Article
Chemistry, Medicinal
Yongpeng Zhang, Fei Luo, Haixia Zhang, Wei He, Ting Liu, Yue Wu, Lei Zhang, Gang Shi
Summary: The study showed that pretreatment with Cryptotanshinone could dose-dependently restore the cardiac dysfunction, cardiac injury, activation of platelets and endothelium, cardiomyocyte apoptosis, and oxidative stress induced by CME surgery. The NF-kappa B signaling pathway was involved in both the development of CME and the preventive effects of Cryptotanshinone. Cryptotanshinone may serve as a potential and promising candidate drug to prevent the occurrence of CME.
DRUG DEVELOPMENT RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Yunzhao Yang, Zhongyuan Xia, Cheng Xu, Chunchun Zhai, Xi Yu, Siqi Li
Summary: Ciprofol protects the heart against ISO-induced myocardial infarction by reducing cardiac oxidative stress, the inflammatory response, and cardiomyocyte apoptosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yu-Ting Wu, Ling-Peng Xie, Yue Hua, Hong-Lin Xu, Guang-Hong Chen, Xin Han, Zhang-Bin Tan, Hui-Jie Fan, Hong-Mei Chen, Jun Li, Bin Liu, Ying-Chun Zhou
Summary: Tanshinone I (Tan I) protects cardiomyocytes against oxidative stress-induced injury by activating the Nrf2 signaling pathway, suggesting its potential therapeutic application for oxidative stress-induced cardiovascular diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Anatomy & Morphology
Jeroen Aeles, Bart Bolsterlee, Nicole Y. Kelp, Taylor J. M. Dick, Francois Hug
Summary: This study developed an approach to quantify muscle fibre lengths in different muscle regions using diffusion tensor imaging and MRI. The research found substantial variability in fibre lengths between different regions within the same muscle and across individuals, supporting the use of subject-specific measurements when evaluating muscle function. The study also did not find significant differences in muscle fibre lengths between sexes, age groups, and muscles at the group level.
JOURNAL OF ANATOMY
(2022)
Article
Biochemistry & Molecular Biology
Peipei Zhang, Hao Lu, Yuan Wu, Danbo Lu, Chenguang Li, Xiangdong Yang, Zhangwei Chen, Juying Qian, Junbo Ge
Summary: Doxorubicin (DOX) can lead to mitochondrial dysfunction and heart failure. COX5A, an important regulator of mitochondrial energy metabolism, plays a protective role in DOX-induced cardiomyopathy. The expression of COX5A is decreased in patients with dilated cardiomyopathy and after DOX treatment. Overexpression of COX5A improves cardiac function, glucose uptake, mitochondrial morphology, COX activity, and ATP content in DOX-stimulated mice. COX5A protects against oxidative stress, mitochondrial dysfunction, and cardiomyocyte apoptosis via the PI3K/Akt signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Toru Miyoshi, Kazufumi Nakamura, Naofumi Amioka, Omer F. Hatipoglu, Tomoko Yonezawa, Yukihiro Saito, Masashi Yoshida, Satoshi Akagi, Hiroshi Ito
Summary: LCZ696 ameliorated DOX-induced cardiotoxicity in rat hearts in vivo and in vitro, possibly by mediating a decrease in oxidative stress.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Patrick Mordel, Fanny Fontaine, Quentin Dupas, Michael Joubert, Stephane Allouche
Summary: This study evaluated the impact of glucose swings on mitochondrial functions in HL-1 cardiomyocytes and found that such swings can lead to time-dependent mitochondrial dysfunctions, potentially contributing to diabetic cardiomyopathy in patients with diabetes.
