Article
Chemistry, Inorganic & Nuclear
Iwona Ufnalska, Simon C. Drew, Igor Zhukov, Kosma Szutkowski, Urszula E. Wawrzyniak, Wojciech Wroblewski, Tomasz Fraczyk, Wojciech Bal
Summary: GHK is a tripeptide with biological functions attributed to its copper-complexed form Cu(II)GHK, but little is known about its molecular mechanism of action. This study investigates the reaction of Cu(II)GHK with the strongest reductant in human plasma, GSH, using spectroscopic techniques and cyclic voltammetry to reveal important reaction intermediates. The findings suggest that the GSH-Cu(II)GHK complex may play a crucial role in copper trafficking as a precursor of Cu(I) ions.
INORGANIC CHEMISTRY
(2021)
Review
Neurosciences
Menglong Jin, Shi-Qing Cai
Summary: This article reviews recent advances in understanding the mechanisms underlying brain aging, comparing normal and pathological conditions and their associations with cognitive impairment. The causative and adaptive mechanisms of brain aging are discussed, aiming to provide guidelines for promoting healthy aging and preventing age-related diseases.
NEUROSCIENCE BULLETIN
(2023)
Review
Biochemistry & Molecular Biology
Hirofumi Kiyokawa, Yuma Hoshino, Kazuhiro Sakaguchi, Shigeo Muro, Junji Yodoi
Summary: Epithelial cells in the respiratory system are directly exposed to exogenous ROS, increasing the risk of oxidative stress; Dysfunction of redox regulation due to cellular aging accelerates COPD pathogenesis; Drugs targeting oxidative stress pathways can help precisely regulate the redox system.
Review
Biochemistry & Molecular Biology
David C. Geary
Summary: Cognitive abilities, brain networks, and mitochondrial energy production are interconnected, playing important roles in health and aging. Integrating cognitive science and cell biology research can lead to more sensitive measures of age- and disease-related declines in cognition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Neurosciences
Federico Gallo, Vincent DeLuca, Yanina Prystauka, Toms Voits, Jason Rothman, Jubin Abutalebi
Summary: Due to advances in healthcare, global life expectancy is increasing steadily. This can, however, result in a higher incidence of age-related diseases like dementia. Research has found that healthy lifestyle factors such as a nutritious diet, physical exercise, and occupational achievement can positively influence cognitive aging. This article critically reviews the neuroscientific evidence for another potential factor - bilingualism - and highlights its importance in understanding cognitive aging trajectories and its socio-economic impact.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Renata Szabo, Zsuzsanna Szabo, Denise Boerzsei, Alexandra Hoffmann, Zelma Nadin Lesi, Patricia Palszabo, Andrea Palszabo, Szabolcs Dvoracsko, Rudolf Gesztelyi, Krisztina Kupai, Daniel Priksz, Bela Juhasz, Anita Altmayer, Csaba Varga, Aniko Posa
Summary: This study aimed to investigate the effects of the endocannabinoid system on cardiac inflammation and oxidative damage. The results showed that the CB1 receptor blocker rimonabant can improve the pathological features of aging heart by enhancing antioxidant defense mechanisms and alleviating inflammatory response.
Review
Geriatrics & Gerontology
Mani Raj Chaudhary, Sakshi Chaudhary, Yogita Sharma, Thokchom Arjun Singh, Alok Kumar Mishra, Shweta Sharma, Mohammad Murtaza Mehdi
Summary: Aging is a complex biological process involving multiple factors such as genetics, environment, and lifestyle, and is accompanied by age-related complications. Oxidative stress, caused by an abundance of reactive oxygen species (ROS), plays a major role in this process. Oxidative stress affects the endoplasmic reticulum (ER) and mitochondria, leading to proteopathies, mitochondrial dysfunction, abnormal cellular senescence, and ultimately inflammaging. Abnormal metabolic pathways and chronic inflammation contribute to the development of degenerative diseases. Various interventions, such as calorie restriction, intermittent fasting, and exercise, have shown beneficial effects in counteracting the aging process. Additionally, targeting senescent cells and activating sirtuins can enhance mechanisms like autophagy and biogenesis to maintain homeostasis.
