Article
Psychiatry
Balwinder Singh, John D. Port, Jennifer L. Vande Voort, Brandon J. Coombes, Jennifer R. Geske, Ian R. Lanza, Robert J. Morgan, Mark A. Frye
Summary: The neurotransmitters GABA and glutamate have been linked to depression and the antidepressant response to ketamine. A study on treatment-resistant depression patients showed a correlation between ketamine's effectiveness and GABA levels in the anterior cingulate cortex, suggesting a potential biomarker for ketamine response.
PSYCHIATRY RESEARCH
(2021)
Article
Neurosciences
Xiaona Fu, Mengting Qin, Xiaoming Liu, Lan Cheng, Lan Zhang, Xinli Zhang, Yu Lei, Qidong Zhou, Peng Sun, Liangjie Lin, Ying Su, Jing Wang
Summary: This study investigated the relationship between GABA levels, cortical thickness, and executive function in MCI patients. The results showed that MCI patients had lower GABA+/Cr levels in the ACC and PCC, while there were no differences in cortical thickness between the two groups. Therefore, GABA in the ACC and PCC could be a potential diagnostic marker for the decline in executive function in MCI.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Norbert Hogrefe, Sigrid M. Blom, Kristina Valentinova, Niels R. Ntamati, Lotte J. E. Jonker, Natalie E. Nevian, Thomas Nevian
Summary: Malfunctioning synaptic plasticity is a major mechanism in the development of chronic pain. This study shows that even after recovery, the impact of chronic compression injury on synaptic plasticity persists.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Geriatrics & Gerontology
Juan L. Terrasa, Pedro Montoya, Carolina Sitges, Marian van Der Meulen, Fernand Anton, Ana M. Gonzalez-Roldan
Summary: The study reveals that age-related changes in resting-state brain activity are associated with increased pain perception in older adults, with older participants showing increased beta2 and beta3 activity in certain brain regions. Furthermore, hyperactivity in the anterior cingulate cortex (ACC) may underlie the altered pain perception observed in older adults.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Neurosciences
Ilias Chaibi, Mohamed Bennis, Saadia Ba-Mhamed
Summary: The study revealed the role of GABA-A receptor in the anterior cingulate cortex in regulating aggression, social, and anxiety-related behaviors in socially isolated mice. Muscimol increased these behaviors, while bicuculline reduced hyper-aggressive behavior and enhanced social behavior.
Article
Multidisciplinary Sciences
Christopher R. Brydges, Oliver Fiehn, Helen S. Mayberg, Henry Schreiber, Siamak Mahmoudian Dehkordi, Sudeepa Bhattacharyya, Jungho Cha, Ki Sueng Choi, W. Edward Craighead, Ranga R. Krishnan, A. John Rush, Boadie W. Dunlop, Rima Kaddurah-Daouk
Summary: The study found that indole sulfate, a metabolite of gut microbiota, was closely associated with anxiety symptoms but not related to post-treatment outcomes. This suggests that cognitive behavioral therapy and antidepressant medications relieve anxiety through mechanisms unrelated to modulation of gut-derived indoles.
SCIENTIFIC REPORTS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xue Chen, Zhou Huang, Xiaojuan Wu, Shuting Han, Peng Wu, Yonggang Li
Summary: This study investigated the changes in glutamate/glutamine (Glx) and gamma-aminobutyric acid (GABA+) levels within the anterior cingulate cortex (ACC) in primary dysmenorrhea (PDM) women. The findings showed that PDM women had significantly increased ACC-Glx levels during the menstrual phase and a positive correlation between GABA+ and Glx levels in PDM women during this phase. Additionally, ACC-GABA+ levels were associated with self-rating distress scale scores and pain catastrophizing scale scores in PDM women during the menstrual phase.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Article
Immunology
Dan-dan Long, Yu-zhuo Zhang, An Liu, Liang Shen, Hong-rui Wei, Qian-qian Lou, Shan-shan Hu, Dan-yang Chen, Xiao-qing Chai, Di Wang
Summary: This study investigates the impact of chronic nicotine exposure on ACC microglia and their interaction with ACC neurons, as well as the effects on nicotine-induced allodynia in mice. The results demonstrate that chronic nicotine treatment leads to alterations in ACC microglia and hyperactivity of ACC glutamatergic neurons. Inhibiting ACC glutamatergic neurons alleviates nicotine-induced allodynia and reduces microglial activation. Furthermore, the neuron-microglia interaction in chronic nicotine-induced allodynia is mediated by increased expression of neuronal CX3CL1, which activates microglia via CX3CR1 receptors.
JOURNAL OF NEUROINFLAMMATION
(2023)
Review
Neurosciences
Xiao Xiao, Ming Ding, Yu-Qiu Zhang
Summary: Pain is a complex experience that can be classified into different categories and stages, with the anterior cingulate cortex playing a role in pain processing. Studying different types of pain in the ACC can aid in the development of new clinical treatment methods.
