Article
Public, Environmental & Occupational Health
Mariana Lima Correa, Bruna Goncalves Cordeiro da Silva, Fernando C. Wehrmeister, Bernardo L. Horta, Helen Goncalves, Luciana Anselmi, Fernando Barros, Ana Maria Baptista Menezes
Summary: Maternal smoking during pregnancy is associated with a decrease in offspring's IQ, and this association is partly mediated by breastfeeding and birth weight.
PREVENTIVE MEDICINE
(2022)
Review
Neurosciences
Mariana Lima Correa, Pedro San Martin Soares, Bruna Goncalves Cordeiro da Silva, Fernando Wehrmeister, Bernardo Lessa Horta, Ana Maria Baptista Menezes
Summary: This systematic review and meta-analysis suggest that exposure to tobacco during pregnancy may lead to lower IQ in offspring. However, caution should be taken when interpreting the findings of this meta-analysis.
Article
Biochemistry & Molecular Biology
Brooke G. McKenna, Cassandra L. Hendrix, Patricia A. Brennan, Alicia K. Smith, Zachary N. Stowe, D. Jeffrey Newport, Anna K. Knight
Summary: The study found that maternal stress during pregnancy was not associated with newborn epigenetic age deceleration, while maternal prenatal depression was linked to epigenetic age deceleration in newborns, though this relationship did not hold when accounting for maternal SSRI use. Conversely, maternal SSRI use significantly predicted newborn epigenetic age deceleration beyond the influence of maternal depression.
Article
Medicine, General & Internal
Hein Odendaal, Kimberly A. Dukes, Amy J. Elliott, Marian Willinger, Lisa M. Sullivan, Tara Tripp, Coen Groenewald, Michael M. Myers, William P. Fifer, Jyoti Angal, Theonia K. Boyd, Larry Burd, Jacob B. Cotton, Rebecca D. Folkerth, Gary Hankins, Robin L. Haynes, Howard J. Hoffman, Perri K. Jacobs, Julie Petersen, Nicolo Pini, Bradley B. Randall, Drucilla J. Roberts, Fay Robinson, Mary A. Sens, Peter Van Eerden, Colleen Wright, Ingrid A. Holm, Hannah C. Kinney
Summary: This cohort study found that dual exposure to drinking and smoking after the first trimester of pregnancy was associated with nearly 3 times the risk of late stillbirth compared with no exposure or quitting before the end of the first trimester, suggesting a significantly increased risk.
Article
Public, Environmental & Occupational Health
Pierre-Antoine Dugue, Allison M. Hodge, Ee Ming Wong, JiHoon E. Joo, Chol-Hee Jung, John L. Hopper, Dallas R. English, Graham G. Giles, Roger L. Milne, Melissa C. Southey
Summary: The study revealed a strong positive association between DNA methylation marks of prenatal exposure to maternal smoking and increased risk of urothelial cancer. Potential negative associations were observed with risk of lung cancer and B-cell lymphoma. No associations were found for other cancers.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Ondine S. von Ehrenstein, Xin Cui, Qi Yan, Hilary Aralis, Beate Ritz
Summary: The study found that offspring of mothers who smoked 20 cigarettes or more per day during pregnancy had an increased risk of autism spectrum disorder (ASD), while associations with lighter smoking were weaker.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Reproductive Biology
Omer Karur, Gil Gutvirtz, Tamar Wainstock, Eyal Sheiner
Summary: Maternal cigarette smoking during pregnancy is associated with an increased risk of long-term gastrointestinal morbidity in offspring.
REPRODUCTIVE TOXICOLOGY
(2021)
Article
Psychology, Clinical
Bereket Duko, Gavin Pereira, Kim Betts, Robert J. Tait, John Newnham, Rosa Alati
Summary: The study found an association between maternal prenatal tobacco exposure and an increased risk of tobacco smoking in offspring, especially when exposed during the first trimester and both trimesters of pregnancy. There was insufficient statistical evidence for an association between paternal smoking during pregnancy and the risk of tobacco smoking in offspring.
ADDICTIVE BEHAVIORS
(2021)
Article
Environmental Sciences
Ariane Guilbert, Jonathan Y. Bernard, Hugo Peyre, Nathalie Costet, Ian Hough, Emie Seyve, Christine Monfort, Claire Philippat, Remy Slama, Itai Kloog, Cecile Chevrier, Barbara Heude, Franck Ramus, Johanna Lepeule
Summary: This study investigated the temporal relationship between pre- and postnatal exposure to PM10, PM2.5, NO2, and child cognitive function. The results showed that increased maternal exposure to these air pollutants during mid-pregnancy was associated with lower cognitive abilities in male children. Additionally, higher postnatal exposure to PM2.5 during the age of 3-4 years was also associated with lower cognitive abilities in males. These findings highlight the importance of understanding the impact of air pollution on child cognitive development and identifying sensitive periods.
