Article
Cardiac & Cardiovascular Systems
F. E. Vervaat, A. van Der Gaag, C. Smetsers, P. C. Barneveld, M. Van't Veer, K. Teeuwen, H. van Suijlekom, L. Dekker, I. F. Wijnbergen
Summary: This study aims to investigate the efficacy of high density spinal cord stimulation in patients with refractory angina pectoris. The primary outcome is the reduction in myocardial ischemia measured by myocardial perfusion positron emission tomography scan. The study uses a randomized crossover design with a 1-year follow-up period.
CLINICAL CARDIOLOGY
(2023)
Article
Medicine, Research & Experimental
Fabienne E. Vervaat, Hans van Suijlekom, Inge Wijnbergen
Summary: This study aimed to investigate the safety of spinal cord stimulation in patients with RAP and a CIED. The results showed that there was no interference between the spinal cord stimulator and CIED in 22 patients with both devices.
Article
Anesthesiology
Brendan Langford, Christine Hunt, Amir Lerman, William D. Mauck
Summary: SCS is utilized to treat refractory angina, and requires a comprehensive evaluation of patients considering their cardiovascular comorbidities. Having baseline data is crucial for assessing treatment success.
Article
Anesthesiology
Brendan Langford, Christine Hunt, Amir Lerman, William D. Mauck
Summary: This study utilized SAQ to evaluate angina symptoms in 18 patients with RAP undergoing SCS treatment. The majority of patients showed reduced physical limitations, favorable angina frequency scores, and high treatment satisfaction, indicating the effectiveness of SAQ in assessing function, pain, and satisfaction in RAP patients.
Review
Cardiac & Cardiovascular Systems
Allan Davies, Kim Fox, Alfredo R. Galassi, Shmuel Banai, Seppo Yla-Herttuala, Thomas F. Luescher
Summary: This review addresses the treatment of refractory angina, covering both traditional pharmacological approaches and advanced revascularization strategies. Emphasizing the importance of treating refractory angina to improve patients' quality of life.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Weijing Liu, Ximin Fan, Jianying Shen, Mengyun Zhu, Xuehua Fan, Yawei Xu, Liqiong Hong
Summary: Cardiac shock wave therapy (CSWT) is a non-invasive and safe treatment option for chronic refractory angina pectoris (CRAP) patients, which can improve myocardial perfusion and reduce clinical symptoms without increasing adverse effects.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
F. E. Vervaat, A. van der Gaag, K. Teeuwen, H. van Suijlekom, L. Dekker, I. F. Wijnbergen
Summary: This study aims to determine the long-term efficacy and safety of spinal cord stimulation (SCS) in patients with refractory angina pectoris (RAP). The results demonstrate that long-term SCS leads to significant improvement in quality of life, reduction in angina frequency, and low risk of complications.
IJC HEART & VASCULATURE
(2023)
Article
Cardiac & Cardiovascular Systems
Jules Mesnier, Gregory Ducrocq, Nicolas Danchin, Roberto Ferrari, Ian Ford, Jean-Claude Tardif, Michal Tendera, Kim M. Fox, Philippe Gabriel Steg
Summary: The study found that angina affects almost one-quarter of stable coronary artery disease patients, but resolves without events or coronary revascularization in most cases. Patients whose angina resolved within one year with conservative management had outcomes similar to those without angina, while persistence or occurrence of angina was associated with worse outcomes.
