Article
Clinical Neurology
Jens Astrup, Finn Gyntelberg
Summary: Tension-type headache and non-specific low back pain share similar clinical features, including tender points and areas, abnormal activation patterns observed in electromyography, and discoordinated motor control of affected muscles and adjacent muscle groups. These common features suggest a potential analogous pathophysiology involving the neuromotor control in the cervical and lumbar regions.
FRONTIERS IN NEUROLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Pui Wah Kong, Tommy Yew Weng Kan, Roslan Abdul Ghani Bin Mohamed Jamil, Wei Peng Teo, Jing Wen Pan, Md Noor Hafiz Abd Halim, Hasan Kuddoos Abu Bakar Maricar, David Hostler
Summary: This study compared two training programs for emergency responders and found that both functional and conventional strength training are effective in improving back muscle characteristics.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Clinical Neurology
Jens Astrup, Finn Gyntelberg
Summary: The natural course of whiplash disease is typically attributed to central neuromotor dysfunction rather than peripheral traumatic pathology. This suggests that the cause of the disease lies within the central nervous system, leading to abnormal activation patterns and muscle coordination.
FRONTIERS IN NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Stefanie Luecke, Adewunmi Adelaja, Xiaolu Guo, Supriya Sen, Roberto Spreafico, Apeksha Singh, Yi Liu, Brooks Taylor, Jessica Diaz, Quen Cheng, Alexander Hoffmann
Summary: Tumor necrosis factor (TNF) is a crucial cytokine involved in inflammatory response. Continuous exposure to TNF conditions the cells to respond differently compared to acute exposure, affecting NF?B signaling dynamics, immune gene expression, and epigenomic reprogramming.
Article
Clinical Neurology
Inna E. Tchivileva, Richard Ohrbach, Roger B. Fillingim, Feng-Chang Lin, Pei Feng Lim, Samuel J. Arbes, Gary D. Slade
Summary: Headache attributed to Temporomandibular Disorder (HATMD) is a common secondary headache among patients with chronic myogenous TMD and primary headaches, often presenting as migraine. Unlike primary headaches, HATMD is associated with higher headache frequency and examination-evoked masticatory muscle pain, but surprisingly few measures of facial pain, general health, and psychological distress. Understanding these differences is important for developing targeted strategies for HATMD management.
JOURNAL OF HEADACHE AND PAIN
(2021)
Article
Clinical Neurology
Cesar Fernandez-de-las-Penas, Maria Palacios-Cena, Juan A. Valera-Calero, Maria L. Cuadrado, Angel Guerrero-Peral, Juan A. Pareja, Lars Arendt-Nielsen, Umut Varol
Summary: Network analysis reveals local associations between psychophysical and headache-related variables in patients with tension-type headache. The strongest weight is observed between pressure pain thresholds over the cervical spine and temporalis area, and depressive levels have the highest centrality in the network.
JOURNAL OF NEUROLOGY
(2022)
Article
Cell Biology
Kyoung-Doo Hwang, Jinhee Baek, Hyun-Hee Ryu, Jaegeon Lee, Hyun Geun Shim, Sun Yong Kim, Sang Jeong, Yong-Seok Lee
Summary: This study identifies a population of neurons in the deep cerebellar nucleus (DCN) with monosynaptic glutamatergic projections to the lateral parabrachial nucleus (lPBN). Suppression of these DCN-lPBN neurons impairs auditory fear memory, while their activation leads to freezing behavior after auditory fear conditioning. Conditioning strengthens the synapses between DCN and lPBN, and following fear conditioning, the auditory cue activates lPBN neurons. Furthermore, activation of DCN-lPBN neuron can replace the auditory cue but not footshock in fear conditioning. These findings suggest that the DCN-lPBN circuit plays a role in modulating auditory fear conditioning.
Review
Clinical Neurology
Bartlomiej Blaszczyk, Marcin Straburzynski, Mieszko Wieckiewicz, Slawomir Budrewicz, Piotr Niemiec, Martyna Staszkiewicz, Marta Waliszewska-Prosol
Summary: This study explores the relationship between alcohol consumption and primary headaches. The findings from systematic review and meta-analysis suggest an inverse correlation between alcohol consumption and migraine, while tension-type headache (TTH) is not associated with drinking. The observation that migraine patients avoid alcohol may explain this relationship, rather than alcohol having a protective role against migraine. Further studies with low risk of bias are needed to investigate the relationship between primary headaches and alcohol consumption.