ENVIRONMENTAL RESEARCH
(2023)
Article
Pediatrics
Bianca Arrhenius, Amir Sariaslan, Auli Suominen, Andre Sourander, David Gyllenberg
Summary: The study found that prenatal smoking was associated with speech and language, scholastic, coordination, and mixed developmental disorders in offspring, but this association may be confounded by familial factors shared by siblings, as the association was no longer significant when comparing siblings.
Article
Neurosciences
Xue Xu, Yong-Chang Li, Yan-Yan Wu, Yu-Cheng Xu, Rui-Xia Weng, Cai-Lin Wang, Ping-An Zhang, Ying Zhang, Guang-Yin Xu
Summary: The study indicates that miR-485 is involved in enterodynia in PMS offspring rats by regulating ASIC1, suggesting a potential therapeutic target for this condition.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Public, Environmental & Occupational Health
Bereket Duko, Amanuel Tesfay Gebremedhin, Gizachew Assefa Tessema, Rosa Alati, Gavin Pereira
Summary: This study examined the impact of maternal prenatal tobacco smoking on childhood developmental vulnerability. The findings showed that children exposed to maternal prenatal tobacco smoking were more likely to be classified as developmentally vulnerable/at-risk in various domains including physical health, social competence, emotional maturity, language and cognitive skills, and communication skills. The study highlights the importance of early intervention to quit tobacco smoking before pregnancy in reducing childhood developmental vulnerability.
ANNALS OF EPIDEMIOLOGY
(2023)
Article
Endocrinology & Metabolism
Jolanda C. Naafs, Jan Pieter Marchal, Eric Fliers, Paul H. Verkerk, Michiel A. J. Luijten, Anita Boelen, A. S. Paul van Trotsenburg, Nitash Zwaveling-Soonawala
Summary: Early treatment of central congenital hypothyroidism (CH) shows comparable cognitive and motor outcomes with siblings in patients with isolated central CH, while patients with multiple pituitary hormone deficiencies (MPHD) exhibit significantly lower full-scale intelligence quotient (FSIQ). Processing speed is lower in both patient groups compared to siblings, and motor difficulties are more prevalent in patients than in siblings.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Public, Environmental & Occupational Health
Marta Cosin-Tomas, Ariadna Cilleros-Portet, Sofia Aguilar-Lacasana, Nora Fernandez-Jimenez, Mariona Bustamante
Summary: Studies have shown that maternal smoking during pregnancy leads to changes in offspring's DNA methylation, with effects potentially lasting for years depending on the length and dosage of exposure. DNA methylation scores have been developed as biomarkers to estimate past exposure to maternal smoking during pregnancy.
CURRENT ENVIRONMENTAL HEALTH REPORTS
(2022)
Article
Medicine, General & Internal
Jingjia Liang, Zuqiang Fu, Qian Liu, Yuehong Shen, Xin Zhang, Zhenkun Weng, Jin Xu, Wenxiang Li, Cheng Xu, Yong Zhou, Aihua Gu
Summary: Maternal smoking and nonbreastfeeding are associated with an increased risk of hypertension in adulthood, but do not modify the offspring's genetic risk on hypertension. Nonmaternal smoking and breastfeeding are associated with a lower risk of hypertension in individuals with high genetic risk.
Article
Oncology
Emma Ulvskog, Linda Drevin, Erik K. Persson, Mats Lambe, Peter Kirrander, Johan Ahlgren
Summary: Penile cancer is a rare disease with poor prognosis when it spreads to multiple inguinal lymph nodes. This study in Sweden investigated the treatment and survival outcomes of men with metastatic penile cancer over a 15-year period. The use of oncological treatments with curative intent increased significantly during the study period, and survival was higher among men treated with curative intent.
Article
Oncology
Lukas Lofling, Shahram Bahmanyar, Helle Kieler, Mats Lambe, Gunnar Wagenius
Summary: The study investigated temporal trends in lung cancer survival in Sweden from 1995 to 2016, revealing an overall increase in survival rates for lung cancer patients, as well as improved survival in subgroups such as those with stage IV disease. There was also a decrease in excess mortality throughout the study period.
Editorial Material
Oncology
Linda Willen, Anders Berglund, Stefan Bergstrom, Johan Isaksson, Michael Bergqvist, Gunnar Wagenius, Mats Lambe
Article
Oncology
Linda Willen, Anders Berglund, Stefan Bergstrom, Johan Isaksson, Michael Bergqvist, Gunnar Wagenius, Mats Lambe
Summary: The study revealed that older patients with metastatic disease received treatment more readily than those with early stage disease. Significant differences were observed in cause-specific survival in early stage, but not late stage disease. This underscores the importance of individualized assessment of health status and life expectancy.
