Article
Health Care Sciences & Services
Tsung-Che Wu, Chih-Hung Hsu, Wei-Zen Sun, Ho-Min Chen, Chih-Peng Lin, Yu-Yun Shao
Summary: The introduction of new strong opioids in Taiwan led to changes in opioid prescription patterns for cancer pain management, aligning more with international guidelines. While the use of strong opioids increased, the use of weak opioids decreased.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2021)
Article
Health Care Sciences & Services
Samy A. Alsirafy, Saad H. Alabdullateef, Ashraf M. Elyamany, Amneh D. Hassan, Mohammed Almashiakhi
Summary: It is not recommended to use TFP in cancer cachexia, but it may be the only option for pain relief. Caution should be taken when switching from TFP, and it is better to avoid TFP unless necessary.
BMJ SUPPORTIVE & PALLIATIVE CARE
(2022)
Article
Pharmacology & Pharmacy
Mariko Kawana, Akime Miyasato, Miyui Funato, Keigo Nagatani, Norifumi Suzuki, Chiharu Onoda, Hidenori Fujimoto, Rintaro Ohno, Ayuko Kusakabe, Mio Kiribayashi, Kazuyo Nakamura, Masayoshi Kondo, Ayumi Ozeki, Kousuke Okamoto, Hideya Kokubun
Summary: This study aimed to evaluate the efficacy and safety of low-dose transdermal fentanyl (TDF) in opioid-naive patients with cancer pain. The results showed that TDF was comparable to oral sustained-release oxycodone (OXY) in pain relief, and both drugs had similar occurrence of adverse events. Therefore, TDF can be considered as a first-line choice for opioid-naive patients with cancer pain.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2023)
Article
Biochemistry & Molecular Biology
Piotr F. J. Lipinski, Joanna Matalinska
Summary: The design of multitarget analgesics is a strategy in the search for safe and effective analgesic drugs. These drugs are intended to target multiple molecular targets involved in pain modulation. This article summarizes attempts to use fentanyl or its substructures as a scaffold for attaching fragments related to non-opioid receptors. The non-opioid targets include various proteins. The article reviews the chemistry, pharmacological properties, and structure-activity relationships of these attempts, and discusses future research directions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Sebastiano Mercadante
Summary: Managing cancer pain is challenging, and opioid therapy remains the cornerstone. Individual characteristics should guide the choice of opioids, and optimizing therapy allows for personalized treatment based on patient characteristics and pain syndromes. Adjuvants and interventional procedures are options in specific circumstances.
Article
Oncology
Judith A. Paice, Kari Bohlke, Debra Barton, David S. Craig, Areej El-Jawahri, Dawn L. Hershman, Lynn R. Kong, Geana P. Kurita, Thomas W. LeBlanc, Sebastiano Mercadante, Kristina L. M. Novick, Ramy Sedhom, Carole Seigel, Joanna Stimmel, Eduardo Bruera
Summary: The purpose of this article is to provide guidance on the use of opioids for managing cancer-related pain in adults. The authors conducted a systematic review of the literature and identified the efficacy and safety of opioid analgesics, approaches to opioid initiation and titration, and strategies for preventing and managing opioid adverse events. The findings indicate that opioids effectively reduce pain in patients with moderate-to-severe cancer pain, but there is limited evidence for some questions of interest, leading to consensus-based recommendations or the absence of recommendations.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Oncology
Stefano Mastrangelo, Michele Antonio Capozza, Silvia Triarico, Giorgio Attina, Palma Maurizi, Alberto Romano, Antonio Ruggiero
Summary: Transdermal delivery system (TDDS) is a non-invasive and cost-effective method for drug delivery, but limited to a restricted group of drugs. Opioids like fentanyl and buprenorphine are suitable for chronic pain management through TDDS, but not approved for pediatric use yet.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Environmental Sciences
Karina Sommerfeld-Klatta, Wiktoria Jiers, Magdalena Lukasik-Glebocka, Artur Tezyk, Klaudia Dolinska-Kaczmarek, Kamil Walter, Pawel Swiderski, Szymon Rzepczyk, Barbara Zielinska-Psuja, Czeslaw Zaba
Summary: In recent years, the administration of fentanyl in transdermal drug delivery systems for chronic pain treatment has increased significantly. This study presents three cases of fentanyl poisonings, including two deaths, due to abuse of transdermal fentanyl delivery systems. The various routes of administration and toxic effects highlight the potential dangers of fentanyl in transdermal drug delivery systems.
