Article
Cell Biology
Jimena Perez-Sanchez, Steven J. Middleton, Luke A. Pattison, Helen Hilton, Mosab Ali Awadelkareem, Sana R. Zuberi, Maria B. Renke, Huimin Hu, Xun Yang, Alex J. Clark, Ewan St John Smith, David L. Bennett
Summary: Hyperexcitability in sensory neurons plays a key role in neuropathic pain, and the chemogenetic system PSAM(4)-GlyR can effectively suppress this hyperexcitability and produce reversible effects in both mouse and human sensory neurons. This system has great potential for application in pain treatment.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Clinical Neurology
Li-Ping Xia, Hao Luo, Qiang Ma, Ya-Kai Xie, Wei Li, Hailan Hu, Zhen-Zhong Xu
Summary: GPR151 in nociceptive dorsal root ganglion neurons plays a crucial role in the pathogenesis of neuropathic pain by controlling neuronal hyperexcitability and promoting spinal microglial activation, indicating its potential as a therapeutic target for neuropathic pain treatment.
Article
Pharmacology & Pharmacy
Mohammad-Reza Ghovanloo, Mark Estacion, Grant P. Higerd-Rusli, Peng Zhao, Sulayman Dib-Hajj, Stephen G. Waxman
Summary: CBG selectively inhibits Na(v)1.7 channels in DRG neurons, contributing to its analgesic properties. At lower concentrations, CBG blocks sodium G(max) and slows recovery from inactivation, while higher concentrations also induce a hyperpolarizing shift in the half-voltage of inactivation. Experimental results suggest that CBG attenuates DRG excitability.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Cell Biology
Bin Pan, Di Guo, Li Jing, Ke Li, Xin Li, Gen Li, Xiao Gao, Zhi-Wen Li, Wei Zhao, Hu Feng, Meng-Han Cao
Summary: This study reveals the role of lncRNA Pvt1 in the repair of peripheral nerve injury and highlights it as a potential treatment target. The findings show that Pvt1 increases c-Jun expression through sponging miRNA-214, enhancing the proliferation and migration of Schwann cells, and improving the regeneration of injured sciatic nerves and locomotor function in mice.
NEURAL REGENERATION RESEARCH
(2023)
Article
Neurosciences
Donghang Zhang, Wenling Zhao, Jin Liu, Mengchan Ou, Peng Liang, Jia Li, Yali Chen, Daqing Liao, Siqi Bai, Jiefei Shen, Xiangdong Chen, Han Huang, Cheng Zhou
Summary: NALCN plays a significant role in chronic neuropathic pain, and knockdown of NALCN can significantly alleviate pain-related symptoms.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Medicine, Research & Experimental
Yiru Wang, Xinyi Wang, Renfei Qi, Ying Lu, Yu Tao, Dongsheng Jiang, Yufang Sun, Xinghong Jiang, Chunfeng Liu, Yuan Zhang, Jin Tao
Summary: The study reveals a novel mechanism by which IL-33/ST2 suppresses A-type K+ currents in sensory neurons, leading to increased neuronal excitability and pain sensitivity. This mechanism involves the suppression of the tumorigenicity 2 (ST2) receptor and the activation of a Syk-dependent p38 beta signaling pathway. Targeting IL-33/ST2-mediated p38 beta signaling may represent a therapeutic approach to ameliorate pain behaviors.
Article
Biology
Yucheng Xiao, Jonathan W. Theile, Agnes Zybura, Yanling Pan, Zhixin Lin, Theodore R. Cummins
Summary: In this study, the authors demonstrate that I-NaR can be reconstituted in a heterologous system by coexpression of sodium channel alpha-subunits and A-type fibroblast growth factor homologous factors (FHFs). They also identify the N-terminus of FHF as the critical molecule responsible for A-type FHFs-mediated I-NaR. Moreover, knockdown of FHF4A significantly reduces I-NaR amplitude and suppresses excitability in nociceptive sensory neurons.
