Article
Medicine, General & Internal
Katsiaryna Vashkevich, Kathryn Janiuk, Nasim Maleki
Summary: This study found that irritable bowel syndrome (IBS) is significantly associated with anxiety disorders, especially in chronic pain patients with comorbid alcohol use disorders. These findings suggest that GI problems resulting from chronic alcohol use may play a key role in the comorbidity of anxiety disorders, chronic pain, and alcohol use disorders. Addressing GI problems in IBS patients with alcohol use disorders may help manage alcohol use disorders and recovery more effectively.
FRONTIERS IN MEDICINE
(2023)
Article
Anesthesiology
Jennifer S. Labus, Chencai Wang, Emeran A. Mayer, Arpana Gupta, Talia Oughourlian, Lisa Kilpatrick, Kirsten Tillisch, Lin Chang, Bruce Naliboff, Benjamin M. Ellingson
Summary: Preliminary evidence suggests sex differences in brain organization among individuals with IBS. This study aimed to investigate further differences in brain microstructure and organization between female and male IBS patients. The results showed extensive microstructural alterations in pain processing and integration areas in female IBS patients compared to male IBS patients. These findings support the hypothesis that symptoms in females with IBS may be driven by greater central sensitivity for multiple sensory stimuli.
Review
Gastroenterology & Hepatology
Vivek C. Goodoory, Mais Khasawneh, Christopher J. Black, Eamonn M. M. Quigley, Paul Moayyedi, Alexander C. Ford
Summary: This article conducted a meta-analysis to study the efficacy of probiotics in the treatment of irritable bowel syndrome (IBS). The study found that certain combinations of probiotics or strains may be beneficial for IBS, but the certainty of the evidence was low.
Article
Gastroenterology & Hepatology
Giovanni Marasco, Cesare Cremon, Maria Raffaella Barbaro, Giulia Cacciari, Francesca Falangone, Anna Kagramanova, Dmitry Bordin, Vasile Drug, Egidia Miftode, Pietro Fusaroli, Salem Youssef Mohamed, Chiara Ricci, Massimo Bellini, Mohammed Masudur Rahman, Luigi Melcarne, Javier Santos, Beatriz Lobo, Serhat Bor, Suna Yapali, Deniz Akyol, Ferdane Pirincci Sapmaz, Yonca Yilmaz Urun, Tugce Eskazan, Altay Celebi, Huseyin Kacmaz, Berat Ebik, Hatice Cilem Binicier, Mehmet Sait Bugdayci, Munkhtsetseg Banzragch Yagci, Husnu Pullukcu, Berrin Yalinbas Kaya, Ali Tureyen, Ibrahim Hatemi, Elif Sitre Koc, Goktug Sirin, Ali Riza Caliskan, Goksel Bengi, Esra Ergun Alis, Snezana Lukic, Meri Trajkovska, Keren Hod, Dan Dumitrascu, Antonello Pietrangelo, Elena Corradini, Magnus Simren, Jessica Sjoelund, Navkiran Tornkvist, Uday C. Ghoshal, Olga Kolokolnikova, Antonio Colecchia, Jordi Serra, Giovanni Maconi, Roberto De Giorgio, Silvio Danese, Piero Portincasa, Antonio Di Sabatino, Marcello Maggio, Elena Philippou, Yeong Yeh Lee, Daniele Salvi, Alessandro Venturi, Claudio Borghi, Marco Zoli, Paolo Gionchetti, Pierluigi Viale, Vincenzo Stanghellini, Giovanni Barbara
Summary: This study aimed to evaluate the prevalence of gastrointestinal symptoms and post-COVID-19 disorders of gut-brain interaction among hospitalized patients with SARS-CoV-2 infection. The results showed that patients with COVID-19 had higher rates of gastrointestinal symptoms on hospital admission and lower rates of constipation and hard stools at 12 months post-infection compared to the control group. Additionally, the rate of irritable bowel syndrome was significantly higher in patients with COVID-19 than in controls.
