the effects of a humour intervention in a palliative care setting. The findings showed that the intervention reduced seriousness, bad mood, and stress, while increasing cheerfulness. However, the intervention setting was too exhausting for most patients.
SUPPORTIVE CARE IN CANCER
(2023)
Review
Nutrition & Dietetics
Olga Protic, Anna Rita Bonfigli, Roberto Antonicelli
Summary: Most nutraceutical combinations are effective against hypercholesterolemia, with red yeast rice being a common component. Increasing the number of clinical studies is essential to verify the efficacy and safety of new NCs.
Article
Health Care Sciences & Services
Xiaochu Yu, Zixing Wang, Lei Wang, Yuguang Huang, Yipeng Wang, Shijie Xin, Guanghua Lei, Shengxiu Zhao, Yali Chen, Xiaobo Guo, Wei Han, Xuerong Yu, Fang Xue, Peng Wu, Wentao Gu, Jingmei Jiang
Summary: This study proposes a new design to reconcile observational studies and randomized controlled trials (RCTs) on transfusion safety. The new design successfully reduces patient heterogeneity and generates transfusion evidence that is consistent with relevant RCTs, accelerating the pace of evidence generation and generalization.
BMC MEDICAL RESEARCH METHODOLOGY
(2022)
Review
Psychiatry
Le Xiao, Han Qi, Wei Zheng, Yu-Tao Xiang, Thomas J. Carmody, Taryn L. Mayes, Madhukar H. Trivedi, Gang Wang
Summary: The meta-analysis indicated that Enhanced Evidence-Based Care (EEC) is more effective than usual care in improving treatment outcomes for depressive disorders, showing higher response and remission rates as well as symptom reduction.
TRANSLATIONAL PSYCHIATRY
(2021)
Review
Medicine, General & Internal
Chetna Malhotra, Mahham Shafiq, Ada Portia Macarubbo Batcagan-Abueg
Summary: This study conducted a systematic review of randomized controlled trials to evaluate the efficacy of advance care planning (ACP) in improving patient outcomes and healthcare use/costs. The results showed mixed evidence regarding the effectiveness of ACP in improving patient outcomes and healthcare use/costs.
Article
Nutrition & Dietetics
Alice H. Lichtenstein, Kristina Petersen, Kathryn Barger, Karen E. Hansen, Cheryl A. M. Anderson, David J. Baer, Johanna W. Lampe, Helen Rasmussen, Nirupa R. Matthan
Summary: RCTs are considered the gold standard in establishing causal relations in human nutrition, and decisions made during the design and conduct of these trials impact the utility and generalizability of the study results. The goal is to maximize generalizability while producing high-quality data within limited resources.
ADVANCES IN NUTRITION
(2021)
Article
Geriatrics & Gerontology
Robert Oliver Barker, Rachel Stocker, Sian Russell, Anthony Roberts, Andrew Kingston, Joy Adamson, Barbara Hanratty
Article
Primary Health Care
Sian Russell, Rachel Stocker, Robert Oliver Barker, Jennifer Liddle, Joy Adamson, Barbara Hanratty
BRITISH JOURNAL OF GENERAL PRACTICE
(2020)
Article
Health Care Sciences & Services
Sarah Cockayne, Alison Pighills, Joy Adamson, Caroline Fairhurst, Shelley Crossland, Avril Drummond, Catherine E. Hewitt, Sara Rodgers, Sarah J. Ronaldson, Jennifer McCaffery, Katie Whiteside, Arabella Scantlebury, Lyn Robinson-Smith, Ann Cochrane, Sarah E. Lamb, Sophie Boyes, Simon Gilbody, Clare Relton, David J. Torgerson
Summary: The study aimed to evaluate the clinical effectiveness and cost-effectiveness of a home hazard assessment and environmental modification delivered by occupational therapists for preventing falls among community-dwelling people aged 65 and older. The results showed no significant reduction in fall rate in the intervention group compared to usual care, with the intervention being more costly and less effective.
HEALTH TECHNOLOGY ASSESSMENT
(2021)
Article
Nursing
Helen Anderson, Arabella Scantlebury, Heather Leggett, Heather Brant, Chris Salisbury, Jonathan Benger, Joy Adamson
Summary: This study explores the streaming of patients to General Practitioners in and alongside Emergency Departments in England. Six key themes influencing the streaming process were identified, leading to key recommendations for improving services.
INTERNATIONAL JOURNAL OF NURSING STUDIES
(2021)
Article
Medicine, Research & Experimental
Arabella Scantlebury, Catriona McDaid, Stephen Brealey, Elizabeth Cook, Hemant Sharma, Arun Ranganathan, Joy Adamson
Summary: This study explored key issues to consider when recruiting to orthopaedic surgical trials from the perspective of staff and patients, using a qualitative process evaluation of UK-wide orthopaedic surgical RCT and mixed methods randomised feasibility study. The findings highlighted the importance of factors such as equipoise, randomisation, communication, patient's circumstances, altruism, and trust in clinical and research teams in recruitment to surgical trials. It emphasized the need for a methodological shift to ensure that existing evidence on factors affecting recruitment to randomised controlled trials is used to optimize recruitment in future trials.
