Article
Clinical Neurology
Zeynab Alshelh, Ludovica Brusaferri, Atreyi Saha, Erin Morrissey, Paulina Knight, Minhae Kim, Yi Zhang, Jacob M. Hooker, Daniel Albrecht, Angel Torrado-Carvajal, Michael S. Placzek, Oluwaseun Akeju, Julie Price, Robert R. Edwards, Jeungchan Lee, Roberta Sclocco, Ciprian Catana, Vitaly Napadow, Marco L. Loggia
Summary: This study suggests that patients with different chronic pain conditions exhibit neuroinflammation, which is accompanied by neurophysiological changes and correlates with clinical presentation. These findings contribute to the subtyping of distinct pain syndromes and provide potential targets for precision medicine.
Review
Medicine, General & Internal
Nebojsa Nick Knezevic, Kenneth D. Candido, Johan W. S. Vlaeyen, Jan Van Zundert, Steven P. Cohen
Summary: Low back pain encompasses various types of pain, with diagnostic and therapeutic methods controversial, requiring a comprehensive approach considering biological, psychological, and social factors. Improvement in diagnostic accuracy, treatment algorithms, and multimodal interdisciplinary treatment are essential.
Article
Public, Environmental & Occupational Health
Melinda Jaromi, Brigitta Szilagyi, Anita Velenyi, Eleonora Leidecker, Bence Laszlo Raposa, Marta Hock, Petra Baumann, Pongrac Acs, Alexandra Makai
Summary: The study found that the health-related quality of life of patients with chronic non-specific low back pain is influenced by factors such as disease duration, functional decline, and low back pain knowledge. Additionally, there is a positive correlation between general health status and low back pain knowledge.
Article
Medicine, General & Internal
Elena Sirbu, Roxana Ramona Onofrei, Simona Szasz, Monica Susan
Summary: This study aimed to assess the relationship between pain intensity, catastrophizing components, depression, and disability in patients with chronic low back pain (CLBP). The results showed that age, pain intensity, catastrophizing, and depression can predict the disability level in CLBP patients.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Bianka Karshikoff, Karin Wahlen, Jenny Astrom, Mats Lekander, Linda Holmstrom, Rikard K. K. Wicksell
Summary: Chronic pain is often accompanied by psychological comorbidity, and the lack of clear pathophysiological factors and valid biomarkers makes it difficult to diagnose. In this study, inflammatory blood biomarkers were found to be associated with psychological comorbidity, but not with pain intensity in a chronic pain population. Specific inflammatory proteins were identified that may be related to anxiety and depression.
Article
Medicine, General & Internal
Jose Antonio Mingorance, Pedro Montoya, Jose Garcia Vivas Miranda, Inmaculada Riquelme
Summary: This study compared differences in postural balance, pain, and depression between patients with chronic and acute low back pain. The results showed that patients with chronic low back pain had higher body sway and faster sway speed compared to patients with acute low back pain and healthy controls. However, these group differences disappeared when depression was taken into account. Therefore, the assessment of postural balance and depression is essential for the design of personalized interventions in pain conditions.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Anesthesiology
Frederik Schlitt, Katharina Schmidt, Christian J. Merz, Oliver T. Wolf, Julian Kleine-Borgmann, Sigrid Elsenbruch, Katja Wiech, Katarina Forkmann, Ulrike Bingel
Summary: Pain-related learning is important in the development and maintenance of chronic pain. A study on patients with chronic back pain and healthy volunteers found impaired threat and safety learning in patients, with greater impairment in those with longer pain duration. These findings contribute to understanding the role of aberrant pain-related learning in chronic pain.
Review
Anesthesiology
Guillaume Christe, Geert Crombez, Shannon Edd, Emmanuelle Opsommer, Brigitte M. Jolles, Julien Favre
Summary: Higher levels of pain-related fear, catastrophizing, and depression are significantly associated with reduced spinal movement amplitudes and increased muscle activity in low back pain patients. Pain intensity has a minimal independent association with spinal motor behavior, and the small effect sizes found in the meta-analyses question the role of psychological factors as major causes of spinal movement avoidance.
