期刊
PAIN
卷 152, 期 2, 页码 254-258出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1016/j.pain.2010.08.047
关键词
Migraine; Chronic migraine; Magnetoencephalography; Visual evoked magnetic field; Visual cortical excitability; Human
资金
- National Science Council (Taiwan) [NSC 94-2314-B-038-014, NSC-96-2314-B-075-073-MY3, NSC-96-2628-B-010-030-MY3, NSC98-2321-B-010-007, NSC-95-2314-B-010-031-MY3]
- Taipei Veterans General Hospital [V98B2-004, V99C1-063, V97ER3-006, VGHUST97-P6-24, V97C1-034, VGH ER3-98-002, VGH-S4-98-018, VGH-C1-99-156, VGH-ER3-99-006]
- Ministry of Education, Aim for the Top University Plan
Episodic migraine (EM) may evolve into the more disabling chronic migraine (CM, monthly migraine days >= 8 and headache days >= 15) with unknown mechanism. Aiming to elucidate the pathophysiology of CM and its relationship with EM, this study characterized the visual cortical responses in CM and EM. Neuromagnetic visual evoked responses to left-hemifield checkerboard reversals were obtained in patients with EM (interictal or ictal states), CM (interictal) and age-matched controls. For each subject, the 1500 evoked responses were sequentially divided into 30 blocks and percentage changes of P100m amplitude in blocks 2, 9, 16, 23, and 30 compared to the first block were computed to assess habituation. At the end of visual stimulation (block 30), P100m amplitude was decreased (habituated) in the controls (n = 32) (35.2 +/- 2.6 nAm vs. 41.9 +/- 2.7, p = 0.005) but increased (potentiated) in the interictal state of EM (n = 29) (39.7 +/- 3.8 vs. 33.5 +/- 3.0, p = 0.007). In CM (n = 25), P100m was habituated (46.5 +/- 2.9 vs. 51.6 +/- 3.7, p = 0.013) but higher at the initial block than in those of the interictal state of EM (p = 0.001). These CM features also characterized the P100m in the ictal state of EM (n = 9). There was no difference of P100m between CM and ictal state of EM. In conclusion, patients with CM demonstrate a persistent ictal-like excitability pattern of the visual cortex between migraine attacks which may implicate central inhibitory dysfunction. (C) 2010 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.
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