Article
Neurosciences
Lewis S. Crawford, Emily P. Mills, Theo Hanson, Paul M. Macey, Rebecca Glarin, Vaughan G. Macefield, Kevin A. Keay, Luke A. Henderson
Summary: Perception of pain can be influenced by expectations and beliefs. This study used ultra-high-field fMRI to investigate the brainstem pathways involved in placebo analgesia and nocebo hyperalgesia, revealing differential activation of key pain modulatory nuclei during these phenomena.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Philipp Graeff, Alina Itter, Katharina Wach, Ruth Ruscheweyh
Summary: Individual differences account for a significant portion of variance in CPM compared to age, sex, and CS intensity. This suggests that predictive capability of commonly considered factors may be limited and future models should take into account individual differences.
Article
Clinical Neurology
Miriam Kunz, Stefanie F. Bunk, Anna J. Karmann, Karl-Juergen Baer, Stefan Lautenbacher
Summary: This study investigated the sensitivity of facial expressions of pain in capturing endogenous pain inhibition during CPM paradigms. The results showed that both pain-relevant facial responses and pain ratings were significantly reduced during phasic heat pain when participants simultaneously immersed their hand in a hot water bath, indicating that facial expressions are sensitive enough to capture CPM effects. Furthermore, the changes in pain-relevant facial responses and NRS ratings were significantly correlated, suggesting that facial expressions can be a promising approach for assessing pain modulation effects.
JOURNAL OF PAIN RESEARCH
(2021)
Article
Neurosciences
Philipp Graeff, Regina Stacheneder, Laura Alt, Ruth Ruscheweyh
Summary: Psychological factors have limited contribution to inter-individual differences in conditioned pain modulation (CPM) in healthy participants, leaving the large inter-individual variability in CPM largely unexplained.
Article
Clinical Neurology
Jessica L. Hoehn, Lynnda M. Dahlquist, Julia A. Zeroth
Summary: This study investigated conditioned pain modulation (CPM) in children and found that even young children as young as 6 years old demonstrate CPM effects. The study controlled for sensory distraction and concluded that the obtained CPM responses were not due to nonspecific effects. The findings suggest that CPM paradigms can be used to study pediatric endogenous pain inhibition and improve pain interventions.
Article
Pharmacology & Pharmacy
Fabrizio Benedetti, Martina Amanzio, Fabio Giovannelli, Karen Craigs-Brackhahn, Aziz Shaibani
Summary: This study revealed that participants who read a list of possible adverse events before receiving a placebo treatment reported more adverse events compared to those who did not read the list. Moreover, increased activity in the hypothalamic-pituitary-adrenal axis and higher state anxiety scores were observed in those who reported multiple adverse events, indicating a potential neuroendocrine mechanism following placebo administration.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Neurosciences
Daniel S. Harvie, Eva Y. Poolman, Victoria J. Madden, Nick A. Olthof, Michel W. Coppieters
Summary: Pain-associated cues may induce hyperalgesia to some degree, particularly in relation to stimulus intensity during and after the initial painful experience.
EXPERIMENTAL BRAIN RESEARCH
(2022)
Article
Multidisciplinary Sciences
Roni Shafir, Maya Israel, Luana Colloca
Summary: The placebo effect demonstrates how positive expectancies shape the effectiveness of various treatments. This study shows that placebo-induced expectancies can improve individuals' internal emotion regulation attempts. The placebo distraction was effective in reducing fear of pain and was preferred by the participants.
SCIENTIFIC REPORTS
(2023)
Article
Biology
Sydney Trask, Jeffrey S. Mogil, Fred J. Helmstetter, Cheryl L. Stucky, Katelyn E. Sadler
Summary: The mechanisms underlying the transition from acute to chronic pain are still unclear, but it may involve the persistence or strengthening of pain memories acquired through associative learning. Recent studies have shown that contextual cues play a critical role in regulating pain memory. Animals and humans exhibit increased pain sensitivity in environments associated with painful experiences. This study suggests that pain perception and activation of endogenous opioid systems can be modified through psychological association with environmental cues.
