Article
Clinical Neurology
Daniel Martin-Vera, Alberto Sanchez-Sierra, Angel Gonzalez-de-la-Flor, Guillermo Garcia-Perez-de-Sevilla, Diego Dominguez-Balmaseda, Jose Angel del-Blanco-Muniz
Summary: Strength-based exercise program showed significant improvements in duration and intensity of headaches, deep cervical muscle thickness, peripheral sensitization reduction, and strength of deep cervical flexors in patients with chronic tension-type headaches. More research is needed to explore the impact of pain normalization and physical factors on headaches.
FRONTIERS IN NEUROLOGY
(2023)
Article
Medicine, Research & Experimental
Antanas Vaitkus, Ovidijus Laucius, Zemyna Kurnickaite, Simona Gylyte
Summary: Tension-type headache is the most common type of headache, but its classification as a primary headache is questionable. Existing studies lack evidence connecting it to other primary headaches, and there are phenotypical differences compared to other primary headaches. Due to the uncertainty of its origin and pathophysiology, treatment options for tension-type headache are limited.
MEDICAL HYPOTHESES
(2022)
Article
Clinical Neurology
Todd J. Schwedt, Joseph G. Hentz, Soma Sahai-Srivastava, Natalia Murinova, Nicole M. Spare, Christina Treppendahl, Vincent T. Martin, Marius Birlea, Kathleen Digre, David Watson, Michael Leonard, Teri Robert, David W. Dodick
Summary: This study aims to determine whether migraine preventive therapy without switching or limiting the frequency of overused medication is noninferior to migraine preventive therapy with switching to an alternative medication that could be used on <= 2 d/wk.
Review
Biology
Valentina Baglioni, Silvia Orecchio, Dario Esposito, Noemi Faedda, Giulia Natalucci, Vincenzo Guidetti
Summary: In pediatric neurology, tension-type headache (TTH) is a common primary headache among children. However, it is often underestimated and difficult to differentiate from secondary and other primary headaches in childhood. There can be clinical overlap between migraine and TTH in children, with migraine attacks presenting tension headache-like features and TTH displaying migraine-like symptoms. Factors such as hormonal changes, triggers, and genetic and epigenetic factors play a role in the complex trajectory of headache evolution. This review aims to summarize the literature on the differential diagnosis of TTH in pediatrics, the possible outcomes during development, and appropriate therapeutic strategies.
Article
Clinical Neurology
Ignacio Elizagaray-Garcia, Gabriela F. Carvalho, Tibor M. Szikszay, Waclaw M. Adamczyk, Gonzalo Navarro-Fernandez, Paula Alvarez-Testillano, Javier Diaz-de-Teran, Kerstin Luedtke, Alfonso Gil-Martinez
Summary: The study compared psychophysical aspects of patients with chronic migraine, chronic tension-type headache, and headache-free controls, finding that neck disability was a significant predictor of headache frequency for both chronic tension-type headache and chronic migraine.
Article
Clinical Neurology
Todd J. Schwedt, Joseph G. Hentz, Soma Sahai-Srivastava, Nicole M. Spare, Vincent T. Martin, Christina Treppendahl, Kathleen Digre, Nathan L. Bennett, Marius Birlea, David Watson, Natalia Murinova, Teri Robert, David W. Dodick
Summary: The study described headache characteristics, medication use, disability, and quality of life in patients with chronic migraine (CM) and medication overuse headache (MOH) from the United States. Findings showed a significant burden on patients with CM and MOH, with higher headache frequency associated with greater impact on functioning, pain interference, and quality of life.
Article
Medicine, General & Internal
Rosalinda Romero-Godoy, Sara Raquel Romero-Godoy, Manuel Romero-Acebal, Mario Gutierrez-Bedmar
Summary: This study found a direct association between chronic tension-type headache (CTTH) and depression, anxiety, and negative affectivity, despite the absence of a previously diagnosed psychiatric disorder or use of medication.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Theodoros Constantinidis, Chryssa Arvaniti, Nikolaos Fakas, Jobst Rudolf, Evangelos Kouremenos, Ermioni D. Giannouli, Dimos Mitsikostas, Hellenic Headache Society
Summary: This study aimed to estimate the prevalence and burden of medication overuse headache in a representative sample of the Greek population. Results showed that the prevalence of medication overuse headache in Greece was 0.7%, with a higher proportion in females. The impact on work performance and productivity was significant. Medication overuse headache is a serious socio-economic health problem that requires immediate health policy planning.