Article
Medicine, General & Internal
Soshi Samejima, Claire Shackleton, Raza N. Malik, Kawami Cao, Anibal Bohorquez, Tom E. Nightingale, Rahul Sachdeva, Andrei V. Krassioukov
Summary: Spinal cord injury (SCI) leads to severe cardiovascular dysfunction, and autonomic dysreflexia (AD) is one of the causes of high blood pressure in SCI patients. Recently, spinal cord stimulation (SCS) has been considered as a potential intervention to alleviate unstable blood pressure after SCI. This case series demonstrates the real-time effect of epidural SCS (eSCS) at the lumbosacral spinal cord in mitigating AD in individuals with SCI.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Anesthesiology
Nantthasorn Zinboonyahgoon, Niruji Saengsomsuan, Naruechit Chaikittiporn, Suratsawadee Wangnamthip, Chayanis Kositamongkol, Pochamana Phisalprapa
Summary: This study evaluated the cost-effectiveness and cost-utility of combining spinal cord stimulation (SCS) with conventional management (CMM) in patients with chronic refractory pain in Thailand. The results showed that SCS was effective in pain control and improving quality of life, but it was not a cost-effective treatment option in the current context in Thailand.
Article
Multidisciplinary Sciences
Jeonghoon Oh, Alexander G. Steele, Blesson Varghese, Catherine A. Martin, Michelle S. Scheffler, Rachel L. Markley, Yi-Kai Lo, Dimitry G. Sayenko
Summary: Transcutaneous spinal stimulation is a promising method for restoring upper limb function in patients with spinal cord injuries. By selectively stimulating different electrode placements, specific groups of upper limb muscles can be activated. This approach may enhance efficacy and help patients recover more diverse motor activities.
Article
Plant Sciences
Lin Chen, Guang Fu, Qi Hua, Hai-Yan Zhu, Yue Deng, Wei Wu, Yu-Jie Zhao, Xi-Yan Yang, Bai-Song Yang, Ya-Bin Zhou, Jun Liu, Ya-Nan Yu, Bing-Wei Chen, Xian Wang, Zhong Wang
Summary: After 28 days of treatment with Danhong injection in patients with unstable angina pectoris, a slight decrease in the total effective rate was observed, while the angina stability score increased.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Alyaa Ajabnoor, Amnah Mukhtar
Summary: This study aimed to explore the effect of adding trimetazidine to other anti-anginal drugs on the functional capacity of ischemic heart disease (IHD) patients not suitable for revascularization. The analysis of six randomized controlled trials showed that trimetazidine can improve walking time and severity of angina in these patients.
Review
Medicine, General & Internal
Xiaohuan Zhou, Yamin Yuan, Zhanglin Wang, Ke Zhang, Weiwei Fan, Yawei Zhang, Pu Ma
Summary: Coronary Artery Disease is a heart disease caused by myocardial hypoxia resulting from coronary artery stenosis or occlusion. Continuous nursing intervention can improve patients' quality of life and reduce the frequency of angina attacks. The study aims to systematically evaluate the efficacy and safety of continuous nursing intervention in Coronary Artery Disease, providing evidence for its clinical application.
Review
Neurosciences
Giuliano Taccola, Ronaldo M. Ichiyama, V. Reggie Edgerton, Parag Gad
Summary: This review discusses the physiological states of spinal networks, highlighting the stochastic modulation by changing ensembles of proprioceptive and supraspinal input. Spinal epidural interfaces offer a platform for studying spinal network dynamics post-injury. Low-frequency epidural pulses can evoke motor responses with oscillatory patterns. The neural variability among spinal networks is seen as a fundamental mechanism of network design rather than noise interfering with movement control.
EXPERIMENTAL NEUROLOGY
(2022)
Review
Anesthesiology
Nicoletta Marchesi, Stefano Govoni, Massimo Allegri
Summary: This review summarizes the pain-relieving effect of non-drug substances, which are prescribed as integrators in the treatment of various types of pain. It highlights the potential of these substances in providing relief for chronic pain, but emphasizes the need for further independent clinical studies to confirm their efficacy in therapy.