Article
Oncology
Anna L. Johansson, Siri Laronningen, Charlotte Wessel Skovlund, Marnar Frioheim Kristiansen, Lina Steinrud Morch, Soren Friis, Tom Borge Johannesen, Tor Age Myklebust, Anna Skog, David Pettersson, Helgi Birgisson, Anni Virtanen, Nea Malila, Janne Pitkaniemi, Tomas Tanskanen, Laufey Tryggvadottir, Giske Ursin, Mats Lambe
Summary: The severity of the COVID-19 pandemic and subsequent mitigation strategies have led to a decline in new cancer cases in the Nordic countries, with Sweden experiencing the most significant reduction. Possible explanations include the severity of the pandemic, temporary halting of screening activities, and changes in healthcare seeking behavior.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
Frida E. Lundberg, Helgi Birgisson, Tom B. Johannesen, Gerda Engholm, Anni Virtanen, David Pettersson, Elinborg J. Olafsdottir, Mats Lambe, Paul C. Lambert, Lina S. Morch, Anna L. Johansson, Therese M-L Andersson
Summary: The survival of patients with colon and rectal cancer has improved in all Nordic countries over the past decades. The study shows that the survival rate has improved for both men and women in all age groups. The largest improvement was observed in Danish men and women with rectal cancer. The probability of death and life-years lost varied across countries.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Oncology
Anna Ravn Landtblom, Therese M-L Andersson, Anna L. Johansson, Sophia Brismar Wendel, Frida E. Lundberg, Jan Samuelsson, Magnus Bjorkholm, Malin Hultcrantz
Summary: Pregnancy and childbirth in women with myeloproliferative neoplasms (MPN) are associated with increased risk of preterm birth and decreased risk of maternal complications compared to previous reports.
Article
Oncology
Anna Marklund, Tobias Lekberg, Elham Hedayati, Annelie Liljegren, Jonas Bergh, Frida E. Lundberg, Kenny A. Rodriguez-Wallberg
Summary: This study found that the use of hormonal stimulation during fertility preservation procedures did not increase the risk of relapse or disease-specific mortality in women with breast cancer.
Article
Oncology
Mate Szilcz, Jonas W. Wastesson, Lucas Morin, Amaia Calderon-Larranaga, Mats Lambe, Kristina Johnell
Summary: This study aimed to identify quality indicators of overtreatment at the end of life among older adults with solid cancer, finding that about one-third of decedents received potentially overtreatment during their last month of life.
Article
Oncology
Frida E. Lundberg, Niels Kroman, Mats Lambe, Therese M. -L. Andersson, Gerda Engholm, Tom Borge Johannesen, Anni Virtanen, David Pettersson, Elinborg J. Olafsdottir, Helgi Birgisson, Paul C. Lambert, Lina Steinrud Morch, Anna L. V. Johansson
Summary: The survival rates for Nordic women with breast cancer improved from 1990 to 2016 in all age groups, with larger country variations among older women where survival rates were lower. Women over the age of 70 have not seen the same level of survival improvement as younger women.
Article
Pediatrics
Kenny A. Rodriguez-Wallberg, Arturo Reyes Palomares, Hanna P. Nilsson, Anna Sara Oberg, Frida Lundberg
Summary: Pregnancies resulting from assisted reproductive technology have a higher risk of adverse perinatal outcomes compared to natural conception. This study aimed to compare the risk of adverse outcomes in singletons conceived through double-embryo transfer (DET) and single-embryo transfer (SET). The results indicate a higher risk of adverse outcomes in singletons born after DET, particularly when using frozen embryos and blastocysts.
Article
Obstetrics & Gynecology
Frida E. Lundberg, Leo Gkekos, Kenny A. Rodriguez-Wallberg, Irma Fredriksson, Anna L. V. Johansson
Summary: Breast cancer diagnosed during pregnancy increases the risks of preterm birth and low birthweight, but is not associated with other maternal pregnancy complications or adverse outcomes in children.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Oncology
Gerda Engholm, Frida E. Lundberg, Simon M. Konig, Elinborg Olafsdottir, Tom B. Johannesen, David Pettersson, Lina S. Morch, Anna L. V. Johansson, Soren Friis
Summary: This study aimed to evaluate the influence of assuming missing N and M as N0 and M0 on available TNM stage, stage distribution, and stage-specific relative survival in cancer patients. The results showed that assuming N0M0 for missing N and M had minor effects on stage-specific one-year relative survival, especially for high completeness of TNM registrations. Therefore, while complete TNM information is preferred, assuming N0M0 for missing N and M may be reasonable in future studies based on Nordic cancer registries. Rating: 8/10
Meeting Abstract
Obstetrics & Gynecology
A. Marklund, F. E. Lundberg, K. A. Rodriguez-Wallberg
HUMAN REPRODUCTION
(2022)
Article
Oncology
Anna Marklund, Tobias Lekberg, Elham Hedayati, Annelie Liljegren, Jonas Bergh, Frida E. Lundberg, Kenny A. Rodriguez-Wallberg
Summary: The study found that undergoing fertility preservation with or without hormonal stimulation at the time of breast cancer diagnosis did not increase the risk of relapse or disease-specific mortality. This provides important evidence on the safety of fertility preservation procedures in women with breast cancer and may impact healthcare practices for young women with breast cancer who wish to preserve their fertility.