Article
Pharmacology & Pharmacy
Shuang Chen, You Li, Shuai Fu, Yang Li, Chao Wang, Ping Sun, Hairu Li, Jiawei Tian, Guo-Qing Du
Summary: High levels of AVP induce cardiomyoblast apoptosis and mitochondrial dysfunction, while melatonin can reduce apoptosis and enhance antioxidative responses through the Mst1-Nrf2 pathway re-activation.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yunfei Deng, Xiaochen Zeng, Yifei Lv, Zhiyuan Qian, Peijie Guo, Yi Liu, Shaoliang Chen
Summary: A circular RNA molecule, circCDYL2, and its protein product, Cdyl2-60aa, are significantly increased in rat heart muscle cells after myocardial infarction, promoting the death of heart muscle cells. Cdyl2-60aa enhances the stability of apoptotic protease activating factor-1 (APAF1) by blocking its ubiquitination by heat shock protein 70 (HSP70).
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Article
Meteorology & Atmospheric Sciences
Shubhi Agrawal, Craig R. Ferguson, Lance Bosart, D. Alex Burrows
Summary: A spectral analysis and objective dynamical jet classification framework were used to investigate the interannual variability of Great Plains 850-hPa winds during the warm season, with a peak in May potentially influenced by teleconnections. Differentiating between jet types revealed significant differences in precipitation and wind intensity in the U.S. south-central plains, with distinct planetary-scale Rossby wave patterns indicating underlying teleconnections. These large-scale teleconnections impact LLJ class frequency and intensity through upper-level geopotential anomalies, modulating near-surface geopotential and temperature gradients.
JOURNAL OF CLIMATE
(2021)
Article
Environmental Sciences
Gobichettipalayam Balasubramaniam Maadurshni, Ganeshmurthy Kanniamal Tharani, Inbamani Udayakumar, Manigandan Nagarajan, Jeganathan Manivannan
Summary: Recent evidences have shown that the release of aluminum oxide nanoparticles (Al2O3-NPs) may pose a risk to the environment and cause adverse effects on living organisms. This study investigated the hepatotoxic effects of Al2O3-NPs on developing chicken embryos and cell cultures. The results revealed that exposure to Al2O3-NPs caused abnormal liver histology, increased tissue damage markers, oxidative stress, impaired antioxidant enzyme function, abnormal red blood cell morphology, and enhanced apoptosis. Additionally, novel mechanisms and prevention strategies were explored.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Agriculture, Multidisciplinary
Xixi Wang, Tong Xu, Dongliu Luo, Shanshan Li, Xinyu Tang, Jiayi Ding, Hang Yin, Shu Li
Summary: It has been found that PFOS causes cardiac toxicity and CBD can attenuate the PFOS-induced heart injury, providing a novel cardioprotective strategy.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Fatma H. Shaker, Marwa O. El-Derany, Sara A. Wahdan, Ebtehal El-Demerdash, Hala O. El-Mesallamy
Summary: The study demonstrated that BBR has a significant neuroprotective effect against DOX-induced cognitive impairment, improving behavioral defects and reversing histopathological abnormalities. Mechanistically, BBR modulated neuroinflammation, anti-oxidative defense, and synaptic plasticity, highlighting its potential as a therapeutic agent for cognitive decline in cancer survivors undergoing DOX-based chemotherapy.