Article
Medicine, General & Internal
Mustafa Abdul Karim, Nadeen Al-Baz, Peter M. Haddad, Shuja M. Reagu, Majid Alabdulla
Summary: This case study suggests that buspirone is effective in treating refractory IBS. Further research is needed to evaluate the role of buspirone in IBS management.
Article
Medicine, General & Internal
Bjorn Gerdle, Karin Wahlen, Torsten Gordh, Bijar Ghafouri
Summary: Chronic widespread pain, including fibromyalgia, is characterized by generalized musculoskeletal pain and increased pain sensitivity. A study found differences in correlation patterns between plasma/muscle proteins and thermal pain thresholds in patients compared to healthy controls, with immune system proteins playing important roles in pain thresholds.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Isabelle Mack, Juliane Schwille-Kiuntke, Nazar Mazurak, Beate Niesler, Kurt Zimmermann, Hubert Moennikes, Paul Enck
Summary: This study investigated the effectiveness of a nonviable probiotic lysate (BL) in the treatment of IBS and found that BL was not effective for all IBS subtypes, but may offer a treatment option for IBS-D which needs further verification through adequately powered drug trials.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Anesthesiology
Anthony Lembo, John M. Kelley, Judy Nee, Sarah Ballou, Johanna Iturrino, Vivian Cheng, Vikram Rangan, Jesse Katon, William Hirsch, Irving Kirsch, Kathryn Hall, Roger B. Davis, Ted J. Kaptchuk
Summary: In the study on irritable bowel syndrome, open-label placebo (OLP) treatment was found to be superior to no-pill control (NPC) and had similar efficacy to double-blind placebo (DBP).
Review
Pharmacology & Pharmacy
Esther Colomier, Joost Algera, Chloe Melchior
Summary: Irritable bowel syndrome is a common disorder affecting the gut-brain axis, with four subtypes and a focus on pharmacological treatment for patients with IBS-D. The treatment remains challenging due to the heterogeneous patient population, lack of effective drugs, and multifactorial pathophysiology. Healthcare professionals can use a proposed algorithm for treating individual patients with IBS-D.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Michael Camilleri, Guy Boeckxstaens
Summary: This article evaluates the evidence that targeted pathophysiological mechanisms and customized treatments can be an alternative approach to treating patients with irritable bowel syndrome (IBS). The authors conducted a literature review on the mechanisms and treatments of IBS, identifying various noninvasive clinical tests that can assess the underlying mechanisms responsible for symptom generation. These mechanisms include rectal evacuation disorders, abnormal transit, visceral hypersensitivity or hypervigilance, bile acid diarrhea, sugar intolerances, barrier dysfunction, the microbiome, immune activation, and chemicals released by these mechanisms. The authors also recognized the basic molecular mechanisms contributing to these pathophysiologies, offering opportunities for interventions with medications targeted at specific food components, receptors, and potentially the microbiome. Although the evidence supporting interventions for each mechanism varies, the current state-of-the-art allows for a shift from symptom-based treatment to individualized treatment guided by pathophysiology and clinically identified biomarkers.
Review
Pediatrics
Elvira Ingrid Levy, Charlotte De Geyter, Abdelhalim Ouald Chaib, Berthold Albert Aman, Badriul Hegar, Yvan Vandenplas
Summary: There are limited randomized controlled trials on managing pediatric IBS, with most intervention trials targeting changes to the gastrointestinal microbiome. Heterogeneity in study designs and outcomes make it difficult to formulate recommendations. Insufficient evidence exists to recommend therapeutic interventions in pediatric IBS, despite the association with dysbiosis. More prospective trials are needed.