Review
Clinical Neurology
Qing-Feng Tao, Xiao-Ying Wang, Si-Jia Feng, Xin-Yu Xiao, Yun-Zhou Shi, Chao-Rong Xie, Hui Zheng
Summary: This study used meta-analysis and trial sequential analysis to verify the effectiveness and safety of acupuncture in reducing tension-type headache frequency. The results showed that acupuncture had a greater reduction in frequency compared to sham acupuncture and no acupuncture. However, the existing sample size is insufficient to draw definitive conclusions.
JOURNAL OF NEUROLOGY
(2023)
Review
Clinical Neurology
Robert Kaniecki
Summary: Recent research has clarified the roles of pathology in the paranasal sinuses and TMJ in patients with headaches, while physiological studies have provided additional insights into tension-type headaches. Better understanding of the origins of headaches can lead to reduced unnecessary diagnostics and improved treatment outcomes.
CURRENT OPINION IN NEUROLOGY
(2021)
Article
Clinical Neurology
Judith A. Pijpers, Dennis A. Kies, Erik W. van Zwet, Frits R. Rosendaal, Gisela M. Terwindt
Summary: This study evaluated the efficacy of behavioral intervention during medication withdrawal therapy. The results suggest that behavioral intervention by a headache nurse can reduce acute medication use during and shortly after the intervention. Further research is needed to determine the long-term effects.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Orthopedics
Kiran Satpute, Nilima Bedekar, Toby Hall
Summary: This study aims to determine the effectiveness of Mulligan Manual Therapy (MMT) compared to placebo and exercise in managing migraine, tension-type headache, and cervicogenic headache. The pragmatic trial includes 297 participants with a primary outcome measure of headache frequency and secondary outcome measures such as headache duration, intensity, and medication intake.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Clinical Neurology
Inna E. Tchivileva, Richard Ohrbach, Roger B. Fillingim, Feng-Chang Lin, Pei Feng Lim, Samuel J. Arbes, Gary D. Slade
Summary: Headache attributed to Temporomandibular Disorder (HATMD) is a common secondary headache among patients with chronic myogenous TMD and primary headaches, often presenting as migraine. Unlike primary headaches, HATMD is associated with higher headache frequency and examination-evoked masticatory muscle pain, but surprisingly few measures of facial pain, general health, and psychological distress. Understanding these differences is important for developing targeted strategies for HATMD management.
JOURNAL OF HEADACHE AND PAIN
(2021)
Article
Clinical Neurology
Rhannon Lobo, Mu Wang, Sean Lobo, Anish Bahra
Summary: New daily persistent headache is a challenging condition characterized by daily headache from onset. A study conducted in London found that most patients experienced chronic migraine, with a subset also experiencing thunderclap-onset headache. Factors like aura types, prior headache history, and premorbid disorders were also observed in the study cohort. Improvement was seen in a small percentage of patients, with some responding well to preventative medications like amitriptyline.
Review
Food Science & Technology
Katarzyna Kepczynska, Izabela Domitrz
Summary: This article presents the common types of headaches and the effects of botulinum toxin in their treatment. Tension-type headache and migraine are the most common types of headaches, and botulinum toxin has shown significant benefits in treating chronic headaches. However, there is still a lack of evidence for its use in other types of headaches.
Meeting Abstract
Gastroenterology & Hepatology
Jenny Sauk, Hyo Jin Ryu, Jennifer Labus, Cathy Liu, Jean Stains, Miriam Dvorsky, Venu Lagishetty, Bruce Naliboff, Jonathan Jacobs, Emeran Mayer
INFLAMMATORY BOWEL DISEASES
(2020)
Meeting Abstract
Gastroenterology & Hepatology
Kimberly Trieschmann, Sarah Park, Bruce Naliboff, Swapna Joshi, Natacha Emerson, Jenny Sauk, Jennifer Labus, Berkeley Limketkai, Joanna Yeh, Emeran Mayer, Lin Chang
INFLAMMATORY BOWEL DISEASES
(2020)
Article
Clinical Neurology
Jennifer Kornelsen, Alyssia Wilson, Jennifer S. Labus, Kelcie Witges, Emeran A. Mayer, Charles N. Bernstein
FRONTIERS IN NEUROLOGY
(2020)
Article
Gastroenterology & Hepatology
Bruce D. Naliboff, Suzanne R. Smith, John G. Serpa, Kelsey T. Laird, Jean Stains, Lynn S. Connolly, Jennifer S. Labus, Kirsten Tillisch
NEUROGASTROENTEROLOGY AND MOTILITY
(2020)
Article
Medicine, General & Internal
Birgitte Berentsen, Bharath Halandur Nagaraja, Erica Pearson Teige, Gulen Arslan Lied, Astri J. Lundervold, Katarina Lundervold, Elisabeth Kjelsvik Steinsvik, Eline Randulff Hillestad, Jorgen Valeur, Ingeborg Bronstad, Odd Helge Gilja, Berge Osnes, Jan Gunnar Hatlebakk, Judit Haasz, Jennifer Labus, Arpana Gupta, Emeran A. Mayer, Alfonso Benitez-Paez, Yolanda Sanz, Arvid Lundervold, Trygve Hausken
Article
Nutrition & Dietetics
Michelle A. Chernikova, Genesis D. Flores, Emily Kilroy, Jennifer S. Labus, Emeran A. Mayer, Lisa Aziz-Zadeh
Summary: There is a need for further research on the mechanisms underlying the relationship between gut microbiota, brain function, social behavior, and ASD development, particularly in individuals with gastrointestinal issues. By exploring the potential role of microbiota-targeted therapies in ASD, there is a possibility of informing new treatments aimed at modulating the gut microbiome system and alleviating behavioral and physiological symptoms in individuals with ASD.