Article
Anesthesiology
Stephen Bruehl, Christopher R. France, Amanda L. Stone, Rajnish Gupta, Asokumar Buvanendran, Melissa Chont, John W. Burns
Summary: The study found that the level of conditioned pain modulation (CPM) was associated with the analgesic and subjective responses to morphine, with greater CPM usually resulting in better effects of the drug. There was minimal moderation by sex or chronic pain status, but men may show a stronger positive relationship between CPM and morphine analgesia in certain aspects of evoked pain.
CLINICAL JOURNAL OF PAIN
(2021)
Article
Psychiatry
Eleonora Maria Camerone, Simone Battista, Fabrizio Benedetti, Elisa Carlino, Lucia Grazia Sansone, Luca Buzzatti, Aldo Scafoglieri, Marco Testa
Summary: This study investigates the role of temporal suggestions in modulating the timing of nocebo hyperalgesia. The results show that hyperalgesia occurs earlier in the group that expected the effect to set in early, while delayed onset of hyperalgesia is observed in the group that expected the effect to set in later.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Biology
Laura R. Koenen, Robert J. Pawlik, Adriane Icenhour, Ljubov Petrakova, Katarina Forkmann, Nina Theysohn, Harald Engler, Sigrid Elsenbruch
Summary: Through functional magnetic resonance imaging studies in healthy humans, Koenen et al. investigated the process of negative pain-related expectations formed and sustained by classical conditioning. They found that conditioned responses to interoceptive threat predictors were enhanced, primarily involving the insula and cingulate cortex. Interoceptive threats had a greater impact on extinction efficacy, suggesting a preference for learning and remembering interoceptive danger signals in the face of multiple threats.
COMMUNICATIONS BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yue-Li Sun, Min Yao, Yue-Feng Zhu, Meng-Chen Yin, Jin-Tao Liu, Xin Chen, Jin Huang, Yu-Xiang Dai, Wen-Hao Wang, Zeng-Bin Ma, Yong-Jun Wang, Xue-Jun Cui
Summary: The study suggests that patients with shorter disease duration are more likely to overestimate their pain severity in neck pain treatment, due to their limited experience in pain perception, tolerance, and analgesia expectation.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, General & Internal
Morton E. Tavel
Summary: The placebo effect refers to improvements in illnesses or subjective symptom reduction caused by interventions with no known physical effects, while the nocebo effect refers to undesirable symptoms or illnesses following interventions with no known physical effects, and it may play a role in chronic illnesses without objective confirmation. Both placebo and nocebo effects are powerful and must be understood by practitioners and researchers in clinical medicine. Individual caregivers can apply these principles to modify patient care outcomes.
AMERICAN JOURNAL OF MEDICINE
(2022)
Article
Neurosciences
Lewis S. Crawford, Emily P. Mills, A. Peek, Vaughan G. Macefield, Kevin A. Keay, Luke A. Henderson
Summary: Prior experiences, conditioning cues, and expectations of improvement play important roles in placebo analgesia expression, which is mediated by the dorsolateral prefrontal cortex (DLPFC). This study investigated the biochemistry and function of DLPFC in 38 healthy individuals during placebo analgesia. The results showed that the concentration of glutamate in DLPFC was inversely correlated with pain rating variability, and there was altered functional connectivity between DLPFC and the midbrain periaqueductal gray. These findings suggest that DLPFC is involved in formulating stimulus-response relationships during conditioning and translating them into altered cortico-brainstem functional relationships for placebo analgesia expression.