Article
Medicine, General & Internal
Matthew K. Bagg, Benedict M. Wand, Aidan G. Cashin, Hopin Lee, Markus Hubscher, Tasha R. Stanton, Neil E. O'Connell, Edel T. O'Hagan, Rodrigo R. N. Rizzo, Michael A. Wewege, Martin Rabey, Stephen Goodall, Sopany Saing, Serigne N. Lo, Hannu Luomajoki, Robert D. Herbert, Chris G. Maher, G. Lorimer Moseley, James H. McAuley
Summary: This study assessed the effect of graded sensorimotor retraining on pain intensity in patients with chronic low back pain. The results showed that this intervention significantly improved pain intensity at 18 weeks. However, the improvements were small, and further research is needed to confirm the generalizability of the findings.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Health Care Sciences & Services
Eric J. Roseen, Adlin Pinheiro, Chelsey M. Lemaster, Dorothy Plumb, Shihwe Wang, A. Rani Elwy, Chris C. Streeter, Susan Lynch, Erik Groessl, Karen J. Sherman, Janice Weinberg, Robert B. Saper
Summary: This study investigated the effects of yoga and education on patients with chronic low back pain and found that yoga was not more effective than education in improving pain and disability outcomes. However, participants in the yoga group reported greater improvements and higher satisfaction with treatment.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
Article
Anesthesiology
Alexis F. Homs, Arnaud Dupeyron, Kjerstin Torre
Summary: Clinical models of chronic low back pain emphasize the role of excessive attention to pain and kinesiophobia in causing disability. This study used a complex systems approach and a distraction task to assess the impact of maladaptive attentional behaviors on patients with chronic low back pain. The findings suggest that excessive attention to pain leads to a loss of complexity and adaptability in motor control among individuals with chronic low back pain.
Article
Medicine, General & Internal
Thomas Matheve, Paul Hodges, Lieven Danneels
Summary: Changes in back muscle function and structure are common in patients with chronic low back pain. The potential role of back muscle dysfunctions in the persistence of low back pain differs between individuals due to heterogeneity in clinical presentation and back muscle dysfunctions within this population. Therefore, tailored interventions based on a thorough clinical examination considering the multidimensional nature of chronic low back pain are necessary. This article provides a state-of-the-art update on back muscle dysfunctions in patients with chronic low back pain and their implications for treatment, including dysfunctions in back muscle structure and function, exercise therapy potential, and the relationship between back muscle dysfunctions and clinical parameters. Additionally, an individualized approach for back muscle training in patients with chronic low back pain is described.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Alberto Ruffilli, Simona Neri, Marco Manzetti, Francesca Barile, Giovanni Viroli, Matteo Traversari, Elisa Assirelli, Fabio Vita, Giuseppe Geraci, Cesare Faldini
Summary: Low back pain (LBP) is a common cause of pain and disability, but current treatments often fail to provide sufficient relief. Identifying reliable biomarkers associated with LBP, such as epigenetic factors, could improve clinical practice. This review examined the literature on epigenetic factors and found promising markers that could significantly impact disease management and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Health Care Sciences & Services
Asimina Lazaridou, Myrella Paschali, Eric S. Vilsmark, Jason Sadora, Dustin Burton, Annie Bashara, Robert R. Edwards
Summary: The aim of this study was to assess the feasibility and potential effectiveness of an 8-week virtual EMG biofeedback intervention for patients with chronic low back pain (CLBP). The results showed that compared to the treatment as usual comparison group, patients in the EMG biofeedback group reported lower pain intensity after completing the intervention, and demonstrated significant reductions in pain interference, disability, and significant increases in low back pain thresholds. In addition, significant changes were observed in muscle tension for the trapezius, latissimus, and low back muscles in the EMG biofeedback group. Therefore, virtual EMG biofeedback shows promise as a potential therapy for reducing pain and disability in individuals with chronic nonspecific low back pain.
Article
Clinical Neurology
Meiyi Huo, Emma Ho, Alice Kongsted, Thomas Patterson, Paulo Ferreira
Summary: This study explored the association between different amounts of physical activity and sedentary behavior with the trajectory of chronic low back pain (LBP). The findings showed that engaging in moderate to vigorous intensity physical activity can lower the probability of developing a severe LBP trajectory. No significant associations were found between sedentary behavior or light intensity physical activity and the probability of developing a severe LBP trajectory.