JOURNAL OF HEADACHE AND PAIN
(2023)
Review
Neurosciences
Marcin Straburzynski, Anna Gryglas-Dworak, Magdalena Nowaczewska, Eliza Brozek-Madry, Paolo Martelletti
Summary: Sinus headache and/or facial pain is a common complaint encountered by otorhinolaryngologists, neurologists and general practitioners. Studies suggest that the majority of these cases may be attributed to primary headaches, supporting a neurologic etiology for most SH cases.
Article
Clinical Neurology
Daniel Martin-Vera, Alberto Sanchez-Sierra, Angel Gonzalez-de-la-Flor, Guillermo Garcia-Perez-de-Sevilla, Diego Dominguez-Balmaseda, Jose Angel del-Blanco-Muniz
Summary: Strength-based exercise program showed significant improvements in duration and intensity of headaches, deep cervical muscle thickness, peripheral sensitization reduction, and strength of deep cervical flexors in patients with chronic tension-type headaches. More research is needed to explore the impact of pain normalization and physical factors on headaches.
FRONTIERS IN NEUROLOGY
(2023)
Review
Clinical Neurology
Alec Giakas, Kiersten Mangold, Anthony Androulakis, Noah Hyduke, Igor Galynker, Melinda Thiam, Guoshuai Cai, X. Michelle Androulakis
Summary: This study conducted a systematic review and meta-analysis on suicidal ideation, attempts, and death in patients with head, neck, and back pain. The findings showed that both migraine and neck/back pain patients have an elevated risk of suicidal ideation and attempt compared to healthy controls, with migraine patients having a particularly higher risk.
FRONTIERS IN NEUROLOGY
(2023)
Article
Emergency Medicine
Kasra Morad Soltani, Hassan Motamed, Kaveh Eslami, Nastaran Majdinasab, Leila Kouti
Summary: This study compared the pain-relieving effects of metoclopramide and ketorolac in acute primary headaches patients, finding no significant difference between the two drugs in pain outcomes with no serious adverse events reported.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Medicine, General & Internal
Rosalinda Romero-Godoy, Sara Raquel Romero-Godoy, Manuel Romero-Acebal, Mario Gutierrez-Bedmar
Summary: This study aimed to evaluate the electrophysiological responses in patients with chronic tension-type headache (CTTH) and correlate them with psychopathological manifestations. The results showed that CTTH patients have reduced ability to recognize non-nociceptive sensory stimuli, increased pain facilitation, and poor central pain control. This is linked to hypoexcitability of A beta nerve fibers and is directly associated with psychological comorbidity.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biology
Lauren Y. Atlas, Troy C. Dildine, Esther E. Palacios-Barrios, Qingbao Yu, Richard C. Reynolds, Lauren A. Banker, Shara S. Grant, Daniel S. Pine
Summary: Recent data suggest that interactions between systems involved in higher order knowledge and associative learning drive responses during value-based learning. These systems dynamically modulate pain perception and influence pain and heat-evoked brain responses. Imaging data also identify three types of neural networks involved in pain generation and value-based learning.
Article
Medicine, General & Internal
Rodrigo Jimenez-Garcia, Ana Lopez-de-Andres, Javier de Miguel-Diez, Jose J. Zamorano-Leon, David Carabantes-Alarcon, Concepcion Noriega, Natividad Cuadrado-Corrales, Napoleon Perez-Farinos
Summary: This study aimed to evaluate the time trend in the prevalence of chronic neck pain, chronic low back pain, and migraine or frequent headache among people with diabetes in Spain from 2014 to 2020. The study found that the prevalence of these pain sites did not improve over time among individuals with diabetes. Women with diabetes had a higher prevalence of these pain sites compared to men with diabetes. Diabetes was associated with reporting in all the pain sites analyzed.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Neurosciences
Soheil Mottaghi, Niloofar Afshari, Oliver Buchholz, Samuel Liebana, Ulrich G. Hofmann
FRONTIERS IN NEUROSCIENCE
(2020)
Editorial Material
Neurosciences
Ulrich G. Hofmann, Jeffrey R. Capadona
FRONTIERS IN NEUROSCIENCE
(2020)
Article
Computer Science, Artificial Intelligence
Nikolas Hesse, Sergi Pujades, Michael J. Black, Michael Arens, Ulrich G. Hofmann, A. Sebastian Schroeder
IEEE TRANSACTIONS ON PATTERN ANALYSIS AND MACHINE INTELLIGENCE
(2020)
Article
Neurosciences
Soheil Mottaghi, Oliver Buchholz, Ulrich G. Hofmann
FRONTIERS IN NEUROSCIENCE
(2020)
Article
Chemistry, Multidisciplinary
Vit Herynek, Michal Babic, Ondrej Kaman, Hana Charvatova, Mariana Vesela, Oliver Buchholz, Magda Vosmanska, Denisa Kubaniova, Jaroslav Kohout, Ulrich G. Hofmann, Ludek Sefc
Summary: The synthesized nanoparticles showed potential as tracers for MPI, with the anionic particles exhibiting higher signal and lower dispersion compared to commercial tracers.