Article
Anesthesiology
Liat Honigman, Ofrit Bar-Bachar, David Yarnitsky, Elliot Sprecher, Yelena Granovsky
Article
Neurosciences
Agustin Melo-Carrillo, Rodrigo Noseda, Rony Nir, Aaron J. Schain, Jennifer Stratton, Andrew M. Strassman, Rami Burstein
JOURNAL OF NEUROSCIENCE
(2017)
Article
Anesthesiology
Keren Grinberg, Michal Granot, Lior Lowenstein, Liora Abramov, Irit Weissman-Fogel
Article
Multidisciplinary Sciences
Rodrigo Noseda, Alice J. Lee, Rony-Reuven Nir, Carolyn A. Bernstein, Vanessa M. Kainz, Suzanne M. Bertisch, Catherine Buettner, David Borsook, Rami Burstein
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Anesthesiology
Keren Grinberg, Michal Granot, Lior Lowenstein, Liora Abramov, Irit Weissman-Fogel
CLINICAL JOURNAL OF PAIN
(2018)
Article
Public, Environmental & Occupational Health
Michal Granot, Yoram Yovell, Eli Somer, Ahuva Beny, Ronit Sadger, Ronit Uliel-Mirkin, Yaara Zisman-Ilani
Article
Clinical Neurology
Pora Kuperman, Yelena Granovsky, Michal Granot, Hany Bahouth, Shiri Fadel, Gila Hyams, Hen Ben Lulu, Osnat Aspis, Rabia Salame, Julia Begal, David Hochstein, Shahar Grunner, Liat Honigman, Maya Reshef, Elliot Sprecher, Noam Bosak, Michele Sterling, David Yarnitsky
Article
Anesthesiology
Roi Treister, Liat Honigman, Oluwadolapo D. Lawal, Ryan K. Lanier, Nathaniel P. Katz
Article
Neurosciences
Mariana Agostinho, Rita Canaipa, Liat Honigman, Roi Treister
FRONTIERS IN NEUROSCIENCE
(2019)
Article
Clinical Neurology
Rita Canaipa, Diogo Mendonca, Mariana Agostinho, Vanda Nascimento, Liat Honigman, Roi Treister
Summary: The study found that professional dancers report their pain with less variability compared to controls, possibly due to their extensive training in attending to body signals. Practice experience and emotional awareness were found to correlate with pain reporting variability.
Article
Anesthesiology
Nitza Segal, Dorit Pud, Hagai Amir, Motti Ratmansky, Pora Kuperman, Liat Honigman, Roi Treister
Summary: Combining mirror therapy with tDCS resulted in a strong and long-lasting analgesic effect for patients with phantom pain, significantly reducing pain intensity and outperforming the effects of mirror therapy alone in the long term. These findings may aid in understanding the underlying mechanisms of phantom pain.
Article
Nursing
Dafna Zontag, Pora Kuperman, Liat Honigman, Roi Treister
Summary: The study found that children's self-reported pain scores were significantly higher than those reported by nurses, both before and after analgesic consumption. There were no significant differences in NPS scores reported by children and parents before and after analgesic consumption.
INTERNATIONAL JOURNAL OF NURSING STUDIES
(2022)
Article
Critical Care Medicine
Josef Haik, Yehuda Ullman, Eyal Gur, Dean Ad-El, Dana Egozi, Dani Kruchevsky, Sivan Zissman, Erik Biros, Rony-Reuven Nir, Rachel Kornhaber, Michelle Cleary, Moti Harats
Summary: This study evaluated the efficacy and safety of a portable electrospun nanofibrous matrix compared with standard dressing techniques in managing donor site wounds. The results showed that the nanofiber matrix had similar effectiveness and safety to standard wound care in terms of dermal healing, re-epithelialization time, adverse events, and pain.
JOURNAL OF BURN CARE & RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
Hadass Goldblatt, Michal Granot, Eti Zarbiv
QUALITATIVE HEALTH RESEARCH
(2019)
Article
Neurosciences
Yelena Granovsky, Hadas Nahman-Averbuch, Mogher Khamaisi, Michal Granot