Review
Gastroenterology & Hepatology
Elton Dajti, Leonardo Frazzoni, Veronica Iascone, Matteo Secco, Amanda Vestito, Lorenzo Fuccio, Leonardo Henry Eusebi, Pietro Fusaroli, Fernando Rizzello, Carlo Calabrese, Paolo Gionchetti, Franco Bazzoli, Rocco Maurizio Zagari
Summary: Faecal calprotectin is a reliable test with high sensitivity and specificity for distinguishing patients with inflammatory bowel disease from those with irritable bowel syndrome. It seems to have a better sensitivity in Western countries and at a cut-off of <= 50 mu g/g.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Pharmacology & Pharmacy
Di Qin, Qing-Feng Tao, Shi-Le Huang, Min Chen, Hui Zheng
Summary: This study compared the efficacy of eluxadoline and antispasmodics in the treatment of irritable bowel syndrome (IBS). The results showed that eluxadoline was as effective as antispasmodics in relieving abdominal pain, but had more reported adverse events. Therefore, antispasmodics remain the first choice for the treatment of IBS.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Madhusudan Grover, Antonio Berumen, Stephanie Peters, Ting Wei, Margaret Breen-Lyles, William S. Harmsen, Irene Busciglio, Duane Burton, Maria Vazquez Roque, Kenneth R. DeVault, Michael Camilleri, Michael Wallace, Surendra Dasari, Helmut Neumann, Lesley A. Houghton
Summary: This study found that patients with irritable bowel syndrome (IBS) had a stronger symptom response to small intestinal lipid infusion, which was associated with the expression of TRPV channels, suggesting that TRPV-mediated small intestinal chemosensitivity may play a role in post-meal symptoms in IBS.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Gastroenterology & Hepatology
Sarah Zaza, John Alverdy
Summary: This article highlights the challenges faced by surgeons when dealing with patients suffering from IBS who present with a defined anatomic abnormality. It emphasizes the importance of a multidisciplinary approach to avoid unnecessary surgery in these patients.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Clinical Neurology
Niklas Stabell, Audun Stubhaug, Trond Flaegstad, Emeran Mayer, Bruce D. Naliboff, Christopher S. Nielsen
Article
Infectious Diseases
Niklas Stabell, Ellen Nordal, Einar Stensvold, Karianne Wiger Gammelsrud, Bendik Lund, Arne Taxt, Frauke Buhring, Margrethe Greve-Isdahl, Hans Petter Fornebo, Gunnar Skov Simonsen, Claus Klingenberg
SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES
(2008)
Article
Oncology
Michael C. Fruhwald, Martin Hasselblatt, Karolina Nemes, Susanne Bens, Mona Steinbugl, Pascal D. Johann, Kornelius Kerl, Peter Hauser, Eduardo Quiroga, Palma Solano-Paez, Veronica Biassoni, Maria Joao Gil--Costa, Martha Perek-Polnik, Marianne van de Wetering, David Sumerauer, Jane Pears, Niklas Stabell, Stefan Holm, Heinz Hengartner, Nicolas U. Gerber, Michael Grotzer, Joachim Boos, Martin Ebinger, Stefan Tippelt, Werner Paulus, Rhoikos Furtwangler, Pablo Hernaiz-Driever, Harald Reinhard, Stefan Rutkowski, Paul-Gerhardt Schlegel, Irene Schmid, Rolf-Dieter Kortmann, Beate Timmermann, Monika Warmuth-Metz, Uwe Kordes, Joachim Gerss, Karsten Nysom, Reinhard Schneppenheim, Reiner Siebert, Marcel Kool, Norbert Graf
Article
Pediatrics
Niklas Stabell, Maria Averina, Trond Flaegstad
Summary: The study found a high prevalence of iron deficiency and anaemia among adolescents aged 15-19, with girls more likely to be affected than boys, and the majority of cases remained chronic two years later. Different lifestyle habits and levels of physical activity were associated with iron deficiency in adolescents.
Article
Clinical Neurology
Niklas Stabell, Trond Flgstad, Audun Stubhaug, Christopher Sivert Nielsen
SCANDINAVIAN JOURNAL OF PAIN
(2014)