Article
Orthopedics
D. Chao, H. Tran, Q. H. Hogan, B. Pan
Summary: GFS produces analgesia in MIA-OA rats at least in part by producing blockade of afferent inputs, possibly also by blocking efferent activity from the dorsal horn.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Neurosciences
Nivanthika K. Wimalasena, Daniel G. Taub, Jaehoon Shim, Sara Hakim, Riki Kawaguchi, Lubin Chen, Mahmoud El-Rifai, Daniel H. Geschwind, Sulayman D. Dib-Hajj, Stephen G. Waxman, Clifford J. Woolf
Summary: Mutations in the Scn9a gene can lead to various pain and neuropathy disorders. Previous studies have shown that the Nav1.7 gene mutation affects sodium conductance and neuronal excitability, but does not affect mechanical and thermal sensitivity in young mice. However, this new research demonstrates that as mice with this mutation age, they develop insensitivity to pain and cold, as well as skin lesions. Electrophysiology and RNA sequencing reveal a loss of sodium conductance and decreased expression of cLTMR genes in aged mice with the mutation.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Chemistry, Multidisciplinary
Yingqiao Wang, Raghav Garg, Jane E. Hartung, Adam Goad, Dipna A. Patel, Flavia Vitale, Michael S. Gold, Yury Gogotsi, Tzahi Cohen-Karni
Summary: Utilizing nanomaterial-assisted photothermal stimulation, Ti3C2Tx (MXene) demonstrates excellent potential as a candidate for remote, non-genetic, optical modulation of neuronal electrical activity with high spatiotemporal resolution. The material's photothermal response, low cytotoxicity, and ease of large-scale synthesis make it a promising tool for modulating electrophysiology at various scales.
Article
Multidisciplinary Sciences
Haohao Wu, Charles Petitpre, Paula Fontanet, Anil Sharma, Carmelo Bellardita, Rolen M. Quadros, Paulo R. Jannig, Yiqiao Wang, J. Alexander Heimel, Kylie K. Y. Cheung, Simone Wanderoy, Yang Xuan, Konstantinos Meletis, Jorge Ruas, Channabasavaiah B. Gurumurthy, Ole Kiehn, Saida Hadjab, Francois Lallemend
Summary: The study identified three main types of proprioceptive neurons (Ia, Ib and II PNs) and found that they segregate into eight distinct subgroups. Importantly, Ia-PN subtypes are plastic, suggesting a role in adaptive proprioception during motor behavior.
NATURE COMMUNICATIONS
(2021)
Article
Clinical Neurology
Yingda Li, Michael Y. Wang
Summary: This study demonstrated the feasibility of direct intraoperative neuromonitoring within Kambin's triangle in transforaminal endoscopic surgery for the first time. The incidence of new onset symptoms increased with lower stimulation thresholds, and 8 milliampere seems to be a reasonable compromise between sensitivity and specificity for this monitoring technique.
Article
Biochemistry & Molecular Biology
Masaki Matsubara, Yukiko Muraki, Noriyuki Hatano, Hiroka Suzuki, Katsuhiko Muraki
Summary: The synthetic compound JT010 selectively activates human TRPA1 (hTRPA1) but has little effect on mouse TRPA1 (mTRPA1). This finding is important for understanding the function of TRPA1 and the mechanisms involved in inflammatory pain sensation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Adam J. Dourson, Zachary K. Ford, Kathryn J. Green, Carolyn E. McCrossan, Megan C. Hofmann, Renita C. Hudgins, Michael P. Jankowski
Summary: The study found that growth hormone (GH) plays an important regulatory role in neonatal pain processing, inhibiting peripheral hypersensitivity through GH receptor (GHr) signaling in primary afferents. After injury, a macrophage-dependent displacement of GH at the injury site was found to regulate neuronal transcription through SRF regulation.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Qing-Rui Qin, Zhong-Qing Xu, Ting-Ting Liu, Xue-Mei Li, Chun-Yu Qiu, Wang-Ping Hu
Summary: The activation of CCK-8/CCK2R enhances ASIC-mediated electrophysiological activity in DRG neurons and nociception in rats, suggesting that CCK-8/CCK2R could be an important therapeutic target for ASIC-mediated pain.