Review
Medicine, General & Internal
Mia Elena Koponen, Patrice Forget
Summary: This study aimed to investigate pharmacological interventions for opioid-induced hyperalgesia caused by different opioids. The majority of interventions were studied in only one trial, with the most common mechanism being the inhibition of N-methyl-D-aspartate (NMDA) receptors.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Health Care Sciences & Services
Jui-Hung Tsai, I-Ting Liu, Pei-Fang Su, Ying-Tzu Huang, Ge-Lin Chiu, Yu-Yeh Chen, Wei-Shu Lai, Peng-Chan Lin
Summary: This study aimed to investigate the efficacy of lidocaine transdermal patches in treating cancer-related neuropathic pain. The results showed that the 5% lidocaine patch reduced pain intensity in patients already receiving opioid treatment. The treatment was well tolerated and effective.
BMC PALLIATIVE CARE
(2023)
Article
Emergency Medicine
Raoul Daoust, Jean Paquet, Verilibe Huard, Jean-Marc Chauny, Gilles Lavigne, David Williamson, Manon Choiniere, Eddy Lang, Justin W. Yan, Jeffrey J. Perry, Marcel Emond, Sophie Gosselin, Alexis Cournoyer
Summary: This study aimed to evaluate the relationship between emergency department (ED) acute pain management with fentanyl compared to other opioids, and the quantity of opioids consumed by patients two weeks after discharge. The results showed that patients treated with fentanyl during their ED stay did not consume more opioids after ED discharge, compared to those treated with other opioids.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Shan Liu, Wen-Jia Kang, Anna Abrimian, Jin Xu, Luca Cartegni, Susruta Majumdar, Patrick Hesketh, Alex Bekker, Ying-Xian Pan
Summary: The OPRM1 gene undergoes extensive alternative splicing to produce multiple splice variants with important pharmacological implications for the actions of opioid drugs. These variants can mediate distinct effects of various mu opioids and be targeted for the development of novel analgesics with potent efficacy against multiple types of pain while reducing side effects associated with traditional opiates.
Article
Medicine, General & Internal
Ryoko Kawanaka, Shoko Sakuma, Hiroshi Kokubun, Shuhei Tetsu, Yugo Tagaito, Toshio Igarashi, Shan-Guang Liang, Tomohiko Aoe
Summary: This study evaluated the effect of combined use of fentanyl and short-acting remifentanil on postoperative pain and pain thresholds. The results showed that the combination of both opioids caused hyperalgesia, and the pain threshold decreased significantly at 3 hours postoperatively regardless of the fentanyl dose.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Keisheni Ganeson, Ain Hafizah Alias, Vikneswaran Murugaiyah, Al-Ashraf Abdullah Amirul, Seeram Ramakrishna, Sevakumaran Vigneswari
Summary: Cancer is a leading cause of death globally and has a significant impact on patients' quality of life and the world economy. Conventional cancer therapies have limitations such as long treatment duration, systemic drug exposure, pain, side effects, and recurrence. Microneedles, a novel technology for transdermal application, are being extensively studied for their potential in cancer therapy, offering benefits like self-administration, painless treatment, and environmental friendliness. This review explores the types, fabrication methods, materials, recent advances, and opportunities of microneedles in cancer therapy, as well as addressing the challenges and limitations while suggesting solutions for their clinical translation.
