期刊
PAIN
卷 148, 期 2, 页码 215-219出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1016/j.pain.2009.09.028
关键词
Nociception; Behavioral assessment; Brain injury; Consciousness; Vegetative state; Minimally conscious state
资金
- Belgian Fund for Scientific Research (FNRS)
- European Commission
- James McDonnell Foundation
- Mind Science Foundation
- French Speaking Community Concerted Research Action [ARC-06/11-340]
- Fondation Medicale Reine Elisabeth, University of Liege
- CNRS/FNRS-CGRI collaboration funds
Assessing behavioral responses to nociception is difficult in severely brain-injured patients recovering from coma. We here propose a new scale developed for assessing nociception in vegetative (VS) and minimally conscious (MCS) coma survivors, the Nociception Coma Scale (NCS), and explore its concurrent validity, inter-rater agreement and sensitivity. Concurrent validity was assessed by analyzing behavioral responses of 48 post-comatose patients to a noxious stimulation (pressure applied to the fingernail) (28 VS and 20 MCS; age range 20-82 years; 17 of traumatic etiology). Patients' were assessed using the NCS and four other scales employed in non-communicative patients: the 'Neonatal Infant Pain Scale' (NIPS) and the 'Faces, Legs, Activity, Cry, Consolability' (FLACC) used in newborns; and the 'Pain Assessment In Advanced Dementia Scale' (PAINAD) and the 'Checklist of Non-verbal Pain Indicators' (CNPI) used in dementia. For the establishment of inter-rater agreement, fifteen patients were concurrently assessed by two examiners. Concurrent validity, assessed by Spearman rank order correlations between the NCS and the four other validated scales, was good. Cohen's kappa analyses revealed a good to excellent inter-rater agreement for the NCS total and subscore measures, indicating that the scale yields reproducible findings across examiners. Finally, a significant difference between NCS total scores was observed as a function of diagnosis (i.e., VS or MCS). The NCS constitutes a sensitive clinical tool for assessing nociception in severely brain-injured patients. This scale constitutes the first step to a better management of patients recovering from coma. (C) 2009 International Association for the Study of Pain. Published by Elsevier B. V. All rights reserved.
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