期刊
PAEDIATRIC RESPIRATORY REVIEWS
卷 11, 期 3, 页码 177-184出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.prrv.2010.05.003
关键词
Pseudomonas aeruginosa; cystic fibrosis; inhaled tobramycin; eradication therapy; colonization
资金
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [T32HL072748] Funding Source: NIH RePORTER
- NHLBI NIH HHS [T32 HL072748] Funding Source: Medline
Pseudomonas aeruginosa (Pa) is the predominant organism infecting the airways of patients with cystic fibrosis (CF). This organism has an armamentarium of survival mechanisms that allows it to survive in the CF airway. Since colonization and chronic infection with Pa is associated with poorer lung function and increased morbidity and mortality, therapies that can prevent infection could significantly improve the lives of patients with CF. Numerous studies have examined the effects of treatment on the eradication of Pa as a means to ameliorate disease. This article outlines the pathophysiology and clinical implication of Pa acquisition, and reviews the existing treatment regimens aimed at early eradication of Pa in patients with CF. (C) 2010 Elsevier Ltd. All rights reserved.
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