Article
Oncology
Justin M. Burgener, Jinfeng Zou, Zhen Zhao, Yangqiao Zheng, Shu Yi Shen, Shao Hui Huang, Sareh Keshavarzi, Wei Xu, Fei-Fei Liu, Geoffrey Liu, John N. Waldron, Ilan Weinreb, Anna Spreafico, Lillian L. Siu, John R. de Almeida, David P. Goldstein, Michael M. Hoffman, Daniel D. De Carvalho, Scott V. Bratman
Summary: The study demonstrates a tumor-naive detection of ctDNA in patients with head and neck squamous cell carcinoma using a multimodal approach of mutations and methylation, providing new avenues for clinical implementation in low ctDNA abundance cases. The results show a correlation between ctDNA abundance and shorter fragment lengths, as well as a high correlation between mutation- and methylation-based ctDNA abundance. Patients with detectable pretreatment ctDNA had worse overall survival, indicating the potential prognostic value of ctDNA detection methods.
CLINICAL CANCER RESEARCH
(2021)
Article
Environmental Sciences
Changqing Jiang, Ould el Moctar, Guiyong Zhang
Summary: Within the Space@Sea project, a multi-use floating concept was proposed to enlarge a floating platform using smaller structures. An analysis was conducted to identify the seakeeping criteria and their impact on functionality. The response of the floating concept was calculated in head waves considering nonlinearities and interactions. Assessments were carried out for safety and comfort criteria, with a focus on rotational motions and vertical acceleration as the determining factors.
FRONTIERS IN MARINE SCIENCE
(2023)
Article
Multidisciplinary Sciences
Caleb M. Brown, Darren H. Tanke, David W. E. Hone
Summary: Mammalian carnivores utilize prey bones to a higher degree than non-avian theropod dinosaurs, as shown by differences in tooth mark frequency and morphology. An isolated adult-sized hadrosaurid pedal ungual from the Dinosaur Park Formation in Alberta exhibits unique bite marks from a small- to medium-sized theropod dinosaur, potentially suggesting late-stage carcass consumption behavior similar to mammalian gnawing.
Article
Geology
Roy E. Smith, David M. Martill
Summary: This passage describes the discovery of a unique tooth from the Ifezouane Formation in eastern Morocco, which exhibits a series of severe paleopathologies, including enhanced inner curvature to the crown and the formation of three deep grooves. This is the first report of external dental pathologies in a spinosaurine spinosaurid tooth.
CRETACEOUS RESEARCH
(2023)
Article
Oncology
Tao Wei, Suyong Choi, Darya Buehler, Denis Lee, Ella Ward-Shaw, Richard A. Anderson, Paul F. Lambert
Summary: HPV infection is associated with a significant percentage of head and neck cancers, with the PI3K signaling pathway being highly activated in HPV-associated cancers. IQGAP1 has been shown to play a role in promoting HNSCC and influencing disease severity in MmuPV1-induced HNSCC, providing potential new insights and drug targets for the treatment of HPV-related neoplastic diseases.
Article
Engineering, Multidisciplinary
Andrea Angeli, Wim Desmet, Frank Naets
Summary: The study uses deep learning to find an approximation of the motion mappings in rigid multibody systems, utilizing an autoencoder neural network for nonlinear dimensionality reduction. A novel neural network training scheme is introduced, optimizing the decoder-function derivatives with the dynamics information of the multibody model to represent the motion manifold effectively.
COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING
(2021)
Article
Engineering, Civil
J. B. Blaauw, J. P. Schilder
Summary: This research presents a novel method to determine transient stresses in fairground attractions using a combination of Ansys' finite element models, model order reduction, and Simscape Multibody. The method provides similar accuracy to a full transient study but requires less computational time, making it suitable for real-time applications. The method also allows for the application of powerful tools within the electrical and control domain. Extensive comparisons are made between the new method and quasi-static structural analysis as well as full transient structural analysis, highlighting the advantages and disadvantages of each method on different structures.