Article
Medicine, General & Internal
Rachel Stocker, Sian Russell, Jennifer Liddle, Robert O. Barker, Adam Remmer, Joanne Gray, Barbara Hanratty, Joy Adamson
Summary: The use of the NEWS intervention in care homes in one area of North-East England accelerated during the COVID-19 pandemic. Stakeholders felt that NEWS, along with its education and support package, improved the response of care homes and healthcare professionals to residents' health deterioration. Healthcare professionals appreciated the ability to remotely monitor resident observations, which facilitated triage and treatment decisions.
Article
Primary Health Care
Helen Anderson, Arabella Scantlebury, Heather Leggett, Chris Salisbury, Jonathan Benger, Joy Adamson
Summary: This study aims to explore the experiences and motivations of GPs choosing to work in GPED services in England, and to identify factors that may support or hinder GPs working in GPED roles. The results show that GPED may extend the clinical careers of experienced GPs and support recruitment and retention of more recently qualified GPs. Despite some benefits, GPED may destabilise core general practice and increase pressure on both environments.
BRITISH JOURNAL OF GENERAL PRACTICE
(2022)
Article
Nursing
Helen Anderson, Arabella Scantlebury, Paul Galdas, Joy Adamson
Summary: This study aims to explore how General Practice Nurses implement change during the COVID-19 pandemic and how it affects their professional wellbeing. The study will use a qualitative case study design, collecting data through focus groups and interviews, and analyzing the data using a framework analysis approach. The findings will contribute to improving care delivery and supporting the wellbeing of General Practice Nurses.
JOURNAL OF ADVANCED NURSING
(2022)
Article
Medicine, General & Internal
Arabella Scantlebury, Joy Adamson, Chris Salisbury, Heather Brant, Helen Anderson, Helen Baxter, Karen Bloor, Sean Cowlishaw, Tim Doran, James Gaughan, Andy Gibson, Nils Gutacker, Heather Leggett, Sarah Purdy, Sarah Voss, Jonathan Richard Benger
Summary: The study examined the effect of general practitioners working in or alongside the emergency department (GPED) on patient outcomes and experience. The results showed variability in the impact of GPED and disagreement regarding its purpose and potential impact. Despite potential influences on certain factors, there was no overall evidence that GPED improves clinical outcomes, patient or staff experience.
Article
Primary Health Care
Joy Adamson, Helen Hanson, Adam Todd, Rachel Duncan, Barbara Hanratty, Louise Robinson
Summary: This study explores the experiences of medication management among nonagenarians and its implications for primary care practice. The findings indicate that most older people do not experience significant problems with medication management. Taking medications becomes a habitual part of daily routines and is generally accepted. However, disruptions to steady states, such as new medical diagnoses or major life events, can cause challenges in medication management.
BRITISH JOURNAL OF GENERAL PRACTICE
(2023)
Article
Nursing
Helen Anderson, Arabella Scantlebury, Paul Galdas, Joy Adamson
Summary: This study explores the experiences of nurses working in general practice during the COVID-19 pandemic and evaluates the impact on nurses' professional well-being. The findings reveal that nurses face various challenges, such as lack of recognition, feeling undervalued, and lack of involvement in decision-making. These issues have significant implications for nurse retention in general practice and the future of the nursing profession.
JOURNAL OF ADVANCED NURSING
(2023)
Article
Nursing
Helen Anderson, Arabella Scantlebury, Paul Galdas, Joy Adamson
Summary: The study explores how nurses working in general practice during the COVID-19 pandemic engage with remote and technology-mediated working. It identifies specific issues of access to technology, workload, hybrid working, disruption to therapeutic relationships, safety risks, and lack of involvement in decision-making.
JOURNAL OF ADVANCED NURSING
(2023)
Article
Public, Environmental & Occupational Health
Laura R. N. Prato, Clare R. N. Abley, Joy Adamson
Summary: This study highlights the importance of online blogs in shaping the identity of caregivers of adults living with dementia. It also emphasizes the crucial role of health and social care service interactions in caregiver identity development. The study identifies six key areas of online identity construction for caregivers, including shifts in family roles, social advocacy, advocacy, guardianship of relative's selfhood, maintaining creative and spiritual individuality, and participation in online and real-life communities.
HEALTH & SOCIAL CARE IN THE COMMUNITY
(2022)
Article
Orthopedics
L. Flett, J. Adamson, E. Barron, S. Brealey, B. Corbacho, M. L. Costa, G. Gedney, N. Giotakis, C. Hewitt, J. Hugill-Jones, D. Hukins, A. Keding, C. McDaid, A. Mitchell, M. Northgraves, G. O'Carroll, A. Parker, A. Scantlebury, L. Stobbart, D. Torgerson, E. Turner, C. Welch, H. Sharma
Summary: The study aims to evaluate the clinical and cost-effectiveness of two surgical interventions commonly used to treat pilon fractures. A randomized controlled trial will compare internal locking plate fixation with external frame fixation in 334 adult patients with closed type C pilon fractures. The primary outcome will be the Disability Rating Index at 12 months.
Article
Medicine, Research & Experimental
Elizabeth Cook, Alison Booth, Elizabeth Coleman, Arabella Scantlebury, Catriona McDaid, Catherine Hewitt, Belen Corbacho, Amar Rangan, Joy Adamson, Arun Ranganathan, Almas Khan, Sashin Ahuja, Emma Turner, Peter May, Catherine Hilton, David J. Torgerson
PILOT AND FEASIBILITY STUDIES
(2020)