Article
Neurosciences
Melih Oezguer Celik, Viola Seitz, Fatih Yergoez, Sandeep Dembla, Nina Kathleen Blum, Stefan Schulz, Christoph Stein
Summary: N-(3-fluoro-1-phenethylpiperidine-4-yl)-N-phenyl propionamide is a newly-designed pain killer that selectively activates G-protein-coupled mu-opioid receptors (MOR) in acidic injured tissues, devoid of central side effects. The inhibitory effects of NFEPP on calcium currents in rat DRG neurons and its pH-dependent MOR signaling were investigated.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Anesthesiology
V. Jokinen, T. O. Lilius, J. Laitila, M. Niemi, P. V. Rauhala, E. A. Kalso
EUROPEAN JOURNAL OF PAIN
(2016)
Article
Obstetrics & Gynecology
Paivi Tommola, Leila Unkila-Kallio, Anders Paetau, Seppo Meri, Eija Kalso, Jorma Paavonen
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2016)
Article
Orthopedics
Ritva A. Markkula, Eija A. Kalso, Jaakko A. Kaprio
BMC MUSCULOSKELETAL DISORDERS
(2016)
Article
Immunology
Zhilin Li, Hong Wei, Sami Piirainen, Zuyue Chen, Eija Kalso, Antti Pertovaara, Li Tian
BRAIN BEHAVIOR AND IMMUNITY
(2016)
Article
Anesthesiology
Kristiina Cajanus, Emil J. Holmstrom, Maija Wessman, Verneri Anttila, Mari A. Kaunisto, Eija Kalso
Article
Anesthesiology
Pekka Vartiainen, Tarja Heiskanen, Harri Sintonen, Risto P. Roine, Eija Kalso
Article
Anesthesiology
Alfred Ultsch, Dario Kringel, Eija Kalso, Jeffrey S. Mogil, Joern Loetsch
Review
Medicine, General & Internal
Reetta M. Sipila, Eija A. Kalso
Summary: The decline in sleep quality increases the risk of pain onset, and existing pain exacerbates the decline in sleep quality. The risk factors for developing insomnia and experiencing severe pain after surgery are similar. Therefore, it is important to understand how to assess and monitor sleep disturbances, and support better sleep through pharmacological and non-pharmacological interventions.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Anesthesiology
Teemu Miettinen, Jaana Sverloff, Olli-Pekka Lappalainen, Steven J. Linton, Kirsi Sipila, Eija Kalso
Summary: Chronic pain and sleep problems often occur together. This study found that pain patients with sleep problems were more likely to have other health conditions and childhood adversities, and used more sleep and pain medications.
Article
Biochemistry & Molecular Biology
Teemu Miettinen, Anni I. Nieminen, Pekka Mantyselka, Eija Kalso, Jorn Lotsch
Summary: Recent scientific evidence suggests that metabolomic changes are associated with chronic pain phenotypes. However, problems such as sleep disorders or obesity may complicate the metabolome pattern. In this study, common metabolomics markers at the interface of persistent pain, sleep, and obesity were identified. Two independent lines of data analysis were used to investigate the complex phenotype. The findings suggest that metabolomic changes associated with co-occurring problems may play a role in the development of severe pain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Anesthesiology
Eija Kalso
Article
Medicine, Legal
Pirkko Kriikku, Eija Kalso, Ilkka Ojanpera
Summary: This study investigated post-mortem oxycodone blood concentrations in oxycodone-related medico-legal cases in hospitals and nursing homes in Finland. It found that cancer patients had significantly higher oxycodone concentrations compared to patients with recent surgery or other diseases. Additionally, the poisoning groups had significantly higher oxycodone concentrations compared to the hospital patient groups.
INTERNATIONAL JOURNAL OF LEGAL MEDICINE
(2022)
Article
Anesthesiology
Sirkku E. E. Ahlstrom, Paula H. H. Bergman, Ritva M. M. Jokela, Klaus T. T. Olkkola, Mari A. A. Kaunisto, Eija A. A. Kalso
Summary: This study aimed to explore the clinical and genetic factors impacting post-operative nausea and vomiting (PONV) by conducting a genome-wide association study. The results indicated that several genetic variants were associated with PONV, and the association with dopamine D-2 receptors was confirmed. Clinical factors such as age, American Society of Anaesthesiologists status, amount of oxycodone used in the post-anaesthesia care unit, smoking status, previous PONV, and history of motion sickness were also found to be related to PONV.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2023)
Article
Pharmacology & Pharmacy
Johanna Kujala, Niklas Wester, Terhi J. Lohela, Mika Kurkela, Janne T. Backman, Bjorn Mikladal, Tomi Laurila, Jari Koskinen, Tuomas O. Lilius, Eija A. Kalso
Summary: This study aimed to validate a novel electrochemical point-of-care (POC) assay for rapid paracetamol concentration determinations. The results showed biases in POC compared with venous plasma and capillary blood HPLC-MS/MS at concentrations >30 μM. The novel POC method is considered a promising tool for paracetamol concentration analysis.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Joern Loetsch, Laura Mustonen, Hanna Harno, Eija Kalso
Summary: This study identified specific proteins related to persistent postsurgical neuropathic pain (PPSNP) in women who had experienced intercostobrachial nerve injury during breast cancer surgery. These proteins play important roles in immune processes such as cell migration, chemotaxis, and cytokine-signaling. The findings provide insights into the neuroinflammatory processes associated with the development of neuropathic pain after intraoperative nerve lesion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)