Article
Neurosciences
Alex M. Dickens, Partho Sen, Matthew J. Kempton, Neus Barrantes-Vidal, Conrad Iyegbe, Merete Nordentoft, Thomas Pollak, Anita Riecher-Rossler, Stephan Ruhrmann, Gabriele Sachs, Rodrigo Bressan, Marie-Odile Krebs, G. Paul Amminger, Lieuwe de Haan, Mark van der Gaag, Lucia Valmaggia, Tuulia Hyotylainen, Matej Oresic, Philip McGuire
Summary: The study discovered that abnormalities in blood lipidomics predate the onset of psychosis in individuals at clinical high risk for psychosis, and can help predict which individuals are most likely to develop psychosis.
BIOLOGICAL PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Thomas A. Pollak, Matthew J. Kempton, Conrad Iyegbe, Angela Vincent, Sarosh R. Irani, Ester Coutinho, David A. Menassa, Leslie Jacobson, Lieuwe de Haan, Stephan Ruhrmann, Gabriele Sachs, Anita Riecher-Roessler, Marie-Odile Krebs, Paul Amminger, Birte Glenthoj, Neus Barrantes-Vidal, Jim van Os, Bart P. F. Rutten, Rodrigo A. Bressan, Mark van der Gaag, Robert Yolken, Matthew Hotopf, Lucia Valmaggia, James Stone, Anthony S. David, Philip McGuire, Maria Calem, Stefania Tognin, Gemma Modinos, Eva Velthorst, Tamar C. Kraan, Daniella S. van Dam, Nadine Burger, Barnaby Nelson, Patrick McGorry, Christos Pantelis, Athena Politis, Joanne Goodall, Stefan Borgwardt, Sarah Ittig, Erich Studerus, Renata Smieskova, Ary Gadelha, Elisa Brietzke, Graccielle Asevedo, Elson Asevedo, Andre Zugman, Araceli Rosa, Anna Racioppi, Manel Monsonet, Lidia Hinojosa-Marques, Thomas R. Kwapil, Mathilde Kazes, Claire Daban, Julie Bourgin, Olivier Gay, Celia Mam-Lam-Fook, Marie-Odile Krebs, Dorte Nordholm, Lasse Randers, Kristine Krakauer, Louise Glenthoj, Birte Glenthoj, Merete Nordentoft, Stephan Ruhrmann, Dominika Gebhard, Julia Arnhold, Joachim Klosterkoetter, Gabriele Sachs, Iris Lasser, Bernadette Winklbaur, Philippe A. Delespaul, Bart P. F. Rutten, Jim van Os
Summary: Neuronal autoantibodies, including NMDAR antibodies, can be detected in a subgroup of CHR subjects at equal rates to controls. These antibodies are associated with affective psychopathology, impairments in verbal memory, and overall cognitive function. Serum status and titre of NMDAR antibodies are related to poorer levels of functioning and the presence of a neuronal autoantibody is associated with larger amygdala volumes.
MOLECULAR PSYCHIATRY
(2021)
Article
Psychology, Clinical
Jim van Os, Lotta-Katrin Pries, Margreet ten Have, Ron de Graaf, Saskia van Dorsselaer, Philippe Delespaul, Maarten Bak, Gunter Kenis, Bochao D. Lin, Jurjen J. Luykx, Alexander L. Richards, Berna Akdede, Tolga Binbay, Vesile Altinyazar, Berna Yalincetin, Guvem Gumus-Akay, Burcin Cihan, Haldun Soygur, Halis Ulas, Eylem Sahin Cankurtaran, Semra Ulusoy Kaymak, Marina M. Mihaljevic, Sanja Andric Petrovic, Tijana Mirjanic, Miguel Bernardo, Gisela Mezquida, Silvia Amoretti, Julio Bobes, Pilar A. Saiz, Maria Paz Garcia-Portilla, Julio Sanjuan, Eduardo J. Aguilar, Jose Luis Santos, Estela Jimenez-Lopez, Manuel Arrojo, Angel Carracedo, Gonzalo Lopez, Javier Gonzalez-Penas, Mara Parellada, Nadja P. Maric, Cem Atbasoglu, Alp Ucok, Koksal Alptekin, Meram Can Saka, Celso Arango, Michael O'Donovan, Bart P. F. Rutten, Sinan Guloksuz