Article
Environmental Sciences
Hend Mohamed Hussien, Mokhtar Ibrahim Yousef
Summary: This study aimed to investigate the neuroprotective effect of ginseng extract against neurological and behavior abnormalities induced by cisplatin. The results showed that ginseng extract could alleviate the memory dysfunction and locomotor disability induced by cisplatin.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Cell Biology
Yong Li, Xiaoguang Wu, Yukang Mao, Chi Liu, Yiting Wu, Junzhe Tang, Kun Zhao, Peng Li
Summary: The study revealed that a high-salt diet could cause cardiac damage independent of blood pressure, and supplementation of exogenous nitric oxide could alleviate the high salt-induced apoptosis and autophagy in cardiomyocytes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Umar Nishan, Danilo M. Damas-Souza, Guilherme Oliveira Barbosa, Nawshad Muhammad, Abdur Rahim, Hernandes F. Carvalho
Article
Biology
Jennifer Wendy Curry, Rodrigo Hohl, Timothy David Noakes, Tertius Abraham Kohn
JOURNAL OF EXPERIMENTAL BIOLOGY
(2012)
Article
Chemistry, Analytical
L. Kovacs, C. B. Zamboni, L. A. S. Nunes, T. F. Lourenco, D. V. Macedo
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
(2013)
Article
Cell Biology
Bernardo Neme Ide, Lazaro Alessandro Soares Nunes, Rene Brenzikofer, Denise Vaz Macedo
MEDIATORS OF INFLAMMATION
(2013)
Meeting Abstract
Sport Sciences
Eduardo B. Fontes, Alexandre H. Okano, Gabriela K. Gastanho, Helio Yoshida, Brunno Campos, Elske Schabort, Rodrigo Hohl, Timothy D. Noakes, Li Min Li
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2014)
Article
Biotechnology & Applied Microbiology
Lazaro Alessandro Soares Nunes, Helena Zerlotti W. Grotto, Rene Brenzikofer, Denise Vaz Macedo
BIOMED RESEARCH INTERNATIONAL
(2014)
Article
Physiology
Taisa Belli, Denise Vaz Macedo, Gustavo Gomes de Araujo, Ivan Gustavo Masselli dos Reis, Pedro Paulo Menezes Scariot, Fernanda Lorenzi Lazarim, Lazaro Alessandro Soares Nunes, Rene Brenzikofer, Claudio Alexandre Gobatto
FRONTIERS IN PHYSIOLOGY
(2018)
Article
Psychology, Biological
Fabien A. Basset, Liam P. Kelly, Rodrigo Hohl, Navin Kaushal
Summary: The study shows that negative self-talk can lead to higher respiratory rate, perceived exertion, and salivary cortisol levels, indicating that self-talk can affect both psychological and physiological responses.
Review
Physiology
Moacir Marocolo, Rodrigo Hohl, Rhai Andre Arriel, Gustavo R. Mota
Summary: The effects of ischemic preconditioning (IPC) on exercise performance are complex and vary depending on the type of exercise, protocols, and participants' training status. Comparisons between IPC and sham/control interventions have resulted in controversial findings. This review aims to explore the potential mechanisms underlying the effects of IPC and sham interventions on exercise performance, including sensorimotor pathways, hemodynamic and metabolic changes. Overall, bidirectional body-brain integration and hemodynamic responses may contribute to the improvements in performance seen following both IPC and sham interventions.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Sport Sciences
Bernardo Neme Ide, Tacito P. Souza-Junior, Steven R. McAnulty, Mariana A. C. de Faria, Karina A. Costa, Lazaro A. S. Nunes
JOURNAL OF HUMAN KINETICS
(2019)
Article
Nursing
Rodrigo Hohl, Andrea Camaz Deslandes, Claudia Helena Cerqueira Marmora
JOURNAL OF HOLISTIC NURSING
(2019)
Article
Public, Environmental & Occupational Health
Taisa Belli, Denise V. de Macedo, Pedro P. M. Scariot, Gustavo G. de Araujo, Ivan G. M. dos Reis, Fernanda L. Lazarim, Lazaro A. S. Nunes, Rene Brenzikofer, Claudio A. Gobatto
WILDERNESS & ENVIRONMENTAL MEDICINE
(2017)
Meeting Abstract
Hematology
Leticia Molina, Anderson Silva, Giselia Lima, Lazaro Nunes
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2016)
Proceedings Paper
Physics, Nuclear
L. Kovacs, C. B. Zamboni, S. Metairon, L. A. S. Nunes, T. F. Lourenco, D. V. Macedo
XXXV BRAZILIAN WORKSHOP ON NUCLEAR PHYSICS
(2013)
Review
Medical Laboratory Technology
Lazaro Alessandro Soares Nunes, Sayeeda Mussavira, Omana Sukumaran Bindhu