Review
Cell Biology
Ji Young Cecilia Park, Aaron King, Victor Bjork, Bradley W. English, Alexander Fedintsev, Collin Y. Ewald
Summary: The extracellular matrix (ECM), an important component of the human body, undergoes changes with age that can lead to age-related diseases and mortality. Despite its significance, ECM aging is understudied in the field of geroscience. This review discusses the concept of ECM integrity, age-related challenges and pathologies, diagnostic methods, and strategies for maintaining ECM homeostasis, providing a framework for future research on interventions to restore ECM integrity and promote healthy aging.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Dan Liu, Yuezhen Ouyang, Ruoxin Chen, Mingfu Wang, Chao Ai, Hesham R. El-Seedi, Md Moklesur Rahman Sarker, Xinhua Chen, Chao Zhao
Summary: Various theories are constantly proposed to explain the mechanisms of aging, including oxidative stress, DNA dysfunction, inflammation, etc., which lead to the development of various diseases. Ulva polysaccharides have emerged as desirable materials for maintaining health due to their special structures and multiple functions.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Cell Biology
Rebecca L. McIntyre, Yasmine J. Liu, Man Hu, Brian J. Morris, Bradley J. Willcox, Timothy A. Donlon, Riekelt H. Houtkooper, Georges E. Janssens
Summary: Life expectancy has increased significantly in the past 150 years, but this also means that most people now experience a longer period of suffering from age-related diseases. Delaying age-related decline and extending the period of healthspan has become a major goal in aging research. Geroprotectors, compounds that target aging pathways, are recognized as a way to extend healthspan. FOXO3 has emerged as a gene involved in aging and healthspan, with its variants linked to longevity and reduced disease risks. This study reviews compounds that activate FOXO3 or influence healthspan and lifespan in a FOXO3-dependent manner, providing a basis for further research on promoting healthy longevity in humans.
AGEING RESEARCH REVIEWS
(2022)
Review
Green & Sustainable Science & Technology
Majed M. Alruwaili, Mostafa Shaban, Osama Mohamed Elsayed Ramadan
Summary: Digital health technologies have the potential to promote healthy aging through enhanced access, monitoring, and self-care. However, thoughtful implementation strategies tailored to user needs and capacities are necessary to achieve equitable benefits. More efficacy research and studies on real-world integration and ethics are needed.
Review
Cell Biology
Sabrina Donati Zeppa, Deborah Agostini, Fabio Ferrini, Marco Gervasi, Elena Barbieri, Alessia Bartolacci, Giovanni Piccoli, Roberta Saltarelli, Piero Sestili, Vilberto Stocchi
Summary: In recent years, improvements in health and social conditions have resulted in increased average lifespan. Aging is the most significant risk factor for chronic diseases, making it crucial to develop therapies and interventions to improve the quality of life of the elderly by targeting age-related illnesses.
Article
Geriatrics & Gerontology
John A. Batsis, Kathryn Daniel, Elizabeth Eckstrom, Kady Goldlist, Halina Kusz, Douglas Lane, Julia Loewenthal, Patrick P. Coll, Susan M. Friedman
Summary: The COVID-19 pandemic has significantly impacted older adults, affecting their healthy aging. This article aims to address the challenges faced by older adults during the pandemic, provide guidance to geriatrics healthcare professionals, and offer strategies to enhance healthy aging in the era of COVID-19.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Review
Geriatrics & Gerontology
Andrew Murphy, Sagar Vyavahare, Sandeep Kumar, Tae Jin Lee, Ashok Sharma, Satish Adusumilli, Mark Hamrick, Carlos M. Isales, Sadanand Fulzele
Summary: This study summarizes the research on age-associated diseases and the efforts to extend a healthy lifespan. It discusses the positive effects of dietary protocols such as caloric restriction and protein restriction on human longevity. The study also analyzes the impacts of these protocols on bone and muscle biology, identifying new genes and signaling pathways involved in musculoskeletal tissue.
Review
Cell Biology
Mengdi Yu, Hongxia Zhang, Brian Wang, Yinuo Zhang, Xiaoying Zheng, Bei Shao, Qichuan Zhuge, Kunlin Jin
Summary: Aging is a fundamental biological process with declines in tissue function, leading to cognitive impairment and other age-related diseases. Understanding the mechanisms regulating aging is critical for promoting healthy aging and combating age-related diseases, with a focus on pathways such as AMPK, SIRT1, and mTOR.
Article
Medicine, General & Internal
Frank B. Hu
Summary: In recent years, global life expectancies have increased significantly, but there has also been a rise in chronic diseases and population aging. This narrative review summarizes recent research findings on the influence of dietary factors on chronic diseases and longevity. Maintaining a healthy weight, the type of dietary fat, protein, and carbohydrates, certain traditional and contemporary dietary patterns, and combining a healthy diet with other lifestyle factors are all associated with lower chronic disease risk and longer lifespan.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Cell Biology
Jiatong Li, Jagadish K. Chhetri, Lina Ma
Summary: Physical resilience is a dynamic concept related to physiological response to stressors, influenced by age, genetics, diseases, as well as psychological, social, and environmental factors. Current research focuses on models and clinical assessment, aiming to improve treatment decisions, personalized diagnosis, disease management, and prevention strategies.