Summary: The study reveals that the impact of genetic and non-genetic risk factors for schizophrenia on psychosis outcomes is partially mediated through an affective pathway.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Eva Velthorst, Josephine Mollon, Robin M. Murray, Lieuwe de Haan, Inez Myin Germeys, David C. Glahn, Celso Arango, Els van der Ven, Marta Di Forti, Miguel Bernardo, Sinan Guloksuz, Philippe Delespaul, Gisela Mezquida, Silvia Amoretti, Julio Bobes, Pilar A. Saiz, Maria Paz Garcia-Portilla, Jose Luis Santos, Estela Jimenez-Lopez, Julio Sanjuan, Eduardo J. Aguilar, Manuel Arrojo, Angel Carracedo, Gonzalo Lopez, Javier Gonzalez-Penas, Mara Parellada, Cem Atbasoglu, Meram Can Saka, Alp Ucok, Koksal Alptekin, Berna Akdede, Tolga Binbay, Vesile Altinyazar, Halis Ulas, Berna Yalincetin, Guvem Gumus-Akay, Burcin Cihan Beyaz, Haldun Soygur, Eylem Sahin Cankurtaran, Semra Ulusoy Kaymak, Nadja P. Maric, Marina M. Mihaljevic, Sanja Andric Petrovic, Tijana Mirjanic, Cristina Marta Del-Ben, Laura Ferraro, Charlotte Gayer-Anderson, Peter B. Jones, Hannah E. Jongsma, James B. Kirkbride, Caterina La Cascia, Antonio Lasalvia, Sarah Tosato, Pierre-Michel Llorca, Paulo Rossi Menezes, Craig Morgan, Diego Quattrone, Marco Menchetti, Jean-Paul Selten, Andrei Szoke, Ilaria Tarricone, Andrea Tortelli, Philip McGuire, Lucia Valmaggia, Matthew J. Kempton, Mark van der Gaag, Anita Riecher-Rossler, Rodrigo A. Bressan, Neus Barrantes-Vidal, Barnaby Nelson, Patrick McGorry, Chris Pantelis, Marie-Odile Krebs, Stephan Ruhrmann, Gabriele Sachs, Bart P. F. Rutten, Jim van Os, Behrooz Z. Alizadeh, Therese van Amelsvoort, Agna A. Bartels-Velthuis, Richard Bruggeman, Nico J. van Beveren, Jurjen J. Luykx, Wiepke Cahn, Claudia J. P. Simons, Rene S. Kahn, Frederike Schirmbeck, Ruud van Winkel, Abraham Reichenberg
Summary: The study examined cognitive functioning in patients with psychotic disorders and their unaffected siblings, revealing medium to large deficits in patients and small deficits in siblings. Age did not affect the severity of impairment, but first-episode patients performed worse than prodromal patients. Adjusting for cannabis use, symptom severity, and antipsychotic medication reduced deficits in siblings but patients still showed significant impairments. Antipsychotic medication accounted for around half of the impairment in patients.
MOLECULAR PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Anna Kuranova, Johanna T. W. Wigman, Claudia Menne-Lothmann, Jeroen Decoster, Ruud van Winkel, Philippe Delespaul, Marjan Drukker, Marc de Hert, Catherine Derom, Evert Thiery, Bart P. F. Rutten, Nele Jacobs, Jim van Os, Albertine J. Oldehinkel, Sanne H. Booij, Marieke Wichers
Summary: Although not statistically significant, some qualitative differences were observed between the networks of the two groups. More studies are needed to determine the value of momentary affect networks for predicting the course of psychopathology.
Article
Psychiatry
Coline van Everdingen, Peter Bob Peerenboom, Koos van der Velden, Philippe Delespaul
Summary: The HOP-TR study in the Netherlands revealed significant health problems among homeless service users, including high rates of mental health issues, addiction, chronic conditions, and intellectual impairments. A comprehensive 3-D public health approach is needed to address the interdependent symptomatic, social, and personal dimensions in order to facilitate recovery for this population.
FRONTIERS IN PSYCHIATRY
(2021)
Review
Anesthesiology
Putu G. Nadinda, Dimitri M. L. van Ryckeghem, Madelon L. Peters
Summary: Psychological interventions can effectively reduce acute and chronic postsurgical pain and disability. Interventions delivered after surgery and by psychologists show better outcomes. Further research is needed to determine the most beneficial intervention for surgical patients. Bias in missing outcome data due to withdrawal and drop out should be addressed in future studies.