NEUROSCIENCE BULLETIN
(2021)
Article
Neurosciences
Aurelie Leplus, Michel Lanteri-Minet, Anne Donnet, Nelly Darmon, Jean Regis, Denys Fontaine
Summary: This study aims to evaluate the feasibility and safety of combining ACC-DBS and thalamic DBS for the treatment of refractory chronic unilateral neuropathic pain. It will assess the efficacy of this combination therapy compared to thalamic DBS alone, and evaluate the safety through neurological, psychiatric, cognitive, and affective function assessments.
Article
Multidisciplinary Sciences
Mario A. Acuna, Fernando Kasanetz, Paolo De Luna, Marta Falkowska, Thomas Nevian
Summary: The perception of pain is a complex experience and understanding how the brain distinguishes pain from other sensory stimuli has been a challenge. In this study, researchers used calcium imaging in mice to investigate the coding of pain in the anterior cingulate cortex. They found that population activity, rather than single-cell responses, allowed the discrimination of painful stimuli. Additionally, they discovered that chronic neuropathic pain led to changes in sensory processing, which were restored by analgesic treatment.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Neurosciences
Qi-Ya Xu, Hai -Long Zhang, Han Du, Yong -Chang Li, Fu-Hai Ji, Rui Li, Guang-Yin Xu
Summary: Chronic visceral pain is a major challenge for both patients and health providers. Research has found that inhibiting or activating CL glutamatergic neurons has no effect on CFA-induced inflammatory pain, but is critical for visceral pain. Further studies have demonstrated a causal link between such neuronal activity and visceral pain behaviors.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Immunology
Qiao-Yun Li, Shao-Xia Chen, Jin-Yu Liu, Pei-Wen Yao, Yi-Wen Duan, Yong-Yong Li, Ying Zang
Summary: In this study, the neuroimmune changes in bilateral ACC region were investigated and compared using unilateral- and mirror-pain models. It was found that CX3CL1 plays a pivotal role in the descending facilitation function, leading to enhanced pain sensitization and mirror-image pain.
JOURNAL OF NEUROINFLAMMATION
(2022)
Review
Pharmacology & Pharmacy
Kevin Lancon, Philippe Seguela
Summary: Chronic pain is a global burden with limited treatment options. Its intractable nature is due to the multifaceted nature of pain itself and a lack of understanding of the physiological mechanisms underlying its initiation and maintenance. Normalizing dysregulated nociceptive pathways is crucial for developing novel non-opioid analgesic approaches. The anterior cingulate cortex plays a significant role in pain modulation and is associated with abnormal activity and impaired cognitive functions in chronic pain conditions.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Behavioral Sciences
Xuan Li, Juan Yao, Ke-hui Hu, Bing Wu, Jian-feng Sui, Jie Gao, Guang-yan Wu, Shu-lei Liu
Summary: This study demonstrated the involvement of prelimbic cortex in itch modulation and revealed the differential roles of caudal anterior cingulate cortex and prelimbic cortex in regulating histaminergic and non-histaminergic itch.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Anesthesiology
Niklas Nielsen, Henrik Kehlet, Kirill Gromov, Anders Troelsen, Henrik Husted, Claus Varnum, Per Kjaersgaard-Andersen, Lasse E. Rasmussen, Lina Pleckaitiene, Nicolai B. Foss
Summary: This study involved 88 patients undergoing TKA with a preoperative pain catastrophising score >20 or regular opioid use, comparing high-dose and intermediate-dose preoperative intravenous dexamethasone. The results showed that high-dose dexamethasone reduced moderate-to-severe pain 24 hours after TKA and improved recovery in high pain responders without apparent side-effects.
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Article
Surgery
Christian T. Bonde, Jens B. Hojvig, Lisa T. Jensen, Mette Wolthers, Faranak N. Sarmady, Kenneth G. Andersen, Henrik Kehlet
Summary: This study demonstrates the use of an enhanced recovery protocol (ERP) in autologous breast reconstruction, showing that a majority of patients can safely be discharged by the third postoperative day using simple discharge criteria. The findings support the standard of care status of ERP in microsurgical breast reconstruction.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2022)
Article
Anesthesiology
N. I. Nielsen, H. Kehlet, K. Gromov, A. Troelsen, N. B. Foss, E. K. Aasvang
Summary: Skipping the post-anaesthesia care unit after knee and hip arthroplasty can be considered for low-risk patients, leading to improved flow and resource utilization in the operating theatre, without compromising safety. Further confirmation is needed, considering variations in peri-operative protocols and settings.