AGEING RESEARCH REVIEWS
(2022)
Article
Biology
Yi Deng, Keming Zhang, Jiali Zhu, Xiaofeng Hu, Rui Liao
Summary: With the global intensification of population aging, the health problems of the elderly have become a major concern. Functional disability, including geriatric syndromes and associated diseases such as frailty, is a prominent issue affecting the quality of life in older individuals. Frailty, as a reversible geriatric syndrome, has gained attention worldwide and requires early screening and interventions to restore independence and reduce incidence. However, there is currently no standardized frailty screening process, but many countries have focused on nutrition, physical activity, and social participation for early detection and prevention of frailty.
Article
Gerontology
Shiyu Lu, Cheryl Chui, Terry Lum
Summary: This article provides a comprehensive theoretical framework for promoting social capital for healthy aging, using timebanking as a case example. The framework includes facilitating emotional meaningfulness through social participation for older adults, incorporating them as co-producers in community development, and nurturing an inclusive and equitable society.
Review
Nutrition & Dietetics
Monika Fekete, Zsofia Szarvas, Vince Fazekas-Pongor, Agnes Feher, Tamas Csipo, Judit Forrai, Norbert Dosa, Anna Peterfi, Andrea Lehoczki, Stefano Tarantini, Janos Tamas Varga
Summary: An increasing number of studies suggest that diet plays an important role in regulating aging processes and modulates the development of age-related diseases. Certain diets with anti-aging action can slow down or prevent the development of cardiovascular and cerebrovascular diseases, neurodegenerative diseases, cognitive impairment, and dementia. The Mediterranean diet, incorporating fasting elements, may play a significant role in healthy aging.
Review
Chemistry, Medicinal
Mudan Cai, Hee Ra Park, Eun Jin Yang
Summary: Post-traumatic stress disorder (PTSD) is characterized by overwhelming fear and anxiety after exposure to traumatic events. Disturbances in the hypothalamic-pituitary-adrenal (HPA) axis play a role in the development of mood disorders, including anxiety, PTSD, and major depressive disorders. The HPA axis regulates the immune system, fear memory, and neurotransmission. Currently, selective serotonin reuptake inhibitors (SSRIs) are the only approved drugs for PTSD treatment. However, SSRIs have limitations in terms of treatment duration and response rates, necessitating additional pharmacological interventions. Complementary and alternative medicine therapies can ameliorate HPA axis disturbances by regulating gut dysbiosis, insomnia, chronic stress, and depression.
Review
Cell Biology
Yuan Li, Laura Berliocchi, Zhiquan Li, Lene Juel Rasmussen
Summary: Current research on human aging has been guided by the hallmarks of aging proposed in 2013. Most studies have focused on individual hallmarks, but recent research has explored the complex interactions between multiple hallmarks and their effects over time. Understanding these interconnections will greatly benefit aging research and the development of effective interventions for promoting healthy aging.
Article
Geriatrics & Gerontology
Hong Guo, Min Cao, Sige Zou, Boping Ye, Yuqing Dong
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2016)
Article
Oncology
Xiaoxia Wang, Min Cao, Yuqing Dong
Article
Chemistry, Applied
Rui Xiao, Xi Yang, Mi Li, Xiang Li, Yanzhang Wei, Min Cao, Arthur Ragauskas, Mark Thies, Junhuan Ding, Yi Zheng
CARBOHYDRATE POLYMERS
(2018)
Article
Geriatrics & Gerontology
Sujay Guha, Min Cao, Ryan M. Kane, Anthony M. Savino, Sige Zou, Yuqing Dong
Article
Microbiology
Sujay Guha, Miranda Klees, Xiaoxia Wang, Jing Li, Yuqing Dong, Min Cao
ARCHIVES OF MICROBIOLOGY
(2013)
Article
Immunology
Francis Alonzo, Gary C. Port, Min Cao, Nancy E. Freitag
INFECTION AND IMMUNITY
(2009)
Article
Geriatrics & Gerontology
Xiaoxia Wang, Lauren F. Cook, Lindsay M. Grasso, Min Cao, Yuqing Dong
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2015)
Article
Multidisciplinary Sciences
Jessica Dinh, Joseph T. Angeloni, Daniel B. Pederson, Xiaoxia Wang, Min Cao, Yuqing Dong
Review
Nutrition & Dietetics
Sujay Guha, Ojas Natarajan, Cole G. Murbach, Jessica Dinh, Ethan C. Wilson, Min Cao, Sige Zou, Yuqing Dong
Article
Multidisciplinary Sciences
Daniel B. Pederson, Yuqing Dong, Levi B. Blue, Sara Smith, Min Cao
Article
Chemistry, Medicinal
Ojas Natarajan, Joseph T. Angeloni, Maxime F. Bilodeau, Kyle E. Russi, Yuqing Dong, Min Cao
Summary: The supplementation of royal jelly can protect C. elegans from Staphylococcus aureus infection and modulate innate immunity pathways like IIS/DAF-16, p38 MAPK, and Wnt, leading to prolonged survival time to bacterial infections in aged worms.
JOURNAL OF MEDICINAL FOOD
(2021)
Article
Biology
Joseph Angeloni, Yuqing Dong, Zeneng Wang, Min Cao
COMMUNICATIONS BIOLOGY
(2020)
Article
Biotechnology & Applied Microbiology
Min Cao, Alan Pavinski Bitar, Helene Marquis
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2007)
Article
Microbiology
Alan Pavinski Bitar, Min Cao, Helene Marquis
JOURNAL OF BACTERIOLOGY
(2008)