Article
Behavioral Sciences
Lin Chen, Song Li, Jie Cai, Tian-Jiao Wei, Ling -Yu Liu, Hong-Yan Zhao, Bo-Heng Liu, Hong-Bo Jing, Zi-Run Jin, Min Liu, You Wan, Guo-Gang Xing
BEHAVIOURAL BRAIN RESEARCH
(2018)
Article
Neurosciences
Qing-Ying Liu, Wen Chen, Shuang Cui, Fei-Fei Liao, Ming Yi, Feng-Yu Liu, You Wan
NEUROSCIENCE RESEARCH
(2019)
Article
Neurosciences
Rui Zhou, Jing Wang, Wenjing Qi, Feng-Yu Liu, Ming Yi, Huailian Guo, You Wan
FRONTIERS IN NEUROSCIENCE
(2018)
Article
Multidisciplinary Sciences
Lupeng Yue, Fengrui Zhang, Xuejing Lu, You Wan, Li Hu
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2019)
Article
Neurosciences
Qingying Liu, Wen Chen, Xiaocen Fan, Jiaxin Wang, Su Fu, Shuang Cui, Feifei Liao, Jie Cai, Xinhong Wang, Yanhua Huang, Li Su, Lijun Zhong, Ming Yi, Fengyu Liu, You Wan
EXPERIMENTAL NEUROLOGY
(2019)
Article
Neurosciences
Longyu Ma, Yuqi Zhang, Lupeng Yue, Xueying Zhang, Shuang Cui, Feng-Yu Liu, You Wan, Ming Yi
JOURNAL OF PHYSIOLOGY-LONDON
(2019)
Article
Neurosciences
Cheng Wang, Yu Zhang, Shan Shao, Shuang Cui, You Wan, Ming Yi
Article
Cell Biology
Longyu Ma, Lupeng Yue, Yuqi Zhang, Yue Wang, Bingxuan Han, Shuang Cui, Feng-Yu Liu, You Wan, Ming Yi
Article
Cell & Tissue Engineering
Jie Zheng, Hong-Lian Li, Na Tian, Fei Liu, Lu Wang, Yaling Yin, Lupeng Yue, Longyu Ma, You Wan, Jian-Zhi Wang
Article
Oncology
Jiheng Chen, Yunxiao Zhang, Xiaoxi Li, You Wan, Xinqiang Ji, Wei Wang, Xiaozheng Kang, Wanpu Yan, Zhiyi Fan
Article
Neurosciences
Jun Ma, Zifang Zhao, Shuang Cui, Feng-Yu Liu, Ming Yi, You Wan
FRONTIERS IN NEUROSCIENCE
(2019)
Article
Multidisciplinary Sciences
Haojie Sun, Su Fu, Shuang Cui, Xiangsha Yin, Xiaoyan Sun, Xuetao Qi, Kun Cui, Jiaxin Wang, Longyu Ma, Feng-Yu Liu, Fei-Fei Liao, Xin-Hong Wang, Ming Yi, You Wan
Editorial Material
Neurosciences
Haojie Sun, Jie Zheng, Ming Yi, You Wan
NEUROSCIENCE BULLETIN
(2021)
Article
Neurosciences
Yue Wang, Naizheng Liu, Longyu Ma, Lupeng Yue, Shuang Cui, Feng-Yu Liu, Ming Yi, You Wan
Summary: As a major component of the limbic system, the hippocampus, specifically the ventral hippocampal CA1 (vCA1) region, is involved in the processing of pain perception and chronicity. This study used in vivo electrophysiological recording to characterize vCA1 pyramidal neurons and their encoding of nociceptive information. It was found that these neurons exhibited inhibitory or excitatory responses to plantar stimuli, with functional heterogeneity observed in neuropathic pain conditions. Increased theta power and theta-spike coupling in vCA1 were correlated with nociceptive behaviors. Optogenetic and chemogenetic manipulations of vCA1 activity further confirmed its role in pain modulation.
NEUROSCIENCE BULLETIN
(2023)
Article
Biochemistry & Molecular Biology
Yin Yang, Qian Li, Qi-Hua He, Ji-Sheng Han, Li Su, You Wan
EXPERIMENTAL AND MOLECULAR MEDICINE
(2018)