JOURNAL OF NANOPARTICLE RESEARCH
(2021)
Article
Engineering, Biomedical
Ian Dryg, Yijing Xie, Michael Bergmann, Gerald Urban, William Shain, Ulrich G. Hofmann
Summary: The study used Optical Coherence Tomography (OCT) to monitor tissue response to chronically implanted neural probes in real time. The results showed that the plasma-coated implants only slightly improved the glial encapsulation in the brain parenchyma, indicating mechanical influences may dominate the encapsulation process. This approach provides valuable insights into long-term monitoring and comparison of tissue response to neural probes with and without plasma coating in living animal models.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Oncology
Matthias Schneider, Lea Vollmer, Anna-Laura Potthoff, Vidhya M. Ravi, Bernd O. Evert, Mohummad A. Rahman, Shahin Sarowar, Jan Kueckelhaus, Paulina Will, David Zurhorst, Kevin Joseph, Julian P. Maier, Nicolas Neidert, Paolo D'Errico, Melanie Meyer-Luehmann, Ulrich G. Hofmann, Andreas Dolf, Paolo Salomoni, Erdem Guresir, Per O. Enger, Martha Chekenya, Torsten Pietsch, Patrick Schuss, Oliver Schnell, Mike-Andrew Westhoff, Jurgen Beck, Hartmut Vatter, Andreas Waha, Ulrich Herrlinger, Dieter H. Heiland
Summary: This study explored the relationship between network architecture and transcriptional profile in glioblastoma cells, finding that meclofenamate (MFA) can effectively disrupt syncytial network structures. MFA treatment led to reduced intercellular cytosolic traffic and breakdown of long membrane protrusions, ultimately affecting the communication networks and response to chemotherapy in glioblastoma cells. These findings suggest a potential therapeutic approach targeting tumor microtubes (TMs) with MFA in clinical settings.
Article
Chemistry, Analytical
Lorenz Kahl, Ulrich G. Hofmann
Summary: This study investigates methods for elimination of cardiogenic artifacts in respiratory sEMG signals and compares their performance in fatigue detection with different algorithms. The TSWD method showed superior results in fatigue detection across different levels of artifact contamination, with SMR5 being determined as the best fatigue detection algorithm.
Article
Cell Biology
Julian P. Maier, Vidhya M. Ravi, Jan Kueckelhaus, Simon P. Behringer, Niklas Garrelfs, Paulina Will, Na Sun, Jasmin von Ehr, Jonathan M. Goeldner, Dietmar Pfeifer, Marie Follo, Luciana Hannibal, Axel Karl Walch, Ulrich G. Hofmann, Jurgen Beck, Dieter Henrik Heiland, Oliver Schnell, Kevin Joseph
Summary: Glioblastoma demonstrates dynamic responses to its microenvironment and resistance to treatment. Glutamate signaling, particularly through the metabotropic receptor 3 (GRM3), plays a crucial role in modulating chemoresistance and transcriptional profile of GBM cells. Inhibition of GRM3 receptor enhances sensitivity of GBM to chemotherapy, providing potential therapeutic strategies for GBM treatment.
