Review
Chemistry, Applied
A. J. M. Santos, S. Khemiri, S. Simo, C. Prista, I. Sousa, A. Raymundo
Summary: Vitamins are essential organic compounds that are necessary for good health but cannot be synthesized by the human body. Vitamins B6 and B12 are hydrophilic vitamins that play vital roles in cellular operation, growth, and development. This review focuses on the important aspects of vitamins B6 and B12, including their roles, consequences of deficiency, food sources, and chromatographic techniques developed in the last two decades for their determination.
Review
Pharmacology & Pharmacy
Ramyia Elangovan, Julien Baruteau
Summary: This review summarizes the complex metabolic pathway of Vitamin B12 deficiency, describes the causes of inherited and acquired Vitamin B12 deficiency, and highlights the differences in international practice regarding prescribing Vitamin B12 replacement therapy. Furthermore, the review discusses the evidence supporting novel modes of B12 replacement such as sublingual, intranasal, and subcutaneous routes, and compares them to intramuscular and oral routes in terms of patient compliance and cost-saving.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biology
Zuzanna Rzepka, Jakub Rok, Mateusz Maszczyk, Artur Beberok, Justyna Magdalena Hermanowicz, Dariusz Pawlak, Dorota Gryko, Dorota Wrzesniok
Summary: Vitamin B12 plays a crucial role in DNA synthesis for cell division, with deficiency particularly impacting rapidly dividing cells like glioblastoma cells. Antagonists of cobalamin have potential as anti-glioma agents, as shown by inducing cobalamin deficiency to inhibit glioblastoma cell growth and promote cell cycle arrest. This study suggests that cobalamin deprivation could be a promising therapeutic strategy for glioblastoma, with further exploration warranted.
Article
Food Science & Technology
Sara Al-Musharaf, Ghadeer S. Aljuraiban, Lama Al-Ajllan, Noura Al-Khaldi, Esra'a A. Aljazairy, Syed Danish Hussain, Abdullah M. Alnaami, Shaun Sabico, Nasser Al-Daghri
Summary: This study found that the abundance and diversity of gut microbiota are associated with vitamin B12 levels and obesity in young females.
Article
Nutrition & Dietetics
Nathalia Cristina Freitas-Costa, Pedro Gomes Andrade, Paula Normando, Keronlainy Silva Salvatte Nunes, Carlos Eduardo Raymundo, Ines Rugani Ribeiro de Castro, Elisa Maria de Aquino Lacerda, Dayana Rodrigues Farias, Gilberto Kac
Summary: This study evaluated the association between vitamins B6, B12, and folate concentrations/status and early childhood development (ECD) and found that vitamin B6 was positively associated with DQ, while vitamin B12 was negatively associated with DQ. There was no significant association between folate status and DQ.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Review
Plant Sciences
Soojin Oh, Gareth Cave, Chungui Lu
Summary: Developing a resilient food supply is crucial in delivering necessary nutrients to consumers and addressing micronutrient deficiencies that can lead to severe health issues. Therefore, focus should be on enhancing minerals and nutrients in food through various methods to improve the sustainability of the food system.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Nutrition & Dietetics
Samuel Berkins, Helgi Birgir Schioth, Gull Rukh
Summary: The study found no significant association between vitamin B6, B12, and folate intakes and both global and subcortical brain volumes among participants with depression. However, vitamin B12 intake was positively associated with right pallidum among non-depressed participants, and a significant interaction between vitamin B12 intake and depression status on the right pallidum was observed. Additionally, a significant interaction between folate intake and depression status on grey matter volume and left thalamus was observed.
Review
Nutrition & Dietetics
Alessandra Vincenti, Laura Bertuzzo, Antonio Limitone, Giuseppe D'Antona, Hellas Cena
Summary: Vitamin B12 is essential and obtained exclusively from diet, with certain population groups at risk of subclinical deficiency. Poor intake of animal products and age-related decrease in intestinal B12 uptake contribute to the risk of deficiency in elderly population.
Article
Chemistry, Applied
Stephane Dubascoux, Janique Richoz Payot, Paul Sylvain, Marine Nicolas, Esther Campos Gimenez
Summary: The new method accurately quantifies vitamin B12 in human milk with high sensitivity and accuracy. It can be used for monitoring vitamin B12 in clinical studies and assessing infant intake in breastfeeding.
Article
Food Science & Technology
Giulia Rampazzo, Elisa Zironi, Giampiero Pagliuca, Teresa Gazzotti
Summary: The analysis of natural cobalamins in dairy products is challenging due to the complexity of the matrix, low concentration level, light sensitivity, and binding to proteins. This study developed a sensitive and selective method using UHPLC-MS/MS to quantitate vitamin B12 in ripened cheeses from different species, revealing species-dependent differences in vitamin B12 concentrations.
Article
Nutrition & Dietetics
R. Deepa, Siddhartha Mandal, Onno C. P. Van Schayck, Giridhara R. R. Babu
Summary: This study aimed to investigate the status of B6, B12, and folate levels in pregnancy and their associations with low birth weight and preterm delivery. The results showed that a large proportion of pregnant women had low levels of B12, folate, and B6. Moreover, low B6 levels and impaired folate status were significantly associated with low birth weight.
Article
Biotechnology & Applied Microbiology
Alexandra Lukacova, Terezia Beck, Lenka Koptasikova, Ales Benda, Lucia Tomeckova, Miriam Trnikova, Diana Lihanova, Juergen Michael Steiner, Juraj Krajcovic, Matej Vesteg
Summary: Euglena gracilis, a freshwater protist, has various biotechnological applications and can be used for biofuel production, pharmaceuticals, and water remediation. However, its large-scale cultivation is limited by the high cost of adding vitamins B1 and B12 to the media. This study demonstrates that E. gracilis can be grown for long periods without the need for added vitamins B1 and B12 in a co-culture system involving the filamentous fungus Cladosporium westerdijkiae and the bacteria Lysinibacillus boronitolerans and Pseudobacillus badius. This finding significantly reduces the cultivation costs and the fungus C. westerdijkiae can be used for effective harvesting of E. gracilis through bioflocculation.
JOURNAL OF BIOTECHNOLOGY
(2022)
Article
Nutrition & Dietetics
Christopher J. Cifelli, Sanjiv Agarwal, Victor L. Fulgoni
Summary: This study found that higher intake of dairy products, especially milk and yogurt, is positively associated with adequate levels of vitamin B-6, B-12, and folate, and lowers the risk of deficiency or inadequacy of these vitamins.
Article
Nutrition & Dietetics
Yacong Bo, Huadong Xu, Huanhuan Zhang, Junxi Zhang, Zhongxiao Wan, Xin Zhao, Zengli Yu
Summary: This study found that higher dietary intake of folate and vitamin B6 is significantly associated with lower all-cause and cardiovascular mortality.
Review
Food Science & Technology
Linnea Barebring, Christel Lamberg-Allardt, Birna Thorisdottir, Alfons Ramel, Fredrik Soderlund, Erik Kristoffer Arnesen, Bright I. Nwaru, Jutta Dierkes, Agneta Akesson
Summary: This systematic review aimed to assess the evidence for whether habitual or different levels of experimental intake of vitamin B12 from diet and supplements is sufficient to ensure adequate B12 status in groups most susceptible to vitamin B12 deficiency. The search yielded 18 included studies, and the conclusion was that the evidence is currently insufficient to determine if or which level of B12 intake is sufficient to maintain adequate status for all included populations.
FOOD & NUTRITION RESEARCH
(2023)