ENGINEERING STRUCTURES
(2022)
Article
Oncology
Jorine A. Vermaire, Cornelis P. J. Raaijmakers, Evelyn M. Monninkhof, C. Rene Leemans, Robert J. Baatenburg de Jong, Robert P. Takes, Irma M. Verdonck-de Leeuw, Femke Jansen, Johannes A. Langendijk, Chris H. J. Terhaard, Caroline M. Speksnijder
Summary: This study aimed to investigate the course of swallowing problems in head and neck cancer patients after treatment and their associations with demographic, clinical, and lifestyle factors. The results showed that before treatment, 53% of patients reported swallowing problems, which changed over time. Swallowing problems were more pronounced in female patients, smokers, those with weight loss, advanced tumor stage, and 3 to 6 months after treatment. Patients with specific tumor sites and receiving specific treatment modalities experienced a longer eating duration after treatment, which did not return to baseline levels.
SUPPORTIVE CARE IN CANCER
(2022)
Review
Oncology
Xiao Han, Ruxian Tian, Cai Wang, Yumei Li, Xicheng Song
Summary: This review systematically summarizes the regulatory mechanisms of circular RNA (CircRNA) in head and neck squamous cell carcinoma (HNSCC), and explores its functions in tumor growth, cell death, angiogenesis, invasion, and metastasis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Ergonomics
Fang Wang, Jiajie Yin, Lin Hu, Mingliang Wang, Xin Liu, Karol Miller, Adam Wittek
Summary: This study investigates the effects of anthropometric differences between Western European and Chinese populations on the predicted pedestrian head kinematics and injury responses using multibody models. The results show that changes in anthropometry have a significant impact on both the initial boundary conditions and head injury indices in car-to-pedestrian collisions.
ACCIDENT ANALYSIS AND PREVENTION
(2022)
Article
Agriculture, Dairy & Animal Science
Carla M. Lusi, Helen M. S. Davies
Summary: In this study, researchers found a unidirectional mechanical connection between the equine forelimb, head and neck. The movements of the front limbs forwards and backwards caused specific movements in the head and neck, while similar movements in the head and neck did not affect the limbs. This mechanical connection may integrate with nervous controls to provide adjustments to postural disturbances and promote rapid locomotion.
Review
Biochemistry & Molecular Biology
Jason Tasoulas, Sonal Srivastava, Xiaonan Xu, Valentina Tarasova, Anastasios Maniakas, Florian A. Karreth, Antonio L. Amelio
Summary: The head and neck region is highly susceptible to cancer, with over 1.5 million new cases reported worldwide in 2020. Significant progress has been made in understanding the disease mechanisms and tailoring treatments to individual tumor characteristics using genetically engineered mouse models. These models have successfully replicated various aspects of head and neck cancers.
Article
Biochemistry & Molecular Biology
Raima Das, Sharbadeb Kundu, Shaheen Laskar, Yashmin Choudhury, Sankar Kumar Ghosh
Summary: This study identified significant germline variants in DNA repair and Tumour Suppressor genes that are associated with the development of head and neck cancer (HNC). These variants affect various mechanisms including DNA repair, tumor suppression, and transcriptional regulation, and can lead to the development of HNC. The findings of this study may be useful in developing preventive measures against HNC.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Oncology
Ines Leao, Catarina Garcia, Pedro Antunes, Ana Campolargo, Isabel Dias, Edite Coimbra, Pedro Oliveira, Horacio Zenha, Horacio Costa, Andreia Capela, Sofia Viamonte, Alberto J. Alves, Ana Joaquim
Summary: Head and neck cancer treatment can have negative impact on health-related quality of life and treatment efficacy. Exercise training may bring benefits to these patients. This study aimed to analyze the acute effects of treatment on patients and their preferences for exercise training. The findings suggest that an exercise training program can improve the physical fitness of patients and reduce toxicities.
Article
Ergonomics
Fang Wang, Junzhi Wu, Lin Hu, Chao Yu, Bingyu Wang, Xiaoqun Huang, Karol Miller, Adam Wittek
Summary: This study analyzed the head protection effectiveness of nine different helmets in two typical cycling accidents. The results showed that helmets can reduce the risk of head injury for cyclists, but they may increase rotational acceleration of the head. The predictions obtained using different injury criteria varied.
JOURNAL OF SAFETY RESEARCH
(2022)