Article
Clinical Neurology
Sylvie Belleville, Simon Cloutier, Samira Mellah, Sherry Willis, Bruno Vellas, Sandrine Andrieu, Nicola Coley, Tiia Ngandu
Summary: This study examines the dose-response relationship in multidomain interventions for dementia prevention and finds that the optimal dose is about half of the potentially available sessions. Factors such as gender, age, frailty, education level, and dementia risk influence individuals' response to the dose.
ALZHEIMERS & DEMENTIA
(2022)
Article
Neurosciences
Julia Maria Falkenreck, Michelle Celine Kunkler, Anja Ophey, Hannah Weigert, Andrea Friese, Petra Jahr, Gereon Nelles, Elke Kalbe, M. Cristina Polidori
Summary: This study compared the short-term effects of multicomponent cognitive training with general health counseling on cognitive abilities and health-related quality of life in healthy adults. The results showed that multicomponent cognitive training did not have a significant impact on overall cognition, but there were improvements in some cognitive subtests and quality of life measures that were clinically meaningful.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Review
Food Science & Technology
Min Wu, Qingying Luo, Rongxuan Nie, Xingpan Yang, Zizhong Tang, Hong Chen
Summary: Polyphenols, as natural compounds derived from plants, have attracted increasing scientific interest for their potential anti-aging benefits in modulating oxidative damage, inflammation, autophagy, and gut microbiota. Research on novel polyphenol-based strategies and clinical trials are encouraged for the development of holistic anti-aging therapy.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Yuyu Zhang, Julia Jelleschitz, Tilman Grune, Weixuan Chen, Yihang Zhao, Mengzhen Jia, Yajie Wang, Zhigang Liu, Annika Hoehn
Summary: Methionine restriction (MR) is a dietary intervention that has been shown to improve aging-related health conditions and diseases, and potentially prolong lifespan. MR appears to be associated with a reduction in oxidative stress and may be one of the underlying mechanisms for lifespan extension and beneficial health effects.
Article
Biochemistry & Molecular Biology
Jae-Min Lee, Joo Hee Lee, Min Kyung Song, Youn-Jung Kim
Summary: Aging is a neurodegenerative disease that leads to cognitive impairment, primarily due to increased oxidative stress. We developed NXP032, a complex of vitamin C and DNA aptamer, to enhance the antioxidant effectiveness of vitamin C. In a study on female mice, NXP032 administration alleviated cognitive impairment, neuronal damage, microglia activity, and oxidative stress caused by aging. NXP032 also activated the Nrf2-ARE pathway, suggesting its potential as a therapeutic intervention for aging-induced cognitive impairment and oxidative stress.
Article
Geriatrics & Gerontology
Sarah T. Stahl, Helene M. Altmann, Mary Amanda Dew, Steven M. Albert, Meryl Butters, Ariel Gildengers, Charles F. Reynolds, Jordan F. Karp
Summary: Evaluating both gait and psychomotor speed in older adults with medical comorbidities and sub-syndromal depression may predict incident mental illness and inform prevention planning. Further research is needed to validate these findings and explore shared neurobiological mechanisms that explain the increased risk.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Article
Cell Biology
Guilherme H. Tamarindo, Marina G. Gobbo, Sebastiao R. Taboga, Eduardo A. Almeida, Rejane M. Goes
Summary: Long-term high-fat diet can cause prostate damage in aging rats, while melatonin supplementation can alleviate the damage to some extent.
CELL BIOLOGY INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Wagner Antonio Tamagno, Wallace Santini, Carla Alves, Ana Paula Vanin, Aline Pompermaier, Denise Bilibio, Nathalia Tafarel Sutorillo, Rosilene Rodrigues Kaizer, Leonardo Jose Gil Barcellos
Summary: The harmful effects of heavy metals on organisms, especially the relationship between neurodegenerative diseases and copper toxicity, have not been fully understood. This study evaluated the effect of H. undatus on zebrafish organisms exposed to copper-induced toxicity and found that it had a protective effect on the behavior and physiological markers of the fish. This research suggests that pitaya could potentially improve senile aging.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)