Letter
Cardiac & Cardiovascular Systems
Scherrenberg Martijn, Bonneux Cindel, Falter Maarten, Hansen Dominique, Mahmood Deeman, Kaihara Toshiki, Xu Linqi, Jaeken Elaine, Schols Lotte, Kindermans Hanne, Coninx Karin, Dendale Paul
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Psychology, Experimental
Marieke J. Schreuder, Marieke Wichers, Catharina A. Hartman, Claudia Menne-Lothmann, Jeroen Decoster, Ruud van Winkel, Philippe Delespaul, Marc De Hert, Catherine Derom, Evert Thiery, Bart P. F. Rutten, Nele Jacobs, Jim van Os, Johanna T. W. Wigman
Summary: This study found that emotional complexity can predict the psychological prognosis of adolescents, and this effect is not related to stressful life events. The results show that impaired emotion representation plays a more important role in vulnerability to mental ill health than does low diversity of emotions.
Article
Multidisciplinary Sciences
Cynthia Lamper, Ivan P. J. Huijnen, Marielle E. A. L. Kroese, Albere J. Koke, Gijs Brouwer, Dirk Ruwaard, Jeanine A. M. C. F. Verbunt
Summary: This feasibility study aims to provide insight into barriers and facilitators for the development, implementation, and transferability of integrated rehabilitation care for chronic musculoskeletal pain patients. Findings suggest that guidelines and treatment protocols can facilitate collaboration and improve consistency. However, the stigma associated with chronic pain and the current organization of health care act as barriers to implementation. The iterative, bottom-up development approach and a critical mass of participating organizations are important facilitators.
Review
Clinical Neurology
Pietro Scarone, Wouter Van Santbrink, Eva Koetsier, Anouk Smeets, Henk Van Santbrink, Madelon L. Peters
Summary: This review aims to summarize and analyze the effect of perioperative psychological interventions on postoperative pain, disability, and quality of life in patients undergoing spinal fusion surgery. The findings suggest that psychological interventions may have a short-term effect in reducing pain and disability, but the long-term effect remains inconclusive.
EUROPEAN SPINE JOURNAL
(2023)
Article
Health Care Sciences & Services
Martijn Scherrenberg, Maarten Falter, Toshiki Kaihara, Linqi Xu, Mayke van Leunen, Hareld Kemps, Hanne Kindermans, Paul Dendale
Summary: The Digital Health Readiness Questionnaire (DHRQ) was developed as a short and user-friendly tool to assess the digital readiness of patients in a clinical setting. Initial validation shows good internal consistency, indicating its potential usefulness in guiding digital care pathways and providing appropriate education programs for patients with low digital readiness but high learnability.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Review
Clinical Neurology
Jantine J. L. M. Boselie, Madelon L. Peters
Summary: The field of pain psychology has shifted from a biomedical perspective to a biopsychosocial model, highlighting the importance of psychological factors in chronic pain. Psychological treatment aims to reduce negative vulnerability factors, such as pain-related fear and catastrophizing, while positive psychology focuses on increasing protective factors like optimism. Both vulnerability and protective factors play unique roles in modulating the experience of pain, and a combination of both should be included in pain research and treatment.
SCANDINAVIAN JOURNAL OF PAIN
(2023)
Article
Public, Environmental & Occupational Health
Bart van den Brink, Matthias Jongkind, Willemijn Wijzenbroek, Mira Duif, Arjan W. Braam, Philippe Delespaul, Hanneke Schaap-Jonker
Summary: This study used an experience sampling method to assess the variability of three religiosity and spirituality parameters in a psychiatric population. The results showed significant variations in these parameters within the day, indicating the feasibility and validity of the method in exploring religiosity and spirituality in psychiatric patients.
JOURNAL OF RELIGION & HEALTH
(2023)
Article
Criminology & Penology
P. Habets, Ph. Delespaul, I. Jeandarme
Summary: The Experience Sampling Method (ESM) is a valuable tool in general psychiatry, with potential applications in forensic psychiatry as well. This study showed that in forensic psychiatry, ESM can provide insights into the relationships between symptoms and mood in different contexts. Activity-related stress was found to be closely related to negative affect, lower positive affect, and more psychotic symptoms.
INTERNATIONAL JOURNAL OF OFFENDER THERAPY AND COMPARATIVE CRIMINOLOGY
(2022)