Article
Cardiac & Cardiovascular Systems
Stefano Ghio, Valentina Mercurio, Andrea Attanasio, Gaetano Asile, Carlo Gabriele Tocchetti, Stefania Paolillo
Summary: There is a strong bidirectional relationship between diabetes mellitus (DM) and heart failure (HF), with DM activating multiple molecular and pathophysiological mechanisms that can damage the heart in the long term. However, the prognostic role of DM in chronic and acute HF is still unclear, with gaps in evidence due to the heterogeneity of patient phenotypes and the necessity to better characterize individual patients and their comorbidities. This review aims to summarize the negative impact of DM on HF and analyze available data on the prognostic implications in both chronic and acute HF.
HEART FAILURE REVIEWS
(2023)
Article
Cell Biology
Pascale Desjardins, Gaetan Le-Bel, Sergio C. Ghio, Lucie Germain, Sylvain L. Guerin
Summary: This study elucidates the molecular mechanisms by which WNK1 contributes to corneal wound healing. By regulating the activity and expression of transcription factors, WNK1 can impact the transcription of multiple genes, thereby controlling the migration, proliferation, and differentiation of corneal epithelial cells.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Clinical Neurology
Vincent Roy, Jay P. Ross, Remy Pepin, Sergio Cortez Ghio, Alyssa Brodeur, Lydia Touzel Deschenes, Gaetan Le-Bel, Daniel E. Phillips, Genevieve Milot, Patrick A. Dion, Sylvain Guerin, Lucie Germain, Francois Berthod, Francois A. Auger, Guy A. Rouleau, Nicolas Dupre, Francois Gros-Louis
Summary: This study reveals that RNF213 may play a crucial role in maintaining cerebral endothelial cell integrity, and its disruption may contribute to the early pathological mechanism of Moyamoya disease. Additionally, the study further emphasizes the importance of blood-brain barrier integrity.
Editorial Material
Cardiac & Cardiovascular Systems
Sandra Schirinzi, Rita Camporotondo, Marco Ferlini, Maurizio Ferrario, Stefano Ghio
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Review
Anesthesiology
Franco Cavaliere, Massimo Allegri, Alparslan Apan, Luca Brazzi, Massimiliano Carassiti, Edmond Cohen, Pierangelo Di Marco, Olivier Langeron, Marco Rossi, Peter Spieth, David Turnbull, Frank Weber
MINERVA ANESTESIOLOGICA
(2022)
Editorial Material
Anesthesiology
Massimo Allegri, Michele Incerti, Sam Eldabe
MINERVA ANESTESIOLOGICA
(2022)
Article
Cell Biology
Marc Parisien, Lucas Lima, Concetta Dagostino, Nehme El-Hachem, Gillian L. Drury, Audrey Grant, Jonathan Huising, Vivek Verma, Carolina B. Meloto, Jaqueline R. Silva, Gabrielle G. S. Dutra, Teodora Markova, Hong Dang, Philippe A. Tessier, Gary D. Slade, Andrea G. Nackley, Nader Ghasemlou, Jeffrey S. Mogil, Massimo Allegri, Luda Diatchenko
Summary: This study investigated the pathophysiological mechanisms underlying the transition from acute to chronic low back pain and found that inflammatory responses may play a protective role against the development of chronic pain. Early treatment with steroids or nonsteroidal anti-inflammatory drugs (NSAIDs) may provide short-term analgesic effects but could have detrimental effects on long-term outcomes of back pain sufferers.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Alessandro Mandurino-Mirizzi, Andrea Munafo, Claudia Raineri, Giulia Magrini, Romina Frassica, Luca Arzuffi, Laura Scelsi, Annalisa Turco, Marco Ferlini, Fabrizio Gazzoli, Maurizio Ferrario, Stefano Ghio, Luigi Oltrona-Visconti, Gabriele Crimi
Summary: In patients with functional mitral regurgitation and pulmonary hypertension, pre-procedural vasodilator challenge with sodium nitroprusside may help predict haemodynamic improvement after transcatheter edge-to-edge repair.
EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE
(2022)
Article
Cell Biology
Gaetan Le-Bel, Pascale Desjardins, Christelle Gross, Sergio Cortez Ghio, Camille Couture, Lucie Germain, Sylvain L. Guerin
Summary: This study evaluated the impact of postmortem/storage time on the properties of human limbal epithelial cells (hLECs) used for tissue-engineered human corneas (hTECs). The results showed that hLECs with a short postmortem/storage time had higher proliferative capacity and faster wound healing compared to those with a long postmortem/storage time, resulting in higher quality hTECs.
Article
Cardiac & Cardiovascular Systems
Stefano Ghio, Mauro Acquaro, Piergiuseppe Agostoni, Giuseppe Ambrosio, Erberto Carluccio, Vincenzo Castiglione, Davide Colombo, Michele D'Alto, Santo Delle Grottaglie, Frank Lloyd Dini, Michele Emdin, Martino Fortunato, Andrea Igoren Guaricci, Francesca Jacoangeli, Alberto M. Marra, Stefania Paolillo, Sivia Papa, Luca Vicini Scajola, Michele Correale, Alberto Palazzuoli
Summary: For a long time, cardiologists have underestimated the role of the right heart in heart failure caused by left heart disease. However, the importance of evaluating right ventricular structure and function in left heart failure is now well recognized and emphasized in the latest heart failure guidelines. Yet, there are still unanswered questions about which imaging techniques and parameters should be used to assess the severity of RV dysfunction, and whether less commonly used diagnostic tools have a role in this field.
HEART FAILURE REVIEWS
(2023)
Article
Cardiac & Cardiovascular Systems
Andrea M. D. 'Armini, Maurizio Pin, Anna Celentano, Leslie J. Te Masiglat, Ermelinda Borrelli, Benedetta Vanini, Catherine Klersy, Giuseppe Silvaggio, Cristian Monterosso, Alessia Alloni, Carlo Pellegrini, Stefano Ghio
Summary: This study showed that in patients with chronic thromboembolic pulmonary hypertension undergoing pulmonary endarterectomy, a higher number of treated pulmonary artery branches is associated with better hemodynamic and clinical outcomes after surgery.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Manuel J. Richter, Federico Fortuni, Fawaz Alenezi, Michele D'Alto, Roberto Badagliacca, Nathan W. Brunner, Arie P. van Dijk, Philipp Douschan, Henning Gall, Stefano Ghio, Francesco Lo Giudice, Ekkehard Grunig, Francois Haddad, Luke Howard, Sudarshan Rajagopal, Niels Stens, Davide Stolfo, Dick H. J. Thijssen, Carmine Dario Vizza, Roham T. Zamanian, Liang Zhong, Werner Seeger, Hossein A. Ghofrani, Khodr Tello
Summary: A meta-analysis of 35 studies found that right atrial (RA) imaging assessment is a relevant prognostic marker in patients with pulmonary hypertension (PH). RA area, RA indexed area, RA peak longitudinal strain, and RA total emptying fraction were significantly associated with combined end-points including death, clinical worsening, and/or lung transplantation. RA volume and volume index showed marginal significant associations.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Cardiac & Cardiovascular Systems
Stefano Ghio, Eduardo Bossone, Valentina Mercurio, Lawrence Rudski, Mani Vannan
Summary: The study aims to characterize the echocardiographic morphology of the tricuspid valve apparatus and the pathophysiology of FTR in heart failure patients, as well as to correlate the severity of FTR with clinical outcomes. With a prospective, multicenter design, the study will provide insights into the pathophysiological mechanisms of FTR across different heart failure phenotypes, potentially guiding future tricuspid valve interventions for patients.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Laura Scelsi, Giuseppe Lanzillo, Eloisa Arbustini, Andrea D'Armini, Alessandra Greco, Federica Meloni, Annalisa Turco, Adele Valentini, Luigi Oltrona Visconti, Stefano Ghio
Summary: Pulmonary veno-occlusive disease is a rare disease that may be associated with genetic mutations. Accurate diagnosis and treatment are crucial for patient survival.
PULMONARY CIRCULATION
(2022)