Letter
Surgery
Henrik Kehlet, Lin Huang, Rene Horsleben Petersen
Article
Anesthesiology
Christoffer C. C. Jorgensen, Pelle B. B. Petersen, Louise O. O. Daugberg, Thomas Jakobsen, Kirill Gromov, Claus Varnum, Mikkel R. R. Andersen, Henrik Palm, Henrik Kehlet
Summary: Routine use of peripheral nerve blocks was not associated with early discharge or 30-days readmissions in fast-track THA and TKA. Future studies should focus on benefits of PNB in high-risk patients.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2023)
Article
Anesthesiology
Nina Brendborg Rasmussen, Henrik Kehlet, Troels Bygum Knudsen, Pernille Printzlau, Christoffer Calov Jorgensen
Summary: Background evaluation of regular medication is crucial in the preanesthetic consultation, especially for elective surgical patients with increasing age and pharmacologically treated comorbidities. However, there is limited data on prescribed drugs and polypharmacy in these patients.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2023)
Article
Anesthesiology
Maja Vejlgaard, Sophia L. Maibom, Ulla N. Joensen, Henrik Kehlet, Morten Bundgaard-Nielsen, Eske K. Aasvang, Andreas Roder
Summary: This study compared the intraoperative and immediate postoperative outcomes between open radical cystectomy (ORC) and robot-assisted radical cystectomy (iRARC). The results showed that iRARC patients had similar recovery compared to ORC patients.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2023)
Article
Anesthesiology
Anders H. Springborg, Claus Varnum, Niklas I. Nielsen, Lasse E. Rasmussen, Per Kjaersgaard-Andersen, Lina Pleckaitiene, Kirill Gromov, Anders Troelsen, Henrik Kehlet, Nicolai B. Foss
Summary: Pain after total knee arthroplasty is a common problem, and perioperative glucocorticoids have been shown to reduce pain and facilitate recovery. However, the optimal timing and dose of glucocorticoids are still unknown. This study aims to evaluate the effect of a repeat moderate dose of glucocorticoids in high pain catastrophizers who experience moderate to severe pain 24 hours after surgery.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2023)
Article
Anesthesiology
M. Cihoric, H. Kehlet, J. Hojlund, M. L. Lauritsen, K. Kanstrup, N. B. Foss
Summary: The feasibility of assessing hydration status and fluid distribution using Bioimpedance spectroscopy Analysis (BIA) in surgical patients was evaluated. BIA measurements correlated with fluid balance, weight changes, and postoperative clinical complications.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2023)
Article
Surgery
Jens H. Hojvig, Birgitte W. Charabi, Irene Wessel, Lisa T. Jensen, Jan Nyberg, Nana Maymann-Holler, Henrik Kehlet, Christian T. Bonde
Summary: This study presents the results of using an enhanced recovery after surgery (ERAS) protocol for microvascular reconstruction in patients with head and neck cancer. The study found that using the ERAS protocol resulted in shorter hospital stay, shorter time to ambulation, shorter time to removal of nasogastric tube, and fewer tracheostomies performed. There were no differences in complications, flap survival, or 30-day re-admissions between the two groups.
Article
Orthopedics
Martin Lindberg-Larsen, Claus Varnum, Thomas Jakobsen, Mikkel Rathsach Andersen, Kim Sperling, Soren Overgaard, Torben Baek Hansen, Christoffer Calov Jorgensen, Henrik Kehlet, Kirill Gromov
Summary: This study aims to investigate the feasibility, safety, and socioeconomic aspects of discharge on the day of surgery after hip and knee arthroplasty in 8 fast-track centers. The study will enroll 9,000 patients over a 3-year period and record the discharge rate, readmissions, complications, and patient-reported information. The outcome data will be used to develop a prediction model for successful discharge on the day of surgery.
Article
Clinical Neurology
Elisabeth Kjaer Jensen, Thomas K. Ringsted, Joakim M. Bischoff, Morten A. Petersen, Kirsten Moller, Henrik Kehlet, Mads U. Werner
Summary: This study aimed to investigate and describe the underlying pathophysiological changes in the groin areas and examine the effects of re-surgery on pain and function using quantitative somatosensory testing (QST). The results showed that re-surgery can improve pain and function, and QST analyses are useful for mechanism-based somatosensory research.
JOURNAL OF PAIN RESEARCH
(2023)
Article
Anesthesiology
Ana-Marija Hristovska, Bodil Uldall-Hansen, Jesper Mehlsen, Louise B. Andersen, Henrik Kehlet, Nicolai B. Foss
Summary: This study aimed to investigate the effects of mild acute blood loss on autonomic function and orthostatic intolerance, simulating postoperative hypovolemia. The results showed a specific hypovolemic component of postoperative orthostatic intolerance, independent of autonomic dysfunction, inflammation, opioids, and pain.
CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE
(2023)
Article
Critical Care Medicine
Mirjana Cihoric, Henrik Kehlet, Jakob Hojlund, Morten Laksafoss Lauritsen, Katrine Kanstrup, Nicolai Bang Foss
Summary: This study examines the fluid distribution and haemodynamic implications in acute high-risk abdominal surgery. It found that there is a progressive increase in fluid balance and extracellular volume throughout the perioperative period, which can lead to overhydration. Patients with overhydration are less haemodynamically stable compared to those with normo- or dehydration.
Letter
Gastroenterology & Hepatology
Henrik Kehlet
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2023)