CELL DEATH & DISEASE
(2021)
Article
Neurosciences
Soheil Mottaghi, Sandra Kohl, Dirk Biemann, Samuel Liebana, Ruth Eneida Montano Crespo, Oliver Buchholz, Mareike Wilson, Carolin Klaus, Michelle Uchenik, Christian Muenkel, Robert Schmidt, Ulrich G. Hofmann
Summary: The study found that 6-OHDA hemi-PD rats exhibit impaired motor performance compared to the sham group, but Deep Brain Stimulation (DBS) can improve their overall performance. High beta band power was identified as an important biomarker for Parkinson's Disease, showing differences between healthy and lesioned hemispheres and between 6-OHDA-lesioned and sham rats.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Engineering, Biomedical
Kevin Joseph, Matthias Kirsch, Midori Johnston, Christian Munkel, Thomas Stieglitz, Carola A. Haas, Ulrich G. Hofmann
Summary: Long-term implantation of (micro-)probes into neural tissue leads to unique responses in glial cells. While animals implanted for 18 weeks show signs of recovery, upregulation of certain genes suggests that structural and functional remodeling is not complete at this time point.
Article
Multidisciplinary Sciences
Vidhya M. Ravi, Nicolas Neidert, Paulina Will, Kevin Joseph, Julian P. Maier, Jan Kueckelhaus, Lea Vollmer, Jonathan M. Goeldner, Simon P. Behringer, Florian Scherer, Melanie Boerries, Marie Follo, Tobias Weiss, Daniel Delev, Julius Kernbach, Pamela Franco, Nils Schallner, Christine Dierks, Maria Stella Carro, Ulrich G. Hofmann, Christian Fung, Roman Sankowski, Marco Prinz, Juergen Beck, Henrike Salie, Bertram Bengsch, Oliver Schnell, Dieter Henrik Heiland
Summary: The study demonstrates that a subset of myeloid cells in Glioblastomas induce dysfunctional T cells through Interleukin-10 signaling, and inhibiting downstream JAK/STAT pathway could restore the responsiveness of immune therapy. The findings are validated using in vitro and in vivo models, providing further evidence of Interleukin-10 release being a driving force of tumor immune escape. Integrative modeling of single cell and spatial transcriptomics data proves to be a valuable tool for studying the tumor immune microenvironment and may contribute to the development of successful immunotherapies.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Vidhya M. Ravi, Paulina Will, Jan Kueckelhaus, Na Sun, Kevin Joseph, Henrike Salie, Lea Vollmer, Ugne Kuliesiute, Jasmin von Ehr, Jasim K. Benotmane, Nicolas Neidert, Marie Follo, Florian Scherer, Jonathan M. Goeldner, Simon P. Behringer, Pamela Franco, Mohammed Khiat, Junyi Zhang, Ulrich G. Hofmann, Christian Fung, Franz L. Ricklefs, Katrin Lamszus, Melanie Boerries, Manching Ku, Jurgen Beck, Roman Sankowski, Marius Schwabenland, Marco Prinz, Ulrich Schueller, Saskia Killmer, Bertram Bengsch, Axel K. Walch, Daniel Delev, Oliver Schnell, Dieter Henrik Heiland
Summary: This study utilizes spatially resolved transcriptomics, metabolomics, and proteomics to characterize glioblastomas and uncover their spatial organization and adaptive mechanisms to inflammatory and metabolic stimuli. The integration of metabolic imaging and imaging mass cytometry reveals the interdependence between tumor and host in a locoregional manner, leading to spatially exclusive adaptive transcriptional programs. The findings confirm the importance of environmental stress in shaping glioblastoma subclones and their transcriptional programs.
Article
Engineering, Biomedical
Moritz Doering, Jochen Kieninger, Julian Kuebler, Ulrich G. Hofmann, Stefan J. Rupitsch, Gerald A. Urban, Andreas Weltin
Summary: This study investigates the electrochemical characteristics of electrodes during current-controlled neurostimulation, revealing the influence of surface status and electrochemical processes on potential traces. The findings emphasize the importance of understanding electrode state and processes to ensure safe and effective stimulation.
JOURNAL OF NEURAL ENGINEERING
(2023)
Review
Engineering, Biomedical
Rand K. Almajidy, Kunal Mankodiya, Mohammadreza Abtahi, Ulrich G. Hofmann
IEEE REVIEWS IN BIOMEDICAL ENGINEERING
(2020)