Article
Anesthesiology
Jennifer S. Labus, Chencai Wang, Emeran A. Mayer, Arpana Gupta, Talia Oughourlian, Lisa Kilpatrick, Kirsten Tillisch, Lin Chang, Bruce Naliboff, Benjamin M. Ellingson
Summary: Preliminary evidence suggests sex differences in brain organization among individuals with IBS. This study aimed to investigate further differences in brain microstructure and organization between female and male IBS patients. The results showed extensive microstructural alterations in pain processing and integration areas in female IBS patients compared to male IBS patients. These findings support the hypothesis that symptoms in females with IBS may be driven by greater central sensitivity for multiple sensory stimuli.
Article
Clinical Neurology
Chencai Wang, Jason J. Kutch, Jennifer S. Labus, Claire C. Yang, Richard E. Harris, Emeran A. Mayer, Benjamin M. Ellingson
Summary: This study found that alterations in white matter microstructure may be associated with persistent pain symptoms in urologic chronic pelvic pain syndrome (UCPPS). The results showed consistent aberrations in mean diffusivity (MD) between UCPPS patients and healthy controls, while fractional anisotropy (FA) differences were unique at baseline and 6-month follow-up visits. Furthermore, abnormal microstructural connectivity was observed in specific brain regions involved in sensory processing and pain modulation.
Article
Gastroenterology & Hepatology
Cecilia Grinsvall, Hyo Jin Ryu, Lukas Van Oudenhove, Jennifer S. Labus, Arpana Gupta, Maria Ljungberg, Hans Tornblom, Emeran A. Mayer, Magnus Simren
Summary: This study found several regional gray matter differences between IBS patients and healthy controls, with higher gray matter volume and cortical thickness in primary somatosensory cortex, secondary somatosensory cortex, and subcortical regions in IBS patients, and lower gray matter volume, surface area, and cortical thickness in posterior insula and superior frontal gyrus. Pain intensity during rectal distension was associated with cortical thickness in the left primary somatosensory cortex, while pain threshold was associated with volume in the right nucleus accumbens. These findings suggest that regional gray matter differences in the sensorimotor network are linked to visceral sensitivity in female IBS patients.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Psychiatry
Vadim Osadchiy, Emeran A. Mayer, Kan Gao, Jennifer S. Labus, Bruce Naliboff, Kirsten Tillisch, Lin Chang, Jonathan P. Jacobs, Elaine Y. Hsiao, Arpana Gupta
TRANSLATIONAL PSYCHIATRY
(2020)
Meeting Abstract
Psychiatry
Hyo Jin Ryu, Jenny Sauk, Jonathan Jacobs, Bruce Naliboff, Jennifer Labus, Emeran Mayer
PSYCHOSOMATIC MEDICINE
(2020)
Meeting Abstract
Psychiatry
Guistinna Tun, Jennifer S. Labus, Kirsten Tillisch, Bruce Naliboff, Arpana Gupta
PSYCHOSOMATIC MEDICINE
(2020)
Meeting Abstract
Psychiatry
Vadim Osadchiy, Emeran A. Mayer, Kan Gao, Jennifer S. Labus, Bruce Naliboff, Lin Chang, Jonathan Jacobs, Arpana Gupta
PSYCHOSOMATIC MEDICINE
(2020)
Meeting Abstract
Gastroenterology & Hepatology
Jenny Sauk, Hyo Jin Ryu, Jennifer Labus, Cathy Liu, Jean Stains, Miriam Dvorsky, Venu Lagishetty, Bruce Naliboff, Jonathan Jacobs, Emeran Mayer
Meeting Abstract
Gastroenterology & Hepatology
Kimberly Trieschmann, Sarah Park, Bruce Naliboff, Swapna Joshi, Natacha Emerson, Jenny Sauk, Jennifer Labus, Berkeley Limketkai, Joanna Yeh, Emeran Mayer, Lin Chung